当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Prospective randomized double-blind trial of 3 versus 6 months of nafarelin therapy for endometriosis associated pelvic pain.

Prospective randomized double-blind trial of 3 versus 6 months of nafarelin therapy for endometriosis associated pelvic pain.

Abstract：

OBJECTIVES:To determine the effectiveness of a 3-month course of nafarelin and, furthermore, to determine the long-term efficacy in patients treated for 3 and 6 months with nafarelin for symptoms associated with endometriosis. DESIGN:Double-blind, prospective, multicenter, clinical trial. SETTING:Fifteen reproductive endocrine clinics throughout the United States. PATIENTS:One hundred seventy-nine women with pelvic pain and endometriosis. INTERVENTIONS:Patients were assigned randomly to 3 months nafarelin followed by 3 months of placebo (n = 91) or to 6 months nafarelin (n = 88) in a prospective, randomized, double-blind multicenter trial. Patients were followed for 12 months after cessation of therapy. MAIN OUTCOME MEASURES:Patient-reported pain scores and physician-reported physical exam findings. RESULTS:Pain scores dropped significantly by the end of treatment in both groups. Symptoms recurred in both groups, and pain scores gradually increased during the follow-up period but always remained below baseline in both groups. No significant difference in efficacy was noted between the groups. A total of 26% of patients in each group underwent retreatment for recurrent symptoms. CONCLUSIONS:A 3-month course of nafarelin provided effective symptom relief for endometriosis. One year follow-up demonstrated continued pain relief but with gradual return of symptoms.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Hornstein MD,Yuzpe AA,Burry KA,Heinrichs LR,Buttram VL Jr,Orwoll ES

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

955-62

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)57530-X

journal_volume

63

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

相关文献

FERTILITY AND STERILITY文献大全
  • Ovarian suppression induced with Buserelin or danazol in the management of endometriosis: a randomized, comparative study.

    abstract：:The effectiveness of Buserelin (Hoechst-Roussel Pharmaceuticals, Inc., Somerville, NJ) (0.2 mg subcutaneously [SC] or 1.2 mg intranasally [IN] per day) and danazol (800 mg per day) in inducing ovarian suppression for the management of endometriosis was compared in a prospective randomized study. During 6 months of tre...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0015-0282(16)60543-5

    authors： Dmowski WP,Radwanska E,Binor Z,Tummon I,Pepping P

    更新日期：1989-03-01 00:00:00

  • Clinical and endocrine effects of a microdose GnRH agonist flare regimen administered to poor responders who are undergoing in vitro fertilization.

    abstract：OBJECTIVE:To assess the endocrine and clinical responses to microdose GnRH agonist (GnRH-a) that was administered in the early follicular phase before controlled ovarian hyperstimulation to poor responders who were candidates for IVF-ET. DESIGN:Prospective nonrandomized trial with historical controls. SETTING:Tertiar...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(97)00575-x

    authors： Surrey ES,Bower J,Hill DM,Ramsey J,Surrey MW

    更新日期：1998-03-01 00:00:00

  • Elevated serum dehydroepiandrosterone sulfate levels in patients with insulin resistance, hirsutism, and acanthosis nigricans.

    abstract：:The association of insulin resistance, hyperandrogenism, and acanthosis nigricans is well established. The ovary is thought to be the site of the excess androgen production. The purpose of this study was to assess the adrenal contribution to the hyperandrogenic state in these women. Twenty-three patients presenting wi...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)50001-6

    authors： Alper MM,Garner PR

    更新日期：1987-02-01 00:00:00

  • The route of administration influences the effect of estrogen on insulin sensitivity in postmenopausal women.

    abstract：OBJECTIVE:To determine the effect of transdermal estrogen on insulin sensitivity in postmenopausal women and to compare this effect with changes observed with oral conjugated equine estrogens. DESIGN:Fourteen postmenopausal women were randomized to receive a transdermal E2 patch, 0.1 mg, for 25 days each month (n = 7)...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0015-0282(16)57181-7

    authors： Lindheim SR,Duffy DM,Kojima T,Vijod MA,Stanczyk FZ,Lobo RA

    更新日期：1994-12-01 00:00:00

  • Acid Tyrode's solution can stimulate parthenogenetic activation of human and mouse oocytes.

    abstract：:Fresh and aged (24 hours after ovulation) human oocytes and recently ovulated mouse oocytes may be activated by exposure to acidified Tyrode's solution. No activation of either type of human oocyte was observed after exposure to hyaluronidase or pronase, but significant numbers of fresh mouse oocytes were activated af...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)53279-8

    authors： Johnson MH,Pickering SJ,Braude PR,Vincent C,Cant A,Currie J

    更新日期：1990-02-01 00:00:00

  • Absence of circulating HL-A lymphocytotoxic antibodies in men 21 to 44 months after vasectomy.

