Abstract：
:The effectiveness of antiestrogens and progestins in the inhibition of capacitation in the rabbit uterus and oviduct was studied. The agents tested were 8 mg/day nafoxidine HCL (NHCL), 4 mg/day fluoxymesterone (FM), 4 and 20 mg/day clomiphene citrate (CC), 8 mg/day testosterone (T), 8 mg/day dydrogesterone (D) 4 and 8 mg/day 20alpha-hyd roxyprogesterone (HP), 4, 8, 40, and 120 mg/day progesterone (P), 4 mg/day norethindrone (NE), and .5, 2, 5, and 20 mg/day chlormadinone acetate (CA). nhcl, fm, cc, d, hp (8 mg/day), NE, and CA reduced fertilization, though capacitation was still possible. The highest dose of P failed to inhibit capacitation in the oviduct. T and HP (4 mg/day) failed to reduce fertilization. However, CC and NE sharply reduced ovulation in all animals (an average of less than 1 egg per rabbit), while 20 mg/day of CC completely inhibited ovulation. CA accelerated the passage of some eggs to the uterus. 8 mg/day of HP, 1 mg/day of P, and 2 mg/day of CA completely inhibited capacitation in the uterus. The capacitation ability of the oviduct was not impaired by P, NE, or, CA. It was found that 2500 units of P were required to completely abolish the effect of 1 unit of estradiol. It is concluded that the contraceptive effect of the drugs tested are not due to inhibition of capacitation, but rather to faulty transport of sperm and eggs, inhibiti on of ovulation, and production of an environment in the female reproductive tract that is hostile to sperm.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Hamner CE,Wilson LA Jrsubject
Has Abstractpub_date
1972-03-01 00:00:00pages
196-200issue
3eissn
0015-0282issn
1556-5653pii
S0015-0282(16)38826-4journal_volume
23pub_type
杂志文章abstract：:We found, by reverse transcription--real time--polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory of three distinct clinical entities. Compared with peritoneal endometriosis, o...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/j.fertnstert.2005.10.041
更新日期：2006-05-01 00:00:00
abstract：:Semen specimens were obtained for analysis from nine men immediately before vasectomy and 3 days following the vasectomy procedure. After vasectomy there was a significant decrease in seminal sperm concentration, percentage of sperm motility, and mean swimming speed. In seven of nine cases the spermatozoa did not surv...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48262-2
更新日期：1984-12-01 00:00:00
abstract：:A new flexible protocol for the induction of recipient endometrial cycles is presented. For stimulation of endometrial growth, a fixed dose of conjugated estrogens, 3.75 mg/d was employed. The duration of the proliferative phase varied from 9 to 14 days, thus being adjusted to match the length of the follicular phase ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60988-3
更新日期：1989-10-01 00:00:00
abstract：OBJECTIVE:To investigate the relationship between body mass index and intercourse compliance in the Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (RMN PPCOS) Trial. DESIGN:Post hoc data analysis of subjects in the RMN PPCOS Trial. SETTING:Academic medical centers. INTERVENTION(S):None. PATI...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2009.05.048
更新日期：2010-09-01 00:00:00
abstract：:This prospective study assessed von Willebrand factor (VWF) expression in the endometrium using immunohistochemical staining in women with menorrhagia with or without von Willebrand disease (VWD) compared with a control group of women with normal menstrual loss. Endometrial VWF expression is significantly lower in wom...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.02.055
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVE:To introduce a combined laparovaginal metroplasty approach to the treatment of bicornuate uterus. DESIGN:Case report. SETTING:Private community hospital. PATIENT:A nulliparous patient with three recurrent spontaneous midtrimester abortions and a double uterus on hysterosalpingogram was evaluated laparoscop...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)58235-1
更新日期：1996-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the impact of chronic GnRH antagonist therapy on the extent of GnRH agonist-induced gonadotrope desensitization. DESIGN:Prospective and controlled. SETTING:Primate Research Center. PARTICIPANTS:Six reproductive age cycling female baboons (Papio cyanocephalus anubis). INTERVENTIONS:The animals ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)57864-9
更新日期：1995-10-01 00:00:00
