Experimental immunological infertility effect of anti-GAPDH-2 antibodies on the fertility of female mice.

Abstract:

OBJECTIVE:To examine the relationship between an antibody against GAPDH-2, a sperm-specific protein, and infertility of female mice. DESIGN:Basic research. SETTING:National Research Institute for Family Planning Beijing, World Health Organization Collaboration Center of Human Reproduction. ANIMAL(S):New Zealand rabbit, NIH and ICR mice. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Enzyme-linked immunoabsorbent assay, Western blot and indirect immunostaining assays, standard fertility assay, and sperm agglutination assay. RESULT(S):Antibodies against the full-length GAPDH-2 were raised. Its specificity was assessed by immunoblotting and indirect immunostaining assays. The antibody immunoreacted with human sperm GAPDH-2 and the mouse homolog GAPDS but did not cross-react with GAPDH. Treatment of female mice with IP injection of anti-GAPDH-2 serum significantly reduced their fertility. Anti-GAPDH-2 serum caused the agglutination of normal mice sperm in vitro. The anti-GAPDH-2 antibody was detectable in the sera and uterine fluid of the mice immunized with GAPDH-2. CONCLUSION(S):These results show that GAPDH-2 should be further evaluated as a promising candidate in the development of an antifertility immunogen. Detecting anti-GAPDH-2 antibodies in the bodily fluid of subjects afflicted with indeterminate infertility may be a new diagnostic index.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Wang Y,Zhang N,Zhang X,Miao S,Zong S,Koide SS,Wang L

doi

10.1016/j.fertnstert.2008.09.001

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

2020-7

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(08)03868-5

journal_volume

92

pub_type

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