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Optimal euploid embryo transfer strategy, fresh versus frozen, after preimplantation genetic screening with next generation sequencing: a randomized controlled trial.

Abstract：

OBJECTIVE:To compare two commonly used protocols (fresh vs. vitrified) used to transfer euploid blastocysts after IVF with preimplantation genetic screening. DESIGN:Randomized controlled trial. SETTING:Private assisted reproduction center. PATIENT(S):A total of 179 patients undergoing IVF treatment using preimplantation genetic screening. INTERVENTION(S):Patients were randomized at the time of hCG administration to either a freeze-all cycle or a fresh day 6 ET during the stimulated cycle. MAIN OUTCOME MEASURE(S):Implantation rates (sac/embryo transferred), ongoing pregnancy rates (PRs) (beyond 8 weeks), and live birth rate per ET in the primary transfer cycle. RESULT(S):Implantation rate per embryo transferred showed an improvement in the frozen group compared with the fresh group, but not significantly (75% vs. 67%). The ongoing PR (80% vs. 61%) and live birth rates (77% vs. 59%) were significantly higher in the frozen group compared with the fresh group. CONCLUSION(S):Either treatment protocol investigated in the present study can be a reasonable option for patients. Freezing all embryos allows for inclusion of all blastocysts in the cohort of embryos available for transfer, which also results in a higher proportion of patients reaching ET. These findings suggest a trend toward favoring the freeze-all option as a preferred transfer strategy when using known euploid embryos. CLINICAL TRIAL REGISTRATION NUMBER:NCT02000349.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Coates A,Kung A,Mounts E,Hesla J,Bankowski B,Barbieri E,Ata B,Cohen J,Munné S

doi

10.1016/j.fertnstert.2016.12.022

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

723-730.e3

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)63094-7

journal_volume

107

pub_type

杂志文章,随机对照试验

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