Abstract:
:Uterus transplantation research has been conducted toward its introduction in the human as a treatment of absolute uterine-factor infertility, which is considered to be the last frontier to conquer for infertility research. In this review we describe the patient populations that may benefit from uterus transplantation. The animal research on uterus transplantation conducted during the past two decades is summarized, and we describe our views regarding a future research-based human attempt.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Brännström M,Diaz-Garcia C,Hanafy A,Olausson M,Tzakis Adoi
10.1016/j.fertnstert.2012.04.001subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1269-76issue
6eissn
0015-0282issn
1556-5653pii
S0015-0282(12)00432-3journal_volume
97pub_type
杂志文章,评审abstract:OBJECTIVE:To evaluate the effectiveness of Interceed(TC7) (Johnson and Johnson, New Brunswick, NJ) in the prevention of postoperative adhesions in a rabbit uterine horn model. Interceed(TC7) was tested in the presence and absence of absorbable suture. DESIGN, SETTING, PARTICIPANTS:Forty-one New Zealand white rabbits h...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:To determine whether the presence of soluble human leukocyte antigen G (sHLA-G) affects implantation and pregnancy outcomes in vitro. DESIGN:A multicenter retrospective study. SETTING:Six certified in vitro fertilization (IVF) units. PATIENT(S):Embryos obtained from 2,040 patients from six different IVF cl...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2013.07.1977
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence and type of Y chromosome microdeletions in 136 consecutively seen intracytoplasmic sperm injection (ICSI) candidates and in 50 consecutively seen azoospermic men attending an infertility clinic. DESIGN:Controlled clinical study. SETTING:Genetics laboratory and infertility clinic ...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(98)00195-2
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To validate recently proposed models of ovarian nongrowing follicle (NGF) decay associated with aging within the context of an independent data set. DESIGN:Prospective investigation. SETTING:Academic medical center. PATIENT(S):Normal appearing ovaries collected from 52 women (age 28-51 years) undergoing oo...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.12.008
更新日期:2014-03-01 00:00:00
abstract::Neutrophil migration did not change during normal menstrual cycles but was significantly reduced during controlled ovarian hyperstimulation (COH). Correlations between neutrophil migration and serum hormone concentrations could not be established. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.05.091
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To determine the long-term survival of frozen-thawed human ovarian tissue as xenografts in severe-combined-immunodeficiency (SCID) mice. DESIGN:Animal study. SETTING:Animal and laboratory facilities at an academic center. PATIENT(S):Ovarian tissue obtained from a 27-year-old woman. INTERVENTION(S):Graftin...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00548-8
更新日期:2000-03-01 00:00:00
abstract::The effect of Korean ginseng (ginseng) on spermatogenesis and cAMP-responsive element modulator (CREM) in rat testes was evaluated using sperm analysis, reverse transcription polymerase chain reaction, and Western blot analysis. The ginseng-treated rats exhibited significantly increased sperm count and motility with e...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.12.014
更新日期:2007-10-01 00:00:00
abstract::Endometriosis has been associated with corpus luteum inadequacy and abnormalities of luteal phase progesterone (P) secretion. In this study, abnormal luteolysis, as a second factor of luteal dysfunction, was assessed in 13 women with endometriosis and 25 control patients by measurement of ovarian vein estradiol (E2) a...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59224-3
更新日期:1987-06-01 00:00:00
abstract:OBJECTIVE:To report an unusual case of embryo implantation and superfetation. DESIGN:Retrospective case analysis. SETTING:Oak Brook Fertility Center. PATIENT(S):A 41-year-old woman underwent two consecutive ovarian stimulation cycles interrupted by a normal menstrual period. Ovulation and implantation occurred durin...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)00244-6
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVES:To determine, in a rabbit model, whether peritoneal exposure to dermoid cyst material produces inflammation and adhesions above control levels and whether saline lavage reduces the degree of peritoneal reaction. DESIGN:A prospective, randomized, blinded, controlled study of adhesion formation. Thirty New Ze...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)58225-9
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of hysteroscopic selective salpingography (HSS) as a method for diagnosing the tubal proximal occlusion shown by hysterosalpingography (HSG). DESIGN:Prospective study. SETTING:Outpatient Department of Obstetrics and Gynecology, Social Insurance Saitama Chuo Hospital, Urawa, Jap...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00324-6
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:To determine if mutations in NELF, a gene isolated from migratory GnRH neurons, cause normosmic idiopathic hypogonadotropic hypogonadism (IHH) and Kallmann syndrome (KS). DESIGN:Molecular analysis correlated with phenotype. SETTING:Academic medical center. PATIENT(S):A total of 168 IHH/KS patients as well ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.01.010
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To study women with a poor response to ovarian hormone stimulation, known as low responders. Genetic defects in the FSH receptor gene (FSHR) were analyzed as well as antimüllerian hormone (AMH) for ovarian reserve. DESIGN:Retrospective cohort study. SETTING:University hospital. PATIENT(S):Two hundred fifty...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.02.012
更新日期:2012-05-01 00:00:00
abstract::Survey results demonstrate that the majority of fertility clinics in California are willing to care for couples affected by human immunodeficiency virus (HIV) if legal restrictions are removed. In response to scientific advances and evolving clinical standards, California reversed the limitations placed on the provisi...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.09.013
更新日期:2009-04-01 00:00:00
