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Effect of body weight on early hormone levels in singleton pregnancies resulting in delivery after in vitro fertilization.

Abstract：

OBJECTIVE:To evaluate which clinical characteristics influence early maternal β-human chorionic gonadotropin (hCG) and progesterone levels in in vitro fertilization (IVF) pregnancies. DESIGN:Retrospective cohort analysis. SETTING:Academic medical center. PATIENT(S):Women with a live birth after single-blastocyst embryo transfer in either a fresh or frozen cycle between 2004 and 2017, comprising 1,282 pregnancies in 1,057 patients. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):The initial human chorionic gonadotropin concentration (β-hCG1) measured a mean of 10 days (range: 9-12 days) after embryo transfer, the rate of increase in β-hCG concentrations, and progesterone concentration, with all analyses controlled for number of days between the embryo transfer and the β-hCG1 measurement. RESULT(S):The clinical factor that positively influenced the β-hCG1 level in the fresh cycle was the stimulation type (antagonist cycle higher than long agonist cycle). The clinical factors that negatively influenced both fresh and frozen cycle β-hCG1 were lower embryo quality and increasing body weight. Increasing weight negatively impacted progesterone levels in both fresh and frozen cycles. A 100 lb (45.4 kg) difference in weight was associated with a 34.8% reduction in β-hCG1 for both fresh and frozen cycle pregnancies. The rate of increase in β-hCG was unaffected by body weight. A 100 lb (45.4 kg) difference in weight was associated with a 53.3% and a 32.8% reduction in progesterone in fresh and frozen cycles, respectively. CONCLUSION(S):Increasing body weight is associated with significantly lower β-hCG and progesterone concentrations in early pregnancy after blastocyst single-embryo transfer in both fresh and frozen cycles. Clinicians should consider this when evaluating these hormone levels for prognostic and diagnostic purposes.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Mejia RB,Cox TW,Nguyen EB,Summers KM,Eyck PT,Sparks AE,Van Voorhis BJ

doi

10.1016/j.fertnstert.2018.08.047

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

1311-1317

issue

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(18)31886-7

journal_volume

110

pub_type

杂志文章

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Effect of body weight on early hormone levels in singleton pregnancies resulting in delivery after in vitro fertilization.