Abstract：
OBJECTIVE:To investigate changes in plasma lipoprotein profile, hemostatic factors, platelet aggregation, endothelin-1, and cardiac function during postmenopausal sequential 6-month hormone replacement therapy (HRT). DESIGN:Open longitudinal prospective study. SETTING:Gynecologic department of a medical center. PATIENT(S):Twenty-one healthy hysterectomized postmenopausal women. INTERVENTION(S):Oral E2 valerate (2 mg/d) combined with medroxyprogesterone acetate (MPA) (10 mg/d) during the last 10 days of each 21-day cycle. The treatment period was 6 months. MAIN OUTCOME MEASURE(S):Plasma lipoprotein profile, hemostatic parameters, platelet aggregation, endothelin-1, and left ventricular function. RESULT(S):After 6 months of treatment, total cholesterol, triglyceride, and low density lipoprotein (LDL) cholesterol were significantly progressively reduced. Atherogenic indices of total cholesterol-to-high-density lipoprotein (HDL) cholesterol and LDL-to-HDL cholesterols also showed a significant progressive decline. The concentrations of antithrombin III were significantly increased. The maximum aggregation and slope of platelet aggregation were significantly reduced, but all parameters were more pronounced at 1 month of HRT than at 3 or 6 months. The concentrations of endothelin-1 were significantly reduced (by 16.1%). In the evaluation of left ventricular function, only peak atrial diastolic velocity was significantly reduced. CONCLUSION(S):Combined HRT had favorable effects on lipids and lipoproteins, hemostatic factors, platelet aggregation, endothelin-1, and left ventricular function. However, further study is needed to evaluate the long-term effects of combined HRT, especially on platelet aggregation and cardiac function.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Chen FP,Lee N,Wang CH,Cherng WJ,Soong YKdoi
10.1016/s0015-0282(97)00487-1subject
Has Abstractpub_date
1998-02-01 00:00:00pages
267-73issue
2eissn
0015-0282issn
1556-5653pii
S0015-0282(97)00487-1journal_volume
69pub_type
杂志文章abstract：:Seven nonionic detergents of the Igepal CO series differing in molecular size and including nonoxynol-9 and a representative anionic (SDS) and cationic (Cepacol) detergent were tested as to their relative cytotoxicity. The biologic effects of these detergents on human W1--38 fibroblasts (DNA and glycosaminoglycans syn...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
abstract：OBJECTIVE:To review the impacts of obesity on women's reproductive health and fertility. DESIGN:Literature review. SETTING:Academic medical center. PATIENT(S):Forty articles are referenced. The number of patients evaluated in each of the studies varies from 33 to 213,208. INTERVENTION(S):Articles were identified fr...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.02.141
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:To assess racial differences in attitudes and knowledge about sterilization. DESIGN:Cross-sectional survey. SETTING:Questionnaires were mailed to participants' home addresses. PATIENT(S):One hundred ninety-three women, aged 18-45, who had undergone tubal sterilization. INTERVENTION(S):None. MAIN OUTCOME ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.05.031
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVE:To assess the predictive value of endocrine gland-derived vascular endothelial growth factor (EG-VEGF) concentrations in follicular fluid (FF) and serum for ovarian hyperstimulation syndrome (OHSS) in patients undergoing controlled ovarian hyperstimulation. DESIGN:Retrospective, case-control study. SETTING:...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.09.044
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To study concordance rates of cryptorchidism (undescended testis) in pairs of boys with varying family structure, to evaluate the risk contribution from the intrauterine environment and genetic factors. DESIGN:Population based study of 1,024,500 Danish boys born from January 1, 1973 to December 31, 2004. Cla...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.09.041
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:To compare the clinical and endocrinologic effects of cyproterone acetate (CPA), an antiandrogen with progestational activity; flutamide, a nonsteroidal antiandrogen, and finasteride, an inhibitor of 5alpha-reductase. DESIGN:Randomized, open, controlled clinical study. SETTING:Department of Obstetrics and G...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(98)00486-5
更新日期：1999-03-01 00:00:00
abstract：OBJECTIVE:To investigate relations between dose of GnRH antagonist and follicular phase characteristics. DESIGN:Randomized controlled multicenter trial. SETTING:Tertiary referral fertility centers. PATIENT(S):Three hundred and twenty-nine IVF patients. INTERVENTION(S):Ovarian stimulation for IVF with recombinant FS...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0015-0282(00)01789-1
