Effects of hormonal therapies and dietary soy phytoestrogens on vaginal cytology in surgically postmenopausal macaques.


OBJECTIVE:To evaluate the effects of conjugated equine estrogens, medroxyprogesterone acetate (MPA), conjugated equine estrogens combined with MPA, tamoxifen, and soybean estrogens on vaginal cytology in surgically postmenopausal cynomolgus macaques (Macaca fascicularis). DESIGN:Randomized long-term experimental trial. SETTING:Cytologic samples were taken from animals in two long-term randomized studies of the effects of hormonal and dietary effects on atherosclerosis. PATIENTS:Surgically postmenopausal cynomolgus macaques. INTERVENTIONS:Conjugated equine estrogens at the doses given do not exert an estrogenic effect on the with MPA, tamoxifen, and soybean estrogens were given via the diet, at doses scaled from those given to women. MAIN OUTCOME MEASURE:Vaginal cytologic maturation index. RESULTS:Conjugated equine estrogens elicited a marked maturation effect, which was antagonized partially by the addition of MPA. Tamoxifen produced a lesser estrogenic response. The cytologic pattern in animals given soybean estrogens or MPA alone did not differ from that of controls. CONCLUSION:Soybean estrogens at the doses given do not exert an estrogenic effect on the vagina of macaques. Conjugated equine estrogens are potent inducers of vaginal keratinization in this model; tamoxifen has a lesser effect. Medroxyprogesterone acetate partially antagonizes the effects of conjugated equine estrogens, and has no effect when given alone. The results support the possibility that soybean estrogens may be a "tissue-selective" estrogen with minimal effects on the reproductive tract.


Fertil Steril


Fertility and sterility


Cline JM,Paschold JC,Anthony MS,Obasanjo IO,Adams MR


Has Abstract


1996-05-01 00:00:00














  • Radiozinc spermatogenesis test: follow-up semen analysis.

    abstract::Semen analysis was performed on 8 men, every 2 months, for a period of 8 months, after the application of the radiozinc spermatogensis test. Semen was examined for volume, cell count, motility, and abnormal forms. Results showed no evidence of any changes in semen parameters. Student's test was used to compare the ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: el-Arini AF,Salama MN,el-Beheiry AH,el-Din Nofal MM

    更新日期:1973-11-01 00:00:00

  • Hormonal treatment of functional ovarian cysts: a randomized, prospective study.

    abstract::Estrogen (E)/progestin therapy for functional ovarian cysts is widely used in clinical practice, but the efficacy of this treatment has not been determined in controlled trials. In this study, we examined the effect of E/progestin administration in a group of infertility patients enrolled in a program of ovulation ind...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Steinkampf MP,Hammond KR,Blackwell RE

    更新日期:1990-11-01 00:00:00

  • Monitoring techniques for improved pregnancy rates during clomiphene ovulation induction.

    abstract::Despite the introduction of new ovulation-inducing agents, CC remains the drug of choice for most anovulatory patients. Before initiating therapy, patients should be evaluated to determine the cause of anovulation. Patients with ovarian failure, hyperprolactinemia, hypothyroidism, or forms of CAH should be treated wit...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Hammond MG

    更新日期:1984-10-01 00:00:00

  • Low concentration of circulating antimüllerian hormone is not predictive of reduced fecundability in young healthy women: a prospective cohort study.

    abstract:OBJECTIVE:To evaluate whether circulating levels of antimüllerian hormone (AMH) predict fecundability in young healthy women. DESIGN:Prospective cohort study. SETTING:General community. PATIENT(S):A total of 186 couples who intended to discontinue contraception to become pregnant were followed until pregnancy or for...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hagen CP,Vestergaard S,Juul A,Skakkebæk NE,Andersson AM,Main KM,Hjøllund NH,Ernst E,Bonde JP,Anderson RA,Jensen TK

    更新日期:2012-12-01 00:00:00

  • Two-dimensional and three-dimensional imaging of uterus and fallopian tubes in female infertility.

    abstract::Noninvasive imaging techniques play an important role in the female infertility diagnostic algorithm. In this review article, a description of the diagnostic performance and potential clinical value of both computerized tomographic virtual hysterosalpingography (CT-VHGS) and magnetic-resonance virtual hysterosalpingog...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Carrascosa P,Capuñay C,Vallejos J,Carpio J,Baronio M,Papier S

    更新日期:2016-06-01 00:00:00

  • Hormonal factors and the risk of invasive ovarian cancer: a population-based case-control study.

