当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > The single or dual administration of the gonadotropin-releasing hormone antagonist Cetrorelix in an in vitro fertilization-embryo transfer program.

The single or dual administration of the gonadotropin-releasing hormone antagonist Cetrorelix in an in vitro fertilization-embryo transfer program.

Abstract：

OBJECTIVE:To assess the ability of a GnRH antagonist (Cetrorelix, Asta Medica AG, Frankfurt, Germany) to prevent premature LH surges in an IVF-ET program using a simple protocol with one or two administrations. DESIGN:Controlled ovarian hyperstimulation was carried out in 17 women with three ampules a day of hMG, starting on day 2 of the menstrual cycle. A dose of 5 mg of Cetrorelix was administered when plasma E2 levels were between 150 and 200 pg/mL (conversion factor to Sl unit, 3.671) per follicle of > or = 14 mm. A second injection was performed 48 hours later if the triggering of ovulation was not decided in the meantime. RESULTS:Six patients received one injection and 11 patients received two administrations. Plasma LH levels showed a marked decrease and remained low after the administration of the GnRH antagonist. In six patients, the first administration of Cetrorelix was performed when a significant rise in LH plasma level was present. Even in these patients the GnRH antagonist was able to prevent an LH surge. The tolerance of the product was good. Six clinical pregnancies were obtained, of which four are ongoing (25% per ET). Two ongoing pregnancies were obtained after the transfer of a frozen-thawed embryo (35.3% per retrieval). CONCLUSIONS:The GnRH antagonist Cetrorelix in a simple, unique or dual administration, protocol was able to prevent premature LH surge in all of the 17 patients studied. If these results are confirmed by larger, randomized studies, the good tolerance and efficacy that we observed suggest a bright future for this product is assisted reproductive technologies.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Olivennes F,Fanchin R,Bouchard P,de Ziegler D,Taieb J,Selva J,Frydman R

doi

10.1016/s0015-0282(16)56933-7

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

468-76

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)56933-7

journal_volume

62

pub_type

临床试验,杂志文章

相关文献

FERTILITY AND STERILITY文献大全
  • Association of human leukocyte antigen-G 14 bp polymorphism with recurrent pregnancy loss in European countries: a meta-analysis of literature studies.

    abstract：OBJECTIVE:To study the controversial association between human leukocyte antigen-G (HLA-G) 14 bp polymorphism and recurrent pregnancy loss (RPL). We performed a meta-analysis of studies in the literature that enrolled only women of European countries who experienced RPL spontaneously or after undergoing IVF. DESIGN:Sy...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.fertnstert.2019.05.003

    authors： Monti M,Lupoli R,Sosa Fernandez LM,Cirillo F,Di Minno MND

    更新日期：2019-09-01 00:00:00

  • Comparison of fertility outcomes after laparoscopic myomectomy for barbed versus nonbarbed sutures.

    abstract：OBJECTIVE:To assess the impact on women's reproductive outcomes of barbed sutures to repair uterine breaches during laparoscopic myomectomy compared with traditional smooth sutures. DESIGN:Retrospective, monocentric cohort study, with information on subsequent pregnancies prospectively acquired for some women. SETTIN...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2020.07.036

    authors： Arena A,Degli Esposti E,Cristani G,Orsini B,Moro E,Raimondo D,Del Forno S,Lenzi J,Casadio P,Seracchioli R

    更新日期：2021-01-01 00:00:00

  • Trial development of the Cognitive Appraisal Scale for Infertility (CASI) (version 1).

    abstract：OBJECTIVE:To develop the Cognitive Appraisal Scale for Infertility (CASI) and assess it for reliability and validity. DESIGN:Cross-sectional and longitudinal study. SETTING:A private fertility institute in Japan. PATIENT(S):223 infertile women being treated at the institute. INTERVENTION(S):Administration of questi...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.03.052

    authors： Saito Y,Matsuo H

    更新日期：2009-06-01 00:00:00

  • Fallopian sperm perfusion versus intrauterine insemination: a randomized controlled trial and metaanalysis of the literature.

