Influence of subfertility and assisted reproductive technology treatment on mortality of women after delivery.


OBJECTIVE:To compare incidence, risk factors, and etiology of women's deaths in fertile, subfertile, and undergoing assisted reproductive technology (ART) in the years after delivery. DESIGN:Retrospective cohort. SETTING:University hospital. PATIENT(S):Women who had delivered in Massachusetts. INTERVENTION(S):This study used data from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System linked to vital records, hospital stays, and the Massachusetts death file. Mortality of patients delivered from 2004-2013 was evaluated through 2015. The exposure groups, determined on the basis of the last delivery, were ART-treated (linked to Society for Assisted Reproductive Technology Clinic Outcome Reporting System), subfertile (no ART but with indicators of subfertility including birth certificate checkbox for fertility treatment, prior hospitalization for infertility [International Classification of Disease codes 9 628 or V23], and/or prior delivery with checkbox or ART), or fertile (neither ART nor subfertile). Numbers (per 100,000 women-years) and causes of death were obtained from the Massachusetts death file. MAIN OUTCOME MEASURE(S):Mortality of women after delivery in each of the three fertility groups and the most common etiology of death in each. RESULT(S):We included 483,547 women: 16,429 ART, 11,696 subfertile, and 455,422 fertile among whom there were 1,280 deaths with 21.1, 25.5, and 44.7 deaths, respectively, per 100,000 women-years. External causes (violence, accidents, and poisonings) were the most common reasons for death in the fertile group. Deaths occurred on average 46 months after delivery. When external causes of death were removed, there were 19.1, 17.0, and 25.6 deaths per 100,000 women-years and leading causes of death in all groups were cancer and circulatory problems. CONCLUSION(S):The study presents reassuring data that death rates within 5 years of delivery in ART-treated and subfertile women do not differ from those in fertile women.


Fertil Steril


Fertility and sterility


Coddington CC,Gopal D,Cui X,Cabral H,Diop H,Stern JE




Has Abstract


2020-03-01 00:00:00














  • Comparison of low-dose human menopausal gonadotropin and micronized 17beta-estradiol supplementation in in vitro maturation cycles with thin endometrial lining.

    abstract:OBJECTIVE:A challenge of in vitro maturation (IVM) treatment in some women is insufficient development of the endometrium prior to embryo transfer. DESIGN:Retrospective study. SETTING:McGill Reproductive Center, Montreal, Canada. PATIENT(S):Women with endometrial thickness <6 mm on days 6-10 ultrasound (US) scan of ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Elizur SE,Son WY,Yap R,Gidoni Y,Levin D,Demirtas E,Tan SL

    更新日期:2009-09-01 00:00:00

  • Use of augmented reality in laparoscopic gynecology to visualize myomas.

    abstract:OBJECTIVE:To report the use of augmented reality (AR) in gynecology. DESIGN:AR is a surgical guidance technology that enables important hidden surface structures to be visualized in endoscopic images. AR has been used for other organs, but never in gynecology and never with a very mobile organ like the uterus. We have...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bourdel N,Collins T,Pizarro D,Debize C,Grémeau AS,Bartoli A,Canis M

    更新日期:2017-03-01 00:00:00

  • Torsion of the fallopian tube and acute pelvic pain: an unusual presentation of genital tuberculosis.

    abstract::A case of a genital tuberculosis found during laparoscopic evaluation for recurrent acute pelvic pain is presented. The symptoms of genital tuberculosis can vary greatly, and a laparoscopic approach is effective for making the diagnosis. Clinicians should consider tuberculosis as a differential diagnosis when encounte...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Perez-Medina T,Bueno B,Redondo T,Gallego I,Bajo-Arenas J

    更新日期:2008-06-01 00:00:00

  • Triphasic expression of interleukin-1 receptor type I in human endometrium throughout the menstrual cycle of fertile women and women with unexplained infertility.

    abstract:OBJECTIVE:To evaluate expression of interleukin-1 receptor type I in the endometrium of fertile women throughout the menstrual cycle and to investigate whether unexplained infertility may be associated with abnormal expression of IL-1 receptor type I. DESIGN:Retrospective study using immunohistochemical technique, Wes...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bigonnesse F,Labelle Y,Akoum A

    更新日期:2001-01-01 00:00:00

  • Controlled ovarian hyperstimulation: are we monitoring the appropriate sex-steroid hormones?

    abstract::We prospectively evaluated the behavior of serum 17-hydroxyprogesterone (17-OHP), sex-steroid hormones, and C-reactive protein (CRP) levels in 27 patients during controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF). While routine measurement of COH via serum 17-OHP may replace estradiol (E(2)) an...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Orvieto R,Hod E,Volodarsky M,Homburg R,Rabinson J,Meltcer S

