Influence of subfertility and assisted reproductive technology treatment on mortality of women after delivery.


OBJECTIVE:To compare incidence, risk factors, and etiology of women's deaths in fertile, subfertile, and undergoing assisted reproductive technology (ART) in the years after delivery. DESIGN:Retrospective cohort. SETTING:University hospital. PATIENT(S):Women who had delivered in Massachusetts. INTERVENTION(S):This study used data from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System linked to vital records, hospital stays, and the Massachusetts death file. Mortality of patients delivered from 2004-2013 was evaluated through 2015. The exposure groups, determined on the basis of the last delivery, were ART-treated (linked to Society for Assisted Reproductive Technology Clinic Outcome Reporting System), subfertile (no ART but with indicators of subfertility including birth certificate checkbox for fertility treatment, prior hospitalization for infertility [International Classification of Disease codes 9 628 or V23], and/or prior delivery with checkbox or ART), or fertile (neither ART nor subfertile). Numbers (per 100,000 women-years) and causes of death were obtained from the Massachusetts death file. MAIN OUTCOME MEASURE(S):Mortality of women after delivery in each of the three fertility groups and the most common etiology of death in each. RESULT(S):We included 483,547 women: 16,429 ART, 11,696 subfertile, and 455,422 fertile among whom there were 1,280 deaths with 21.1, 25.5, and 44.7 deaths, respectively, per 100,000 women-years. External causes (violence, accidents, and poisonings) were the most common reasons for death in the fertile group. Deaths occurred on average 46 months after delivery. When external causes of death were removed, there were 19.1, 17.0, and 25.6 deaths per 100,000 women-years and leading causes of death in all groups were cancer and circulatory problems. CONCLUSION(S):The study presents reassuring data that death rates within 5 years of delivery in ART-treated and subfertile women do not differ from those in fertile women.


Fertil Steril


Fertility and sterility


Coddington CC,Gopal D,Cui X,Cabral H,Diop H,Stern JE




Has Abstract


2020-03-01 00:00:00














  • Danazol binding to rat androgen, glucocorticoid, progesterone, and estrogen receptors: correlation with biologic activity.

    abstract::Danazol was found to possess androgenic and glucocorticoid activity in rat bioassays. In contrast, danazol displayed no significant estrogenic activity. In support of these findings, danazol bound to the 8 S androgen receptor of rat prostate cytosol and to the glucocorticoid receptor of rat liver cytosol, but danazol ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Barbieri RL,Lee H,Ryan KJ

    更新日期:1979-02-01 00:00:00

  • Diagnostic evaluation of sexual dysfunction in the male partner in the setting of infertility: a committee opinion.

    abstract::It is the responsibility of the clinician to assess for the presence of erectile dysfunction, ejaculatory dysfunction, or diminished libido related to hypoandrogenism among men presenting with a primary complaint of infertility. Referral to a reproductive urologist or other appropriate specialist with requisite expert...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Practice Committee of the American Society for Reproductive Medicine in Collaboration With the Society for Male Reproduction and Urology. Electronic address:,Practice Committee of the American Society for Reproductive Medicine in Collab

    更新日期:2018-10-01 00:00:00

  • Peritoneal fluid plasminogen activator activity in endometriosis and pelvic adhesive disease.

    abstract::Plasminogen activator activity in PF was assayed by the fibrinolysis method described by Strickland and Beers. In 45 patients studied, there were no discernible differences according to whether patients had endometriosis and/or pelvic adhesive disease. No differences were detected according to when in the menstrual cy...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Batzofin JH,Holmes SD,Gibbons WE,Buttram VC Jr

    更新日期:1985-08-01 00:00:00

  • Immunoneutralization of gonadotropin-releasing hormone and subsequent treatment with testosterone Silastic implants in rats: an approach toward developing a male contraceptive.

    abstract:STUDY OBJECTIVE:To determine the extent to which increasing doses of exogenous testosterone (T) administered via Silastic implants can restore spermatogenesis and fertility to rats made azoospermic by active immunization against gonadotropin-releasing hormone (GnRH). DESIGN:Male rats were made azoospermic by active im...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Awoniyi CA,Kim WK,Hurst BS,Schlaff WD

    更新日期:1992-08-01 00:00:00

  • Relation between the anatomical genital phenotype and cystic fibrosis transmembrane conductance regulator gene mutations in the absence of the vas deferens.

    abstract:OBJECTIVE:To study the correlation between genital phenotype and cystic fibrosis genotype in men lacking at least one vas deferens. DESIGN:Prospective study. SETTING:Institut Rhônalpin pour la Reproduction Humaine, Lyon-Bron, France. PATIENT(S):Forty-seven infertile men lacking at least one vas deferens. INTERVENTI...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Robert F,Bey-Omar F,Rollet J,Lapray JF,Morel Y

