Abstract：
OBJECTIVE:To determine the levels of postacrosomal WW binding protein (PAWP) in the spermatozoa of men that were used clinically for intracytoplasmic sperm injection (ICSI) and to correlate them with infertility treatment outcomes. DESIGN:Prospective clinical and laboratory study. SETTING:University-based laboratory and infertility clinic. PATIENT(S):Men undergoing ICSI for the treatment of couples' infertility (n=110). INTERVENTION(S):Quantitative analysis of sperm PAWP levels by flow cytometry and developmental analysis of PAWP expression by immunoblotting, immunofluorescence, and immunohistochemistry. MAIN OUTCOME MEASURE(S):PAWP flow-cytometric levels and immunolocalization in spermatozoa. RESULT(S):A strong positive correlation was found between PAWP expression levels and fertilization rates after ICSI, with high levels of PAWP being associated with higher fertilization rates; the positive correlation was independent of age, DNA fragmentation index, and other sperm parameters. PAWP expression levels were correlated with embryonic development, with high levels of PAWP being associated with a lower number of arrested embryos within 3-5 days post-ICSI. PAWP expression was detected during the late stages of human spermiogenesis in elongating spermatids, confirming previous findings in various animal models. CONCLUSION(S):Our clinical data from infertile couples demonstrate significant correlations between sperm PAWP levels and both fertilization rates and normal embryonic development after ICSI. Considering its proposed role in the initiation of oocyte activation, we suggest that PAWP could have potential applications in the diagnosis and treatment of infertility.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Aarabi M,Balakier H,Bashar S,Moskovtsev SI,Sutovsky P,Librach CL,Oko Rdoi
10.1016/j.fertnstert.2014.05.003subject
Has Abstractpub_date
2014-08-01 00:00:00pages
440-7issue
2eissn
0015-0282issn
1556-5653pii
S0015-0282(14)00415-4journal_volume
102pub_type
杂志文章abstract：OBJECTIVE:To examine the relationship between an antibody against GAPDH-2, a sperm-specific protein, and infertility of female mice. DESIGN:Basic research. SETTING:National Research Institute for Family Planning Beijing, World Health Organization Collaboration Center of Human Reproduction. ANIMAL(S):New Zealand rabb...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.09.001
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVE:To present an unusual side effect of therapy for adolescent menorrhagia, with commentary on management options. DESIGN:Case report. SETTING:Tertiary gynecologic center. PATIENT(S):A 13-year-old girl presenting with profuse uterine bleeding. INTERVENTION(S):Dysfunctional uterine bleeding was diagnosed, and...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.07.997
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:To compare the expression of the prostaglandin (PG) E(2) transporter multidrug resistance-associated protein 4 (MRP4) in eutopic and ectopic endometrial tissue from endometriosis patients with that of control subjects and to examine whether MRP4 is regulated by the antiinflammatory lipid lipoxin A(4) (LXA(4))...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.01.146
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:To review the effectiveness of rectal probe electroejaculation in terms of pregnancy in treatment of anejaculatory males due to spinal cord injury. The characteristics of electroejaculates also are examined. DATA IDENTIFICATION:All English language studies reporting pregnancies as a result of electroejaculat...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：
更新日期：1995-07-01 00:00:00
abstract：OBJECTIVE:To identify aldosterone and precursors in ovarian follicles and to relate levels of mineralocorticoids to previously described renin-angiotensin system follicular fluid content. DESIGN:Experimental. SETTING:Academic laboratory and affiliated large private practice. PATIENT(S):Women undergoing oocyte retrie...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.06.028
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVE:To determine which protocols work better between cetrorelix and long protocols in older patients in a randomized controlled study. DESIGN:A controlled randomized study in a single private IVF center. SETTING:Infertile women referred to a private IVF center. PATIENT(S):Five hundred sixty-four women 40 years...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2008.02.165
更新日期：2009-05-01 00:00:00
abstract：:The transcervical division of uterine septa is usually described as a simple procedure associated with minimal morbidity. Two cases are presented describing late hemorrhage after this procedure. Approaches to avoiding this complication as well as management principles are described. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54984-x
