Type of stimulation protocol affects oocyte maturity, fertilization rate, and cleavage rate after intracytoplasmic sperm injection.

Abstract:

OBJECTIVE:To compare oocyte maturity, fertilization rate and cleavage rate after a short and long GnRH agonist (GnRH-a) stimulation protocol and intracytoplasmic sperm injection (ICSI). DESIGN:Retrospective study of 34 sequential ICSI cycles stimulated with a short or long GnRH-a protocol. SETTING:A university-based tertiary care center for assisted reproductive treatment. RESULTS:Significantly more oocytes were mature (metaphase II) after a long GnRH-a protocol then after a short GnRH-a protocol (25.6% and 80.8%, respectively). The long protocol resulted in more cleaving embryos (36/152 versus 9/132) and more cycles of ET (12/17 versus 5/17) than the short group. CONCLUSION:A greater percentage of mature oocytes results from ovarian stimulation with a long GnRH-a protocol than a short GnRH-a protocol. Maturity could be assessed accurately after cumulus stripping that is required before ICSI. Fertilization rate and cleavage rate with ICSI was superior after a long GnRH-a stimulation protocol for superovulation.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Greenblatt EM,Meriano JS,Casper RF

doi

10.1016/s0015-0282(16)57792-9

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

557-63

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)57792-9

journal_volume

64

pub_type

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