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Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients.

Abstract：

OBJECTIVE:To investigate the proportional changes of CD4(+)CD25(+) regulatory T cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion (URSA) and normal pregnant (NP) women. DESIGN:Prospective, case-control study. SETTING:Large public hospital in a major city in China. PATIENT(S):Twenty-five URSA patients and 34 normal, early pregnant, control women. INTERVENTION(S):Measurements of CD4(+)CD25(+) regulatory T cells in decidua and peripheral blood. MAIN OUTCOME MEASURE(S):The proportion of CD4(+)CD25(bright) regulatory T cells; the percentage of CD25(bright) cells in the CD4(+) T-cell population. RESULT(S):The proportions of CD4(+)CD25(bright) T cells in both decidua and peripheral blood in URSA patients were statistically significantly lower than those in control women. Meanwhile, the percentage of CD25(bright) cells in the CD4(+) T-cell population in decidua was statistically significantly lower in URSA patients than in control women. The percentage of CD25(bright) cells in the CD4(+) T-cell population in decidua was statistically significantly higher than that in peripheral blood in control women, whereas the difference was not significant in patients who have URSA. CONCLUSION(S):Human CD4(+)CD25(bright) T cells play a major role in tolerating conceptus antigens and therefore may contribute to the maintenance of pregnancy. The data suggest that CD4(+)CD25(+) regulatory T cells may be a novel target in URSA therapy.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Yang H,Qiu L,Chen G,Ye Z,Lü C,Lin Q

doi

10.1016/j.fertnstert.2007.03.037

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

656-61

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(07)00656-5

journal_volume

89

pub_type

杂志文章

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