Abstract:
OBJECTIVE:To determine the effect of transdermal estrogen on insulin sensitivity in postmenopausal women and to compare this effect with changes observed with oral conjugated equine estrogens. DESIGN:Fourteen postmenopausal women were randomized to receive a transdermal E2 patch, 0.1 mg, for 25 days each month (n = 7) or transdermal E2 with added medroxyprogesterone acetate (MPA), 10 mg, from days 16 to 25 each month (n = 7). An insulin tolerance test (ITT) was performed at baseline and between days 23 and 25 during the 2nd month of treatment to assess insulin sensitivity. Values for the disappearance of glucose (K(itt)) were calculated and compared with values obtained from women receiving 1.25 mg of oral equine estrogens (n = 8). SETTING:University Clinical Research Center. PATIENTS:Healthy postmenopausal women not receiving hormonal replacement. INTERVENTION:Insulin tolerance tests before and after treatment. MAIN OUTCOME MEASURE:Disappearance of glucose and insulin (K(itt)) before and after treatment. RESULTS:Women receiving transdermal E2 alone demonstrated improved insulin sensitivity. The K(itt) glucose values increased by 13.2%, compared with a 23.9% decrease in K(itt) values observed with 1.25 mg of conjugated equine estrogen. The group treated with transdermal E2 and MPA had a reduction in insulin sensitivity. Insulin clearance was enhanced only with transdermal estrogen and was significantly delayed (blunted clearance) with the addition of MPA to transdermal E2 and with oral estrogen. CONCLUSION:We previously demonstrated a bimodal effect of oral equine estrogens on insulin sensitivity with an improvement occurring with the lower dose of 0.625 mg but with a deterioration with the dose of 1.25 mg. Here we suggest that this effect may be related to a first-pass hepatic-portal effect in that transdermal E2 (0.1 mg), which may be equated more closely with the larger dose of oral estrogen (1.25 mg), improved insulin sensitivity. Progestin, however, appeared to attenuate the beneficial effects of transdermal estrogen and may alter the clearance of insulin.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Lindheim SR,Duffy DM,Kojima T,Vijod MA,Stanczyk FZ,Lobo RAdoi
10.1016/s0015-0282(16)57181-7subject
Has Abstractpub_date
1994-12-01 00:00:00pages
1176-80issue
6eissn
0015-0282issn
1556-5653pii
S0015-0282(16)57181-7journal_volume
62pub_type
临床试验,杂志文章,随机对照试验abstract:OBJECTIVE:To determine the sensitivity and clinical significance of fluorescein isothiocyanate wheat germ agglutinin (FITC-WGA) staining of human spermatozoa. DESIGN:Percentage FITC-WGA staining was assessed in the different morphological zones of human spermatozoa and compared with fertilization rates of metaphase II...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57499-8
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVE:To investigate cell invasiveness and the production of matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 in endometrial stromal cells (ESCs) of adenomyosis. DESIGN:Prospective study. SETTING:Tertiary university hospital. PATIENT(S):Twenty-one women with ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.05.090
更新日期:2009-05-01 00:00:00
abstract::The result of the hormone concentration of one blood sample was used to determine the accuracy of predicting not only the hormone concentrations of a second and third sample drawn 15 minutes apart, but also the mean value of the three samples. Three blood specimens from 73 men involved in two previously reported studi...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59662-9
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To assess the ability of a GnRH antagonist (Cetrorelix, Asta Medica AG, Frankfurt, Germany) to prevent premature LH surges in an IVF-ET program using a simple protocol with one or two administrations. DESIGN:Controlled ovarian hyperstimulation was carried out in 17 women with three ampules a day of hMG, star...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)56933-7
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:To compare incidence, risk factors, and etiology of women's deaths in fertile, subfertile, and undergoing assisted reproductive technology (ART) in the years after delivery. DESIGN:Retrospective cohort. SETTING:University hospital. PATIENT(S):Women who had delivered in Massachusetts. INTERVENTION(S):This ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2019.10.007
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:To determine which protocols work better between cetrorelix and long protocols in older patients in a randomized controlled study. DESIGN:A controlled randomized study in a single private IVF center. SETTING:Infertile women referred to a private IVF center. PATIENT(S):Five hundred sixty-four women 40 years...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2008.02.165
