Abstract:
OBJECTIVE:To determine if androstenedione (A) and progesterone (P) concentrations in preovulatory follicular fluid (FF) correlate with successful fertilization and cleavage of human oocytes in vitro. DESIGN:A retrospective randomized trial. SETTING:Hospital department of obstetrics and gynecology. PATIENTS:Fifty-five patients, ages 24 to 39 years, with normal menstrual cycles undergoing in vitro fertilization (IVF) for tubal infertility. INTERVENTIONS:Multiple follicular development was induced with clomiphene citrate and human menopausal gonadotropin. MAIN OUTCOME MEASURES:Relationships among FF steroid hormone, morphological maturity of oocyte-corona-cumulus complexes, and fertilization and cleavage of oocytes. RESULTS:Follicles with mature oocyte-corona-cumulus complexes and unfertilized oocytes contained significantly greater amounts of A (P less than 0.05) than those with mature oocyte-corona-cumulus complexes and fertilized ova, indicating the occurrence of atretic changes. Follicles yielding successfully fertilized and cleaved ova had significantly greater amounts of P (P less than 0.05) and A (P less than 0.01) but similar levels of 17 beta-estradiol compared with follicles yielding fertilized ova that failed to cleave. CONCLUSIONS:Follicles yielding oocytes that cleaved as a result of IVF have both a shift in steroidogenesis from estrogen to progestin accumulation and declining aromatase activity, thus reflecting progressive luteinization of the follicles.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Kobayashi T,Oda T,Yoshimura Y,Takehara Y,Natori M,Nozawa Sdoi
10.1016/s0015-0282(16)54489-6subject
Has Abstractpub_date
1991-08-01 00:00:00pages
301-5issue
2eissn
0015-0282issn
1556-5653pii
S0015-0282(16)54489-6journal_volume
56pub_type
临床试验,杂志文章,随机对照试验abstract:OBJECTIVE:To provide a detailed summary of current scientific knowledge of somatic stem cells (SSCs) in murine and human myometrium and their putative implication in leiomyoma formation, as well as to establish new therapeutic options. DESIGN:Pubmed and Scholar One manuscripts were used to identify the most relevant s...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2014.04.051
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:To achieve maximum post-thaw survival of frozen embryos. DESIGN:Historical controlled study. SETTING:Hospital-based fertility center. PATIENT(S):One hundred forty-five patients whose embryos were frozen and thawed according to the standard method, and 56 patients whose embryos were frozen and thawed accord...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.04.054
更新日期:2005-11-01 00:00:00
abstract::Synthetic LH-RH is a polypeptide that is structurally identical to natural LH-RH. It has been used as a safe ovulation induction agent. A case is presented in which a patient had an anaphylactic reaction when treated with LH-RH by IV infusion. Positive skin testing confirmed this as an IgE-mediated reaction. This is t...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59428-x
更新日期:1987-09-01 00:00:00
abstract:OBJECTIVE:To analyze the expression of estrogen (ER) and progesterone (PR) receptors in the smooth muscle component (SMC) of deep infiltrating endometriosis (DIE). DESIGN:A prospective clinical and pathologic study of 60 cases of DIE. SETTING:University Hospital Department of Gynacology. PATIENT(S):Sixty patients wi...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.12.114
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To establish the prevalence of endometriosis metastatic to pelvic sentinel lymph nodes (PSLN) in women with ovarian and/or peritoneal endometriosis. DESIGN:Prospective clinical study. SETTING:Academic research institution. PATIENT(S):Women with a laparoscopic diagnosis of ovarian and/or peritoneal endometr...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.06.070
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To assess semen analysis, testicular volume, and hormone levels in fertile and infertile patients with varicoceles and fertile men without varicoceles. DESIGN:Retrospective study. SETTING:Academic medical center. PATIENT(S):Patients were divided into three groups: fertile men with varicoceles (n = 79), inf...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.06.047
更新日期:2005-01-01 00:00:00
abstract::A case of intramural but not interstitial pregnancy, established after IVF/ET, is described. The etiologic, diagnostic, and therapeutic aspects of this clinical dilemma are discussed. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)54804-3
更新日期:1992-01-01 00:00:00