    abstract：OBJECTIVE:To determine whether fallopian sperm perfusion significantly improves pregnancy rates over intrauterine insemination (IUI) in infertile patients. DESIGN:Prospective, randomized, controlled trial and metaanalysis of the literature. SETTING:University-based infertility practice. PATIENT(S):Patients undergoin...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,meta分析,随机对照试验

    doi：10.1016/s0015-0282(99)00068-0

    authors： Trout SW,Kemmann E

    更新日期：1999-05-01 00:00:00

  • Partial androgen insensitivity--are all tissues equal?

    abstract：:Nonaromatizable androgens, administered in high doses to an adult patient with partial androgen insensitivity, failed to result in a change in phallic size despite a clear decline in SHBG and gonadotropin levels. These findings raise the question of differential tissue sensitivity to androgens. Because ancillary labor...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)56114-7

    authors： Keely EJ,Belsham DD,Wrogemann K,Faiman C

    更新日期：1993-08-01 00:00:00

  • Diagnosis and management of out-of-phase endometrial biopsies among patients receiving clomiphene citrate for ovulation induction.

    abstract：:Eighty-seven patients who underwent a late secretory phase endometrial biopsy while taking clomiphene citrate (CC) for ovulation induction were studied. Of the endometrial biopsies, 21 (24%) showed an endometrium greater than 2 days out of phase (OOP) with respect to the subsequent menstrual cycle. All 87 patients wer...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)60726-4

    authors： Keenan JA,Herbert CM,Bush JR,Wentz AC

    更新日期：1989-06-01 00:00:00

  • Evaluation of risk factors associated with endometriosis.

    abstract：OBJECTIVE:To investigate the association between several factors such as demographics, personal habits, reproductive factors, menstrual characteristics, contraception, and clinical profile and the probability of having endometriosis. SETTING:Ten clinical institutions in the Montreal area. PATIENT(S):A total of 2777 s...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2003.10.038

    authors： Hemmings R,Rivard M,Olive DL,Poliquin-Fleury J,Gagné D,Hugo P,Gosselin D

    更新日期：2004-06-01 00:00:00

  • Child with Beckwith-Wiedemann syndrome born after assisted reproductive techniques to an human immunodeficiency virus serodiscordant couple.

    abstract：OBJECTIVE:To report a child with Beckwith-Wiedemann syndrome (BWS) born after assisted reproductive technology (ART) to an HIV serodiscordant couple. DESIGN:Case report. SETTING:Academic medical center. PATIENT(S):A child with BWS born after ART to an HIV serodiscordant couple. INTERVENTION(S):Assisted reproductive...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2011.04.030

    authors： Kuentz P,Bailly A,Faure AC,Blagosklonov O,Amiot C,Bresson JL,Roux C

    更新日期：2011-07-01 00:00:00

  • Undetectable serum anti-Müllerian hormone levels and occurrence of ongoing pregnancy.

    abstract：OBJECTIVE:To discuss, on the basis of the experience of two clinical cases and extensive literature review, the significance of extremely low levels of anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting substance, in infertile women. DESIGN:Case report. SETTING:University-based infertility clinic at a m...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2007.03.084

    authors： Fraisse T,Ibecheole V,Streuli I,Bischof P,de Ziegler D

    更新日期：2008-03-01 00:00:00

  • Paradoxical effects of D-Trp6-luteinizing hormone-releasing hormone on the hypothalamic-pituitary-gonadal axis in immature female rats.

    abstract：:The effect of administration of a superactive and long-acting analog of luteinizing hormone-releasing hormone (LH-RH), D-Trp6-LH-RH, in doses of 0.05 or 1 microgram/day for 10 days on the hypothalamic-pituitary-gonadal axis was studied in immature female rats. Treatment with a 0.05-microgram dose of analog produced fe...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)44061-6

    authors： Vilchez-Martinez JA,Pedroza E,Arimura A,Schally AV

    更新日期：1979-06-01 00:00:00

  • Effects of soy on the mammary glands of premenopausal female monkeys.