    更新日期:2008-05-01 00:00:00

  • Failure of seminal plasma to enter the uterus and oviducts of the rabbit following artificial insemination.

    abstract::Twelve adult does in estrus were artificially inseminated with 1 ml of semen from bucks that had received injections of 3H-thymidine 22 to 32 days previously. The ejaculates contained radioactive seminal plasma and unlabeled sperm. The reproductive tracts of the does were removed at selected intervals after inseminati...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Asch RH,Balmaceda J,Pauerstein CJ

    更新日期:1977-06-01 00:00:00

  • Thyroxine replacement during super-ovulation for in vitro fertilization: a potential gap in management?

    abstract:OBJECTIVE:Our objective is to report observed changes in thyroid-stimulating hormone (TSH) in two patients undergoing super-ovulation for IVF. DESIGN:Case report. SETTING:Private assisted reproduction practices. PATIENT(S):Two hypothyroid women taking thyroxine replacement therapy undergoing super-ovulation for IVF....

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Stuckey BG,Yeap D,Turner SR

    更新日期:2010-05-01 00:00:00

  • Effect of indomethacin on the vascular architecture of preovulatory ovine follicles: possible implication in the luteinized unruptured follicle syndrome.

    abstract::Ovarian follicles sometimes fail to rupture and accumulate large quantities of fluid, yet undergo luteinization and form a steroidogenically competent luteal structure, the luteinized unruptured follicle syndrome. This condition can be mimicked in mammals by administration of indomethacin, an inhibitor of biosynthesis...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Murdoch WJ,Cavender JL

    更新日期:1989-01-01 00:00:00

  • Ultrasonic evidence for luteinization of unruptured preovulatory follicles.

    abstract::Luteinization of an unruptured ovarian follicle has been reported as a cause of infertility and has heretofore been diagnosed only by direct visualization of the ovarian surface. Four patients who demonstrated defects in ovulation requiring therapy to induce ovulation and who were not achieving desired conception desp...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Coulam CB,Hill LM,Breckle R

    更新日期:1982-04-01 00:00:00

  • Selecting cryopreserved semen for assisted reproductive techniques based on the level of sperm nuclear DNA fragmentation resulted in pregnancy.

    abstract::A cryopreserved sperm sample with a low level of DNA fragmentation was used for intracytoplasmic sperm injection and resulted in a twin birth from a couple with a 10-year history of idiopathic infertility. ...

    journal_title:Fertility and sterility

    pub_type: 信件


    authors: Alvarez JG,Ollero M,Larson-Cook KL,Evenson DP

    更新日期:2004-03-01 00:00:00

  • Spontaneous pregnancy during the infertility evaluation.

    abstract::Of 299 patients evaluated for infertility between July 1, 1974, and December 31, 1976, 21 (7.2%) became pregnant during the initial evaluation prior to any recognized therapy. A comparative analysis was made between these 21 couples and the 223 completely evaluated infertility couples. No significant difference in sex...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Drake TS,Tredway DR

    更新日期:1978-07-01 00:00:00

  • Fertility preservation in women with breast cancer undergoing adjuvant chemotherapy: a systematic review.

    abstract:OBJECTIVE:To investigate methods of fertility preservation in younger women exposed to adjuvant chemotherapy for breast cancer. DESIGN:Systematic review of literature. SETTING:Academic Department of Medical Oncology. PATIENT(S):Premenopausal women exposed to adjuvant chemotherapy for breast cancer. MAIN OUTCOME MEA...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Cruz MR,Prestes JC,Gimenes DL,Fanelli MF

    更新日期:2010-06-01 00:00:00

  • An observational study of women with müllerian agenesis and their need for vaginal dilator therapy.

    abstract:OBJECTIVE:To assess vaginal development, sexual activity, and the efficacy of vaginal dilator therapy in women with vaginal agenesis (Mayer-Rokitansky-Kuster-Hauser syndrome). DESIGN:Retrospective case review. SETTING:Tertiary referral university teaching hospital clinic for disorders of sexual development and differ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bach F,Glanville JM,Balen AH

    更新日期:2011-08-01 00:00:00

  • Endocervical metaplasia of the endometrium in a patient with cystic fibrosis: a case report.

    abstract:OBJECTIVE:To report the case of an infertile female patient with cystic fibrosis who was diagnosed with endocervical metaplasia of the endometrium at diagnostic hysteroscopy and successfully treated with an oral estroprogestinic formulation. DESIGN:Case report. SETTING:University hospital. PATIENT(S):A 27-year-old i...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Piccoli R,Di Spiezio Sardo A,Insabato L,Acunzo G,Guida M,Nappi C