    abstract:OBJECTIVE:To examine the influence of hormone-related factors on the risk of invasive epithelial ovarian cancer (ovarian cancer). DESIGN:Population-based case-control study using in-person interviews. SETTING:Academic department of preventive medicine. PATIENT(S):Four hundred seventy-seven ovarian cancer patients an...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Pike MC,Pearce CL,Peters R,Cozen W,Wan P,Wu AH

    更新日期:2004-07-01 00:00:00

  • Disruption of protein phosphatase 1 complexes with the use of bioportides as a novel approach to target sperm motility.

    abstract:OBJECTIVE:To design protein phosphatase 1 (PP1)-disrupting peptides covalently coupled to inert cell-penetrating peptides (CPPs) as sychnologically organized bioportide constructs as a strategy to modulate sperm motility. DESIGN:Experimental study. SETTING:Academic research laboratory. PATIENT(S)/ANIMAL(S):Normozoos...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Silva JV,Freitas MJ,Santiago J,Jones S,Guimarães S,Vijayaraghavan S,Publicover S,Colombo G,Howl J,Fardilha M

    更新日期:2020-09-22 00:00:00

  • Embryo implantation during menstruation in the absence of adequate estradiol and progesterone support, with subsequent normal response to ovulation induction and superfetation.

    abstract:OBJECTIVE:To report an unusual case of embryo implantation and superfetation. DESIGN:Retrospective case analysis. SETTING:Oak Brook Fertility Center. PATIENT(S):A 41-year-old woman underwent two consecutive ovarian stimulation cycles interrupted by a normal menstrual period. Ovulation and implantation occurred durin...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Dmowski WP,DeOrio L,Rana N

    更新日期:1997-09-01 00:00:00

  • Ophthalmologic findings in patients using oral contraception.

    abstract::A detailed study was initiated to investigate thoroughly the possibility that any significant ophthalmologic changes might have occurred in patients using oral contraceptives (OCs) for varying periods. There were 212 patients and 50 control patients who were selected at random, 1/2 from private ophthalmology practice...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Faust JM,Tyler ET

    更新日期:1966-01-01 00:00:00

  • Use by gynecologists of a modified sensate focus technique to treat vaginismus causing infertility.

    abstract::Of 5,341 infertile couples seen over an 8-year period, 76 (1.4%) had primary vaginismus, of whom 63 were treated with the use of a simplified sensate focus technique. There was complete symptomatic resolution of vaginismus in 60 women, and pregnancy was achieved in 33. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jindal UN,Jindal S

    更新日期:2010-11-01 00:00:00

  • Gene expression during successful implantation in a natural cycle.

    abstract:OBJECTIVE:To determine the human endometrial transcriptome during embryonic implantation. DESIGN:Case report. SETTING:Tertiary fertility center. PATIENT(S):A 24-year-old woman who inadvertently became pregnant during an endometrial biopsy procedure. INTERVENTION(S):An endometrial biopsy was performed with a Pipelle...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Van Vaerenbergh I,McIntire R,Van Lommel L,Devroey P,Giudice L,Bourgain C

    更新日期:2010-01-01 00:00:00

  • Induction of midtrimester abortion by the combined method of continuous extravovular infusion of prostaglandin F2alpha and intracervical laminaria tents.

    abstract::Midtrimester abortion was successfully induced in 55 of 60 patients with continuous extraovular infusion of prostaglandin F2alpha (PGF2alpha) following the insertion of intracervical laminaria tents. Intravenous oxytocin was also used in 38 (63%) of the 60 patients. The mean induction-abortion time (IAT) was 11.72 hou...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hodgson JE,Van Gorp PE

    更新日期:1976-12-01 00:00:00

  • Male obesity and alteration in sperm parameters.

    abstract:OBJECTIVE:To study the effect of male obesity on sperm parameters and erectile dysfunction. DESIGN:Retrospective analysis. SETTING:Referral fertility center. PATIENT(S):Couples presenting for infertility treatment. INTERVENTION(S):On presentation, all men reported their weight and height and filled out an intake fo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hammoud AO,Wilde N,Gibson M,Parks A,Carrell DT,Meikle AW

    更新日期:2008-12-01 00:00:00

  • Endometrial infusion of human chorionic gonadotropin at the time of blastocyst embryo transfer does not impact clinical outcomes: a randomized, double-blind, placebo-controlled trial.