    abstract：:Nineteen vasectomized men were followed for 21 to 42 months after surgery, and their sera were tested for the presence of HL-A lymphocytoxic antibodies. In a previous study, the sera of two of these men had shown a definite increase in serum reactivity 6 to 12 months after surgery. Only one of the nineteen tested in t...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)42494-5

    authors： Jennings PB,Wettlaufer JN,Paulsen CA

    更新日期：1977-04-01 00:00:00

  • Impact of retained embryos on the outcome of assisted reproductive technologies.

    abstract：OBJECTIVE:To assess the impact of embryo retention in the embryo transfer catheter followed by "immediate" retransfer on pregnancy outcome in women undergoing assisted reproduction. DESIGN:Retrospective analysis of embryo transfer following in vitro fertilization. SETTING:Assisted reproductive technology practice in ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2004.01.035

    authors： Lee HC,Seifer DB,Shelden RM

    更新日期：2004-08-01 00:00:00

  • Inhibition of ovarian luteinizing hormone (LH) and follicle-stimulating hormone receptor levels with an LH-releasing hormone agonist during the estrous cycle in the rat.

    abstract：:A single injection of the luteinizing hormone (LH)-releasing hormone (LHRH) agonist [D-Ala6,des-Gly-NH2(10)]LHRH ethylamide to female rats on diestrus I produced a marked reduction in ovarian LH/human chorionic gonadotropin (hCG) and follicle-stimulating hormone (FSH) receptor levels, uterine weight, and plasma proges...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)43524-7

    authors： Kledzik GS,Cusan L,Auclair C,Kelly PA,Labrie F

    更新日期：1978-09-01 00:00:00

  • Late hemorrhage after transcervical division of a uterine septum: a report of two cases.

    abstract：:The transcervical division of uterine septa is usually described as a simple procedure associated with minimal morbidity. Two cases are presented describing late hemorrhage after this procedure. Approaches to avoiding this complication as well as management principles are described. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)54984-x

    authors： Kazer RR,Meyer K,Valle RF

    更新日期：1992-04-01 00:00:00

  • Long-acting gonadotropin hormone-releasing hormone analog used to treat uteri.

    abstract：:Because the size of leiomyomata uteri often decreases significantly after menopause, the authors elected to employ a long-acting gonadotropin hormone-releasing hormone analog (GnRH-alpha) (imbzl-D-His6-Pro9-Net-GnRH) to create a state of pseudomenopause in six patients with leiomyomata uteri diagnosed on the basis of ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)49332-5

    authors： Coddington CC,Collins RL,Shawker TH,Anderson R,Loriaux DL,Winkel CA

    更新日期：1986-05-01 00:00:00

  • Effects of hormone replacement therapy on cardiovascular risk factors in postmenopausal women.

    abstract：OBJECTIVE:To investigate changes in plasma lipoprotein profile, hemostatic factors, platelet aggregation, endothelin-1, and cardiac function during postmenopausal sequential 6-month hormone replacement therapy (HRT). DESIGN:Open longitudinal prospective study. SETTING:Gynecologic department of a medical center. PATI...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(97)00487-1

    authors： Chen FP,Lee N,Wang CH,Cherng WJ,Soong YK

    更新日期：1998-02-01 00:00:00

  • A computerized sperm motion analysis [published erraturm appears in Fertil Steril 1986 Nov;46(5):980].

    abstract：:Semen samples from 35 fertile men and husbands of 32 infertile couples were evaluated with the use of a rapid computerized sperm motion analysis (CSA). The counts and percentages of motile sperm measured by routine semen analysis (RSA) and CSA were comparable in both groups. In CSA, mean values of swimming speed (micr...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Mathur S,Carlton M,Ziegler J,Rust PF,Williamson HO

    更新日期：1986-09-01 00:00:00

  • Discovery of a novel biomarker in the urine in women with endometriosis.

    abstract：OBJECTIVE:To investigate whether proteins secreted in urine differ between women with and without endometriosis. DESIGN:Laboratory study using human urine. SETTING:University-based laboratory. PATIENT(S):Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. INTERVENTION(S):Urine c...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2010.05.016

    authors： Tokushige N,Markham R,Crossett B,Ahn SB,Nelaturi VL,Khan A,Fraser IS

    更新日期：2011-01-01 00:00:00

  • Association of ethnicity with involuntary childlessness and perceived reasons for infertility: baseline data from the Study of Women's Health Across the Nation (SWAN).

    abstract：OBJECTIVE:To evaluate whether ethnicity is associated with involuntary childlessness and perceived reasons for difficulties in becoming pregnant. DESIGN:Cross-sectional analysis of baseline data from a longitudinal cohort. SETTING:Multiethnic, community-based observational study of US women. PATIENT(S):Women in midl...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.fertnstert.2011.08.039

    authors： Karmon A,Hailpern SM,Neal-Perry G,Green RR,Santoro N,Polotsky AJ

    更新日期：2011-11-01 00:00:00

  • Effect of curcumin on aflatoxin-induced biochemical changes in testis of mice.