    更新日期:2002-05-01 00:00:00

  • Early ovarian hyperstimulation syndrome is completely prevented by gonadotropin releasing-hormone agonist triggering in high-risk oocyte donor cycles: a prospective, luteal-phase follow-up study.

    abstract::In this prospective, follow-up study of 102 high-risk oocyte donors in their luteal phase, we found a complete absence of ovarian hyperstimulation syndrome (no signs of hemoconcentration or ascites) after the donors were triggered with a gonadotropin releasing-hormone (GnRH) agonist. Due to its powerful preventive eff...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Bodri D,Guillén JJ,Trullenque M,Schwenn K,Esteve C,Coll O

    更新日期:2010-05-01 00:00:00

  • The different routes of administration and the effect of hormone replacement therapy on osteoporosis.

    abstract:OBJECTIVE:To review osteoporosis, a disease characterized by low bone mass, microarchitectural deterioration of bone tissue leading to increased bone fragility and a consequent increase in fracture risk. The disorder has become a major health problem in the West, where increased life expectancy has placed new emphasis ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Christiansen C

    更新日期:1994-12-01 00:00:00

  • Effect of incubating human sperm at room temperature on capacitation-related events.

    abstract:OBJECTIVE:To determine the effect of human sperm incubation at room temperature (20 degrees C) upon capacitation-related events. DESIGN:Prospective study. SETTING:Basic research laboratory. PATIENT(S):Semen samples were obtained from normozoospermic volunteers. Human follicular fluid (hFF) was collected from women u...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Marín-Briggiler CI,Tezón JG,Miranda PV,Vazquez-Levin MH

    更新日期:2002-02-01 00:00:00

  • Congenital obstructive azoospermia in a man with Marfan syndrome.

    abstract:OBJECTIVE:To present a case of Marfan syndrome and concurrent congenital obstructive azoospermia. DESIGN:Case report. SETTING:Tertiary-care academic hospital. PATIENT(S):A man with Marfan syndrome and obstructive azoospermia. INTERVENTION(S):The patient was evaluated for azoospermia that was proved to be due to con...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kukuvitis A,Georgiou I,Ioannidis S,Tarlatzis B,Bontis J,Papadimas J

    更新日期:2001-12-01 00:00:00

  • Gonadotropin-releasing hormone agonists and the skeleton.

    abstract:OBJECTIVE:To review and evaluate published studies that have assessed the effect on the skeleton of treatment with gonadotropin-releasing hormone agonists (GnRH-a). The effects on bone biochemistry and bone density are presented. DATA IDENTIFICATION:Major studies reporting on bone and GnRH-a use were identified throug...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Fogelman I

    更新日期:1992-04-01 00:00:00

  • Lack of correlation between oocyte-corona-cumulus complex morphology and nuclear maturity of oocytes collected in stimulated cycles for intracytoplasmic sperm injection.

    abstract:OBJECTIVE:To evaluate the usefulness of morphology grading of the oocyte-corona-cumulus complex (OCCC) as a marker of oocyte nuclear maturity, fertilizability, embryo cleavage, and likelihood of pregnancy. DESIGN:Prospective cohort study. SETTING:Academic fertility center. PATIENT(S):Eighty-three infertile couples u...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Rattanachaiyanont M,Leader A,Léveillé MC

    更新日期:1999-05-01 00:00:00

  • Significance of mRNA levels of connexin37, connexin43, and connexin45 in luteinized granulosa cells of controlled hyperstimulated follicles.

    abstract:OBJECTIVE:To evaluate the mRNA levels of connexins in different sizes of luteinized follicles. DESIGN:Semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) to determine the connexin mRNA levels in the granulosa cells of 91 luteinized follicles. SETTING:Academic tertiary care medical center and res...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tsai MY,Lan KC,Huang KE,Huang FJ,Kung FT,Chang SY

    更新日期:2003-12-01 00:00:00

  • Induction of menstruation by an antiprogesterone steroid (RU 486) in primates: site of action, dose-response relationships, and hormonal effects.

    abstract::The antiprogesterone compound RU 486 (17 beta-hydroxy-11 beta-[4-dimethylaminophenyl]-17 alpha-[ 1-propynyl]estra-4,9-dien-3-one; Roussel-Uclaf, Paris, France) was used to induce menstruation in a randomized controlled trial. Castrated adult female cynomolgus monkeys (n = 17) received sequential subcutaneous Silastic ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Healy DL,Baulieu EE,Hodgen GD

    更新日期:1983-08-01 00:00:00

  • Criteria for number of embryos to transfer: a committee opinion.

    abstract::Based on American Society for Reproductive Medicine (ASRM) and Society for Assisted Reproductive Technology data available for 2010, ASRM's guidelines for the number of embryos to be transferred in in vitro fertilization cycles have been further refined in continuing efforts to reduce the number of higher-order multip...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,实务指引


    authors: Practice Committee of the American Society for Reproductive Medicine and the Practice Committee of the Society for Assisted Reproductive Technology.

