当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Deoxyribonucleic acid repair and apoptosis in testicular germ cells of aging fertile men: the role of the poly(adenosine diphosphate-ribosyl)ation pathway.

Deoxyribonucleic acid repair and apoptosis in testicular germ cells of aging fertile men: the role of the poly(adenosine diphosphate-ribosyl)ation pathway.

Abstract：

OBJECTIVE:To explore the relationship between men's age and DNA damage repair proteins related to apoptosis in human testicular germ cells. DESIGN:Retrospective case-control study. SETTING:Academic institutions. PATIENT(S):Testicular specimens were obtained from 22 fertile volunteers aged 20-82 years. INTERVENTION(S):Deoxyribonucleic acid repair markers were assessed using immunohistochemical staining for the cell proliferation marker [proliferating cell nuclear antigen (PCNA)]; DNA repair markers [poly(adenosine diphosphate-ribose) polymerase-1 (PARP-1), poly(adenosine diphosphate-ribose) (PAR), X-ray repair cross-complementing1(XRCC1), and apurinic/apyrimidinic endonuclease 1 (APE1)]; and apoptosis-associated markers (caspase 9, active caspase 3, and cleaved PARP-1). MAIN OUTCOME MEASURE(S):The prevalence and cellular localization of the above markers in testicular tissues of young, middle aged, and old men. RESULT(S):Statistically significant differences in DNA damage repair-associated proteins (PARP-1, PAR, XRCC1, and APE1), and apoptosis markers (caspase 9, active caspase 3, and cleaved PARP-1) were observed in testicular samples from older men. These differences were most marked in spermatocytes. CONCLUSION(S):The study demonstrates that there is an age-related increase in human testicular germ cell DNA break repair and apoptosis with age.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

El-Domyati MM,Al-Din AB,Barakat MT,El-Fakahany HM,Xu J,Sakkas D

doi

10.1016/j.fertnstert.2008.03.027

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

2221-9

issue

5 Suppl

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(08)00598-0

journal_volume

91

pub_type

杂志文章

相关文献

FERTILITY AND STERILITY文献大全
  • Low fertility awareness in United States reproductive-aged women and medical trainees: creation and validation of the Fertility & Infertility Treatment Knowledge Score (FIT-KS).

    abstract：OBJECTIVE:To create, validate, and use a fertility awareness survey based on current U.S. DATA: DESIGN:Cross-sectional study. SETTING:Not applicable. PATIENT(S):Phase 1 included U.S. women ages 18-45; phase 2 included female medical students and obstetrics and gynecology trainees at two urban academic programs. IN...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2017.07.1158

    authors： Kudesia R,Chernyak E,McAvey B

    更新日期：2017-10-01 00:00:00

  • The origin of orchiopexy-induced testicular lesions in the pig.

    abstract：:Cooling experiments of abdominal testes in adult, naturally cryptorchid pigs indicate that spermatogenic arrest in abdominal testes is not due to an inborn defect, but is caused solely by maintenance of the testis at abdominal temperature. It is postulated that failure of spermatogenic cells to differentiate after orc...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)44364-5

    authors： Frankenhuis MT,Wiegerinck MA,Schoorl M,Kremer J,Wensing CJ

    更新日期：1979-11-01 00:00:00

  • Plasma lipids and desogestrel and ethinyl estradiol: a meta-analysis.

    abstract：OBJECTIVE:To review the literature to determine the magnitude of the effect of 150 micrograms desogestrel-30 micrograms ethinyl E2, an oral contraceptive (OC) formulation, on plasma lipid concentrations in healthy women using meta-analysis techniques. DATA SOURCES:All English-language published reports (1981 to 1991) ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,meta分析

    doi：

    authors： Lobo RA,Skinner JB,Lippman JS,Cirillo SJ

    更新日期：1996-06-01 00:00:00

  • A one-year experience with a capitated health care plan for infertility.

    abstract：OBJECTIVE:To report on a one-year experience participating in a capitated healthcare plan for infertility. DESIGN:Prospective study. SETTING:University population. PATIENT(S):Reproductive-age women 15 to 50 years. INTERVENTION(S):The first-generation Lewin infertility algorithm and CATHI software were used to negot...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(01)01673-9

    authors： Blackwell RE,Hammond KR,Steinkampf MP

    更新日期：2001-04-01 00:00:00

  • Compound genetic abnormalities in patients with cystic fibrosis transmembrane regulator gene mutation.

