Endometrial dating in the conception cycle.

Abstract:

OBJECTIVE:To investigate endometrial dating during the conception cycle. DESIGN:Endometrial biopsies of the last half of the luteal phase of conception cycles were dated based on urinary luteinizing hormone (LH) surges. SETTING:Endometrial samples were obtained from women attending the fertility clinic of the Department of Obstetrics and Gynecology at Gunma University Hospital. PATIENTS:One hundred eighty-five women, of whom 15 (8.1%) conceived during this study. MAIN OUTCOME MEASURES:Urinary LH surge, serum progesterone (P) levels, and endometrial dating. RESULTS:All 10 women who conceived showed 2 or within 2 days in-phase endometrial biopsies on days 7 to 11 after the LH surge. In 4 of 5 women biopsied on day 12, an unequivocally delay in the stroma was found, i.e., a persistence of edema and poor development of predecidual reaction. Since serum P levels in conception cycles were significantly higher than in nonconception cycles on days 10, 11, and 12, we interpreted this delay in the stroma as a consequence of conception. CONCLUSION:Endometrial specimens during the last half of the luteal phase of conception cycles are in-phase until day 12. On day 12, gestational hyperplasia causes apparent out-of-phase.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Andoh K,Mizunuma H,Nakazato Y,Yamada K,Michishita M,Ibuki Y

keywords:

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

1127-30

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)55556-3

journal_volume

58

pub_type

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