    abstract：OBJECTIVE:To investigate the effect of curcumin on aflatoxin-induced biochemical changes in testis of mice. DESIGN:Controlled research laboratory study. SETTING:Aflatoxin was obtained by growing Aspergillus parasiticus in SMKY liquid medium. Pure curcumin (97% purity) was purchased from Hi-Media Laboratories Pvt. Ltd...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2007.11.053

    authors： Verma RJ,Mathuria N

    更新日期：2009-02-01 00:00:00

  • Normal pregnancies resulting from testicular sperm extraction and intracytoplasmic sperm injection for azoospermia due to maturation arrest.

    abstract：OBJECTIVE:To see whether testicular sperm extraction could be used to perform intracytoplasmic sperm injection (ICSI) for men with nonobstructive azoospermia caused by maturation arrest. DESIGN:Uncontrolled prospective trial of an attempt to find occasional elongated spermatids or spermatozoa in testes of azoospermic ...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0015-0282(16)58396-4

    authors： Silber SJ,van Steirteghem A,Nagy Z,Liu J,Tournaye H,Devroey P

    更新日期：1996-07-01 00:00:00

  • Live birth after orthotopic grafting of autologous cryopreserved ovarian tissue and spontaneous conception in Italy.

    abstract：OBJECTIVE:To describe a live birth obtained in Italy after autologous orthotopic transplantation of cryopreserved ovarian cortical tissue. DESIGN:Case report. SETTING:University department of gynecology and obstetrics, reproductive medicine and IVF unit. PATIENT(S):A 29-year-old patient affected by β-thalassemia (in...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2012.09.029

    authors： Revelli A,Marchino G,Dolfin E,Molinari E,Delle Piane L,Salvagno F,Benedetto C

    更新日期：2013-01-01 00:00:00

  • Sperm DNA fragmentation and mitochondrial membrane potential combined are better for predicting natural conception than standard sperm parameters.

    abstract：OBJECTIVE:To evaluate whether DNA fragmentation and/or mitochondrial membrane potential (MMP) predict natural conception better than standard sperm parameters. DESIGN:Prospective cross-sectional study. SETTING:University medical center. PATIENT(S):Eighty-five infertile and 51 fertile men. INTERVENTION(S):Assessment...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2015.11.037

    authors： Malić Vončina S,Golob B,Ihan A,Kopitar AN,Kolbezen M,Zorn B

    更新日期：2016-03-01 00:00:00

  • Liver function tests in women using intravaginal spermicide nonoxynol-9.

    abstract：:The effects of intravaginal application of nonoxynol-9 (N-9) on hematological parameters, routine liver function biochemistry (bilirubin, serum bile acid, SGOT, SGPT, GGT, alkaline phosphatase), and serum lipids (cholesterol and triglyceride) were evaluated in 10 normal women who received 150 mg N-9 daily for 14 conse...

    journal_title：Fertility and sterility

    pub_type： 信件

    doi：10.1016/s0015-0282(16)46058-9

    authors： Chvapil M,Droegemueller W,Earnest DL

    更新日期：1982-02-01 00:00:00

  • Salpingitis isthmica nodosa: a review of the literature, discussion of clinical significance, and consideration of patient management.

    abstract：OBJECTIVES:To examine and discuss the pathology, diagnosis, incidence, and patient profile of salpingitis isthmica nodosa and to question its natural history, propose management strategies, and identify areas of promising research. DESIGN:Over 50 studies were reviewed, evaluated, and compared to offer the clinician a ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/s0015-0282(16)56207-4

    authors： Jenkins CS,Williams SR,Schmidt GE

    更新日期：1993-10-01 00:00:00

  • Maturation and apoptosis of human oocytes in vitro are age-related.

    abstract：OBJECTIVE:To study the morphological changes of apoptotic oocytes, and rates of in vitro maturation and apoptosis of human oocytes in relation to age. DESIGN:Prospective comparative study. SETTING:Reproductive medicine center. PATIENT(S):Women undergoing surgery for ovarian cysts. INTERVENTION(S):Oocytes were incub...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(00)01597-1

    authors： Wu J,Zhang L,Wang X

    更新日期：2000-12-01 00:00:00

  • Essure hysteroscopic tubal occlusion device for the treatment of hydrosalpinx prior to in vitro fertilization-embryo transfer in patients with a contraindication for laparoscopy.

