A firstborn boy is suggestive of a strong prognostic factor in secondary recurrent miscarriage: a confirmatory study.


OBJECTIVE:To test our previously generated hypothesis that women with secondary recurrent miscarriages with a firstborn boy have a poorer pregnancy prognosis than those with a firstborn girl. DESIGN:A study of a retrospective and a prospective cohort. SETTING:The Danish recurrent miscarriage clinic. PATIENT(S):Two cohorts of 175 and 130 consecutive patients with unexplained secondary recurrent miscarriage referred from 1986 to 1999 (cohort 1) and 2000 to 2005 (cohort 2), respectively. MAIN OUTCOME MEASURE(S):The odds ratio (OR) for a live birth in the first pregnancy after referral in those with a firstborn boy compared with a firstborn girl in each of the two cohorts. The corresponding OR for a live birth adjusted for relevant prognostic variables in the combined group of patients. RESULT(S):The crude ORs for a live birth in those with a firstborn boy compared with a firstborn girl were very similar in cohorts 1 and 2 (OR = 0.35, 0.33). In the adjusted analysis only two of five included variables significantly predicted live birth: a firstborn boy and the number of previous miscarriages. CONCLUSION(S):Male sex of the firstborn child is a strong negative prognostic factor in women with secondary recurrent miscarriage. A possible explanation is an abnormal maternal immune response against male-specific minor histocompatibility (HY) antigens.


Fertil Steril


Fertility and sterility


Nielsen HS,Andersen AM,Kolte AM,Christiansen OB




Has Abstract


2008-04-01 00:00:00














  • Seminal vesicles: a source of trophoblast lymphocyte cross-reactive antigen.

    abstract::Maternal recognition of allotypic trophoblast lymphocyte cross-reactive (TLX) antigens is proposed to be involved in immunologic acceptance of the allogeneic fetus. The presence of TLX antigens in seminal plasma suggests that sensitization can occur before fertilization and implantation. In this study, the origin of T...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Thaler CJ,Critser JK,McIntyre JA,Faulk WP

    更新日期:1989-09-01 00:00:00

  • A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia.

    abstract:OBJECTIVE:To determine the efficacy of combined l-carnitine and l-acetyl-carnitine therapy in infertile males with oligo-astheno-teratozoospermia. DESIGN:Placebo-controlled double-blind randomized trial. SETTING:University tertiary referral center. PATIENT(S):Sixty infertile patients (aged 20-40 years) with the foll...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lenzi A,Sgrò P,Salacone P,Paoli D,Gilio B,Lombardo F,Santulli M,Agarwal A,Gandini L

    更新日期:2004-06-01 00:00:00

  • Vaccination guidelines for female infertility patients: a committee opinion.

    abstract::Encounters for infertility care are opportunities to assess and update immunization status. Women of reproductive age are often unaware of their need for immunization, their own immunization status, and the potentially serious consequences of preventable disease on pregnancy outcome. The purpose of this ASRM Practice ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Practice Committee of American Society for Reproductive Medicine.

    更新日期:2013-02-01 00:00:00

  • The cation composition of the seminal plasma and prostatic fluid and its correlation to semen quality.

    abstract::The concentrations of calcium, magnesium, and zinc were measured by atomic absorption spectrometry. The concentrations of all three cations were found to be strongly correlated with one another and with acidity (pH). Analysis of the relative concentrations in prostatic fluid, split ejaculates, and whole seminal plasma...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Homonnai ZT,Matzkin H,Fainman N,Paz G,Kraicer PF

    更新日期:1978-05-01 00:00:00

  • Nonapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on interleukin-6, leukemia inhibitory factor, interleukin-8, and monocyte chemoattractant protein 1 vary between undifferentiated and decidualized human endometrial stromal ce

    abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which is known to exert death-inducing as well as nonapoptotic functions, has been shown to be expressed by the early trophoblast. Here we report that TRAIL has no apoptotic effects on human endometrial stromal cells, but differentially regulates cytokin...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Fluhr H,Sauter G,Steinmüller F,Licht P,Zygmunt M

    更新日期:2009-10-01 00:00:00

  • Sperm content of postacrosomal WW binding protein is related to fertilization outcomes in patients undergoing assisted reproductive technology.

    abstract:OBJECTIVE:To determine the levels of postacrosomal WW binding protein (PAWP) in the spermatozoa of men that were used clinically for intracytoplasmic sperm injection (ICSI) and to correlate them with infertility treatment outcomes. DESIGN:Prospective clinical and laboratory study. SETTING:University-based laboratory ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Aarabi M,Balakier H,Bashar S,Moskovtsev SI,Sutovsky P,Librach CL,Oko R

    更新日期:2014-08-01 00:00:00

  • Criteria, prevalence, and phenotypes of polycystic ovary syndrome.