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVE:To determine whether the G1733A polymorphism of the androgen receptor gene is associated with an increased risk for recurrent spontaneous abortion (RSA). DESIGN:Case-control study. SETTING:Division of Genetics and Biotechnology, Department of Biology, University of Athens. PATIENT(S):A total of 131 women w...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.04.071
更新日期：2008-11-01 00:00:00
abstract：:Expanded carrier screening refers to identification of carriers of single-gene disorders outside of traditional screening guidelines. New genetic testing technologies allow for such screening at costs that are comparable to single-gene testing. There is a high degree of variability among genetic testing laboratories a...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2017.11.030
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:To report a case of parasitic leiomyoma of the abdominal wall after laparoscopic myomectomy. DESIGN:Case report. SETTING:Large medical center. PATIENT(S):A 31-year-old woman with a newly developed palpable mass in the abdominal wall near the trocar site of a previous laparoscopic myomectomy. INTERVENTION(...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.08.068
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVE:To investigate the potential effects of TAT-PRDX2 protein supplementation to the cryopreservation medium on post-thaw sperm quality and function. DESIGN:In vitro prospective study. SETTING:Medical university hospital. PATIENT(S):Fifty normozoospermic, 50 asthenozoospermic, and 50 oligoasthenozoospermic men...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2018.07.008
更新日期：2018-11-01 00:00:00
abstract：:Examination of 12 paired peritoneal ectopic and eutopic endometria for histochemical binding of Dolichos biflorus agglutinin, normally found in the mid-late secretory part of the cycle, showed a failure of lectin binding in 9 of 11 secretory-phase lesions although the eutopic specimens generally stained normally. This...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.11.032
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:To assess whether IV tramadol before outpatient hysteroscopy could reduce procedure-related pain. DESIGN:A randomized double-blind placebo controlled trial. SETTING:Outpatient Hysteroscopy Centre in the Department of Obstetrics and Gynaecology of Cagliari University. PATIENT(S):Fifty healthy, parous, women...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2006.05.072
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy of elagolix, an oral GnRH antagonist, for the reduction of fatigue in women with moderate or severe endometriosis-associated pain. DESIGN:Randomized, double-blind, multicenter, placebo-controlled phase III trial. SETTING:Clinics. PATIENT(S):A total of 860 women treated with elagoli...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.fertnstert.2019.02.031
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:To describe a case of superior mesenteric vein thrombosis associated with IVF. DESIGN:Case report. SETTING:University teaching hospital. PATIENT(S):A 33-year-old female developed progressive abdominal pain several days after ET in her first IVF cycle. A computed tomography scan 12 days after ET showed a su...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.06.081
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of transforming growth factor (TGF)-beta1 on the extracellular signal-regulated kinase (ERK) and Smad pathway and the role of peroxisome proliferator-activated receptor (PPAR)-gamma in cultured human endometrial stromal cells. DESIGN:Experimental study. SETTING:Infertility center o...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.09.010
更新日期：2008-10-01 00:00:00
abstract：:A specially designed rigid salpingoscope has been developed to allow inspection of the tubal mucosa during laparoscopy. The presence and extent of intratubal adhesion formation can be evaluated more accurately by this technique than by either HSG or laparoscopy. In 22 patients with bilateral hydrosalpinges, an intraut...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60501-0
更新日期：1989-02-01 00:00:00
abstract：OBJECTIVE:To introduce an effective approach for excision of ovarian endometrioma by "water injection"-assisted laparoscopy treatment. DESIGN:Step-by-step video explanation of the surgical procedure with still pictures and surgical video clips to demonstrate the detailed technique, approved by the Shengjing Hospital o...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2019.05.014
更新日期：2019-09-01 00:00:00
