A firstborn boy is suggestive of a strong prognostic factor in secondary recurrent miscarriage: a confirmatory study.

Abstract:

OBJECTIVE:To test our previously generated hypothesis that women with secondary recurrent miscarriages with a firstborn boy have a poorer pregnancy prognosis than those with a firstborn girl. DESIGN:A study of a retrospective and a prospective cohort. SETTING:The Danish recurrent miscarriage clinic. PATIENT(S):Two cohorts of 175 and 130 consecutive patients with unexplained secondary recurrent miscarriage referred from 1986 to 1999 (cohort 1) and 2000 to 2005 (cohort 2), respectively. MAIN OUTCOME MEASURE(S):The odds ratio (OR) for a live birth in the first pregnancy after referral in those with a firstborn boy compared with a firstborn girl in each of the two cohorts. The corresponding OR for a live birth adjusted for relevant prognostic variables in the combined group of patients. RESULT(S):The crude ORs for a live birth in those with a firstborn boy compared with a firstborn girl were very similar in cohorts 1 and 2 (OR = 0.35, 0.33). In the adjusted analysis only two of five included variables significantly predicted live birth: a firstborn boy and the number of previous miscarriages. CONCLUSION(S):Male sex of the firstborn child is a strong negative prognostic factor in women with secondary recurrent miscarriage. A possible explanation is an abnormal maternal immune response against male-specific minor histocompatibility (HY) antigens.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Nielsen HS,Andersen AM,Kolte AM,Christiansen OB

doi

10.1016/j.fertnstert.2007.04.029

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

907-11

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(07)00988-0

journal_volume

89

pub_type

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