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Comparisons of pregnancy loss patterns after intracytoplasmic sperm injection and other assisted reproductive technologies.

Abstract：

OBJECTIVE:To compare outcome of pregnancies after intracytoplasmic sperm injection (ICSI) with those of other assisted reproductive technologies. DESIGN:Pregnancy outcomes after ICSI were followed prospectively and compared with pregnancy outcomes after IVF with fresh and frozen ETs and donor oocyte cycles. SETTING:A private tertiary referral center for genetics and infertility in Fairfax, Virginia. PATIENTS:One hundred thirty-six couples achieving pregnancy after undergoing ICSI, 71 after IVF, 35 donor oocyte recipients, and 19 after transfer of frozen-thawed embryos. INTERVENTIONS:In vitro fertilization and/or ET for all couples. Dilatation and curettage to obtain products of conception for chromosome analysis in 28 women experiencing spontaneous abortion. MAIN OUTCOME MEASURES:Pregnancy outcomes were classified as preclinical loss, clinical loss, and ongoing pregnancy. RESULTS:The mean frequency of preclinical pregnancy loss was 26% after ICSI, 28% after IVF, 3% after ET using donor oocytes, and 11% after frozen ET. The rate of clinical loss after ICSI (21%) was compared with IVF (18%), donor oocyte cycles (11%), and frozen ETs (21%). CONCLUSIONS:Intracytoplasmic sperm injection is not associated with an increase in pregnancy losses, clinical or preclinical, compared with conventional IVF.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Coulam CB,Opsahl MS,Sherins RJ,Thorsell LP,Dorfmann A,Krysa L,Fugger E,Schulman JD

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

1157-62

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)58331-9

journal_volume

65

pub_type

杂志文章

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