    abstract：OBJECTIVE:To evaluate the interactive effects of dietary soy and menstrual cycle phase on breast proliferation, apoptosis, and sex steroid receptor expression in premenopausal female cynomolgus monkeys. DESIGN:Animals were randomized to receive diets with either casein lactalbumin or soy as the protein source for 12 m...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2005.08.059

    authors： Wood CE,Kaplan JR,Stute P,Cline JM

    更新日期：2006-04-01 00:00:00

  • Bisphenol A and ovarian steroidogenesis.

    abstract：:Bisphenol A is widely used as a component in polycarbonate plastics for food and beverage packaging, epoxy linings for canned foods, and dental sealants, among other applications. Experimental literature demonstrates BPA's affinity for estrogen receptors and downstream effects on estrogen-responsive genes. Additional ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2016.08.021

    authors： Bloom MS,Mok-Lin E,Fujimoto VY

    更新日期：2016-09-15 00:00:00

  • Minnesota Multiphasic Personality Inventory (MMPI-2) profiles in the assessment of ovum donors.

    abstract：OBJECTIVE:To examine the relationship between MMPI-2 scores and oocyte donation outcome. DESIGN:Descriptive chart review. SETTING:Two oocyte donation programs. SUBJECT(S):Five hundred anonymous oocyte donor applicants. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Demographics, MMPI-2 scores and donation outcome. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2009.08.064

    authors： Klock SC,Covington SN

    更新日期：2010-10-01 00:00:00

  • Numbers and quality of oocytes after induction of multiple folliculogenesis in women and in mice with different lots of human menopausal gonadotropins.

    abstract：OBJECTIVE:To develop a murine in vivo bioassay that is sensitive to inherent variability of hMG. DESIGN:Female F1 hybrid mice were mated after injection with fixed dosages of each of four lots of hMG. Oocytes/embryos were collected and monitored during 5 days of culture. Outcome measures were compared with retrospecti...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)56414-0

    authors： Rector NA,Markusen TE,Stone BA,Marrs RP

    更新日期：1993-12-01 00:00:00

  • The use of transvaginal color flow imaging after in vitro fertilization to identify optimum uterine conditions before embryo transfer.

    abstract：OBJECTIVE:To assess whether a measure of uterine blood flow impedance (the pulsatility index, PI) as determined by transvaginal ultrasonography with color blood flow imaging, may be used to assess endometrial receptivity immediately before the time of embryo transfer (ET) after assisted conception. DESIGN:A prospectiv...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)54848-1

    authors： Steer CV,Campbell S,Tan SL,Crayford T,Mills C,Mason BA,Collins WP

    更新日期：1992-02-01 00:00:00

  • Number of biopsied trophectoderm cells is likely to affect the implantation potential of blastocysts with poor trophectoderm quality.

    abstract：OBJECTIVE:To evaluate whether the developmental potential of the blastocyst is affected by the number of trophectoderm (TE) cells biopsied in preimplantation genetic diagnosis (PGD) cycles. DESIGN:Retrospective study. SETTING:University-affiliated center. PATIENT(S):Women underwent PGD cycles of blastocyst biopsy an...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2016.01.011

    authors： Zhang S,Luo K,Cheng D,Tan Y,Lu C,He H,Gu Y,Lu G,Gong F,Lin G

    更新日期：2016-05-01 00:00:00

  • Morphologic and functional studies of immature rat oocyte-cumulus complexes after cryopreservation.

    abstract：:The effects of freezing and thawing (F/T) on functional activity of immature rat oocyte-cumulus complexes (OCC) were studied. The OCC were divided into three groups according to the number of cumulus-cell layers surrounding them. The OCC were then frozen and thawed (F/T), with dimethyl sulfoxide (DMSO) as cryoprotecta...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Pellicer A,Lightman A,Parmer TG,Behrman HR,De Cherney AH