    更新日期:2006-03-01 00:00:00

  • Complete evaluation of anatomy and morphology of the infertile patient in a single visit; the modern infertility pelvic ultrasound examination.

    abstract::The comprehensive "one-stop shop" ultrasound evaluation of an infertile woman, performed around cycle days 5 to 9, will reveal abundant information about the anatomy and morphology of the pelvic organs and thereby avoid costly radiation and iodinated contrast exposure. We propose a two-dimensional and three-dimensiona...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Groszmann YS,Benacerraf BR

    更新日期:2016-06-01 00:00:00

  • Adverse outcome in women with thrombophilia and bilateral uterine artery notches.

    abstract::Discrepancies about a possible relationship between prothrombotic mutations and a decreased uteroplacental blood flow are present in literature. We prospectively evaluated a cohort of pregnant women (n = 41) with bilateral uterine artery notches and found that women with inherited thrombophilia showed a sixfold higher...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Grandone E,Colaizzo D,Martinelli P,Paladini D,di Minno G,Margaglione M

    更新日期:2006-09-01 00:00:00

  • Reactive oxygen species in human semen: validation and qualification of a chemiluminescence assay.

    abstract:OBJECTIVE:To standardize and validate an assay for reactive oxygen species (ROS) in human semen. DESIGN:ROS levels assayed in blanks, negative and positive control samples (30% H2O2), and human semen, with the use of a luminol-based chemiluminescence assay measured in a single tube luminometer. SETTING:Andrology labo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Vessey W,Perez-Miranda A,Macfarquhar R,Agarwal A,Homa S

    更新日期:2014-12-01 00:00:00

  • Inadequate cervical mucus--a cause of "idiopathic" infertility.

    abstract::The purpose of this study was to investigate and treat a group of patients referred for "idiopathic" infertility in whom no apparent cause for infertility, apart from inadequate cervical mucus, was found. Hormone investigations revealed that these patients could be divided into two groups: those with low sex steroid p...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sher G,Katz M

    更新日期:1976-08-01 00:00:00

  • Analysis of spindle characteristics and embryo quality in mice stimulated with letrozole using Polscope imaging.

    abstract:OBJECTIVE:To explore the effect of letrozole as an ovulation inducing agent on oocyte and embryo quality in mice model. DESIGN:Prospective study. SETTING:Institute of Reproductive Medicine, Kolkata, India. ANIMAL(S):Sixty-nine sexually mature female Swiss Albino mice 6-7 weeks old. INTERVENTION(S):Metaphase II (MII...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ganesh A,Chattopadhyay R,Narendra Babu K,Chakravarty B,Chaudhury K

    更新日期:2010-03-15 00:00:00

  • Determination of insulin and insulin-like growth factors in the ovarian circulation.

    abstract::Recent in vitro studies implicate the ovary as an extra-hepatic source of insulin-like growth factors (IGFs) with production regulated by gonadotropins and local steroids. Because previous studies have failed to show any significant variations in IGF levels in peripheral blood during the menstrual cycle, we measured t...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jesionowska H,Hemmings R,Guyda HJ,Posner BI

    更新日期:1990-01-01 00:00:00

  • Unified diagnostic criteria for chronic endometritis at fluid hysteroscopy: proposal and reliability evaluation through an international randomized-controlled observer study.

    abstract:OBJECTIVE:To develop a consensus on the diagnostic criteria for chronic endometritis (CE) at hysteroscopy (HSC), and to evaluate these proposed criteria in a randomized-controlled observer study. DESIGN:Systematic review of studies evaluating the diagnostic accuracy of HSC in CE diagnosis; Delphi consensus on hysteros...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Cicinelli E,Vitagliano A,Kumar A,Lasmar RB,Bettocchi S,Haimovich S,International Working Group for Standardization of Chronic Endometritis Diagnosis.