    abstract::Polycystic ovary syndrome (PCOS) is a highly prevalent disorder effecting reproductive-aged women worldwide. This article addresses the evolution of the criteria used to diagnosis PCOS; reviews recent advances in the phenotypic approach, specifically in the context of the extended Rotterdam criteria; discusses limitat...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Lizneva D,Suturina L,Walker W,Brakta S,Gavrilova-Jordan L,Azziz R

    更新日期:2016-07-01 00:00:00

  • Prospective, randomized trial of metformin and vitamins for the reduction of plasma homocysteine in insulin-resistant polycystic ovary syndrome.

    abstract::One hundred and two women with insulin-resistant polycystic ovary syndrome were randomized to treatment with a vitamin B preparation, metformin, or both, in conjunction with standard infertility treatment. Plasma homocysteine levels were significantly reduced by both B vitamins and metformin, but to a greater degree b...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Schachter M,Raziel A,Strassburger D,Rotem C,Ron-El R,Friedler S

    更新日期:2007-07-01 00:00:00

  • Insulin and insulin-like growth factor-I responsiveness in polycystic ovarian syndrome.

    abstract:OBJECTIVE:To assess insulin and insulin-like growth factor I (IGF-I) action in women with polycystic ovarian syndrome (PCOS). DESIGN:Hyperinsulinemia was determined by measuring the insulin responses during a 2-hour oral glucose tolerance test (OGTT). Quantification of in vivo insulin action was determined by a freque...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Buyalos RP,Geffner ME,Bersch N,Judd HL,Watanabe RM,Bergman RN,Golde DW

    更新日期:1992-04-01 00:00:00

  • Preimplantation genetic diagnosis for Marfan syndrome.

    abstract:OBJECTIVE:To develop and apply efficient and reliable protocols for preimplantation genetic diagnosis (PGD) for Marfan syndrome. DESIGN:Two mutation-specific protocols were developed, and the markers D15S1028, D15S992, D15S196, D15S576, D15S123, and D15S143 were used to set up four multiplex polymerase chain reactions...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Spits C,De Rycke M,Verpoest W,Lissens W,Van Steirteghem A,Liebaers I,Sermon K

    更新日期:2006-08-01 00:00:00

  • Intrafollicular cortisol levels inversely correlate with cumulus cell lipid content as a possible energy source during oocyte meiotic resumption in women undergoing ovarian stimulation for in vitro fertilization.

    abstract:OBJECTIVE:To determine whether follicular fluid (FF) cortisol levels affect cumulus cell (CC) lipid content during oocyte meiotic resumption, and whether CCs express genes for glucocorticoid action. DESIGN:Prospective cohort study. SETTING:Academic medical center. PATIENT(S):Thirty-seven nonobese women underwent ova...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Simerman AA,Hill DL,Grogan TR,Elashoff D,Clarke NJ,Goldstein EH,Manrriquez AN,Chazenbalk GD,Dumesic DA

    更新日期:2015-01-01 00:00:00

  • Pregnancies and deliveries after transfer of human blastocysts derived from in vitro matured oocytes in in vitro maturation cycles.

    abstract::A total of 82 patients underwent 106 cycles in which immature oocytes were recovered after hCG priming and transferred at blastocyst-stage. After transfer, the implantation rate was 26.8%, and the clinical pregnancy rate was 51.9%. We found that the oocytes retrieved after hCG priming in women with high risk of ovaria...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Son WY,Lee SY,Yoon SH,Lim JH

    更新日期:2007-06-01 00:00:00

  • Potential chemoprotective effect of melatonin in cyclophosphamide- and cisplatin-induced testicular damage in rats.

    abstract:OBJECTIVE:To evaluate the effect of melatonin on cyclophosphamide (CP)- and cisplatin-induced testicular toxicity with use of sperm parameters and biochemical and histopathologic approaches. DESIGN:Experimental study. SETTING:Vakif Gureba Hospital, Istanbul, Turkey. ANIMALS:Six-week-old adult male Wistar albino rats...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ilbey YO,Ozbek E,Simsek A,Otunctemur A,Cekmen M,Somay A

    更新日期:2009-09-01 00:00:00

  • The antiprogesterone Org 31710 inhibits human blastocyst-endometrial interactions in vitro.

    abstract:OBJECTIVE:To investigate the effect of the anti-P Org 31710 on human blastocyst attachment to cultured endometrial epithelial cells. DESIGN:Experimental in vitro study. SETTING:University hospital. PATIENT(S):Eleven fertile endometrial donors. INTERVENTION(S):Timed endometrial biopsy for cell cultures. MAIN OUTCOM...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Petersen A,Bentin-Ley U,Ravn V,Qvortrup K,Sørensen S,Islin H,Sjögren A,Mosselmann S,Hamberger L

    更新日期:2005-04-01 00:00:00

  • Assisted reproductive technologies (ART) in Canada: 2001 results from the Canadian ART Register.

    abstract:OBJECTIVE:To present the success rates of assisted reproductive technologies (ART) cycles performed in 2001 in Canada. DESIGN:Retrospective cohort study. SETTING:Nineteen of 22 ART centers in Canada. PARTICIPANTS:Couples undergoing ART treatment in Canada during 2001. METHODS:Data on each ART cycle performed during...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Gunby J,Daya S,IVF Directors Group of the Canadian Fertility and Andrology Society.

