The likelihood of finding mature sperm cells in men with AZFb or AZFb-c deletions: six new cases and a review of the literature (1994-2010).

Abstract:

OBJECTIVE:To reassess the predictive value of detecting sperm cells in men with AZFb or AZFb-c deletions. DESIGN:Retrospective analysis of previously reported men with AZFb or AZFb-c deletions and the addition of six new cases. SETTING:Fertility institution. PATIENT(S):Men with both sequence tagged site marker identification and testicular cytology/histology findings. INTERVENTION(S):Systematic review of reported men with microdeletions that included eligibility, data extraction and analysis. MAIN OUTCOME MEASURE(S):Availability of sperm cells for intracytoplasmic sperm injection (ICSI) in men with AZFb/AZFb-c microdeletions. RESULT(S):The average prevalences reported for AZFb, AZFb-c, partial AZFb, and partial AZFb-c in azoospermic men were 0.9%±0.07%, 2.7%±0.93%, 1.23%±0.9%, and 1%±0.6%, respectively. Sperm cells were identified in 7% and 3% of the 28 and 71 men with complete AZFb and AZFb-c and in 57% and 43% of the 14 and 7 men with partial AZFb and AZFb-c deletions, respectively. The likelihood of finding sperm cells in men with complete versus partial AZFb and AZFb-c deletions was significantly lower. As yet, no clinical or chemical pregnancy after ICSI in cases with complete AZFb/b-c microdeletions has been reported. CONCLUSION(S):Determining the extent of AZFb or AZFb-c deletions is critical considering the frequency and the reasonable prospect of finding sperm cells in partial AZFb/AZFb-c deletions. Referring men with complete AZFb/b-c microdeletions to testicular sperm extraction/ICSI programs should be revaluated.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Kleiman SE,Yogev L,Lehavi O,Hauser R,Botchan A,Paz G,Yavetz H,Gamzu R

doi

10.1016/j.fertnstert.2011.01.162

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

2005-12, 2012.e1-4

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(11)00241-X

journal_volume

95

pub_type

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