The likelihood of finding mature sperm cells in men with AZFb or AZFb-c deletions: six new cases and a review of the literature (1994-2010).


OBJECTIVE:To reassess the predictive value of detecting sperm cells in men with AZFb or AZFb-c deletions. DESIGN:Retrospective analysis of previously reported men with AZFb or AZFb-c deletions and the addition of six new cases. SETTING:Fertility institution. PATIENT(S):Men with both sequence tagged site marker identification and testicular cytology/histology findings. INTERVENTION(S):Systematic review of reported men with microdeletions that included eligibility, data extraction and analysis. MAIN OUTCOME MEASURE(S):Availability of sperm cells for intracytoplasmic sperm injection (ICSI) in men with AZFb/AZFb-c microdeletions. RESULT(S):The average prevalences reported for AZFb, AZFb-c, partial AZFb, and partial AZFb-c in azoospermic men were 0.9%±0.07%, 2.7%±0.93%, 1.23%±0.9%, and 1%±0.6%, respectively. Sperm cells were identified in 7% and 3% of the 28 and 71 men with complete AZFb and AZFb-c and in 57% and 43% of the 14 and 7 men with partial AZFb and AZFb-c deletions, respectively. The likelihood of finding sperm cells in men with complete versus partial AZFb and AZFb-c deletions was significantly lower. As yet, no clinical or chemical pregnancy after ICSI in cases with complete AZFb/b-c microdeletions has been reported. CONCLUSION(S):Determining the extent of AZFb or AZFb-c deletions is critical considering the frequency and the reasonable prospect of finding sperm cells in partial AZFb/AZFb-c deletions. Referring men with complete AZFb/b-c microdeletions to testicular sperm extraction/ICSI programs should be revaluated.


Fertil Steril


Fertility and sterility


Kleiman SE,Yogev L,Lehavi O,Hauser R,Botchan A,Paz G,Yavetz H,Gamzu R




Has Abstract


2011-05-01 00:00:00


2005-12, 2012.e1-4












  • Adhesion formation from release of dermoid contents in the peritoneal cavity and effect of copious lavage: a prospective, randomized, blinded, controlled study in a rabbit model.

    abstract:OBJECTIVES:To determine, in a rabbit model, whether peritoneal exposure to dermoid cyst material produces inflammation and adhesions above control levels and whether saline lavage reduces the degree of peritoneal reaction. DESIGN:A prospective, randomized, blinded, controlled study of adhesion formation. Thirty New Ze...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Fielder EP,Guzick DS,Guido R,Kanbour-Shakir A,Krasnow JS

    更新日期:1996-04-01 00:00:00

  • Criteria for number of embryos to transfer: a committee opinion.

    abstract::Based on American Society for Reproductive Medicine (ASRM) and Society for Assisted Reproductive Technology data available for 2010, ASRM's guidelines for the number of embryos to be transferred in in vitro fertilization cycles have been further refined in continuing efforts to reduce the number of higher-order multip...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,实务指引


    authors: Practice Committee of the American Society for Reproductive Medicine and the Practice Committee of the Society for Assisted Reproductive Technology.

    更新日期:2013-01-01 00:00:00

  • Characterization of aneuploidy rates, protamine levels, ultrastructure, and functional ability of round-headed sperm from two siblings and implications for intracytoplasmic sperm injection.

    abstract:OBJECTIVE:To characterize and contrast protamine levels, chromatin decondensation, chromosome aneuploidy rates, and functional ability of round-headed sperm from two brothers with round-headed sperm syndrome. DESIGN:Analysis of semen samples from siblings with round-headed sperm syndrome and comparison with semen of f...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Carrell DT,Emery BR,Liu L

    更新日期:1999-03-01 00:00:00

  • Agonist "flare-up" versus antagonist in the management of poor responders undergoing in vitro fertilization treatment.

    abstract:OBJECTIVE:To compare the agonist flare-up and antagonist protocols in the management of poor responders to the standard long down-regulation protocol. DESIGN:Retrospective comparative study. SETTING:Assisted conception center. PATIENT(S):One hundred thirty-four patients undergoing IVF/ intracytoplasmic sperm injecti...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Mohamed KA,Davies WA,Allsopp J,Lashen H

    更新日期:2005-02-01 00:00:00

  • Congenital Müllerian anomalies: diagnostic accuracy of three-dimensional ultrasound.

    abstract:OBJECTIVE:To determine whether it is possible to identify and diagnose accurately Müllerian anomalies with three-dimensional (3-D) ultrasound (US). DESIGN:Controlled blinded clinical study. SETTING:Normal human volunteers undergoing infertility evaluation in a university hospital. PATIENTS:Forty-two patients who und...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Raga F,Bonilla-Musoles F,Blanes J,Osborne NG

