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The nitrofurans as sperm-immobilizing agents, their tissue toxicity, and their clinical application in vasectomy.

Abstract：

:Nitrofurantoin sodium and nitorfurazone, in certain critical concentrations, have the ability to immobilize spermatozoa. In this study, this effect was consisitent with both 5:1, and 10:1 dilutions. Histologic examination of the effects of these drugs as intraoperative vas irrigants revealed no apparent tissue toxicity in the guinea pig. Clinically, we found intraoperative vas irrigation with both of these nontoxic drugs to be of value in attaining azoospermia immediately postvasectomy. Therefore, they appear to be useful supplements to vasectomy.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Albert PS,Salerno RG,Kapoor SN,Davis JE

doi

10.1016/s0015-0282(16)41168-4

keywords:

subject

Has Abstract

pub_date

1975-06-01 00:00:00

pages

485-91

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)41168-4

journal_volume

26

pub_type

杂志文章

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