更新日期:2009-05-01 00:00:00
abstract::Diagnostic laparoscopy is commonly performed on patients as part of a complete infertility investigation. Recently published protocols have investigated the efficacy of using empiric ovulation induction, intrauterine insemination, or both before beginning in vitro fertilization. Because many patients enrolled in these...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60374-6
更新日期:1988-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the cryopreservation of immature human oocytes obtained from unstimulated ovarian tissue. DESIGN:Immature prophase I oocytes were obtained from unstimulated follicles and were either cryopreserved or cultured as controls. Cryopreservation was performed in a programmable freezing machine using one...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::We have previously observed that preimplantation embryo biopsy in the mouse causes a reduction in implantation rate in utero. After minor modifications to the technique, we now find that sampling a single blastomere from the 4-cell mouse embryo does not compromise continued development in vitro or in vivo. When transf...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60564-2
更新日期:1989-03-01 00:00:00
abstract::Uterus transplantation research has been conducted toward its introduction in the human as a treatment of absolute uterine-factor infertility, which is considered to be the last frontier to conquer for infertility research. In this review we describe the patient populations that may benefit from uterus transplantation...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2012.04.001
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To investigate a new role of interleukin (IL)-17A in endometriosis. DESIGN:Laboratory study. SETTING:University hospital. PATIENT(S):Patients with ovarian endometrioma undergoing laparoscopy or laparotomy. INTERVENTION(S):Primary culture of endometrioma stromal cells (EoSCs) was stimulated with IL-17A. Se...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.07.1117
更新日期:2012-11-01 00:00:00
abstract::Some see an "alarming inconsistency" in candidate-screening practices of assisted reproductive technology (ART) programs and call for common guidelines. However, reasonable people can disagree about who should be prevented from having children and why. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.05.028
更新日期:2005-11-01 00:00:00
abstract::A patient with Nelson's syndrome whose pregnancy was complicated by symptomatic enlargement of an ACTH-producing pituitary tumor was described. Emergency ablative surgery was performed with successful outcomes for both mother and infant. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)48932-6
更新日期:1985-10-01 00:00:00
abstract:OBJECTIVE:To investigate the use of preimplantation genetic diagnosis (PGD) as a method for increasing pregnancy success rates in patients at high risk for aneuploidy. DESIGN:Literature review and discussion of current evidence. CONCLUSION(S):Preimplantation genetic diagnosis selects euploid embryos for transfer in a...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2005.06.045
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To report the occurrence of spontaneous regression of three endometrial polyps detected by hysteroscopy. DESIGN:Case series. SETTING:A uterine imaging unit in an academic medical center. PATIENT(S):Three patients diagnosed as having an endometrial polyp of 5-8 mm on hysteroscopy. INTERVENTION(S):Patient d...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.04.054
更新日期:2009-08-01 00:00:00
abstract::The key global issue surrounding gamete donation is not the well-rehearsed known vs. anonymous donation argument but rather one of providing patients with a flexible dual-track system (i.e., ability to know or not to know donor identity), complete with psychosocial support and education that enables them to make well-...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.07.1304
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:To identify transcripts whose expression is restricted to germ cells. DESIGN:Expressed sequence tags (ESTs) from unfertilized egg libraries were utilized to perform in silico subtraction and identify germ cell-specific transcripts. SETTING:Baylor College of Medicine, Houston, Texas. ANIMAL(S):C57BL/6J/129S...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)01966-5
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the possible relationship between total acrosin activity in spermatozoa and fertility potential after fertilization in vitro. DESIGN:Total acrosin activity of spermatozoa was measured in 101 in vitro fertilization (IVF) cases by an observer unaware of fertilization and cleavage results. SETTING:...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract::The role of the macromolecular constituents of human oviductal fluid (hOF) in reproductive physiology is poorly understood. Oviductal fluid contains proteins derived by transudation from serum and those synthesized and secreted by the tubal mucosa. In this communication, we describe purification of hOF-specific protei...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60433-8