    更新日期:1996-03-01 00:00:00

  • Higher chromosomal aberration rate in miscarried conceptus from polycystic ovary syndrome women undergoing assisted reproductive treatment.

    abstract:OBJECTIVE:To assess the potential association between polycystic ovary syndrome (PCOS) and chromosomally aberrant miscarriage during treatment with assisted reproductive technology (ART). DESIGN:A retrospective, single-center study. SETTING:University-affiliated reproductive center. PATIENT(S):A total of 328 patient...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Li Y,Wang L,Xu J,Niu W,Shi H,Hu L,Zhang Y,Zhang M,Bao X,Zhang N,Sun Y

    更新日期:2019-05-01 00:00:00

  • Professionalism and member attitudes.

    abstract::A recent survey of American Society for Reproductive Medicine (ASRM) members indicates that they express a commitment to professional standards and a desire for advocacy. Their attitudes echo traditional values of professionalism, upon which ASRM should capitalize. ...

    journal_title:Fertility and sterility

    pub_type: 评论,杂志文章


    authors: Brzyski RG

    更新日期:2004-09-01 00:00:00

  • Frozen-thawed day 5 blastocyst transfer is associated with a lower risk of ectopic pregnancy than day 3 transfer and fresh transfer.

    abstract:OBJECTIVE:To determine the ectopic pregnancy rate with fresh versus frozen-thawed embryo transfers, and factors associated with ectopic pregnancy in patients undergoing IVF-ET. DESIGN:Retrospective analysis. SETTING:Institutional IVF center. PATIENT(S):A total of 3,183 patients who received 3,340 blastocysts transfe...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Fang C,Huang R,Wei LN,Jia L

    更新日期:2015-03-01 00:00:00

  • Cryopreservation of human spermatozoa: correlations of ultrastructural sperm head configuration with sperm motility and ability to penetrate zona-free hamster ova.

    abstract::Freezing and storage of human male gametes is associated with a reduction in the overall semen quality and establishment of pregnancy. This study was done to evaluate the integrity of sperm head ultrastructure (SHU) with computerized and vapor freezing. Comparisons were made between the effect of cryopreservatives gly...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Serafini PC,Hauser D,Moyer D,Marrs RP

    更新日期:1986-10-01 00:00:00

  • Lipid peroxidation and vitamin E in serum and follicular fluid of infertile women with peritoneal endometriosis submitted to controlled ovarian hyperstimulation: a pilot study.

    abstract:OBJECTIVE:To assess the level of lipid peroxidation (LP) and vitamin E in the follicular fluid and serum of infertile patients, with or without endometriosis, who were submitted to ovulation induction for assisted reproduction procedures. DESIGN:Prospective study. SETTING:Assisted conception unit, university hospital...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Campos Petean C,Ferriani RA,dos Reis RM,de Moura MD,Jordão AA Jr,Navarro PA

    更新日期:2008-12-01 00:00:00

  • Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis.

    abstract:OBJECTIVE:To investigate types of nerve fibers in endometrium and myometrium in women with endometriosis. DESIGN:Laboratory study using human tissue. SETTING:University-based laboratory. PATIENT(S):Women with and without endometriosis undergoing hysterectomy. INTERVENTION(S):Histologic sections of contiguous endome...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tokushige N,Markham R,Russell P,Fraser IS

    更新日期:2007-10-01 00:00:00

  • Importance of the biopsy date in autologous endometrial cocultures for patients with multiple implantation failures.

    abstract:OBJECTIVE:To analyze the effectiveness of autologous endometrial coculture by the cycle day of the endometrial biopsy. DESIGN:Retrospective study. SETTING:University-based IVF center. PATIENT(S):Two hundred eight patients with multiple IVF failures. INTERVENTION(S):Embryos were split and randomly allocated to growt...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Spandorfer SD,Barmat LI,Navarro J,Liu HC,Veeck L,Rosenwaks Z

    更新日期:2002-06-01 00:00:00

  • The endocrine effects of spironolactone used as an antiandrogen.

    abstract::Eight castrate, estrogen-replaced women were given 200 mg spironolactone daily for 4 weeks. The response of plasma dehydroepiandrosterone sulfate (DHEAS), testosterone (T), and androstenedione (delta 4A), all indicators of adrenal C19-steroid production, varied greatly among individuals. Sixteen women with idiopathic ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Young RL,Goldzieher JW,Elkind-Hirsch K

