Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis.

Abstract:

OBJECTIVE:To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. DESIGN:Clinical trial. SETTING:Reproductive unit of a university teaching hospital. PATIENT:A patient of obstructive azoospermia with defective spermiogenesis. INTERVENTION:Testicular biopsy after scrotal exploration and spermatid injection into the cytoplasm of oocyte. MAIN OUTCOME MEASURES:Fertilization and cleavage. RESULTS:Four of 13 spermatid injections achieved normal fertilization and 2 of them cleaved. CONCLUSION:Intracytoplasmic spermatid injection may be a possible treatment for patients of defective spermiogenesis who have no viable spermatozoa available.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Chen SU,Ho HN,Chen HF,Tsai TC,Lee TY,Yang YS

doi

10.1016/s0015-0282(16)58406-4

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

157-60

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)58406-4

journal_volume

66

pub_type

临床试验,杂志文章
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    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章

    doi:

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    更新日期:1995-01-01 00:00:00

  • Gonadotropin-releasing hormone antagonist use is associated with increased pregnancy rates in ovulation induction-intrauterine insemination to in vitro fertilization conversions, independent of age and estradiol level on the day of human chorionic gonadot

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  • Induction of menstruation by an antiprogesterone steroid (RU 486) in primates: site of action, dose-response relationships, and hormonal effects.

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    更新日期:2008-09-01 00:00:00

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    更新日期:2020-09-01 00:00:00

  • The nitrofurans as sperm-immobilizing agents, their tissue toxicity, and their clinical application in vasectomy.

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    pub_type: 杂志文章

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    更新日期:1975-06-01 00:00:00

  • Diagnosis and prevalence of persistent chlamydia infection in infertile women: tissue culture, direct antigen detection, and serology.

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    doi:

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

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    更新日期:2009-05-01 00:00:00

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  • Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum.

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  • Risk factors for extrauterine pregnancy in women using an intrauterine device.

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    authors: Sharpe K,Karovitch AJ,Claman P,Suh KN

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    pub_type: 杂志文章,meta分析

    doi:

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    更新日期:1996-06-01 00:00:00