abstract::Earlier studies have shown inherited thrombophilia to be a risk factor for recurrent implantation failure, raising the question of whether this risk is related to the underlying cause of unexplained infertility or to the mechanisms involved in the implantation process. When nine thrombophilic gene polymorphisms were c...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.07.1782
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To determine if pentoxifylline has an in vitro effect on human sperm motility in subjects with normal semen analysis. DESIGN:Prospective, longitudinal study of the effect of pentoxifylline on normospermic semen samples using computerized analysis. SETTING:The Assisted Conception Unit, Royal Maternity Hospit...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55708-2
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:To investigate whether the embryotoxic effect of peritoneal fluid (PF) from infertile women with mild endometriosis on mouse oocytes and embryos is associated with changes in embryonic epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I), and their receptors. DESIGN:Experimental animal study. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.11.011
更新日期:2010-05-15 00:00:00
abstract:OBJECTIVE:The response to subcutaneous (SC) gonadotropin replacement therapy, using human chorionic gonadotropin (hCG) and human menopausal gonadotropin (hMG) or hCG alone, was evaluated in male hypothalamic hypogonadism. DESIGN:Sixteen patients with hypothalamic hypogonadism were treated with gonadotropins for induct...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)54493-8
更新日期:1991-08-01 00:00:00
abstract:OBJECTIVE:To report a live birth after successful preimplantation genetic diagnosis (PGD) for carriers of complex chromosomal rearrangements (CCRs) with translocation and deletion. DESIGN:Fluorescent in situ hybridization (FISH) was applied to PGD for CCR carriers. SETTING:University-based centers for reproductive me...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.08.016
更新日期:2008-11-01 00:00:00
abstract::Constant infusion of gonadotropin-releasing hormone agonist (GnRH-A) in the rhesus monkey leads to far greater suppression of spermatogenesis than its intermittent administration. To assess whether administration of GnRH-A by constant subcutaneous infusion will also lead to greater inhibition of gonadal function, we a...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)48684-x
更新日期:1985-07-01 00:00:00
abstract:OBJECTIVE:To evaluate vaginal bleeding profiles with lower doses of conjugated equine estrogens (CEE) and medroxyprogesterone acetate (MPA) as continuous combined therapy. DESIGN:The Women's Health, Osteoporosis, Progestin, Estrogen (Women's HOPE) study, a randomized, double-blind, placebo-controlled trial. SETTING:S...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0015-0282(01)01792-7
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:To determine if ultrastructural tissue trauma occurs in the junctional zone in uteri in adenomyosis. DESIGN:A case-control experimental study. SETTING:Endometriosis research center. PATIENT(S):Twelve uteri with adenomyosis, and 9 uteri without adenomyosis, were gained during laparoscopy-assisted vaginal hy...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.09.002
更新日期:2015-12-01 00:00:00
abstract::Ham's F-10 medium (Gibco, Grand Island, NY) and medium T6 with and without 15% fetal calf serum (FCS) were compared for their ability to support development of murine blastocysts with the capacity to implant and produce normal fetuses when transferred to pseudopregnant females. All media supported equal rates of blast...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59545-4
更新日期:1987-11-01 00:00:00
abstract::To assess whether procedures of semen preparation can reduce the proportion of antibody-coated spermatozoa, semen samples with positive direct mixed antiglobulin reaction (MAR) were washed in media supplemented with 10% or 50% fetal cord serum (FCS). Washing reduced the MAR to a negative level, but the MAR was identic...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53169-0
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVE:To present two cases of ectopic twin pregnancy in a Cesarean section scar following IVF-embryo transfer. DESIGN:Case report. SETTING:Tertiary referral case center. PATIENT(S):Two women who had ectopic twin pregnancy in a Cesarean section scar, in both cases following IVF and embryo transfer. INTERVENTION(...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.11.091
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the benefit of Y microdeletion testing. DESIGN:Retrospective analysis. SETTING:University-based male fertility clinic and genetics laboratory. PATIENT(S):A total of 1,591 men with sperm concentrations less than 5 million sperm/mL. INTERVENTION(S):Semen analysis, Y microdeletion testing, microd...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.09.006
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To identify factors influencing the development of endometrial autografts in a monkey model of endometriosis. DESIGN:Prospective, comparative study. SETTING:Animal research unit. SUBJECTS:Thirty regularly cycling cynomolgus monkeys in three groups of 10 each. INTERVENTIONS:Endometrium was minced and spill...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)58521-5
更新日期:1996-09-01 00:00:00
abstract::Direct effects of a gonadotropin-releasing hormone agonist (GnRHa), danazol, or estrogen/progestogen (E/P) on experimental endometriosis were evaluated in castrated female rats. Endometrial explants decreased in size following castration, but there was no further change in the treatment groups. Histologic examination ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59727-1
更新日期:1988-02-01 00:00:00
abstract:OBJECTIVE:To determine, for a woman aged >45 years, whether selected hormonal, health status, and demographic measures are related to the time to final menstrual period (FMP) from a point where 6 weeks separate the shortest and longest cycles experienced to date. DESIGN:Cohort study. SETTING:Volunteers in an academic...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)03231-4
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:To investigate the molecular mechanism for declining sperm motility in older men. DESIGN:Retrospective and prospective study. SETTING:University-based andrology unit. PATIENT(S):Semen was collected from 2,111 patients and sperm donors. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Age, sperm concentratio...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.05.020
更新日期:2005-11-01 00:00:00