Alterations in progesterone metabolism and luteal function in infertile women with endometriosis.

Abstract:

:The concentrations of pregnanediol-3-glucuronide (PGD) and pregnanolone (PN) were measured in daily morning urine specimens from 66 infertile women (40 with varying degrees of endometriosis and 26 control subjects) and correlated with daily changes in basal body temperature (BBT) and with midluteal levels of serum progesterone (P). PN and BBT rose at midcycle in women with endometriosis, as expected, indicating secretion of some P at that time. However, PGD, the major endpoint of P metabolism, was delayed in its excretion. Endometrial biopsies were similarly delayed (out of phase) in women with endometriosis, and a significantly higher incidence of follicular luteinization was seen. It appears that while P secretion begins at midcycle, the bulk of P secretion is delayed, perhaps because of the process of follicular luteinization, and that a shortened functional luteal phase thus exists in women with endometriosis.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Cheesman KL,Cheesman SD,Chatterton RT Jr,Cohen MR

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

590-5

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)47414-5

journal_volume

40

pub_type

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