更新日期：1992-04-01 00:00:00
abstract：OBJECTIVE:To determine the aneuploidy rate in embryos of women with idiopathic recurrent miscarriages and to evaluate whether preimplantation genetic diagnosis for aneuploidy screening could be a feasible approach to improve the possibility of successful pregnancy in these couples. DESIGN:Prospective cohort study. SE...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.06.071
更新日期：2005-02-01 00:00:00
abstract：OBJECTIVE:To determine whether the presence of a Y microdeletion confers any adverse effects on in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) outcome. DESIGN:Retrospective case-control study. SETTING:Academic infertility center. PATIENT(S):A total of 17 patients with Y microdeletions who atte...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2003.06.030
更新日期：2004-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the plasma asymmetric dimethyl arginine (ADMA) levels and carotid intima-media thickness (IMT) in patients with polycystic ovary syndrome (PCOS). DESIGN:Prospective study. SETTING:University medical center. PATIENT(S):Thirty-five patients with PCOS and 31 healthy controls. INTERVENTION(S):Peri...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.10.073
更新日期：2010-03-01 00:00:00
abstract：:There was no difference in the density of nerve fibers across the menstrual cycle in peritoneal endometriotic lesions. These findings may explain why patients with peritoneal endometriosis often have painful symptoms throughout the menstrual cycle. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.01.150
更新日期：2011-06-30 00:00:00
abstract：OBJECTIVE:To compare buoyant density and sedimentation kinetics of human immunodeficiency virus 1 (HIV-1) in two sperm-washing media, Percoll and Pureception. DESIGN:Laboratory study. SETTING:University hospital. PATIENT(S):None. INTERVENTION(S):Buoyant density and sedimentation kinetics of HIV-1 particles (MOLT-4/...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.09.025
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVE:Analysis of sperm heads using three different computer morphometrical tools and experimental conditions to find a more reliable and secure strategy among them. DESIGN:Controlled experiments on sperm morphology analysis from volunteers. SETTING:Laboratory of microscopy and imaging processing. PATIENT(S):Ten...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(03)00978-6
更新日期：2003-09-01 00:00:00
abstract：:In the early years of in vitro fertilization, overall pregnancy rates were low, and it was considered necessary to transfer more than one embryo to increase the chances of pregnancy. It was not until advances in assisted reproductive technologies resulting in increased pregnancy rates that the concept of transferring ...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2020.09.003
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the effects of resveratrol on growth and function of granulosa cells. Previously, we demonstrated that resveratrol exerts profound proapoptotic effects on theca-interstitial cells. DESIGN:In vitro study. SETTING:Research laboratory. ANIMAL(S):Immature Sprague-Dawley female rats. INTERVENTION(S...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2012.08.004
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:To test our previously generated hypothesis that women with secondary recurrent miscarriages with a firstborn boy have a poorer pregnancy prognosis than those with a firstborn girl. DESIGN:A study of a retrospective and a prospective cohort. SETTING:The Danish recurrent miscarriage clinic. PATIENT(S):Two c...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.04.029
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:To evaluate surgical outcome and long-term follow-up of conservative laparoscopic management of urinary tract endometriosis (UTE). DESIGN:Prospective study. SETTING:Tertiary-care university hospital. PATIENT(S):Women with laparoscopic diagnosis and histologic confirmation of urinary bladder or ureteral end...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/j.fertnstert.2009.04.019
更新日期：2010-08-01 00:00:00
abstract：:The use of modified natural-cycle in vitro fertilization (IVF) is a valuable alternative to controlled ovarian hyperstimulation in young poor responders and should be considered in patients who require IVF and demonstrate endocrinologic evidence of ovarian aging and in those who have had one or two canceled controlled...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.09.052
更新日期：2011-11-01 00:00:00