abstract：:Plasminogen activator activity in PF was assayed by the fibrinolysis method described by Strickland and Beers. In 45 patients studied, there were no discernible differences according to whether patients had endometriosis and/or pelvic adhesive disease. No differences were detected according to when in the menstrual cy...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48752-2
更新日期：1985-08-01 00:00:00
abstract：:The varicocele may be a cofactor that, when potentiated by other cofactors (i.e., gonadotoxins), causes male infertility. This hypothesis could explain the unpredictable effects of the varicocele on fertility. Male rats with experimental varicoceles, sham surgery, or no surgery were treated for 30 days with the known ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：OBJECTIVE:To study the direct effects of progesterone (P) and its antagonist RU486 (mifepristone) on sperm hyperactivation (HA) and acrosome reaction. DESIGN:Prospective evaluation of semen samples incubated in capacitation media with P and/or RU486. SETTING:University-affiliated tertiary care center. PATIENTS:Norma...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:Infertile men with azo- or oligospermia of unknown cause were investigated for evidence of testicular autoimmunity. Testicular germinal cell antibodies were found in 14% of the patients, compared with 5% of normal men, and 21% had spermatozoal antibodies, compared with 5% of the normal subjects. One-third had positive...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41421-4
更新日期：1975-10-01 00:00:00
abstract：OBJECTIVE:To develop a reliable, reproducible, and sensitive method for investigating gene-expression profiles from individual human oocytes. DESIGN:Five commercially available protocols were investigated for their efficiency to amplify messenger RNA (mRNA) from 54 single human oocytes. Protocols resulting in sufficie...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.10.025
更新日期：2016-02-01 00:00:00
abstract：:In summary, the luteal phase defect is a deficiency of corpus luteum progesterone steroidogenesis, either in amount or duration, or both. The clinical manifestations include either primary infertility or repeated first trimester abortions. The diagnosis can only be made clinically on the basis of a well-timed endometr...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41769-3
更新日期：1976-04-01 00:00:00
abstract：OBJECTIVE:To investigate methods of fertility preservation in younger women exposed to adjuvant chemotherapy for breast cancer. DESIGN:Systematic review of literature. SETTING:Academic Department of Medical Oncology. PATIENT(S):Premenopausal women exposed to adjuvant chemotherapy for breast cancer. MAIN OUTCOME MEA...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2009.02.055
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:To compare two commonly used protocols (fresh vs. vitrified) used to transfer euploid blastocysts after IVF with preimplantation genetic screening. DESIGN:Randomized controlled trial. SETTING:Private assisted reproduction center. PATIENT(S):A total of 179 patients undergoing IVF treatment using preimplanta...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2016.12.022
更新日期：2017-03-01 00:00:00
abstract：:In this study, both IVF-ET cycle and pregnancy outcome were compared with increases seen in P concentration during the 24-hour period from 12 hours before to 12 hours after hCG administration. A significantly higher PR (P < 0.001) was seen in women who had at least a threefold increase in P during this time period. Fu...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：OBJECTIVE:To see if clinicians' impressions were influenced by expert opinion on patient selection criteria that influence magnetic resonance-guided focused ultrasound (MRgFUS) leiomyoma treatment. DESIGN:Survey-based study. SETTING:First international symposium devoted to MRgFUS, "MRgFUS 2008," October 6-7, 2008, Wa...
journal_title：Fertility and sterility
pub_type：
doi：10.1016/j.fertnstert.2009.02.083
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:To compare the expression of HOXA-10 and E-cadherin in the endometrium of women with recurrent implantation failure (RIF), women with recurrent miscarriage (RM), and women with proven fertility (normal control; NC). DESIGN:Observational cohort study. SETTING:University assisted reproductive unit. PATIENT(S...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2016.09.016
更新日期：2017-01-01 00:00:00
abstract：:Hemochromatosis is a rare disorder of iron storage. This report illustrates a case of hypogonadotropic-hypogonadism in a female with biopsy-proven hemochromatosis. Dynamic pituitary and gonadal testing revealed subnormal gonadotropin responses to gonadotropin-releasing hormone (GnRH) but normal ovarian reserve, as sho...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)53842-4
更新日期：1990-10-01 00:00:00