abstract::The dietary, behavioral and in vitro methods of sex selection are evaluated for physicians to advise patients who desire to plan the gender of their families, but for whom chorionic villus sampling and elective abortion is unacceptable. A diet based on high potassium and sodium, and low magnesium and calcium for coup...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60000-6
更新日期:1988-07-01 00:00:00
abstract:OBJECTIVE:To examine the association between the midfollicular FSH-LH ratio and the number of follicles, and the multifollicular ovarian response to gonadotropin stimulation in patients with polycystic ovary syndrome (PCOS) with normal basal LH and FSH levels. SUBJECT(S):Eighteen patients who had an abandoned treatmen...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)80069-6
更新日期:1997-03-01 00:00:00
abstract::The results of reinsemination of 150 morphologically mature oocytes that failed to fertilize within 15 to 20 hours after initial insemination were evaluated. Only 41 oocytes (27.3%) were fertilized after reinsemination, which is significantly lower than the percentage obtained after initial insemination (74%). However...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)49097-7
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:To determine whether endometrial hCG infusion at the time of human blastocyst transfer impacts implantation rates. DESIGN:Randomized double-blinded placebo-controlled trial. SETTING:Academic. PATIENT(S):Infertile couples with the female partner less than 43 years old (n = 300) undergoing fresh or frozen ET...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2014.08.006
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To investigate hypoestrogenic "inactive phases" (IP) in the follicular phase of the menstrual cycle, with respect to age, reproductive stage, and follicular depletion. DESIGN:Analysis of prospectively collected menstrual bleed and estrone-3-glucuronide data. SETTING:Center for Population and Health, Georget...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.07.1101
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To analyze sonographically the endometrium in patients undergoing controlled ovarian stimulation with menotropins in order to determine the significance of endometrial pattern and thickness on pregnancy rate. DESIGN:This is a prospective, nonrandomized study comparing pregnancy rates in patients with hyperec...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)58447-7
更新日期:1996-08-01 00:00:00
abstract::Tamoxifen therapy in premenopausal women with breast cancer may be associated with the development of ovarian cysts. In this report, a case of ovarian torsion associated with TAM therapy is described. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55688-x
更新日期:1993-02-01 00:00:00
abstract::In young women receiving chemotherapy for Hodgkin's disease, the combined use of triptorelin and tibolone cotreatment may be a useful tool for preserving ovarian function because all but three (10%) of the women in this treatment group returned to spontaneous ovulation and menses, in contrast to 23% of subjects in the...
journal_title:Fertility and sterility
pub_type: 信件
doi:10.1016/j.fertnstert.2006.10.004
更新日期:2007-03-01 00:00:00
abstract::To show that in the dysgenetic gonads of 104 Turner syndrome patients no significant difference was found regarding the expression of the genes DAX1, FOG2, GATA4, OCT4, SF1, SRY, TSPY, WT1, and STRA8 compared with controls, except for genes OCT4, SRY, and TSPY in both gonads of a patient whose chromosomal constitution...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.02.036
更新日期:2010-11-01 00:00:00
abstract::Detection of bacteria with molecular techniques has enabled the study of low biomass microbiomes in tissues and organs previously considered sterile, such as the endometrium. Subsequently, an abnormal endometrial microbiota has been associated with implantation failure, pregnancy loss, and other gynecological and obst...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2017.05.034
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To compare the mRNA expression of vascular endothelial growth factor (VEGF) 121 and 165 isoforms and thrombospondin-1 (TSP-1) after raloxifene, 17beta-E(2), and P administration in cultured Ishikawa cells. DESIGN:Prospective basic research study. SETTING:Jones Institute for Reproductive Medicine, Eastern Vi...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(03)00350-9
更新日期:2003-06-01 00:00:00
abstract::Our meta-analysis analyzed the relationship between levels of reactive oxygen species (ROS) and fertilization rate after in vitro fertilization (IVF), and showed a statistically significant correlation between the ROS levels and the IVF fertilization rate (estimated overall correlation -0.374 [95% CI, -0.520, -0.205])...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析