    abstract：OBJECTIVE:To investigate the success rate of proximal tubal occlusion with Essure devices in subfertile women with hydrosalpinges, and to observe the results of subsequent treatment with IVF. DESIGN:Prospective, single-arm, clinical study. SETTING:University hospital and teaching hospital. PATIENT(S):Ten women with ...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.fertnstert.2008.11.022

    authors： Mijatovic V,Veersema S,Emanuel MH,Schats R,Hompes PG

    更新日期：2010-03-01 00:00:00

  • Autoantibodies to markers of oxidative stress are elevated in women with endometriosis.

    abstract：OBJECTIVE:To measure autoantibodies that recognize oxidatively modified proteins in the sera of women with surgically proven endometriosis. DESIGN:Prospective study. SETTING:Tertiary care academic medical center. PATIENT(S):Women undergoing surgery for endometriosis or tubal ligation. INTERVENTION(S):None. MAIN OU...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(99)00145-4

    authors： Shanti A,Santanam N,Morales AJ,Parthasarathy S,Murphy AA

    更新日期：1999-06-01 00:00:00

  • Robotic single-site myomectomy: a step-by-step tutorial.

    abstract：OBJECTIVE:To provide a step-by-step description of our published technique of single-site robot-assisted laparoscopic myomectomy with the goal of promoting its safe adoption. DESIGN:Surgical video tutorial. SETTING:University medical center. PATIENT(S):Ten women undergoing single-site robot-assisted laparoscopic myo...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2015.07.1159

    authors： Gargiulo AR,Lewis EI,Kaser DJ,Srouji SS

    更新日期：2015-11-01 00:00:00

  • Spontaneous heterotopic triplets: a case report.

    abstract：OBJECTIVE:To present a case report of a spontaneous, heterotopic, triplet conception of a patient without any risk factors. DESIGN:Case report. SETTING:Community hospital in Park Ridge, Illinois. PATIENT(S):One patient, 30-year-old multigravida, sent to the emergency room for evaluation of right lower quadrant pain ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2006.12.034

    authors： Cholkeri-Singh A,LaBarge A

    更新日期：2007-10-01 00:00:00

  • Surgically induced ovulation in the polycystic ovary syndrome: wedge resection revisited in the age of laparoscopy.

    abstract：OBJECTIVE:To provide an up-to-date comprehensive review of published data on laparoscopic methods of ovulation induction in the polycystic ovary syndrome (PCOS). Areas to be considered include the historical background of these procedures, their outcomes as reported in the literature, and their potential adverse effect...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/s0015-0282(16)57408-1

    authors： Donesky BW,Adashi EY

    更新日期：1995-03-01 00:00:00

  • Predictive factors of health-related quality of life in patients with polycystic ovary syndrome: a structural equation modeling approach.

    abstract：OBJECTIVE:To determine association between health-related quality of life (HRQOL) and psychosexual variables in patients with polycystic ovary syndrome (PCOS). DESIGN:Cross-sectional study. SETTING:Two private gynecology clinics. PATIENT(S):A sample of 300 women with PCOS were entered into the study and were subdivi...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.fertnstert.2013.06.043

    authors： Bazarganipour F,Ziaei S,Montazeri A,Foroozanfard F,Kazemnejad A,Faghihzadeh S

    更新日期：2013-11-01 00:00:00

  • Impact of elagolix treatment on fatigue experienced by women with moderate to severe pain associated with endometriosis.

    abstract：OBJECTIVE:To evaluate the efficacy of elagolix, an oral GnRH antagonist, for the reduction of fatigue in women with moderate or severe endometriosis-associated pain. DESIGN:Randomized, double-blind, multicenter, placebo-controlled phase III trial. SETTING:Clinics. PATIENT(S):A total of 860 women treated with elagoli...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.fertnstert.2019.02.031

    authors： Surrey ES,Soliman AM,Agarwal SK,Snabes MC,Diamond MP

    更新日期：2019-08-01 00:00:00

  • Hammen semen quality classification and pregnancies obtained during a twenty-year follow-up period.

    abstract：:The Hammen semen quality classification system is a fertility index with six qualities based on sperm count, assessment of sperm motility, number of immotile spermatozoa, number of abnormal sperm heads, and sperm viability. It was developed by Hammen during the 1940s. In the present study, the fertility of 1077 men cl...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)45624-4

    authors： Bostofte E,Serup J,Rebbe H

    更新日期：1981-07-01 00:00:00

  • Therapeutic use of gonadoliberin (follicle-stimulating hormone/luteinizing hormone-releasing hormone) in women.

    abstract：:Certain conclusions may be drawn from the present review: 1. Synthetic FSH/LH-RH may induce ovulation; therefore, a therapeutic effect has been established in some cases of anovulatory infertility, but it is still difficult to assess the correct dose of FSH/LH-RH because of individual variations in response. 2. Gonado...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)42188-6

    authors： Zárate A,Canales ES,Soria J,Forsbach G,Kastin AJ,Schally AV

    更新日期：1976-11-01 00:00:00