    abstract:OBJECTIVE:To determine whether endometrial hCG infusion at the time of human blastocyst transfer impacts implantation rates. DESIGN:Randomized double-blinded placebo-controlled trial. SETTING:Academic. PATIENT(S):Infertile couples with the female partner less than 43 years old (n = 300) undergoing fresh or frozen ET...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Hong KH,Forman EJ,Werner MD,Upham KM,Gumeny CL,Winslow AD,Kim TJ,Scott RT Jr

    更新日期:2014-12-01 00:00:00

  • Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging.

    abstract:OBJECTIVE:The aim of this article is to summarize the recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria. The 2011 STRAW + 10 reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period. ...

    journal_title:Fertility and sterility

    pub_type: 共识发展会议,杂志文章,实务指引


    authors: Harlow SD,Gass M,Hall JE,Lobo R,Maki P,Rebar RW,Sherman S,Sluss PM,de Villiers TJ,STRAW + 10 Collaborative Group.

    更新日期:2012-04-01 00:00:00

  • Anti-annexin V antibodies in patients with early pregnancy loss or implantation failures.

    abstract:OBJECTIVE:To describe the prevalence of annexin V antibodies (aANX) in women with early recurrent pregnancy losses (RPLs) or recurrent IVF-ET failure. DESIGN:Retrospective data analysis. SETTING:Tokai University Hospital, Kanagawa, Japan. PATIENT(S):Two hundred thirty-eight patients with RPLs, 48 patients with recur...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Matsubayashi H,Arai T,Izumi S,Sugi T,McIntyre JA,Makino T

    更新日期:2001-10-01 00:00:00

  • Birth records from Swiss married couples analyzed over the past 35 years reveal an aging of first-time mothers by 5.1 years while the interpregnancy interval has shortened.

    abstract::Although the general trend for delaying childbearing is generally viewed as causing infertility, its consequences on the interpregnancy interval have been unknown. A study of birth records for Swiss married women from 1969 to 2006 revealed that the woman's age at first birth has increased from 25.0 to 30.1 years, wher...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kalberer U,Baud D,Fontanet A,Hohlfeld P,de Ziegler D

    更新日期:2009-12-01 00:00:00

  • Comparison of different sources of platelet-rich plasma as treatment option for infertility-causing endometrial pathologies.

    abstract:OBJECTIVE:To study the effect of human plasma from different sources, namely, umbilical cord blood and adult blood platelet-rich plasma (PRP), on the regeneration of endometrial damage. DESIGN:Composition analysis, in vitro approaches, and a preclinical murine model using plasma to promote endometrial regeneration. S...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: de Miguel-Gómez L,López-Martínez S,Campo H,Francés-Herrero E,Faus A,Díaz A,Pellicer A,Domínguez F,Cervelló I

    更新日期:2020-08-24 00:00:00

  • Semen leukocytes: friends or foes?

    abstract:OBJECTIVE:To test the hypothesis that male reproductive tract leukocytes function in the elimination of abnormal spermatozoa from ejaculated semen. DESIGN:Semen specimens with > or = 2 x 10(6) nonspermatozoal cells/mL were examined for leukocytes and for mature sperm with ideal morphology. SETTING:Andrology laborator...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kiessling AA,Lamparelli N,Yin HZ,Seibel MM,Eyre RC

    更新日期:1995-07-01 00:00:00

  • Successful induction of ovulation using highly purified follicle-stimulating hormone in a woman with Kallmann's syndrome.

    abstract:OBJECTIVE:To describe a woman with Kallmann's syndrome who was treated successfully with highly purified FSH to achieve ovulation induction and pregnancy. DESIGN:Case report. SETTING:University hospital. PATIENT(S):A 32-year-old woman with Kallmann's syndrome who had been treated with oral contraceptives to prime se...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Battaglia C,Salvatori M,Regnani G,Giulini S,Primavera MR,Volpe A

    更新日期:2000-02-01 00:00:00

  • Noncompliance among a group of women using a novel method of contraception.

    abstract:OBJECTIVE:To compare the incidence of noncompliance measured objectively by a home use fertility monitor with the traditional self-reported incidence of compliance in a study of a new method of contraception. DESIGN:Prospective cohort study. SETTING:A large family planning clinic in Edinburgh. PATIENT(S):Thirty-two ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hapangama DK,Glasier AF,Baird DT

    更新日期:2001-12-01 00:00:00

  • The effect of legislation on outcomes of assisted reproduction technology: lessons from the 2004 Italian law.

    abstract:OBJECTIVE:To evaluate the effect of the 2004 Italian regulations (insemination of