abstract：OBJECTIVE:To investigate the possible role of phthalate, a ubiquitous chemical used in consumer products, in the pathogenesis of uterine leiomyoma. DESIGN:Experimental and prospective case-control study using human samples. SETTING:University hospital. PATIENT(S):Fifty-three women with histologic evidence of uterine...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2017.01.015
更新日期：2017-04-01 00:00:00
abstract：:A prospective longitudinal and standardized study is presented, dealing with ultrasonographic and hormonal characteristics of the luteinized unruptured follicle (LUF) syndrome. Among 600 cycles monitored in 270 infertility patients, 40 cycles in 27 patients showed no evidence of follicle rupture, in spite of signs of ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48494-3
更新日期：1985-04-01 00:00:00
abstract：:A prospective randomized study was conducted in 100 women with leiomyomas in order to evaluate the effect of gestrinone, a synthetic derivative of ethynil-nor-testosterone. Patients in group A received capsules containing 2.5 mg of gestrinone three times weekly orally. Those in group B received capsules containing 5.0...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(16)60722-7
更新日期：1989-06-01 00:00:00
abstract：OBJECTIVE:To develop the Cognitive Appraisal Scale for Infertility (CASI) and assess it for reliability and validity. DESIGN:Cross-sectional and longitudinal study. SETTING:A private fertility institute in Japan. PATIENT(S):223 infertile women being treated at the institute. INTERVENTION(S):Administration of questi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.03.052
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVE:To determine the concentrations of angiopoietin 1 (ANGPT1) and ANGPT2 in individual human preovulatory follicles in relation to their diameter or volume to clarify the role of these molecules in folliculogenesis. DESIGN:Prospective study. SETTING:Research laboratory at Kansai Medical University, Osaka, Japa...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/j.fertnstert.2011.09.031
更新日期：2011-12-01 00:00:00
abstract：:A couple may be considered to have fertility problems if they have been trying to conceive for over 1 year with no success. Worldwide, the inability to have children affects 10% to 15% of all couples. Subfertility can be divided into either male or female factor, or both partners can be affected. However, for some cou...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2018.05.028
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:To determine if adult human endometrium possesses an intact müllerian-inhibiting substance (MIS) signal transduction system and, if so, whether MIS can modulate endometrial cell viability. DESIGN:Adult human endometrial tissue was subjected to reverse transcription polymerase chain reaction (RT-PCR) analysis...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.01.028
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:Determine whether peritoneal macrophages from women with endometriosis-associated infertility express more inducible nitric oxide synthase (NOS2) and produce more NO than fertile controls. DESIGN:Unblinded clinical study. PATIENT(S):Nine infertile women with endometriosis and nine normal fertile women under...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)02940-5
更新日期：2002-01-01 00:00:00
abstract：:After long-term estradiol deficiency, female rats displayed body mass gain accompanied by an increase in the size of adipocytes, an increase in hyperglycemia, and a decrease in insulinemia. The effects were reversed by daily estradiol treatment. Adiposity was suggested by the increased vascular endothelial growth fact...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.01.020
更新日期：2011-03-15 00:00:00
abstract：:We hypothesized that diminished endothelin 1 (ET-1) expression at the spermatic vein wall level might be responsible for the development of varicocele. However, immunohistochemical evaluation of spermatic and control vein samples from 55 patients with varicocele showed overexpression of ET-1 and its receptors ETA and ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.04.062
更新日期：2011-06-30 00:00:00
abstract：OBJECTIVE:To report preferences of recipient couples for genetic testing of their oocyte donors. DESIGN:Observational report of results from a genetic testing-options form implemented as part of routine care. SETTING:Private practice. PATIENT(S):Recipients and oocyte donors. INTERVENTION(S):Recipient couples comple...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.10.069
更新日期：2008-12-01 00:00:00
abstract：OBJECTIVE:To determine the expression profiles of the DAZ gene family in men with and without spermatogenic failure. DESIGN:Prospective case study. SETTING:University-based reproductive clinics and genetics laboratory. PATIENT(S):Thirty-four infertile men presenting with azoospermia. INTERVENTION(S):The mRNA transc...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2003.08.047