abstract：OBJECTIVE:To investigate whether quantitative analysis performed on one testicular specimen is adequate for quantitative evaluation of spermatogenic process. DESIGN:Comparison of quantitative analysis of spermatogenic cell types in testicular cytologic aspirates of various sites of each testis. SETTING:In each aspira...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)57741-3
更新日期：1995-08-01 00:00:00
abstract：OBJECTIVE:To summarize the procedures and outcomes of assisted reproductive technology (ART) initiated in the United States in 1997. DESIGN:Data were collected electronically by using Society for Assisted Reproductive Technology Clinical Outcome Reporting System software and were submitted to the American Society for ...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(00)01559-4
更新日期：2000-10-01 00:00:00
abstract：:A comparison has been established retrospectively between clomiphene citrate-human menopausal gonadotropin (CC-hMG) and buserelin acetate-hMG treatments in in vitro fertilization trials performed over a 3-year period. The analysis of 466 CC-hMG and 319 buserelin acetate-hMG trials shows that buserelin acetate-hMG stim...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
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更新日期：1990-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the mRNA levels of connexins in different sizes of luteinized follicles. DESIGN:Semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) to determine the connexin mRNA levels in the granulosa cells of 91 luteinized follicles. SETTING:Academic tertiary care medical center and res...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2003.05.015
更新日期：2003-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the place of ultrasound-directed transvaginal transmyometrial ET in a protocol using both the transcervical and transmyometrial routes in a step-wise fashion. DESIGN:A prospective descriptive clinical study. SETTING:A university-based assisted conception unit. PATIENTS:Thirteen patients who had...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：:Effective contraception and easily available abortion have contributed to the decline of adoptable children. This decline has resulted in a marked increase in the demand for AID. The provider of donor semen must establish minimal semen criteria to meet this demand effectively. During the past 8 years the authors have ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)45923-6
更新日期：1981-12-01 00:00:00
abstract：OBJECTIVE:To describe a woman with a nonmosaic (45,X) form of Turner's syndrome who gave birth to a girl with 45,X Turner syndrome. DESIGN:Patient report. SETTING:Outpatient clinic of a university hospital. PATIENT(S):A woman with typical phenotypic features of Turner syndrome and a 45,X karyotype and her daughter w...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.02.129
更新日期：2004-10-01 00:00:00
abstract：OBJECTIVE:To identify and treat the gamete responsible for complete fertilization failure with intracytoplasmic sperm injection (ICSI) using a newly proposed assisted gamete treatment (AGT). DESIGN:Prospective cohort study. SETTING:Center for reproductive medicine. PATIENT(S):One-hundred and fourteen couples with an...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2020.04.044
更新日期：2020-09-01 00:00:00
abstract：:Since the late 1980s premature progesterone elevation has repeatedly caught the attention of investigators, not only for its importance, but also because studies have shown differing results and conclusions, constituting an unexplainable sequence of doubts and uncertainties. This issue's Views and Reviews section seek...
journal_title：Fertility and sterility
pub_type：
doi：10.1016/j.fertnstert.2018.02.134
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the influence of the opioid system on the hypothalamic-pituitary-adrenal axis in women with polycystic ovary syndrome (PCOS). DESIGN:Controlled clinical study. SETTING:Academic research environment. PATIENT(S):Eight lean and 12 obese women with PCOS, and seven lean and 5 obese control subjects....
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(99)00602-0
更新日期：2000-04-01 00:00:00
abstract：:Cell-mediated immunity in rhesus monkeys that had been vasectomized for 2, 4, 7, or 11 years was measured by lymphocyte blastogenesis following stimulation with concanavalin A, phytohemagglutinin (PHA), and pokeweed mitogens. Several of the 7- and 11-year vasectomized animals had significantly reduced PHA reactivity w...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)42983-3
更新日期：1977-12-01 00:00:00
abstract：:Klemetti's birth registry study is put in context of other major studies. Summary advice is offered to practitioners as to what they should tell parents who conceive with assisted reproductive technology. ...
journal_title：Fertility and sterility
pub_type： 评论,信件
doi：10.1016/j.fertnstert.2005.04.067
更新日期：2005-11-01 00:00:00