    abstract：OBJECTIVE:To determine the prevalence of compound genetic abnormalities in patients who are carriers of cystic fibrosis mutations. DESIGN:Case report. SETTING:Tertiary referral center for male infertility. PATIENT(S):Between 2000 and 2005, 65 patients were identified to be carriers of cystic fibrosis transmembrane r...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2006.07.1537

    authors： Karpman E,Williams DH 4th,Wilberforce S,Lipshultz LI

    更新日期：2007-06-01 00:00:00

  • Localization and cellular distribution of pregnancy-associated plasma protein-a and major basic protein in human ovary and corpora lutea throughout the menstrual cycle.

    abstract：OBJECTIVE:To assess the expression and cellular distribution of pregnancy-associated plasma protein-A (PAPP-A) and major basic protein (MBP) in human ovarian tissue during the menstrual cycle. DESIGN:Ovarian tissues (n = 50) and corpora lutea (n = 18) were obtained from patients undergoing hysterectomy/oophorectomy fo...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(03)00077-3

    authors： Rhoton-Vlasak A,Gleich GJ,Bischof P,Chegini N

    更新日期：2003-05-01 00:00:00

  • Poor response cycles: when should we cancel? Comparison of outcome between egg collection, intrauterine insemination conversion, and follow-up cycles after abandonment.

    abstract：OBJECTIVE:To determine optimal management with one or two mature follicles after stimulation. DESIGN:Retrospective analysis. SETTING:Lister fertility clinic. PATIENT(S):A total of 1,350 IVF/intracytoplasmic sperm injection cycles (7.3% of total) during 1998-2009 were found to have one or two mature follicles. INTER...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2010.05.030

    authors： Nicopoullos JD,Abdalla H

    更新日期：2011-01-01 00:00:00

  • Isolated spermatogonia protrude active pseudopodia in vitro.

    abstract：:When dispersed spermatogenic cells obtained by enzymatic digestion from prepuberal mice, adult male mice, nonazoospermic men and normospermic men were observed live using Normarski optics, it was found that, respectively, 47.4%, 1.4%, 5.1%, and 2.4% of them protruded active pseudopodia. These cells were 8 to 10 mum in...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2007.06.055

    authors： Tanaka A,Nagayoshi M,Awata S,Himeno N,Tanaka I,Kusunoki H

    更新日期：2008-08-01 00:00:00

  • Factors associated with the quality before freezing and after thawing of sperm obtained by microsurgical epididymal aspiration.

    abstract：OBJECTIVE:To identify whether the cause, site of ductal obstruction, and characteristics of fluid aspirates are associated with the cryosurvival and fertility after thawing of sperm obtained during reconstruction of the excurrent ducts with microsurgical epididymal sperm aspiration, vasal sperm aspiration, or both. DE...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(97)00274-4

    authors： Sharma RK,Padron OF,Thomas AJ Jr,Agarwal A

    更新日期：1997-10-01 00:00:00

  • Luteal-phase defect: the role of Georgeanna Seegar Jones.

    abstract：:The study and treatment of luteal phase defect since the late 1940s, particularly the work of Georgeanna Seegar Jones, are summarized. ...

    journal_title：Fertility and sterility

    pub_type： 传,历史文章,杂志文章

    doi：10.1016/j.fertnstert.2007.08.036

    authors： Jones HW Jr

    更新日期：2008-11-01 00:00:00

  • Effects of tumor necrosis factor-alpha on porcine oocyte meiosis progression, spindle organization, and chromosome alignment.

    abstract：OBJECTIVE:To evaluate the effects of tumor necrosis factor-alpha (TNF-alpha) on porcine oocyte maturation, spindle dynamics, and chromosome alignment. DESIGN:Controlled, prospective study. SETTING:University hospital and IVF research laboratory. ANIMAL(S):Ovaries collected from slaughtered prepubertal gilts. MAIN O...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2009.01.131

    authors： Ma CH,Yan LY,Qiao J,Sha W,Li L,Chen Y,Sun QY

    更新日期：2010-02-01 00:00:00

  • Transfer of human sperm into the perivitelline space of human oocytes after zona-drilling or zona-puncture.

    abstract：:To evaluate the transfer of sperm from severely oligozoospermic men into the perivitelline space of mature oocytes, zona-drilling with acid phosphate-buffered saline (PBS) and direct zona-puncture in the presence of cytochalasin D were studied. Zona-drilling also was done for eggs from patients with previous failed in...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)60792-6

    authors： Ng SC,Bongso A,Chang SI,Sathananthan H,Ratnam S

    更新日期：1989-07-01 00:00:00

  • Peritoneal fluid and serum steroids in infertility patients.

    abstract：:Peritoneal fluid and serum were collected from 78 patients at the time of laparoscopy. Twenty-two were fertile controls (CTL), and 56 were infertility patients, who were subdivided into three main groups: endometriosis (EMS), pelvic adhesions (ADH), and ovarian dysfunction (OvDF). Based on control group data, biochemi...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)48020-9

    authors： Lesorgen PR,Wu CH,Green PJ,Gocial B,Lerner LJ

    更新日期：1984-08-01 00:00:00

  • In vitro maturation remains an interesting procedure.

