Abstract：
:Chronic treatment with highly active analogs of luteinizing hormone (LH)-releasing hormone (LH-RH) induces "paradoxical" antifertility effects. Intact male rats, a reduction in testosterone production is observed after the administration of [D-Ser(But)6]-LH-RH(1-9)ethylamide (burserelin, Hoe 766), 50 ng/day subcutaneously for 4 weeks. In castrated male rats treated with the same dose of analog, plasma LH levels were reduced from days 14 to 28 and plasma follicle-stimulating hormone (FSH) levels were reduced from days 21 to 28 of treatment. Pituitary LH and FSH concentrations were also decreased. The plasma prolactin level was reduced at 14 days of treatment. The hypothalamic LH-RH content remained unchanged and the adrenal corticosterone content was lowered. These findings indicate a direct inhibitory effect of the analog on gonadotropin secretion in the absence of the gonads, and may explain some paradoxical antifertility effects observed with high doses of LH-RH analogs which exceed the physiologic dose range.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Sandow J,Von Rechenberg W,Jerzabek G,Stoll Wdoi
10.1016/s0015-0282(16)43461-8subject
Has Abstractpub_date
1978-08-01 00:00:00pages
205-9issue
2eissn
0015-0282issn
1556-5653pii
S0015-0282(16)43461-8journal_volume
30pub_type
杂志文章abstract：OBJECTIVE:To study fertility among women treated by means of ultrasound-guided drainage and antibiotics for tubo-ovarian abscess (TOA). DESIGN:Retrospective cohort study. SETTING:A tertiary referral center. PATIENT(S):One hundred women of reproductive age treated for TOA between June 1986 and July 2003. INTERVENTIO...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2012.03.054
更新日期：2012-07-01 00:00:00
abstract：:The first subsequent pregnancy rate in a group of women who accepted a variety of contraceptive methods after delivery and after therapeutic abortion is reviewed. Regardless of method chosen, 20 to 30% of postdelivery and 18 to 20% of postabortion patients were pregnant again after 1 year. In those patients who chose ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Earlier studies have shown inherited thrombophilia to be a risk factor for recurrent implantation failure, raising the question of whether this risk is related to the underlying cause of unexplained infertility or to the mechanisms involved in the implantation process. When nine thrombophilic gene polymorphisms were c...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.07.1782
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:To determine the ectopic pregnancy rate with fresh versus frozen-thawed embryo transfers, and factors associated with ectopic pregnancy in patients undergoing IVF-ET. DESIGN:Retrospective analysis. SETTING:Institutional IVF center. PATIENT(S):A total of 3,183 patients who received 3,340 blastocysts transfe...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2014.11.023
更新日期：2015-03-01 00:00:00
abstract：:Surgical ablation of the inferior mesenteric plexus in the rat results in an excessive accumulation of sperm within the cauda epididymidis. The present study examined the effect of ablation of the inferior mesenteric plexus on the motility of cauda epididymal spermatozoa. One to 8 weeks after ablation of the inferior ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：OBJECTIVE:To see if clinicians' impressions were influenced by expert opinion on patient selection criteria that influence magnetic resonance-guided focused ultrasound (MRgFUS) leiomyoma treatment. DESIGN:Survey-based study. SETTING:First international symposium devoted to MRgFUS, "MRgFUS 2008," October 6-7, 2008, Wa...
journal_title：Fertility and sterility
pub_type：
doi：10.1016/j.fertnstert.2009.02.083
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy of a dry versus humidified incubator on human embryo development ex vivo. DESIGN:Prospective, double-blind, randomized, controlled trial. SETTING:Private fertility centers. PATIENT(S):A total of 297 women undergoing in vitro fertilization randomized into two groups. INTERVENTION(S...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.fertnstert.2017.05.036
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:To define a therapeutic strategy adapted to acute urine retention resulting from uterine incarceration in early pregnancy. DESIGN:Case report and review of the literature. SETTING:University hospital. PATIENT(S):Two cases of acute urine retention induced by severe fibroid incarceration in first trimester. ...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2007.10.008
更新日期：2008-10-01 00:00:00
abstract：:The effects of maternal preovulatory serum and human fetal cord serum supplement in culture medium in human in vitro fertilization and embryo development were compared in 208 cases over an 8-month period when there were no significant changes in other variables. A significantly higher pregnancy rate was observed in th...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)47537-0
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVE:To determine the concentrations of angiopoietin 1 (ANGPT1) and ANGPT2 in individual human preovulatory follicles in relation to their diameter or volume to clarify the role of these molecules in folliculogenesis. DESIGN:Prospective study. SETTING:Research laboratory at Kansai Medical University, Osaka, Japa...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/j.fertnstert.2011.09.031
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:To compare fecundity rates following intrauterine insemination (IUI) with donor sperm frozen conventionally versus an IUI-ready preparation. DESIGN:Both retrospective results and a prospective, randomized study where recipients were assigned to one of two sperm cryopreservation methods in each cycle of intra...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(01)01857-x
更新日期：2001-07-01 00:00:00
abstract：OBJECTIVE:To introduce a technique for hysteroscopic resection of submucous myoma arising from the uterine fundus. DESIGN:Case report. SETTING:University hospital. PATIENT(S):A 43-year-old nulliparous Japanese woman. INTERVENTION(S):An original combination technique of hysteroresectoscopy using circumferential myom...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.03.066
更新日期：2006-11-01 00:00:00
abstract：:A rabbit model was used to examine adhesion formation after ovarian wedge resection with and without reapproximation of the ovarian cortex. A wedge resection was completed on one ovary with a scalpel, and the ovarian cortex was reapproximated using microsurgical technique. In the contralateral ovary, a wedge resection...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：OBJECTIVE:To investigate whether antitrophoblast antibodies are associated with unexplained recurrent miscarriages, we used choriocarcinoma cells JEG-3, since these cells are negative for class I and II antigens, but they do express HLA-G, resembling an antigen expression of endovascular and interstitial trophoblasts. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.11.014