    更新日期：1988-11-01 00:00:00

  • The International Committee Monitoring Assisted Reproductive Technologies (ICMART) glossary on ART terminology.

    abstract：:The International Committee Monitoring Assisted Reproductive Technologies (ICMART) is an independent international nonprofit organization that has taken a leading role in the development, collection, and dissemination of worldwide data on assisted reproductive technology (ART). Information on availability, efficacy, a...

    journal_title：Fertility and sterility

    pub_type：

    doi：10.1016/j.fertnstert.2006.04.018

    authors： Zegers-Hochschild F,Nygren KG,Adamson GD,de Mouzon J,Lancaster P,Mansour R,Sullivan E,International Committee Monitoring Assisted Reproductive Technologies.

    更新日期：2006-07-01 00:00:00

  • Growth hormone enhances estradiol production follicle-stimulating hormone-induced in the early stage of the follicular maturation.

    abstract：OBJECTIVE:To investigate the ability of GH to increase the steroidogenic response of the ovary to FSH in the early stage of human follicle development in vivo. DESIGN:Ovarian sensitivity to FSH and/or GH during the early follicular phase of the human menstrual cycle was evaluated in a prospective study. SETTING:Norma...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0015-0282(16)58688-9

    authors： Lanzone A,Fortini A,Fulghesu AM,Soranna L,Caruso A,Mancuso S

    更新日期：1996-12-01 00:00:00

  • Laser-assisted hatching of embryos is better than the chemical method for enhancing the pregnancy rate in women with advanced age.

    abstract：OBJECTIVE:Assisted hatching may enhance embryo implantation. This study was conducted to examine the efficacy of the laser- and chemical-assisted hatching for promotion of implantation (IR), pregnancy (PR), and delivery rate (DR) in older women undergoing IVF cycles. DESIGN:Prospective study. SETTING:An IVF unit of a...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0015-0282(02)03172-2

    authors： Hsieh YY,Huang CC,Cheng TC,Chang CC,Tsai HD,Lee MS

    更新日期：2002-07-01 00:00:00

  • Relation between indices of semen analysis and pregnancy rate in infertile couples.

    abstract：:Both partners of 198 consecutive infertile couples were evaluated. Studies in the female included clinical evaluation of ovulation for a minimum of two menstrual cycles, investigation of tubal patency, and evaluation of sperm survival in cervical mucus. Six semen specimens were analyzed from each male. Laparoscopy, sc...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)42976-6

    authors： Smith KD,Rodriguez-Rigau LJ,Steinberger E

    更新日期：1977-12-01 00:00:00

  • The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production.

    abstract：OBJECTIVE:To assess the endocrine, paracrine, and autocrine milieu in patients with endometriosis on the basis of the measurement of several cytokines in serum and follicular fluid (FF) and in vitro culture of granulosa luteal cells. DESIGN:Case-control study. SETTING:In vitro fertilization program at the Instituto V...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(98)00204-0

    authors： Pellicer A,Albert C,Mercader A,Bonilla-Musoles F,Remohí J,Simón C

    更新日期：1998-09-01 00:00:00

  • Erectile dysfunction: does insulin resistance play a part?

    abstract：OBJECTIVE:To review MEDLINE literature for correlations between insulin resistance and erectile dysfunction (ED). DESIGN:MEDLINE literature review (1966 to present). SETTING:Academic medical center. PATIENT(S):None. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):None. RESULT(S):Erectile dysfunction affects more th...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2007.01.116

    authors： Trussell JC,Legro RS

    更新日期：2007-10-01 00:00:00

  • Immature spermatids are not prevalent in semen from men who are receiving androgen-based contraceptive regimens.