doi:10.1016/j.fertnstert.2004.12.057
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To determine the effect of hormone replacement therapy (HRT) on cardiac structure and function and whether these changes are related to changes in blood volume. DESIGN:Open-label pilot study. SETTING:Academic medical center. PATIENT(S):Eighteen healthy postmenopausal women. INTERVENTION(S):We administered...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(98)00398-7
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To assess the direct effects of three endometriosis chemotherapeutic agents (medroxyprogesterone acetate [MPA], danazol, and leuprolide acetate [LA]) on endometrial cell proliferation. DESIGN:Analysis of cell proliferation in vitro. SETTING:Proliferative phase endometrial stromal cells isolated from biopsy ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract:OBJECTIVE:To assess the discriminative capacity of Chlamydia antibody titers in the diagnosis of tubed pathology in subfertile patients. DESIGN:Meta-analysis of studies comparing Chlamydia antibody titers and laparoscopy for tubal patency and peritubal adhesions. PATIENTS:A total of 2,729 patients with subfertility i...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析
doi:10.1016/s0015-0282(97)81435-5
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:To assess racial differences in attitudes and knowledge about sterilization. DESIGN:Cross-sectional survey. SETTING:Questionnaires were mailed to participants' home addresses. PATIENT(S):One hundred ninety-three women, aged 18-45, who had undergone tubal sterilization. INTERVENTION(S):None. MAIN OUTCOME ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.05.031
更新日期:2011-01-01 00:00:00
abstract::DNA methylation at H19 ICR1 was investigated in the placenta from pregnancies conceived by in vitro fertilization, intracytoplasmic sperm injection, and from natural conception. Our results showed that there were no significant differences in mean methylation between all pregnancy groups; therefore, assisted reproduct...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2011.05.047
更新日期:2011-06-30 00:00:00
abstract::The aim of this work is to review the need for new diagnostic tools for sperm, the relevance of sperm mRNA in reproductive success, and the potential of a state-of-the-art microarray-based diagnostic tool for improving reproductive results. ...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2013.02.006
更新日期:2013-03-15 00:00:00
abstract::In an attempt to improve the motility of thawed spermatozoa after 1 week of its being frozen, we treated ten normal semen samples with 16.7 nmol relaxin and 6 mmol caffeine. Motility and grade of forward progression were examined after thawing. Caffeine significantly improved motility of spermatozoa. Relaxin, when add...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)48868-0
更新日期:1985-09-01 00:00:00
abstract::We found, by reverse transcription--real time--polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory of three distinct clinical entities. Compared with peritoneal endometriosis, o...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/j.fertnstert.2005.10.041
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To study the fusiogenic ability of human spermatozoa and oocytes. DESIGN:Retrospective study of 3,027 oocytes included in a program of subzonal insemination (SUZI). SETTING:Assisted fertilization program in an academic research environment. PATIENT(S):Couples with characterized male factor infertility or p...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)81445-8
更新日期:1997-06-01 00:00:00
abstract::Physicians who are told or discover information that would be material to another party's participation in an assisted reproductive technology (ART) arrangement (such as lawyer's, donor's, gestational carrier's, or intended parent's) should encourage disclosure to that party. In some instances, it is ethically and leg...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2013.11.007
更新日期:2014-01-01 00:00:00
abstract::Three groups of women with different types of ovulatory dysfunction who had failed to conceive on conventional therapy were treated with pulsatile gonadotropin-releasing hormone (GnRH). Group A consisted of nine patients with luteal phase defect; group B included four patients with apparently normal menstrual cycles b...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)48971-5
更新日期:1985-11-01 00:00:00