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the importance of salpingoscopy together with laparoscopy in the diagnosis of tubal pathology. DESIGN:Salpingoscopy was performed as a complementary method in patients who were subjected to diagnostic laparoscopy. The relationship between the salpingoscopy and (1) the patient's previous history o...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54952-8
更新日期：1992-04-01 00:00:00
abstract：OBJECTIVE:To compare the pregnancy outcomes in the setting of a single- vs. double-donor sperm intrauterine insemination (IUI) treatment cycle. DESIGN:Retrospective cohort study. SETTING:Large, private assisted reproductive technology practice. PATIENT(S):Donor sperm IUI recipients. INTERVENTION(S):None. MAIN OUTC...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2014.05.018
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVE:To test the efficacy of endometrial preparation with exogenous steroids, without pretreatment with gonadotropin-releasing hormone (GnRH) agonist, in women with normal ovarian function. DESIGN:Prospective randomized study. SETTING:Private outpatient infertility clinic. PATIENT(S):Two hundred ninety-six wome...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(02)02960-6
更新日期：2002-05-01 00:00:00
abstract：OBJECTIVE:To develop and test a simple, feasible approach to improve spindle assembly and developmental competence of human in vitro matured oocytes by parthenogenetic activation in maturation medium. DESIGN:Prospective, randomized study. SETTING:University research laboratory-based assisted reproductive technology l...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2011.04.077
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:To study the oocyte quality in patients with ovarian hyperstimulation syndrome (OHSS). DESIGN:Retrospective study. SETTING:The Egyptian IVF-ET Center. PATIENT(S):Forty-two patients who developed severe OHSS (group A) were studied for the mean number of oocytes retrieved, percentage of high-quality oocytes,...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)00409-3
更新日期：1997-12-01 00:00:00
abstract：:In a qualitative interview study of 77 families with stored frozen embryos, we found that while embryo disposition decision making was influenced by individual life circumstances, embryo quantity/quality, personal values, embryo conceptualization, and clinic information, it was a stepwise process that could be represe...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.06.027
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the effects of conjugated equine estrogens, medroxyprogesterone acetate (MPA), conjugated equine estrogens combined with MPA, tamoxifen, and soybean estrogens on vaginal cytology in surgically postmenopausal cynomolgus macaques (Macaca fascicularis). DESIGN:Randomized long-term experimental trial...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the remodeling of large arteries according to age at menopause, duration of menopause, and use of hormone therapy (HT). DESIGN:A cross-sectional study consisting of baseline measurements of a multicentric randomized trial were used to evaluate arterial parameters. SETTING:The study was conducted...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.fertnstert.2011.09.010
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the expression pattern of Dazl (deleted in azoospermia-like) protein in the mouse preimplantation embryo. DESIGN:Experimental study. SETTING:Medical research laboratory in a university hospital. ANIMAL(S):Twenty female 28- to 35-day-old FVB mice. INTERVENTION(S):Embryo collection at 1.5, 2.5, ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.03.041
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:To investigate methods of fertility preservation in younger women exposed to adjuvant chemotherapy for breast cancer. DESIGN:Systematic review of literature. SETTING:Academic Department of Medical Oncology. PATIENT(S):Premenopausal women exposed to adjuvant chemotherapy for breast cancer. MAIN OUTCOME MEA...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2009.02.055
更新日期：2010-06-01 00:00:00
abstract：:Twelve women of normal weight (ages 17 to 36 years) with scanty menstrual bleeding were studied. They had no signs of virilization, gynecologic or endocrine pathology, or past history of hormonal treatment. Five women (group 1) experienced withdrawal bleeding after a 3-day course of chlormadinone acetate (2 mg/day) an...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)43213-9
更新日期：1978-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the effects of coital lubricants and oils on sperm motility. DESIGN:Comparative prospective in vitro study. SETTING:University Andrology laboratory. PATIENT(S):Twenty-two normozoospermic donors. INTERVENTION(S):Semen samples were incubated in modified human tubal fluid (mHTF) control and in 10...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.12.024
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:To determine the expression of glutathione peroxidase (GPx) in the eutopic and ectopic endometria during the menstrual cycle in endometriosis and adenomyosis. DESIGN:Immunohistochemical identification of GPx in endometrial tissues identified using the polyclonal antibody. SETTING:Department of obstetrics an...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(00)00638-5
更新日期：2000-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the association between adiposity, physical activity (PA), and fecundability. DESIGN:Prospective cohort study. SETTING:Not applicable. PATIENT(S):A total of 2,062 female pregnancy planners from the United States and Canada who were enrolled during the preconception period. INTERVENTION(S):None...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2016.04.011
更新日期：2016-08-01 00:00:00
abstract：:A randomized comparison trial was performed to evaluate whether follicular reaspiration with use of a double-lumen retrieval needle improves oocyte recovery when compared with direct follicular aspiration among low-responding patients undergoing ART. There were no differences observed in the number of oocytes retrieve...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2008.04.034
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:This study was designed to assess the ovarian response in the same patient in consecutive IVF cycles. DESIGN:Retrospective study. SETTING:Assisted reproductive unit at a university hospital. PATIENT(S):One hundred ninety women who underwent three consecutive cycles of IVF. INTERVENTION(S):All women used a...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)03237-x
更新日期：2002-04-01 00:00:00