更新日期：2004-04-01 00:00:00
abstract：:Mean monthly values for ejaculate volume, sperm density, and percentage of motile sperm were calculated from semen analyses performed on volunteered donors to the laboratory from 1979 to 1986. The data of 4,196 ejaculates were computerized by the single Cosinor method for searching on circannual rhythms of the paramet...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60738-0
更新日期：1989-06-01 00:00:00
abstract：OBJECTIVE:To determine whether blood leukocyte populations could be modulated in endometriosis. DESIGN:Case-control study. SETTING:Eight clinical institutions of the Montreal area. PATIENT(S):Women with regular menstrual cycles who underwent laparoscopy or laparotomy between 1997 and 2001 and who were not under horm...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(03)00552-1
更新日期：2003-07-01 00:00:00
abstract：OBJECTIVE:To investigate whether women who conceive after assisted reproductive technology (ART) are at higher risk for emergency peripartum hysterectomy. DESIGN:A case-control study using a prospectively maintained institutional database. SETTING:A tertiary referral university teaching maternity hospital. PATIENT(S...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2016.05.005
更新日期：2016-09-01 00:00:00
abstract：:The effects of various concentrations of rosiglitazone on in vitro rat embryo growth and morphology during the critical period of organogenesis was evaluated. We found that rosiglitazone has no significant effects on growth and morphology of in vitro early embryo development, even at very high concentrations. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.12.069
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that male reproductive tract leukocytes function in the elimination of abnormal spermatozoa from ejaculated semen. DESIGN:Semen specimens with > or = 2 x 10(6) nonspermatozoal cells/mL were examined for leukocytes and for mature sperm with ideal morphology. SETTING:Andrology laborator...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
abstract：OBJECTIVE:To identify and characterize a novel sperm motility-stimulating protein (MSP) from caprine serum. DESIGN:Prospective experimental study. SETTING:Research laboratory. ANIMAL(S):Rabbits and male and female BALB/c mice. INTERVENTION(S):Protein purification by conventional methods and functional and immunolog...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.03.012
更新日期：2013-07-01 00:00:00
abstract：:Predictors of weight at resumption of menses were studied in 118 subjects with lifetime anorexia nervosa who recovered their ovarian function without hormonal therapies. About 64% of subjects had menses resumption during spring/summer season. The body mass index (BMI) at resumption of menses was significantly predicte...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.04.055
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:To study whether specific congenital anomalies occur more often with a history of subfertility and/or the use of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). DESIGN:Case-only analyses. SETTING:Not applicable. PATIENT(S):We included live births, stillbirths, and terminated pregnanci...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2014.12.113
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:The present study investigates the effect of prenatal hyperandrogenization on lipid metabolism and oxidant/antioxidant balance. DESIGN:Experimental study. SETTING:Research institute. ANIMAL(S):Pregnant Sprague Dawley rats were subcutaneously injected with 2 mg free T between days 16 and 19 of pregnancy, an...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2012.10.017
更新日期：2013-02-01 00:00:00
abstract：:We found that there was no significant difference in endometrial responses to vaginal or IM P. But the response was suboptimal in cycles treated with dydrogesterone, suggesting that dydrogesterone treatment is not the preferred progestin for use in artificial cycles. ...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(16)56840-x
更新日期：1994-07-01 00:00:00
abstract：:An improved knowledge of cryopreservation of primate embryos will have important research and clinical application. Fifty-six 4- to 8-cell in vitro fertilized embryos were frozen in HEPES-buffered Tyrode's solution containing 1.5 M dimethylsulfoxide (DMSO) and cooled at the rate of 0.3 degrees C/minute to -39 degrees ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)49225-3
更新日期：1986-03-01 00:00:00
