Abstract:
OBJECTIVE:To assess the occult pregnancy rate after "negative" first post-embryo transfer (ET) serum β-hCG results. DESIGN:Two-part retrospective cohort study and nested case series. SETTING:University-based fertility center. PATIENT(S):A total of 1,571 negative first post-ET serum β-hCG results were included in the study; 1,326 results (primary cohort, June 2009-December 2013) were initially reported as <5 mIU/mL and 245 results (secondary cohort, January 2014-March 2015) were reported as discrete values from 1.0 to 5.0 mIU/mL. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Rates of occult pregnancy, ectopic pregnancy, and complications after negative first post-ET serum β-hCG results. RESULT(S):A total of 88.8% (1,178/1,326) of the negative first post-ET results reported as <5 were actually <1.0 mIU/mL. Occult pregnancy was incidentally identified in 1.2% (12/1,041) of subjects with follow-up. Six had ectopic pregnancies, and seven experienced serious complications; 11 (91.7%) of the 12 occult pregnancies had a first post-ET serum β-hCG level of 1.0-5.0 mIU/mL and 1 (8.3%) <1.0 mIU/mL. All pregnancies with serious complications had initial β-hCG levels of 1.0-5.0 mIU/mL. Of the 245 results reported as discreet values, occult pregnancies were diagnosed in 5.5% (9/163) of subjects with follow-up. One had an ectopic pregnancy, which was treated with methotrexate. There were no serious complications in the secondary cohort. CONCLUSION(S):The majority of negative first post-ET serum β-hCG levels are <1.0 mIU/mL. Results from 1.0 to 5.0 mIU/mL may fail to exclude abnormal pregnancy and are associated with poor outcomes compared with β-hCG levels <1.0 mIU/mL. Serial serum β-hCG may be warranted in this population.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Maslow BS,Bartolucci A,Sueldo C,Engmann L,Benadiva C,Nulsen JC 3rddoi
10.1016/j.fertnstert.2015.11.049subject
Has Abstractpub_date
2016-04-01 00:00:00pages
938-945.e1issue
4eissn
0015-0282issn
1556-5653pii
S0015-0282(15)02133-0journal_volume
105pub_type
杂志文章abstract:OBJECTIVE:To investigate whether the insulin receptor substrate (IRS)-2 G1057D polymorphism is associated with the risk of endometriosis, and to evaluate potential correlation of IRS2 gene polymorphism with the stages of endometriosis. DESIGN:Case-control study. SETTING:Gynecology clinics in university hospital. PAT...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.09.023
更新日期:2010-10-01 00:00:00
abstract::The effect of danazol on steroidogenesis in cultured human granulosa cells was studied. Granulosa cells obtained from antral follicles in the mid to late follicular phase were cultured for 2 to 6 days. Danazol (0.1 to 5 micrograms/ml) and human chorionic gonadotropin (hCG, 10 IU/ml), alone or in combination, were adde...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1986-08-01 00:00:00
abstract::Rabbits were immunized with homologous spermatozoa to investigate their autoimmunogenic nature. Major sperm autoantigens that elicit antisperm antibodies were analyzed molecularly by the sodium dodecylsulfate (SDS) gel/protein blot radioimmunobinding method. IgG fractions of the autoimmune sera were purified by a prot...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the mRNA levels of connexins in different sizes of luteinized follicles. DESIGN:Semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) to determine the connexin mRNA levels in the granulosa cells of 91 luteinized follicles. SETTING:Academic tertiary care medical center and res...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2003.05.015
更新日期:2003-12-01 00:00:00
abstract::Semen analysis was performed on 8 men, every 2 months, for a period of 8 months, after the application of the radiozinc spermatogensis test. Semen was examined for volume, cell count, motility, and abnormal forms. Results showed no evidence of any changes in semen parameters. Student's test was used to compare the ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)40037-3
更新日期:1973-11-01 00:00:00
abstract::Buserelin acetate, a luteinizing hormone-releasing hormone agonist, is known to be effective in the shrinkage of uterine fibroids. A prospective trial was undertaken (1) to compare the efficacy of intranasal (IN) and subcutaneous (SC) administration of buserelin acetate and (2) to assess if tumor regression correlated...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(16)54001-1
更新日期:1990-12-01 00:00:00
abstract:OBJECTIVE:To analyze the effect of human papilloma virus (HPV) sperm infection on sperm parameters and in vitro fertilization (IVF) outcomes. DESIGN:Systematic review and meta-analysis. SETTING:Not applicable. PATIENTS:Men with HPV sperm infection and couples undergoing IVF. INTERVENTIONS:Searches were conducted in...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2020.01.010