    abstract：:The number of live births from IVM oocytes has been increasing over the past two decades. Data concerning the health of IVM infants are reported by the authors of this Views and Reviews. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2013.02.044

    authors： Frydman R

    更新日期：2013-04-01 00:00:00

  • Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization.

    abstract：OBJECTIVE:To identify biomarkers associated with reproductive outcome using proton nuclear magnetic resonance ((1)H NMR) metabolomic profiling of embryo culture media. DESIGN:Retrospective study. SETTING:An academic assisted reproductive technology (ART) program; a university research center. PATIENT(S):Women underg...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.07.1739

    authors： Seli E,Botros L,Sakkas D,Burns DH

    更新日期：2008-12-01 00:00:00

  • Association between sperm autoantibodies and enhanced embryo implantation rates during in vitro fertilization.

    abstract：:Previous investigations have demonstrated the propensity of strong IgA-class sperm autoantibodies to impede fertilization. However, because there has not been a general consensus on this issue, the aim of this retrospective analysis was to focus on the effects of different levels of IgA-class antibodies on each stage ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2006.02.089

    authors： Clarke GN

    更新日期：2006-09-01 00:00:00

  • The bipolar needle for vasectomy. I. Experience with the first 1000 cases.

    abstract：:A battery-powered, bipolar electrocoagulator has been specifically developed for sealing the cut ends of the divided vas at vasectomy. With a minimum of electric power, the electrocoagulator destroys only the mucosa and one or two muscle cell layers of the vas, which leads to optimal fibrosis of the cut ends. This ins...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Schmidt SS,Free MJ

    更新日期：1978-06-01 00:00:00

  • Predicting pregnancy outcome after in vitro fertilization and embryo transfer using estradiol, progesterone, and human chorionic gonadotropin beta-subunit.

    abstract：:Two hundred twenty consecutive in vitro fertilization (IVF) conception cycles were studied prospectively in order to examine the predictive value of serum human chorionic gonadotropin beta-subunit (beta-hCG), estradiol (E2), and progesterone (P) in predicting pregnancy outcome between 2 and 4 weeks after oocyte collec...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)60495-8

    authors： Yamashita T,Okamoto S,Thomas A,MacLachlan V,Healy DL

    更新日期：1989-02-01 00:00:00

  • Endometrial dating in the conception cycle.

    abstract：OBJECTIVE:To investigate endometrial dating during the conception cycle. DESIGN:Endometrial biopsies of the last half of the luteal phase of conception cycles were dated based on urinary luteinizing hormone (LH) surges. SETTING:Endometrial samples were obtained from women attending the fertility clinic of the Departm...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Andoh K,Mizunuma H,Nakazato Y,Yamada K,Michishita M,Ibuki Y

    更新日期：1992-12-01 00:00:00

  • Serum is more effective than albumin in promoting human embryo development and implantation.

    abstract：OBJECTIVE:To compare the effects of serum with those of Albuminar-5 (Armour Pharmaceutical Co., Eastbourne, Sussex, United Kingdom) as medium supplements to Earl's balanced salt solution (EBSS) for IVF and subsequent embryo development. DESIGN:A retrospective study. Gametes and embryos from 318 patients were cultured ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)57978-3

    authors： Hargreaves CA,Rahman F,Cowan D,Santis M,Keefe T,Howell RJ,Chard T,Homa ST

    更新日期：1995-12-01 00:00:00

  • Fat tissue morphology of long-term sex steroid deficiency and estrogen treatment in female rats.

    abstract：:After long-term estradiol deficiency, female rats displayed body mass gain accompanied by an increase in the size of adipocytes, an increase in hyperglycemia, and a decrease in insulinemia. The effects were reversed by daily estradiol treatment. Adiposity was suggested by the increased vascular endothelial growth fact...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2011.01.020

    authors： Santana AC,Soares da Costa CA,Armada L,de Paula Lopes Gonzalez G,dos Santos Ribeiro M,de Sousa dos Santos A,de Carvalho JJ,do Nascimento Saba CC

    更新日期：2011-03-15 00:00:00

  • The uterus and fertility.

    abstract：OBJECTIVE:To review the current understanding of the role the uterus plays in embryo implantation and to outline congenital anomalies and acquired diseases that impact normal uterine function. DESIGN:The publications related to the embryo implantation, Mullerian anomalies, uterine polyps, uterine synechiae, and myomas...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2007.09.069

    authors： Taylor E,Gomel V

    更新日期：2008-01-01 00:00:00

  • Heparin for assisted reproduction: summary of a Cochrane review.

