Abstract：
OBJECTIVE:To assess the efficiency of the addition of pentoxifylline to spermatozoa for in vitro fertilization (IVF) in cases with previous fertilization failure. DESIGN:After retrieval, oocytes were divided at random and inseminated with spermatozoa prepared with or without pentoxifylline. SETTING:In vitro fertilization program of the Centre for Reproductive Medicine of the Dutch-speaking Brussels Free University, Belgium, a tertiary referral institution. PATIENTS:Couples in this study were undergoing a second or third IVF attempt for the treatment of male factor infertility. INTERVENTIONS:Sperm samples were divided into two equal parts. The first part was prepared with 3.6 mM pentoxifylline (treatment group) and the other part without pentoxifylline (control group). After swim-up, oocytes were randomly inseminated with spermatozoa from either treatment. MAIN OUTCOME MEASURES:Fertilization and cleavage rates after IVF. RESULTS:Overall a fertilization rate of 8.8% was achieved with no significant differences between treatment and control groups. Cleavage rate was 81.5% and was not different between groups. CONCLUSIONS:This study demonstrates no therapeutic advantage of using pentoxifylline in IVF for male factor infertility in cases with previous fertilization failure.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Tournaye H,Janssens R,Camus M,Staessen C,Devroey P,Van Steirteghem Adoi
10.1016/s0015-0282(16)55641-6subject
Has Abstractpub_date
1993-01-01 00:00:00pages
210-5issue
1eissn
0015-0282issn
1556-5653pii
S0015-0282(16)55641-6journal_volume
59pub_type
临床试验,杂志文章,随机对照试验abstract：OBJECTIVE:To study pain in women undergoing oocyte retrieval with a reduced needle (20/17 gauge) compared to a standard needle (16 gauge). DESIGN:Single-center randomized controlled trial. SETTING:Fertility clinic. PATIENTS:Women undergoing their first oocyte retrieval for in vitro fertilization or intracytoplasmic ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2020.06.040
更新日期：2020-10-16 00:00:00
abstract：OBJECTIVE:To evaluate sperm morphology assessment using the IVOS (Hamilton-Thorne Research Version 3 Dimension Program, Beverly, MA) system in prediction of fertilization rate in vitro after intracytoplasmic sperm injection (ICSI). DESIGN:A prospective clinical study. SETTING:Diagnostic andrology laboratory and assis...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)00555-4
更新日期：1998-03-01 00:00:00
abstract：OBJECTIVE:To study the effect of human plasma from different sources, namely, umbilical cord blood and adult blood platelet-rich plasma (PRP), on the regeneration of endometrial damage. DESIGN:Composition analysis, in vitro approaches, and a preclinical murine model using plasma to promote endometrial regeneration. S...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2020.07.053
更新日期：2020-08-24 00:00:00
abstract：:The relaxin content of 92 normal semen samples and 85 semen samples selected at random was correlated to the parameters measured on routine semen analysis in those samples. The concentration of immunoactive relaxin in a sample of semen plasma did not correlate with any of the parameters commonly used for semen analysi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)59130-4
更新日期：1987-04-01 00:00:00
abstract：OBJECTIVE:To review the use of radiotherapy for relieving the symptoms of recurrent endometriosis caused by functioning ovarian remnants. DESIGN:Retrospective study (case report). PATIENT(S):A woman with recurrent endometriosis of 14 years' duration. INTERVENTION(S):After hysterectomy and bilateral oophorectomy, hor...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)00342-7
更新日期：1997-11-01 00:00:00
abstract：OBJECTIVE:To study and evaluate a sequential, extended embryo culture system. DESIGN:Prospective study. SETTING:University-affiliated IVF clinic. PATIENT(S):All couples who were treated between October 1997 and July 1998. INTERVENTION(S):A standard human tubal fluid plus 10% serum substitute supplement (SSS) cultur...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(99)00294-0
更新日期：1999-09-01 00:00:00
abstract：:The association between educational level and cycle outcomes was quantified by applying multivariable logistic and linear regression within a prospective cohort of 2,569 women commencing their first in vitro fertilization (IVF) cycle. Although a woman's educational attainment was not associated with the likelihood of ...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2011.05.015
更新日期：2011-06-30 00:00:00