    更新日期:2005-09-01 00:00:00

  • Nasal embryonic LHRH factor (NELF) mutations in patients with normosmic hypogonadotropic hypogonadism and Kallmann syndrome.

    abstract:OBJECTIVE:To determine if mutations in NELF, a gene isolated from migratory GnRH neurons, cause normosmic idiopathic hypogonadotropic hypogonadism (IHH) and Kallmann syndrome (KS). DESIGN:Molecular analysis correlated with phenotype. SETTING:Academic medical center. PATIENT(S):A total of 168 IHH/KS patients as well ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Xu N,Kim HG,Bhagavath B,Cho SG,Lee JH,Ha K,Meliciani I,Wenzel W,Podolsky RH,Chorich LP,Stackhouse KA,Grove AM,Odom LN,Ozata M,Bick DP,Sherins RJ,Kim SH,Cameron RS,Layman LC

    更新日期:2011-04-01 00:00:00

  • Mayer-Rokitansky-Küster-Hauser syndrome with rare findings of inferior crossed-fused renal ectopia and Gartner's duct cyst: a video case report.

    abstract:OBJECTIVE:To describe the treatments of a patient using the laparoscopic Davydov's method for Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome and ureteral reimplantation for hydronephrosis and hydroureter. DESIGN:Surgical video article. A consent form from the patient was obtained as appropriate; the nature of the stud...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Liang G,Xia W,Liang Y,Zhu Q,Zou L,Zhang J,Jiang H

    更新日期:2020-10-14 00:00:00

  • Spontaneous fertility and in vitro fertilization outcome: new evidence of human papillomavirus sperm infection.

    abstract:OBJECTIVE:To evaluate the reproductive outcome of infertile couples undergoing assisted reproduction techniques (ART) with or without human papillomavirus (HPV) semen infection. DESIGN:Cross-sectional clinical study. SETTING:Units of andrology, reproductive medicine, and gynecology. PATIENT(S):A total of 226 inferti...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Garolla A,Engl B,Pizzol D,Ghezzi M,Bertoldo A,Bottacin A,Noventa M,Foresta C

    更新日期:2016-01-01 00:00:00

  • Transforming growth factor (TGF)-beta1-induced human endometrial stromal cell decidualization through extracellular signal-regulated kinase and Smad activation in vitro: peroxisome proliferator-activated receptor gamma acts as a negative regulator of TGF-

    abstract:OBJECTIVE:To investigate the effect of transforming growth factor (TGF)-beta1 on the extracellular signal-regulated kinase (ERK) and Smad pathway and the role of peroxisome proliferator-activated receptor (PPAR)-gamma in cultured human endometrial stromal cells. DESIGN:Experimental study. SETTING:Infertility center o...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Chang HJ,Lee JH,Hwang KJ,Kim MR,Chang KH,Park DW,Min CK

    更新日期:2008-10-01 00:00:00

  • Classic congenital adrenal hyperplasia and its impact on reproduction.

    abstract::Women with classic congenital adrenal hyperplasia (CAH) can suffer from impaired fertility rates as a result of increased androgen secretion or impaired sex steroid production. In virilizing CAH forms, such as 21-hydroxylase and 11β-hydroxylase deficiency, the low reported pregnancy rate is mainly secondary to a dimin...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Gomes LG,Bachega TASS,Mendonca BB

    更新日期:2019-01-01 00:00:00

  • Mechanisms regulating invasiveness and growth of endometriosis lesions in rat experimental model and in humans.

    abstract:OBJECTIVE:To compare the expression of MMP-2, TIMP-2, and TGFbeta2 mRNA in experimental and human endometriotic lesions and to assess the possibility of its cytokine regulation. DESIGN:Experimental laboratory study. SETTING:Medical center. ANIMALS AND PATIENT(S): Thirty female Wistar rats, 17 women with endometriosis...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sotnikova NY,Antsiferova YS,Posiseeva LV,Shishkov DN,Posiseev DV,Filippova ES

    更新日期:2010-05-15 00:00:00

  • Magnetic resonance imaging using "fat-saturation" technique is useful for diagnosing small endometrioma: a case report.

    abstract::Preoperative MRI using fat-saturation technique was performed in a patient with endometriosis. Endometrial implants as small as 3 mm were accurately diagnosed by MRI. The fat-saturation technique is useful for diagnosing small endometrioma. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Takahashi K,Okada S,Kitao M,Sugimura K

