Semen leukocytes: friends or foes?

Abstract:

OBJECTIVE:To test the hypothesis that male reproductive tract leukocytes function in the elimination of abnormal spermatozoa from ejaculated semen. DESIGN:Semen specimens with > or = 2 x 10(6) nonspermatozoal cells/mL were examined for leukocytes and for mature sperm with ideal morphology. SETTING:Andrology laboratory of a Center of Assisted Reproductive Technology. RESULTS:Semen specimens with elevated concentrations of leukocytes contained a significantly higher frequency of sperm with ideal morphology than semen specimens with elevated numbers of immature germ cells and low numbers of leukocytes. CONCLUSIONS:The direct correlation between leukocyte density and sperm with ideal morphology supports the concept that sperm surveillance is a normal function of male reproductive tract leukocytes. Understanding such germ cell-leukocyte interactions may provide valuable new insights into immunologic control mechanisms in male reproductive tract tissues.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Kiessling AA,Lamparelli N,Yin HZ,Seibel MM,Eyre RC

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

196-8

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)57681-X

journal_volume

64

pub_type

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