abstract：:The aim of this study was to investigate the effects of pure genistein therapy on asymmetric dimethylarginine in healthy postmenopausal women. Healthy postmenopausal women received pure genistein (n=21) or placebo (n=17) for 6 months, and no statistically significant effects on plasma asymmetric dimethylarginine level...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2009.09.057
更新日期：2010-07-01 00:00:00
abstract：:We describe a cotyledonoid dissecting leiomyoma in a 33-year-old nulliparous woman treated by laparoscopy. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.08.131
更新日期：2009-04-01 00:00:00
abstract：:The key global issue surrounding gamete donation is not the well-rehearsed known vs. anonymous donation argument but rather one of providing patients with a flexible dual-track system (i.e., ability to know or not to know donor identity), complete with psychosocial support and education that enables them to make well-...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.07.1304
更新日期：2006-02-01 00:00:00
abstract：OBJECTIVE:To determine whether IgG subclass patterns differed between nonpregnant women, healthy pregnant women, and pregnant women with a history of recurrent miscarriage. DESIGN:Controlled clinical study. SETTING:An academic setting. PATIENT(S):Group 1 was comprised of 10 nonpregnant women, group 2 of 10 healthy p...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)02857-6
更新日期：2001-11-01 00:00:00
abstract：:A human embryo consisting of two cells, each containing two pronuclei, was found in the IVF laboratory. The most likely explanation for this phenomenon is a parthenogenetic activation of an oocyte leading to immediate cleavage and followed by double fertilization. Human chimerism may originate in this way. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)53780-7
更新日期：1990-09-01 00:00:00
abstract：OBJECTIVE:Since little is known about the actual incidence and fate of vacuoles at different stages of development this preliminary study was set up to accurately measure vacuoles and track them to day 5. DESIGN:Prospective study. SETTING:Women's General Hospital in Austria. PATIENT(S):A total of 223 consecutive IVF...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.02.009
更新日期：2005-06-01 00:00:00
abstract：OBJECTIVE:To investigate the prepubertal serum inhibin B levels in monorchid boys with compensatory testicular hypertrophy (CTH) and in surgically treated cryptorchid boys with normal testicular volume. DESIGN:Prospective study. SETTING:Pediatric Division, University of Verona, Italy. PATIENT(S):Thirty-two prepubert...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.10.017
更新日期：2008-12-01 00:00:00
abstract：OBJECTIVE:To assess the effectiveness of intracytoplasmic sperm injection (ICSI) combined with piezoelectric stimulation in infertile couples with a history of total fertilization failure (TFF). DESIGN:Prospective controlled trial. SETTING:Clinical IVF laboratory. PATIENT(S):Seventy-one couples undergoing ICSI on si...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2009.03.107
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:To investigate whether interleukin-1beta (IL-1beta) and interleukin-1alpha (IL-1alpha) affect the implantation rate of patients undergoing IVF-ET. DESIGN:Follicular fluid and serum were obtained on the day of hCG administration, the day of oocyte retrieval, and the day of embryo transfer. SETTING:Cellular i...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(98)00243-x
更新日期：1998-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the impact of deep endometriosis (DE) on bladder function, focusing on detrusor pattern, in patients without preoperative urinary symptoms. DESIGN:Prospective study. SETTING:Academic research center. PATIENT(S):A total of 25 asymptomatic patients: 12 patients with DE (group 1) and 13 patients w...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.06.044
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:To report the use of cumulative live-birth rates (CLBRs) per ovarian stimulation cycle to measure the success of IVF is proving to be the most accurate method for advising couples who failed to conceive, although the accuracy yielded is relatively low, and cycle outcome is highly dependent on the number of em...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.05.008
更新日期：2011-07-01 00:00:00
abstract：:Obesity seems to exert a small but important extraovarian effect that may influence cycle outcome during assisted reproduction. Future investigation should focus on elucidating whether the endometrium is truly responsible for this deficit, and if it is, determining the mechanisms involved. ...