更新日期:2020-05-01 00:00:00
abstract::Nonaromatizable androgens, administered in high doses to an adult patient with partial androgen insensitivity, failed to result in a change in phallic size despite a clear decline in SHBG and gonadotropin levels. These findings raise the question of differential tissue sensitivity to androgens. Because ancillary labor...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56114-7
更新日期:1993-08-01 00:00:00
abstract::Previous data suggested a subtle increase in serum P at the time of hCG injection without LH surge reduces the PR of women having oocyte retrievals for IVF; this study compared PRs of recipients in a shared oocyte program according to the donors' pre-hCG P level. There was no difference in viable PRs between recipient...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56514-5
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVE:To develop molecular tools increasing the sensitivity of breast cancer micrometastases detection within ovarian tissue cryopreserved for fertility preservation. DESIGN:Expression of breast markers was evaluated by quantitative polymerase chain reaction in ovarian tissue from patients with benign or cancerous...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.04.036
更新日期:2015-08-01 00:00:00
abstract::We report the complications observed after transvaginal oocyte retrieval guided by ultrasound in 7,098 IVF cycles. The frequency of severe complications in our patients was 0.08%, of which four cases were intraperitoneal bleeding (0.06%) and two were cases of ovarian abscess (0.003%). ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.07.1054
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of carrying a BRCA1 or BRCA2 mutation on the probability of experiencing premature natural menopause. DESIGN:Observational study. SETTING:Patients in an academic research environment. PATIENT(S):Women who carry a BRCA1 or BRCA2 mutation (case subjects) and women who do not carry a mu...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2013.01.109
更新日期:2013-05-01 00:00:00
abstract::The comprehensive "one-stop shop" ultrasound evaluation of an infertile woman, performed around cycle days 5 to 9, will reveal abundant information about the anatomy and morphology of the pelvic organs and thereby avoid costly radiation and iodinated contrast exposure. We propose a two-dimensional and three-dimensiona...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2016.03.026
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of adding follicular-fluid meiosis-activating sterol (FF-MAS) in a novel 0.2% recombinant human albumin-based formulation to cumulus-enclosed oocytes on chromosomal status and development of pre-embryos. DESIGN:Multicenter, prospective, randomized, open (double-blind for vehicle and FF...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.fertnstert.2005.05.017
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:To report a case of severe ovarian hyperstimulation syndrome (OHSS) after inadvertent GnRH long protocol/hMG stimulation in a pre-existing early pregnancy. DESIGN:Case report. SETTING:Private infertility clinic. PATIENT(S):A 28-year-old woman who conceived spontaneously following IVF and cryo-embryo transf...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.05.069
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:To present a case report of a spontaneous, heterotopic, triplet conception of a patient without any risk factors. DESIGN:Case report. SETTING:Community hospital in Park Ridge, Illinois. PATIENT(S):One patient, 30-year-old multigravida, sent to the emergency room for evaluation of right lower quadrant pain ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.12.034
更新日期:2007-10-01 00:00:00
abstract::Women who exercise heavily may develop secondary amenorrhea. Since the mechanism of so-called "runner's amenorrhea" has not been conclusively established, the authors examined the occurrence of amenorrhea in one of the most intensively exercising groups of female runners in the United States (average, 70 miles/week): ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVE:To enable serodiscordant couples to reproduce while minimizing the risk of infecting the female partner and to demonstrate the feasibility of including these couples in an insemination program. DESIGN:Prospective follow-up study. SETTING:Ambulatory IUIs. PATIENT(S):Fifty-six HIV-1-serodiscordant couples wi...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/j.fertnstert.2004.02.128
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:To determine the correlation between semen basic parameters and the expression and activity of signaling proteins. DESIGN:In vitro studies with human spermatozoa. SETTING:Academic research institute. PATIENT(S):Thirty-seven men provided semen samples for routine analysis. INTERVENTION(S):None. MAIN OUTCO...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.06.039
