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Discovery of a novel biomarker in the urine in women with endometriosis.

Abstract：

OBJECTIVE:To investigate whether proteins secreted in urine differ between women with and without endometriosis. DESIGN:Laboratory study using human urine. SETTING:University-based laboratory. PATIENT(S):Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. INTERVENTION(S):Urine collection from women with and without endometriosis. MAIN OUTCOME MEASURE(S):Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. RESULT(S):On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. CONCLUSION(S):Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Tokushige N,Markham R,Crossett B,Ahn SB,Nelaturi VL,Khan A,Fraser IS

doi

10.1016/j.fertnstert.2010.05.016

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

46-9

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(10)00804-6

journal_volume

95

pub_type

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