journal_title：Fertility and sterility
pub_type： 评论,杂志文章
doi：10.1016/j.fertnstert.2007.03.079
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To study the association between two single-nucleotide polymorphisms (SNPs) variants (rs2241766 and rs1501299) of the adiponectin gene (ADIPOQ) and polycystic ovary syndrome (PCOS) in PCOS family trios. DESIGN:Family-based study. SETTING:University hospital. PATIENT(S):A total of 224 unrelated PCOS proband...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2014.01.035
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVE:To investigate endometrial dating during the conception cycle. DESIGN:Endometrial biopsies of the last half of the luteal phase of conception cycles were dated based on urinary luteinizing hormone (LH) surges. SETTING:Endometrial samples were obtained from women attending the fertility clinic of the Departm...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：OBJECTIVE:To summarize the available evidence for the efficacy of various treatments for unexplained infertility. DESIGN:Systematic review. SETTING:Not applicable. PATIENT(S):Patients aged 18-40 years with unexplained infertility. INTERVENTION(S):Clomiphene citrate, letrozole, timed intercourse, IUI, gonadotropins,...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2016.02.001
更新日期：2016-06-01 00:00:00
abstract：:Halving the standard daily dose of triptorelin at the start of ovarian stimulation in down-regulated women stimulated with recombinant FSH is enough for pituitary suppression and was associated with higher LH serum concentrations in the follicular phase. However, this did not translate into higher serum concentrations...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/j.fertnstert.2004.10.032
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVE:To review the effectiveness of rectal probe electroejaculation in terms of pregnancy in treatment of anejaculatory males due to spinal cord injury. The characteristics of electroejaculates also are examined. DATA IDENTIFICATION:All English language studies reporting pregnancies as a result of electroejaculat...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：
更新日期：1995-07-01 00:00:00
abstract：:The effects of estradiol (E2) administered by a transdermal system on the induction of hypothalamic opioid activity was examined in 18 postmenopausal women. Women were given 25, 50, 100, or 200 micrograms/d dosages of E2 for 28 days each. Naloxone at a dosage of 2 mg/h was infused intravenously for 4 hours, and serum ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：:Infertile couples who had failed to achieve fertilization of oocytes in previous trials of in vitro fertilization (IVF) were treated by IVF with zona pellucida drilling. Zona drilling entails use of micromanipulation to introduce a gap in the zona pellucida either mechanically or by localized application of a zona sol...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60010-9
更新日期：1988-07-01 00:00:00
abstract：OBJECTIVE:To review the literature concerning the regulation of follicle growth, to describe a model for unifollicular ovulation based upon the information gleaned, and to discuss some clinical implications in reproductive endocrinology underscored by this expanding knowledge. DESIGN:Studies relating to follicular gro...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(16)58077-7
更新日期：1996-02-01 00:00:00
abstract：OBJECTIVE:To compare the effects of the aromatase inhibitor letrozole (7.5 mg) and clomiphene citrate (CC; 100 mg) in women undergoing superovulation and IUI. DESIGN:Prospective randomized trial. SETTING:University teaching hospital. PATIENT(S):We studied a total of 238 cycles of superovulation and IUI in women with...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2004.04.070
更新日期：2004-12-01 00:00:00
abstract：OBJECTIVE:To determine whether levels of human chorionic gonadotropin (hCG), 17 beta-estradiol (E2), and progesterone (P) are different in the peri-implantation phase of fresh versus frozen embryos. DESIGN:Hormonal secretions were measured on days 9 and 11 after implantation and at 4, 5, and 6 weeks gestation. PATIEN...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(16)54792-x
更新日期：1992-01-01 00:00:00
abstract：:We found that there was no significant difference in endometrial responses to vaginal or IM P. But the response was suboptimal in cycles treated with dydrogesterone, suggesting that dydrogesterone treatment is not the preferred progestin for use in artificial cycles. ...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(16)56840-x
更新日期：1994-07-01 00:00:00