更新日期:1989-01-01 00:00:00
abstract::Reducing exposure to toxic environmental agents is a critical area of intervention for obstetricians, gynecologists, and other reproductive health care professionals. Patient exposure to toxic environmental chemicals and other stressors is ubiquitous, and preconception and prenatal exposure to toxic environmental agen...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.08.043
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:To study the association between two single-nucleotide polymorphisms (SNPs) variants (rs2241766 and rs1501299) of the adiponectin gene (ADIPOQ) and polycystic ovary syndrome (PCOS) in PCOS family trios. DESIGN:Family-based study. SETTING:University hospital. PATIENT(S):A total of 224 unrelated PCOS proband...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.01.035
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To compare the expression of the prostaglandin (PG) E(2) transporter multidrug resistance-associated protein 4 (MRP4) in eutopic and ectopic endometrial tissue from endometriosis patients with that of control subjects and to examine whether MRP4 is regulated by the antiinflammatory lipid lipoxin A(4) (LXA(4))...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.01.146
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To describe two cases of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) with testicular sperm in men with immotile cilia syndromes. DESIGN:Case report. SETTING:A university-based male infertility clinic and assisted reproduction unit. PATIENT(S):Two couples with male factor infert...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)01974-4
更新日期:2001-09-01 00:00:00
abstract::This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Authors. The entire group of investigators contributing to this study requests to withdraw this article. We ...
journal_title:Fertility and sterility
pub_type: 杂志文章,撤回出版物
doi:10.1016/j.fertnstert.2020.09.001
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To evaluate binding characteristics of a specific zona pellucida (ZP) protein 3 (ZP3) antiserum to human oocytes in order to determine its usefulness as a clinical marker for human ZP integrity and function and its correlation with IVF outcome. DESIGN:Prospectively designed, blinded, internally controlled st...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)58041-8
更新日期:1996-01-01 00:00:00
abstract::The Ethics Committee recommends development of evidence-based policies that are patient centered for each IVF center. In most cases, the provision of futile therapies is not ethically justifiable. For those treatments with very poor success rates, clinicians must be vigilant in their presentation of risks, benefits, a...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2009.07.979
更新日期:2009-10-01 00:00:00
abstract::Our meta-analysis analyzed the relationship between levels of reactive oxygen species (ROS) and fertilization rate after in vitro fertilization (IVF), and showed a statistically significant correlation between the ROS levels and the IVF fertilization rate (estimated overall correlation -0.374 [95% CI, -0.520, -0.205])...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析
doi:10.1016/j.fertnstert.2004.12.057
更新日期:2005-07-01 00:00:00
abstract::Neutrophil migration did not change during normal menstrual cycles but was significantly reduced during controlled ovarian hyperstimulation (COH). Correlations between neutrophil migration and serum hormone concentrations could not be established. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.05.091
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVES:To determine if the total motile sperm count is predictive of IUI success and to apply life-table analysis to a large database of IUI procedures. DESIGN:Contingency table and life-table analyses were used to analyze a large group of couples (n = 546) undergoing 1,205 cycles of therapeutic IUI with husband's...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56831-9
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:To investigate whether levothyroxine (LT4) treatment has beneficial effects on IVF results and pregnancy outcome in infertile patients with subclinical hypothyroidism undergoing IVF/intracytoplasmic sperm injection (ICSI). DESIGN:Prospective, randomized trial. SETTING:University-affiliated infertility clini...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2010.12.004
更新日期:2011-04-01 00:00:00