    abstract：:It is suggested that heparin given in the peri-implantation period may improve clinical outcomes in women undergoing assisted reproduction techniques (ART). This systematic review evaluates the use of heparin in subfertile women undergoing ART. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.fertnstert.2014.09.005

    authors： Akhtar MA,Sur S,Raine-Fenning N,Jayaprakasan K,Thornton J,Quenby S,Marjoribanks J

    更新日期：2015-01-01 00:00:00

  • A factor in human seminal plasma which affects carnitine accumulation in bovine epididymal sperm.

    abstract：:This study was initiated to determine whether factors are present in human sperm-free seminal plasma (HSP) that regulate the uptake and release of carnitine from sperm. Bovine caput epididymal sperm cells accumulated more carnitine than caudal sperm cells. A significant reduction in carnitine uptake by caput sperm was...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Carter AL,Cho SH,Bishop ER,Boldt J

    更新日期：1988-05-01 00:00:00

  • Proximal ectopic pregnancy: a descriptive general population-based study and results of different management options in 86 cases.

    abstract：OBJECTIVE:To describe different approaches for diagnosis and management of proximal ectopic pregnancies (PP) in general population. DESIGN:Observational population based-study. SETTING:Regional ectopic pregnancy registry. PATIENT(S):Eighty-six PP registered from 1992 to 2008. INTERVENTION(S):Surgical (radical or co...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2010.10.025

    authors： Larraín D,Marengo F,Bourdel N,Jaffeux P,Aublet-Cuvelier B,Pouly JL,Mage G,Rabischong B

    更新日期：2011-03-01 00:00:00

  • Involvement of catalase in the endometrium of patients with endometriosis and adenomyosis.

    abstract：OBJECTIVE:To determine the distribution of catalase in eutopic and ectopic endometria in patients with endometriosis or adenomyosis. DESIGN:Retrospective randomized study. SETTING:Department of obstetrics and gynecology in a university hospital. PATIENT(S):Thirty-three patients with endometriosis, 36 with adenomyosi...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(02)03344-7

    authors： Ota H,Igarashi S,Sato N,Tanaka H,Tanaka T

    更新日期：2002-10-01 00:00:00

  • Luteal phase support.

    abstract：OBJECTIVE:To develop a consensus regarding the need for luteal phase support during assisted reproductive technology (ART), and to establish the optimal compound and route of administration for this purpose. DESIGN:Review of the published literature on luteal phase support. PATIENT(S):Women undergoing assisted reprod...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/s0015-0282(01)02961-2

    authors： Penzias AS

    更新日期：2002-02-01 00:00:00

  • Angiopoietin 1 and angiopoietin 2 in follicular fluid of women undergoing a long protocol.

    abstract：OBJECTIVE:To determine the concentrations of angiopoietin 1 (ANGPT1) and ANGPT2 in individual human preovulatory follicles in relation to their diameter or volume to clarify the role of these molecules in folliculogenesis. DESIGN:Prospective study. SETTING:Research laboratory at Kansai Medical University, Osaka, Japa...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.fertnstert.2011.09.031

    authors： Nishigaki A,Okada H,Tsuzuki T,Cho H,Yasuda K,Kanzaki H

    更新日期：2011-12-01 00:00:00

  • Induction of endometrial cycles and ovulation in a woman with combined 17alpha-hydroxylase/17,20-lyase deficiency due to compound heterozygous mutations on the p45017alpha gene.

    abstract：OBJECTIVE:To describe the case of a Japanese woman with combined 17alpha-hydroxylase/17,20-lyase deficiency (congenital adrenal hyperplasia type V) and to discuss possible therapeutic procedures in such patients. DESIGN:Case report. SETTING:University hospital. PATIENT(S):A 26-year-old woman with secondary amenorrhe...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(00)00500-8

    authors： Matsuzaki S,Yanase T,Murakami T,Uehara S,Nawata H,Yajima A

    更新日期：2000-06-01 00:00:00

  • Importance of reactive oxygen species in the peritoneal fluid of women with endometriosis or idiopathic infertility.

    abstract：OBJECTIVE:To determine whether reactive oxygen species in peritoneal fluid might be a factor in infertility. DESIGN:Prospective study. SETTING:Andrology laboratory and gynecology clinic at a tertiary care facility. PATIENT(S):Women with endometriosis (n = 15) or idiopathic infertility (n = 11) who underwent laparosc...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(97)00343-9

    authors： Wang Y,Sharma RK,Falcone T,Goldberg J,Agarwal A

    更新日期：1997-11-01 00:00:00