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the factors affecting the pregnancy rate after microsurgical reversal of tubal ligation. DESIGN:Retrospective clinical study. SETTING:Private practice affiliated with a tertiary care center. One hundred twenty-eight consecutive patients who underwent tubal reversal between October 1992 and May 2...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(03)00661-7
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of L-carnitine (LC) or L-acetyl-carnitine (LAC) or combined LC and LAC treatment in improving semen kinetic parameters and the total oxyradical scavenging capacity in semen. DESIGN:Placebo-controlled, double-blind, randomized trial. SETTING:Andrology unit, Department of Interna...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2005.03.064
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:To assess cycle outcomes when antimüllerian hormone (AMH) is ultralow (≤0.16 ng/mL) and to determine which parameters contribute to the probability of cycle cancellation and/or outcome. DESIGN:Retrospective analysis. SETTING:Not applicable. PATIENT(S):5,087 (7.3%) fresh and 243 (1.5%) thawed cycles with ul...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.10.004
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To investigate the incidence of complications in the use of assisted reproductive technology in the management of infertile couples. DESIGN:Retrospective study. SETTING:The Egyptian IVF & ET Center, Maadi, Cairo, Egypt. PATIENT(S):Two thousand nine hundred twenty-four patients underwent IVF-ET or intracyto...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(98)00250-7
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:To review the definition and diagnosis of interstitial and heterotopic interstitial pregnancy and to evaluate the conservative management of these conditions. DESIGN:A MEDLINE computer search was used to identify relevant studies. The mean values for the duration of amenorrhea, serum beta-hCG level, size of ...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(99)00242-3
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:To develop a reliable, reproducible, and sensitive method for investigating gene-expression profiles from individual human oocytes. DESIGN:Five commercially available protocols were investigated for their efficiency to amplify messenger RNA (mRNA) from 54 single human oocytes. Protocols resulting in sufficie...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.10.025
更新日期:2016-02-01 00:00:00
abstract::Recent in vitro studies implicate the ovary as an extra-hepatic source of insulin-like growth factors (IGFs) with production regulated by gonadotropins and local steroids. Because previous studies have failed to show any significant variations in IGF levels in peripheral blood during the menstrual cycle, we measured t...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53221-x
更新日期:1990-01-01 00:00:00
abstract::The immunobead test was used to study the immunoglobulin class of antibodies on sperm before and after penetration through a microcolumn of cervical mucus. Sixteen men with positive sperm antibodies (positive sperm immobilization test) and sperm that penetrated cervical mucus in prior tests were selected for study. Ho...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)48916-8
更新日期:1985-10-01 00:00:00
abstract::Female mice were superovulated with pregnant mare serum gonadotropin (PMSG) and human chorionic gonadotropin (hCG) and mated with male mice. One-cell (n = 429) and 2-cell (n = 450) embryos were collected 20 and 42 hours after hCG and cultured in Ham's F-10 medium (Gibco, Grand Island, NY) (282 mOsm/l, pH 7.4) and in m...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59783-0
更新日期:1988-03-01 00:00:00
abstract::Since the late 1980s premature progesterone elevation has repeatedly caught the attention of investigators, not only for its importance, but also because studies have shown differing results and conclusions, constituting an unexplainable sequence of doubts and uncertainties. This issue's Views and Reviews section seek...
journal_title:Fertility and sterility
pub_type:
doi:10.1016/j.fertnstert.2018.02.134
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To investigate the proportional changes of CD4(+)CD25(+) regulatory T cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion (URSA) and normal pregnant (NP) women. DESIGN:Prospective, case-control study. SETTING:Large public hospital in a major city in China. PATIENT(S):Twenty-...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.03.037
更新日期:2008-03-01 00:00:00