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Congenital anomalies in offspring of subfertile couples: a registry-based study in the northern Netherlands.

Abstract：

OBJECTIVE:To study whether specific congenital anomalies occur more often with a history of subfertility and/or the use of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). DESIGN:Case-only analyses. SETTING:Not applicable. PATIENT(S):We included live births, stillbirths, and terminated pregnancies with congenital anomalies without a known cause that had a birth year between 1997 and 2010 (n = 4,525). A total of 4,185 malformed cases were born to fertile couples and 340 to subfertile couples, of whom 139 had conceived after IVF/ICSI and 201 had conceived naturally after >12 months. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):The contribution, expressed in odds ratios (ORs), of a history of subfertility and IVF/ICSI to each specific type of congenital anomaly, imprinting disorder, and syndromal disorder. RESULT(S):We found subfertility to be associated with an increase in abdominal wall defects (adjusted OR [aOR] 2.43, 95% CI 1.05-5.62), penoscrotal hypospadia (aOR 9.83, 95% CI 3.58-27.04), right ventricular outflow tract obstruction (aOR 1.77, 95% CI 1.06-2.97), and methylation defects causing imprinting disorders (aOR 13.49, 95% CI 2.93-62.06). In vitro fertilization/ICSI was associated with an increased risk of polydactyly (OR 4.83, 95% CI 1.39-16.77) and more specifically polydactyly of the hands (OR 5.02, 95% CI 1.43-17.65). CONCLUSION(S):In our registry-based study, parental subfertility was associated with an increase in abdominal wall defects, penoscrotal hypospadia, right ventricular outflow tract obstruction, and methylation defects causing imprinting disorders. In vitro fertilization/ICSI was associated with an increase in polydactyly, mainly of the hands.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Seggers J,de Walle HE,Bergman JE,Groen H,Hadders-Algra M,Bos ME,Hoek A,Haadsma ML

doi

10.1016/j.fertnstert.2014.12.113

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

1001-1010.e3

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(14)02544-8

journal_volume

103

pub_type

杂志文章

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