    更新日期:1987-08-01 00:00:00

  • Plasminogen activator inhibitor 1 and miscarriage after metformin treatment and laparoscopic ovarian drilling in patients with polycystic ovary syndrome.

    abstract::In women with polycystic ovary syndrome, metformin administration, not laparoscopic ovarian drilling, reduces plasminogen activator inhibitor 1 (PAI-1) activity. The lack of a decrease in PAI-1 activity is related to a high risk for miscarriage. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Palomba S,Orio F Jr,Falbo A,Russo T,Tolino A,Zullo F

    更新日期:2005-09-01 00:00:00

  • Menses resumption after cancer treatment-induced amenorrhea occurs early or not at all.

    abstract:OBJECTIVE:To identify factors associated with cancer treatment-induced amenorrhea and time to return of menses. DESIGN:Population-based cohort study. SETTING:Not applicable. PATIENT(S):Female cancer survivors who were diagnosed with cancer between the ages of 20 and 35 and were at least 2 years postdiagnosis at the ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jacobson MH,Mertens AC,Spencer JB,Manatunga AK,Howards PP

    更新日期:2016-03-01 00:00:00

  • Tumor necrosis factor-alpha regulates vascular endothelial growth factor secretion by human oviductal epithelial cells and stromal fibroblasts.

    abstract::Tumor necrosis factor-alpha stimulates the secretion of vascular endothelial growth factor by cultured human oviductal epithelial cells and stromal fibroblasts. Tumor necrosis factor-alpha-stimulated vascular endothelial growth factor secretion by these cells may control oviductal fluid secretion by regulating vascula...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Nasu K,Itoh H,Yuge A,Nishida M,Kawano Y,Narahara H

    更新日期:2007-01-01 00:00:00

  • A potential role for colony-stimulating factor 1 in the genesis of the early endometriotic lesion.

    abstract:OBJECTIVE:To investigate the role(s) of colony-stimulating factor 1 (CSF-1) on the development of early endometriosis in a murine model by comparing rate of lesion formation in mice [1] homozygous for a CSF-1 mutation versus syngeneic controls and [2] after treatment with imatinib, a commercially available tyrosine kin...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jensen JR,Witz CA,Schenken RS,Tekmal RR

    更新日期:2010-01-01 00:00:00

  • Ultrasonographic predictors of implantation after assisted reproduction.

    abstract:OBJECTIVE:To assess the utility of endometrial thickness, echogenic endometrial pattern, and uterine artery impedance measured as pulsativity index in predicting implantation. DESIGN:Prospective case-controlled study of infertile patients undergoing assisted reproductive technologies (ARTs). PATIENTS:Four hundred fiv...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Coulam CB,Bustillo M,Soenksen DM,Britten S

    更新日期:1994-11-01 00:00:00

  • Evaluation of polyacrylamide gel as substitute for human cervical mucus in the sperm penetration test.

    abstract:OBJECTIVE:To compare polyacrylamide gel as synthetic medium with human cervical mucus (CM) for the in vitro sperm-penetration test during infertility investigation. PATIENTS:One hundred sixty-nine randomly chosen couples with a median duration of infertility of 4 (range, 1 to 16) years presenting at the infertility un...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Eggert-Kruse W,Schwalbach B,Rohr G,Klinga K,Tilgen W,Runnebaum B

    更新日期:1993-09-01 00:00:00

  • Expression of secretory leukocyte protease inhibitor in women with endometriosis.

    abstract:OBJECTIVE:To explore endometriosis-related molecules in patients with use of differential display analysis. DESIGN:Prospective study. SETTING:Nagoya City University Medical School, Nagoya, Japan. PATIENT(S):Women with endometriosis (n = 27) and without endometriosis (n = 21). INTERVENTION(S):Surgery was scheduled i...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Suzumori N,Sato M,Yoneda T,Ozaki Y,Takagi H,Suzumori K

    更新日期:1999-11-01 00:00:00

  • Coordination of early antral follicles by luteal estradiol administration provides a basis for alternative controlled ovarian hyperstimulation regimens.

    abstract:OBJECTIVE:To investigate whether luteal E(2) administration reduces size discrepancies of early antral follicles. DESIGN:Prospective, crossover study. SETTING:ART unit, Clamart, France. PATIENT(S):Sixty women and 120 cycles. INTERVENTION(S):On cycle day 3 (baseline day 3), all women underwent measurements of early ...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Fanchin R,Cunha-Filho JS,Schonäuer LM,Kadoch IJ,Cohen-Bacri P,Frydman R

    更新日期:2003-02-01 00:00:00

  • Mindfulness-Based Program for Infertility: efficacy study.