    更新日期:2019-07-01 00:00:00

  • Evaluation of the impact of concurrent gonadotropin-releasing hormone (GnRH) antagonist administration on GnRH agonist-induced gonadotrope desensitization.

    abstract:OBJECTIVE:To evaluate the impact of chronic GnRH antagonist therapy on the extent of GnRH agonist-induced gonadotrope desensitization. DESIGN:Prospective and controlled. SETTING:Primate Research Center. PARTICIPANTS:Six reproductive age cycling female baboons (Papio cyanocephalus anubis). INTERVENTIONS:The animals ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Illions EH,Scott RT,Carey KD,Navot D

    更新日期:1995-10-01 00:00:00

  • Blood glucose and plasma insulin studies during three months' use of a low-estrogen type oral contraceptive.

    abstract::Blood glucose and plasma insulin levels were measured during an oral glucose tolerance test in 18 women before and after 3 months' use of a low-estrogen oral contraceptive containing 0.035 mg of ethinylestradiol and 0.5 mg of norethindrone. There was no significant change in either of these two metabolic parameters. I...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Spellacy WN,Buhi WC,Birk SA,Buggie J

    更新日期:1981-07-01 00:00:00

  • Genotyping analyses for polymorphisms of ANXA5 gene in patients with recurrent pregnancy loss.

    abstract:OBJECTIVE:To investigate whether polymorphisms at the promoter or 5'-untranslated region of annexin A5 gene (ANXA5) influence miscarriage. DESIGN:Case-control study and nested case-control study. SETTING:Hospitals. PATIENT(S):A total of 264 patients with two to nine recurrent pregnancy losses (RPLs) and 195 fertile ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hayashi Y,Sasaki H,Suzuki S,Nishiyama T,Kitaori T,Mizutani E,Suzumori N,Sugiura-Ogasawara M

    更新日期:2013-10-01 00:00:00

  • Fertilization after standard in vitro fertilization versus intracytoplasmic sperm injection in subfertile males using sibling oocytes.

    abstract:OBJECTIVE:To compare conventional IVF with ICSI in the subfertile male population using sibling oocytes. Results from males with isolated severe teratozoospermia also are analyzed. DESIGN:Prospective experimental study. SETTING:University based IVF clinic. PATIENT(S):Group A: 18 patients with one or more abnormaliti...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pisarska MD,Casson PR,Cisneros PL,Lamb DJ,Lipshultz LI,Buster JE,Carson SA

    更新日期:1999-04-01 00:00:00

  • Evidence for a histaminergic system in the human testis.

    abstract::The complete lack of information about mast cells as a source of histamine and potential target cells for histamine in human testes prompted us to investigate these issues in testes of fertile and infertile patients using a combination of laser microdissection, reverse transcription-polymerase chain reaction (RT-PCR),...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Albrecht M,Frungieri MB,Gonzalez-Calvar S,Meineke V,Köhn FM,Mayerhofer A

    更新日期:2005-04-01 00:00:00

  • Plasminogen activator inhibitor 1 and miscarriage after metformin treatment and laparoscopic ovarian drilling in patients with polycystic ovary syndrome.

    abstract::In women with polycystic ovary syndrome, metformin administration, not laparoscopic ovarian drilling, reduces plasminogen activator inhibitor 1 (PAI-1) activity. The lack of a decrease in PAI-1 activity is related to a high risk for miscarriage. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Palomba S,Orio F Jr,Falbo A,Russo T,Tolino A,Zullo F

    更新日期:2005-09-01 00:00:00

  • Somatostatin treatment reduces the exaggerated response of adrenocorticotropin hormone and cortisol to corticotropin-releasing hormone in polycystic ovary syndrome.

    abstract:OBJECTIVE:To evaluate the influence of somatostatin analogue (octreotide) in the function of hypothalamic-pituitary-adrenal (HPA) axis in women with polycystic ovary syndrome (PCOS). SETTING:Women referred to the Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore. PATIENT(S):Twelve PCOS wom...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lanzone A,Fulghesu AM,Guido M,Cucinelli F,Caruso A,Mancuso S

    更新日期:1997-01-01 00:00:00

  • Oxyphenbutazone--an adjuvant to be used in prevention of adhesions in operations for fertility.

    abstract::A laparotomy was performed in 40 rats and the cecum was subjected to a standardized trauma. Half the rats were treated with oxyphenbutazone in a dose of 40 mg/kg body weight daily for 14 days. The remaining 20 rats served as controls. All of the rats were killed 2 weeks after the laparotomy, and the number of intraper...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Larsson B,Svanberg SG,Swolin K

    更新日期:1977-08-01 00:00:00

  • Plasma lipids and desogestrel and ethinyl estradiol: a meta-analysis.

    abstract:OBJECTIVE:To review the literature to determine the magnitude of the effect of 150 micrograms desogestrel-30 micrograms ethinyl E2, an oral contraceptive (OC) formulation, on plasma lipid concentrations in healthy women using meta-analysis techniques. DATA SOURCES:All English-language published reports (1981 to 1991) ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析


    authors: Lobo RA,Skinner JB,Lippman JS,Cirillo SJ

    更新日期:1996-06-01 00:00:00