    更新日期:2013-01-01 00:00:00

  • Reproductive sequelae of parental severe illness before the pandemic: implications for the COVID-19 pandemic.

    abstract:OBJECTIVE:To investigate, with pre-COVID-19 data, whether parental exposure to severe systemic infections near the time of conception is associated with pregnancy outcomes. DESIGN:Retrospective cohort study. SETTING:Population-based study covering births within the United States from 2009 to 2016. PARTICIPANTS:The I...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kasman AM,Bhambhvani HP,Li S,Zhang CA,Stevenson DK,Shaw GM,Simard JF,Eisenberg ML

    更新日期:2020-12-01 00:00:00

  • Variations in seminal plasma constituents from fertile, subfertile, and vasectomized azoospermic men.

    abstract::Freshly ejaculated semen specimens from 20 normal fertile, 11 subfertile, and 20 vasectomized men whose semen analyses had reached complete azoospermia were compared. The mean levels of seminal acid phosphatase were significantly higher in the vasectomized men. The mean values of sialic acid in normal and postvasect...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Nun S,Musacchio I,Epstein JA

    更新日期:1972-05-01 00:00:00

  • Nitric oxide is associated with poor embryo quality and pregnancy outcome in in vitro fertilization cycles.

    abstract:OBJECTIVE:To evaluate the association between follicular and serum nitric oxide (NO) levels and embryo development and outcome in IVF. DESIGN:Prospective, case-control study. SETTING:University hospital, tertiary medical center. PATIENT(S):Eighteen patients with tubal or peritoneal factor infertility and 18 female p...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lee TH,Wu MY,Chen MJ,Chao KH,Ho HN,Yang YS

    更新日期:2004-07-01 00:00:00

  • Perinatal morbidity after in vitro fertilization is lower with frozen embryo transfer.

    abstract:OBJECTIVE:To study the association of perinatal outcome and IVF transfer type in a group of infertility patients with standardized treatment and similar prognosis. DESIGN:Retrospective cohort study. SETTING:University-based infertility center, January 1998 to June 2006. PATIENT(S):Two hundred eighteen IVF pregnancie...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kansal Kalra S,Ratcliffe SJ,Milman L,Gracia CR,Coutifaris C,Barnhart KT

    更新日期:2011-02-01 00:00:00

  • Androstenedione and progesterone concentrations in preovulatory follicular fluid correlate with successful fertilization and cleavage of human oocytes in vitro.

    abstract:OBJECTIVE:To determine if androstenedione (A) and progesterone (P) concentrations in preovulatory follicular fluid (FF) correlate with successful fertilization and cleavage of human oocytes in vitro. DESIGN:A retrospective randomized trial. SETTING:Hospital department of obstetrics and gynecology. PATIENTS:Fifty-fiv...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kobayashi T,Oda T,Yoshimura Y,Takehara Y,Natori M,Nozawa S

    更新日期:1991-08-01 00:00:00

  • Epidermal growth factor (urogastrone) in human seminal plasma from fertile and infertile males.

    abstract::Epidermal growth factor/urogastrone (EGF/URO) was measured in the seminal plasma of 214 untreated patients attending an infertility clinic. Patients were assigned groups according to sperm density and progressive motility and in the case of azoospermia into an obstructive etiology or germinal failure. There was no sig...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Richards RC,Lewis-Jones DI,Walker JM,Desmond AD

    更新日期:1988-10-01 00:00:00

  • Metformin treatment in patients with polycystic ovary syndrome undergoing in vitro fertilization: a prospective randomized trial.

    abstract::In the present study, we investigated the impact of metformin therapy on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes in patients with polycystic ovary syndrome (PCOS). Metformin does not lead to any improvement in IVF/ICSI outcomes among patients with PCOS. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Onalan G,Pabuçcu R,Goktolga U,Ceyhan T,Bagis T,Cincik M

    更新日期:2005-09-01 00:00:00

  • A randomized, placebo-controlled, double-blind study evaluating leuprolide acetate depot treatment before myomectomy.