    abstract:OBJECTIVE:To present and determine the impact of the Mindfulness-Based Program for Infertility (MBPI). DESIGN:Controlled clinical trial. SETTING:University research unit. PATIENT(S):Fifty-five infertile women completed the MBPI, and 37 infertile women were assigned to a control group. INTERVENTION(S):The MBPI inclu...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Galhardo A,Cunha M,Pinto-Gouveia J

    更新日期:2013-10-01 00:00:00

  • Fluoroscopically guided synechiolysis for patients with Asherman's syndrome: menstrual and fertility outcomes.

    abstract:OBJECTIVE:To describe a 5-year experience of fluoroscopically guided hysteroscopic synechiolysis for Asherman's syndrome. DESIGN:Retrospective, uncontrolled cohort study. SETTING:Department of Endo-Gynaecology, University of New South Wales, Royal Hospital for Women, Randwick, Sydney, New South Wales, Australia. PAT...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Thomson AJ,Abbott JA,Kingston A,Lenart M,Vancaillie TG

    更新日期:2007-02-01 00:00:00

  • Genome-based expression profiling as a single standardized microarray platform for the diagnosis of endometrial disorder: an array of 126-gene model.

    abstract:OBJECTIVE:To assess the molecular signatures underlying endometrial disorder using cDNA microarray. DESIGN:Gene expression-based oligonucleotide array of the normal endometrium. SETTING:University hospital. PATIENT(S):Humans. INTERVENTION(S):Endometrial tissues were obtained from 28 normal cycling women undergoing ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tseng LH,Chen I,Chen MY,Yan H,Wang CN,Lee CL

    更新日期:2010-06-01 00:00:00

  • Androgen biosynthesis in experimental cryptorchidism.

    abstract::This study was conducted to investigate the effects of unilateral cryptorchidism on androgen production and testicular maturation. Experimental cryptorchidism was produced in small and large prepuberal guinea pigs by forcing the testis to remain in the abdomen for a period of 30 days. Small prepuberal animals, which d...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hoscholan JC,Andrada JA

    更新日期:1975-07-01 00:00:00

  • Relevance of assessing the uterine microbiota in infertility.

    abstract::Technical advances in massive parallel sequencing have allowed the characterization of the whole reproductive tract microbiome in all the compartments beyond the vagina. The microbiota in the uterine cavity seem to be a continuum from the microbiota in the vagina, but several works have reported significant difference...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Moreno I,Simon C

    更新日期:2018-08-01 00:00:00

  • Influence of progesterone on endometrial nitric oxide synthase expression.

    abstract:OBJECTIVE:To determine the effect of P on nitric oxide synthase (NOS) expression in human endometrial epithelial cells. DESIGN:Laboratory-based study. SETTING:University-based research institute. PATIENT(S):None. INTERVENTION(S):The effect of P on the expression of NOS protein isoforms was examined in an in vitro p...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Khorram O,Han G

    更新日期:2009-05-01 00:00:00

  • Twin tubal pregnancy: a rising complication?

    abstract:OBJECTIVE:To present four cases of twin tubal pregnancies and discuss possible etiologies. Twin tubal pregnancies are a rare event, with incidence rates estimated as 1 out of 725-1,580 of tubal pregnancies. DESIGN:Case series. SETTING:Department of obstetrics and gynecology at a tertiary health care facility. PATIEN...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Svirsky R,Maymon R,Vaknin Z,Mendlovic S,Weissman A,Halperin R,Herman A,Pansky M

    更新日期:2010-10-01 00:00:00

  • Vaginal-cervical epithelial permeability decreases after menopause.

    abstract:OBJECTIVE:To determine the effects of menopause (aging and E) on vaginal-cervical epithelial paracellular permeability. DESIGN:Experimental, basic clinical research. SETTING:Academic research environment. PATIENT(S):Premenopausal, perimenopausal, and postmenopausal women, aged 35-65 years. INTERVENTION(S):Primary t...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Gorodeski GI

    更新日期:2001-10-01 00:00:00

  • Incomplete and inconsistent reporting of maternal and fetal outcomes in infertility treatment trials.

    abstract::Pregnancy outcomes and adverse outcomes in infertility trials are reported to varying extents; for example, 35% of clinical trials reported no information on pregnancy loss, only 43% reported adverse events during the preconception treatment period, and only 7% reported any serious adverse events. Incomplete reporting...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Dapuzzo L,Seitz FE,Dodson WC,Stetter C,Kunselman AR,Legro RS

    更新日期:2011-06-30 00:00:00