Effect of sperm treatment with exogenous platelet-activating factor on the outcome of intrauterine insemination.

Abstract:

OBJECTIVE:To evaluate the effect of sperm treatment with exogenous platelet-activating factor (PAF) on IUI clinical pregnancy rate. DESIGN:Prospective randomized study. SETTING:Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece. SUBJECT(S):Fifty-two couples with unexplained infertility, candidates for IUI. INTERVENTION(S):Sperm treatment with an exogenous mixture of PAF (final concentration, 10(-7) mol/L) in sperm-washing medium, direct swim-up technique of sperm preparation, a maximum of six IUI cycles per couple with or without PAF treatment. MAIN OUTCOME MEASURE(S):Clinical pregnancy rate (pregnancies confirmed by ultrasonography per hundred cycles). RESULT(S):The overall clinical pregnancy rate after a maximum of six IUI cycles was significantly higher when sperm was treated with PAF compared with the rate after the direct swim-up technique (23.07% vs. 7.92%). CONCLUSION(S):Treatment of sperm with exogenous PAF might improve the clinical outcome of IUI in cases of unexplained infertility.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Grigoriou O,Makrakis E,Konidaris S,Hassiakos D,Papadias K,Baka S,Creatsas G

doi

10.1016/j.fertnstert.2004.07.980

keywords:

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

618-21

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(04)03188-7

journal_volume

83

pub_type

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