    abstract::Eighteen premenopausal women with symptomatic leiomyomata uteri were enrolled in a stratified, randomized, double-blind, placebo-controlled study evaluating the efficacy of leuprolide acetate (LA) depot treatment before myomectomy. Stratification was based on pretreatment uterine volume (less than 600 cm3 versus great...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Friedman AJ,Rein MS,Harrison-Atlas D,Garfield JM,Doubilet PM

    更新日期:1989-11-01 00:00:00

  • Ectopic pregnancy rates with frozen compared with fresh blastocyst transfer.

    abstract:OBJECTIVE:To compare the rate of ectopic pregnancy (EP) with fresh versus frozen blastocyst transfer in our program during the same time period. DESIGN:Retrospective analysis. SETTING:University IVF program. PATIENT(S):Women who achieved a clinical pregnancy after IVF between 1998 and 2005. INTERVENTION(S):In our p...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jun SH,Milki AA

    更新日期:2007-09-01 00:00:00

  • Testicular sperm aspiration and intracytoplasmic sperm injection for persistent infection of the ejaculate.

    abstract:OBJECTIVE:To report the successful use of testicular sperm aspiration and intracytoplasmic sperm injection in the presence of an Escherichia coli-infected ejaculate that previously caused repeated embryo degeneration. DESIGN:Case report. SETTING:University medical center. PATIENT(S):A 38-year-old woman who did not c...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Seidman DS,Madjar I,Levron J,Levran D,Mashiach S,Dor J

    更新日期:1999-03-01 00:00:00

  • An analysis of endometrial biopsies performed for infertility.

    abstract::The authors evaluated 774 endometrial biopsies that were performed for infertility. Complications arose in 3.6%. Lag of more than 2 days was found in 19%; luteal phase defect (LPD) was diagnosed in 5.7%. Most of the incidence of LPD can be predicted from chance occurrence. There was no association between abnormal bio...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Davidson BJ,Thrasher TV,Seraj IM

    更新日期:1987-11-01 00:00:00

  • Thrombophilic gene polymorphisms are risk factors for unexplained infertility.

    abstract::Earlier studies have shown inherited thrombophilia to be a risk factor for recurrent implantation failure, raising the question of whether this risk is related to the underlying cause of unexplained infertility or to the mechanisms involved in the implantation process. When nine thrombophilic gene polymorphisms were c...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Coulam CB,Jeyendran RS

    更新日期:2009-04-01 00:00:00

  • Peroxisome proliferator-activated receptor gamma and early folliculogenesis during an acute hyperandrogenism condition.

    abstract::Acute hyperandrogenism decreases serum P levels and induces early apoptosis of antral follicles by a mechanism mediated by the peroxisome proliferator-activated receptor gamma system and independent of the steroidogenic acute regulator protein. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Faut M,Elia EM,Parborell F,Cugnata NM,Tesone M,Motta AB

    更新日期:2011-01-01 00:00:00

  • Nitric oxide synthase isoforms expression in fibroblasts isolated from human normal peritoneum and adhesion tissues.

    abstract:OBJECTIVE:To determine the expression of nitric oxide synthases (NOSs) and their modulation by hypoxia in human peritoneal (NF) and adhesion fibroblasts (ADF). DESIGN:Prospective experimental study. SETTING:University medical center. PATIENT(S):Fibroblasts from peritoneum and adhesion tissues. INTERVENTION(S):Hypox...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jiang ZL,Zhu X,Diamond MP,Abu-Soud HM,Saed GM

    更新日期:2008-09-01 00:00:00

  • Abnormal distribution of epididymal antigens on spermatozoa from infertile men.

    abstract::An antiserum raised against human epididymal proteins associated with ejaculated sperm was used to test the hypothesis that the amount and/or localization of these antigens may be altered in men with infertility. With the use of immunofluorescence we found that in sperm from fertile donors 88.4% of the cells had the a...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Blaquier JA,Cameo MS,Stephany D,Piazza A,Tezon J,Sherins RJ

    更新日期:1987-02-01 00:00:00

  • Association of the 17-hydroxysteroid dehydrogenase type 5 gene polymorphism (-71A/G HSD17B5 SNP) with hyperandrogenemia in polycystic ovary syndrome (PCOS).

    abstract:OBJECTIVE:To evaluate the association of an activating single-nucleotide polymorphism (SNP) at position -71 of the promoter of 17beta-hydroxysteroid dehydrogenase type 5 gene (-71A/G HSD17B5 SNP) and polycystic ovary syndrome (PCOS) in a well characterized cohort of caucasian PCOS women with biochemical hyperandrogenem...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Marioli DJ,Saltamavros AD,Vervita V,Koika V,Adonakis G,Decavalas G,Markou KB,Georgopoulos NA

    更新日期:2009-08-01 00:00:00