    更新日期:1992-11-01 00:00:00

  • Effects of melatonin on histomorphology and on the expression of steroid receptors, VEGF, and PCNA in ovaries of pinealectomized female rats.

    abstract:OBJECTIVE:To evaluate the effect of melatonin both on the ovaries of pinealectomized female rats through histomorphometric analysis and on steroid receptors, proliferating cell nuclear antigen (PCNA), and vascular endothelial growth factor (VEGF) expression. DESIGN:Experimental study. SETTING:Federal University of Sã...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Romeu LR,da Motta EL,Maganhin CC,Oshima CT,Fonseca MC,Barrueco KF,Simões RS,Pellegrino R,Baracat EC,Soares-Junior JM

    更新日期:2011-03-15 00:00:00

  • Androstenedione and progesterone concentrations in preovulatory follicular fluid correlate with successful fertilization and cleavage of human oocytes in vitro.

    abstract:OBJECTIVE:To determine if androstenedione (A) and progesterone (P) concentrations in preovulatory follicular fluid (FF) correlate with successful fertilization and cleavage of human oocytes in vitro. DESIGN:A retrospective randomized trial. SETTING:Hospital department of obstetrics and gynecology. PATIENTS:Fifty-fiv...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kobayashi T,Oda T,Yoshimura Y,Takehara Y,Natori M,Nozawa S

    更新日期:1991-08-01 00:00:00

  • Differences in seminal parameters in specimens collected via intercourse and incomplete intercourse (coitus interruptus)

    abstract::Whatever the mechanism of such improvements may be, the results in this study point out that coitus interruptus in the human may not be the method of choice for collection of semen specimens, especially in patients with spermatogenic dysfunctions such as hypospermia, oligospermia, and asthenospermia. It should also be...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Zavos PM,Kofinas GD,Sofikitis NV,Zarmakoupis PN,Miyagawa I

    更新日期:1994-06-01 00:00:00

  • Intramural pregnancy after in vitro fertilization and embryo transfer.

    abstract::A case of intramural but not interstitial pregnancy, established after IVF/ET, is described. The etiologic, diagnostic, and therapeutic aspects of this clinical dilemma are discussed. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hamilton CJ,Legarth J,Jaroudi KA

    更新日期:1992-01-01 00:00:00

  • Using semen flow cytometry to evaluate association of ploidy status and chromatin condensation of spermatozoa with conventional semen parameters: clinical application in intrauterine insemination.

    abstract:OBJECTIVE:To evaluate the association between the ploidy status and the nuclear chromatin condensation of spermatozoa with conventional semen parameters by using semen flow cytometry (SFC). The prognostic value of SFC on the successful outcome of intrauterine insemination (IUI) was examined. DESIGN:Prospective study. ...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Lazaros L,Kaponis A,Vartholomatos G,Hatzi E,Botsari S,Plachouras N,Makrydimas G,Zikopoulos K,Sofikitis N,Georgiou I

    更新日期:2011-01-01 00:00:00

  • Progestins activate vascular endothelial growth factor gene transcription in endometrial adenocarcinoma cells.

    abstract:OBJECTIVE:To determine whether progestins activate vascular endothelial growth factor (VEGF) gene transcription in endometrial adenocarcinoma cells. DESIGN:In vitro study. SETTING:University reproductive biology laboratories. PATIENT(S):None. INTERVENTION(S):Ishikawa cells were transfected with VEGF promoter-lucife...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Mueller MD,Vigne JL,Pritts EA,Chao V,Dreher E,Taylor RN

    更新日期:2003-02-01 00:00:00

  • A prospective, randomized study of pregnancy rates after transuterotubal and intrauterine insemination.

    abstract:OBJECTIVE:To assess the relative efficacy, in terms of clinical pregnancy rates (PRs), of transuterotubal insemination versus the more traditional intrauterine insemination (IUI) procedure. DESIGN:Prospective, randomized, cross-over. SETTING:University-affiliated tertiary care center. PATIENTS:One hundred sixty infe...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Oei ML,Surrey ES,McCaleb B,Kerin JF

    更新日期:1992-07-01 00:00:00

  • Role of the follistatin gene in women with polycystic ovary syndrome.

    abstract:OBJECTIVE:To search for mutations in the coding exons of the follistatin gene of women diagnosed with polycystic ovary syndrome (PCOS). DESIGN:Controlled clinical study. SETTING:Tertiary institutional hospital. PATIENT(S):Thirty-four women diagnosed with PCOS and 15 healthy control women. INTERVENTION(S):Whole bloo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Calvo RM,Villuendas G,Sancho J,San Millán JL,Escobar-Morreale HF

    更新日期:2001-05-01 00:00:00