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: La Sala GB,Villani MT,Nicoli A,Valli B,Iannotti F,Blickstein I

    更新日期:2008-04-01 00:00:00

  • The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production.

    abstract:OBJECTIVE:To assess the endocrine, paracrine, and autocrine milieu in patients with endometriosis on the basis of the measurement of several cytokines in serum and follicular fluid (FF) and in vitro culture of granulosa luteal cells. DESIGN:Case-control study. SETTING:In vitro fertilization program at the Instituto V...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Pellicer A,Albert C,Mercader A,Bonilla-Musoles F,Remohí J,Simón C

    更新日期:1998-09-01 00:00:00

  • Development of a rapid, sensitive, and reproducible laboratory test kit for the assessment of plasma membrane integrity of human sperm.

    abstract:OBJECTIVE:To develop a rapid, sensitive, and reproducible hypoosmotic swelling test kit for the assessment of plasma membrane integrity of human sperm in vitro. DESIGN:Prospective comparison of results with the World Health Organization (WHO) method, performed simultaneously. SETTING:Infertility center in a major cit...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Misro MM,Chaki SP

    更新日期:2008-01-01 00:00:00

  • Semen analysis by electron and fluorescence microscopy in a case of partial hydatidiform mole reveals a high incidence of abnormal morphology, diploidy, and tetraploidy.

    abstract:OBJECTIVE:To perform a highly detailed semen analysis in a man whose wife had a partial mole. DESIGN:Case report. SETTING:Gynecology departments of two university hospitals and a laboratory of histology/embryology. PATIENT(S):A 32-year-old man whose wife had a partial mole. INTERVENTION(S):Sperm characteristics wer...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Chatzimeletiou K,Sioga A,Oikonomou L,Charalampidou S,Kantartzi P,Zournatzi V,Panidis D,Goulis DG,Papadimas I,Tarlatzis BC

    更新日期:2011-06-01 00:00:00

  • Reliability of narrow-band imaging (NBI) hysteroscopy: a comparative study.

    abstract:OBJECTIVE:To evaluate the usefulness of narrow-band imaging (NBI) technology for improving the diagnostic reliability of hysteroscopy. DESIGN:Prospective controlled clinical study (Canadian Task Force classification II-2). SETTING:University hospital. PATIENT(S):Three hundred ninety-five outpatient women undergoing ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Cicinelli E,Tinelli R,Colafiglio G,Pastore A,Mastrolia S,Lepera A,Clevin L

    更新日期:2010-11-01 00:00:00

  • Use of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles: a pilot study.

    abstract:OBJECTIVE:To compare the clinical outcomes between letrozole and clomiphene citrate (CC) in gonadotropin-combined intrauterine insemination (IUI) cycles. DESIGN:Prospective pilot study. SETTING:One university hospital and two private infertility clinics. PATIENT(S):Ninety-three infertile couples eligible for superov...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jee BC,Ku SY,Suh CS,Kim KC,Lee WD,Kim SH

    更新日期:2006-06-01 00:00:00

  • Failure of seminal plasma to enter the uterus and oviducts of the rabbit following artificial insemination.

    abstract::Twelve adult does in estrus were artificially inseminated with 1 ml of semen from bucks that had received injections of 3H-thymidine 22 to 32 days previously. The ejaculates contained radioactive seminal plasma and unlabeled sperm. The reproductive tracts of the does were removed at selected intervals after inseminati...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Asch RH,Balmaceda J,Pauerstein CJ

    更新日期:1977-06-01 00:00:00

  • Isolated spermatogonia protrude active pseudopodia in vitro.

    abstract::When dispersed spermatogenic cells obtained by enzymatic digestion from prepuberal mice, adult male mice, nonazoospermic men and normospermic men were observed live using Normarski optics, it was found that, respectively, 47.4%, 1.4%, 5.1%, and 2.4% of them protruded active pseudopodia. These cells were 8 to 10 mum in...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tanaka A,Nagayoshi M,Awata S,Himeno N,Tanaka I,Kusunoki H

    更新日期:2008-08-01 00:00:00

  • Effects of sulpiride-induced hyperprolactinemia on human ovarian follicles during the late follicular phase.

    abstract::The effect of hyperprolactinemia during the midfollicular through the late follicular phase of the menstrual cycle on follicular development and follicular fluid hormone concentrations was studied. Fourteen women underwent laparotomy in the late follicular phase for gynecologic reasons; 6 were treated with sulpiride d...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sowa M,Tsuji K,Nakano R

    更新日期:1986-12-01 00:00:00