Lipopolysaccharide-promoted proliferation of endometriotic stromal cells via induction of tumor necrosis factor alpha and interleukin-8 expression.

Abstract:

OBJECTIVE:To evaluate the effect of lipopolysaccharide (LPS) on the expression of tumor necrosis factor alpha (TNFalpha) and interleukin-8 (IL-8) protein in endometriotic stromal cells (ESC) and their effect on the proliferation of ESC. DESIGN:Prospective study. SETTING:Department of Obstetrics and Gynecology, Tottori University Hospital, Yonago, Japan. PATIENT(S):Seventeen patients who underwent laparoscopic surgery. INTERVENTION(S):Endometriotic stromal cells were obtained from chocolate cyst linings of the ovary. MAIN OUTCOME MEASURE(S):We determined the effect of LPS on the production of TNFalpha and IL-8 and the effect of IL-8 antisense oligonucleotide and nuclear factor-kappaB (NF-kappaB) inhibitor on IL-8 production using ELISA. TNFalpha production was examined by immunocytochemical staining. We determined the effect of LPS and the effect of IL-8 antisense oligonucleotide and NF-kappaB inhibitor on LPS-promoted ESC proliferation. RESULT(S):LPS-stimulated ESC produced significant amounts of TNFalpha and IL-8 in a dose- and time-dependent fashion. Adding LPS promoted ESC proliferation. Anti-TNFalpha antibody and anti-IL-8 antibody inhibited the stimulatory effects of LPS. IL-8 antisense oligonucleotide and NF-kappaB inhibitor significantly decreased LPS-induced IL-8 protein production and LPS-induced ESC proliferation. CONCLUSION(S):Pelvic inflammation may promote the progression of endometriosis.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Iba Y,Harada T,Horie S,Deura I,Iwabe T,Terakawa N

doi

10.1016/j.fertnstert.2004.04.038

keywords:

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

1036-42

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(04)01294-4

journal_volume

82 Suppl 3

pub_type

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