    abstract：OBJECTIVE:To determine whether immature spermatids increase in semen in response to hormonal contraceptive treatments. Such a finding would support the existence of a defect in spermiogenesis, which in turn may explain the reported variability in sperm output. DESIGN:Semen smears were obtained from healthy men undergo...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0015-0282(97)00426-3

    authors： Zhengwei Y,Wreford NG,Bremner WJ,Matsumoto AM,Anawalt BA,McLachlan RI

    更新日期：1998-01-01 00:00:00

  • Precarious preoperative diagnostics and hints for the laparoscopic excision of uterine adenomatoid tumors: two exemplary cases and literature review.

    abstract：OBJECTIVE:To present two exemplary cases of adenomatoid tumors. DESIGN:Case report. SETTING:Two laparoscopic centers in Germany. PATIENT(S):Two women of reproductive age with uterine adenomatoid tumors. INTERVENTION(S):Laparoscopic tumor excision. MAIN OUTCOME MEASURE(S):Differential diagnostics of uterine masses....

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2010.10.017

    authors： Alkatout I,Bojahr B,Dittmann L,Warneke V,Mettler L,Jonat W,Schollmeyer T

    更新日期：2011-03-01 00:00:00

  • Peritoneal ectopic lesions from women with endometriosis show abnormalities in progesterone-dependent glycan expression.

    abstract：:Examination of 12 paired peritoneal ectopic and eutopic endometria for histochemical binding of Dolichos biflorus agglutinin, normally found in the mid-late secretory part of the cycle, showed a failure of lectin binding in 9 of 11 secretory-phase lesions although the eutopic specimens generally stained normally. This...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.11.032

    authors： Jones CJ,Nardo LG,Litta P,Fazleabas AT

    更新日期：2009-04-01 00:00:00

  • Measurement of the ovarian follicle by ultrasound in ovulation induction.

    abstract：:Ultrasonic monitoring of ovarian follicles and estimation of serum estradiol were carried out in 12 patients with clomiphene therapy, in 5 patients with gonadotropin therapy, and in 7 normal controls. The average diameter of preovulatory follicles in normal controls was 12,8 mm; in ovulation induction groups it was 2 ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)44055-0

    authors： Ylöstalo P,Rönnberg L,Jouppila P

    更新日期：1979-06-01 00:00:00

  • Inhibition of G protein in human sperm and its influence on acrosome reaction and zona pellucida binding.

    abstract：OBJECTIVE:To evaluate human sperm acrosomal status, zona pellucida (ZP)-binding capacity, and sperm motion characteristics after treatment with pertussis toxin followed by exposure to increasing concentrations of solubilized human ZP. DESIGN:Prospective analytical study. SETTING:Normal human sperm donors in an academ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Franken DR,Morales PJ,Habenicht UF

    更新日期：1996-12-01 00:00:00

  • Mouse embryo culture as quality control for human in vitro fertilization: the one-cell versus the two-cell model.

    abstract：:Female mice were superovulated with pregnant mare serum gonadotropin (PMSG) and human chorionic gonadotropin (hCG) and mated with male mice. One-cell (n = 429) and 2-cell (n = 450) embryos were collected 20 and 42 hours after hCG and cultured in Ham's F-10 medium (Gibco, Grand Island, NY) (282 mOsm/l, pH 7.4) and in m...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)59783-0

    authors： Davidson A,Vermesh M,Lobo RA,Paulson RJ

    更新日期：1988-03-01 00:00:00

  • Twin tubal pregnancy: a rising complication?

    abstract：OBJECTIVE:To present four cases of twin tubal pregnancies and discuss possible etiologies. Twin tubal pregnancies are a rare event, with incidence rates estimated as 1 out of 725-1,580 of tubal pregnancies. DESIGN:Case series. SETTING:Department of obstetrics and gynecology at a tertiary health care facility. PATIEN...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2010.03.017

    authors： Svirsky R,Maymon R,Vaknin Z,Mendlovic S,Weissman A,Halperin R,Herman A,Pansky M

    更新日期：2010-10-01 00:00:00