Abstract:
OBJECTIVE:To study pain in women undergoing oocyte retrieval with a reduced needle (20/17 gauge) compared to a standard needle (16 gauge). DESIGN:Single-center randomized controlled trial. SETTING:Fertility clinic. PATIENTS:Women undergoing their first oocyte retrieval for in vitro fertilization or intracytoplasmic sperm injection. INTERVENTIONS:Oocyte retrieval with a reduced needle (20/17 gauge) or with a standard needle (16 gauge). MAIN OUTCOME MEASURES:The primary outcome measure was intraoperative pain on an 11-point visual analogue scale (VAS). Secondary outcome measures included the following: dosage of fentanyl requested; pain at 5, 15 and 30 minutes after retrieval; and pain and analgesia until 4 days after retrieval. RESULTS:A total of 47 women were randomized for the reduced needle (RN) and 48 for the standard needle (SN). Pain scores were significantly lower during and after retrieval with the RN. During retrieval, mean VAS scores in the RN group were 4.3 versus 6.3 in the SN group. Pain remained significantly lower in the RN group after retrieval, with VAS-scores of 1.2 vs. 2.1 directly after retrieval, 0.0 versus 2.0 5 minutes after retrieval, and 0.0 versus 1.0 30 minutes after retrieval. In the RN group, three patients (6.4%) requested more fentanyl during the procedure, versus 16 (33.3%) in the SN group. A total of 79 patients submitted their follow-up questionnaire (response rate 83%). Pain on the first 2 days following retrieval was significantly less in the RN group, with VAS scores of 1.6 versus 2.4 in the SN group, and 1.2 versus 2.5. In line with this finding, fewer patients in the RN group took analgesia on the days after the procedure. This difference was statistically significant only on day 3. CONCLUSION:Use of a thinner needle results in significantly and clinically relevant lower pain scores during oocyte retrieval, and patients in the reduced needle group requested significantly less analgesia during oocyte retrieval than patients in the standard needle group. Pain scores remained significantly lower up until 2 days after the procedure. DUTCH TRIAL REGISTRATION NUMBER:NTR6064 (www.trialregister.nl).
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Iduna Antigoni Buisman ET,de Bruin JP,Maria Braat DD,van der Steeg JWdoi
10.1016/j.fertnstert.2020.06.040subject
Has Abstractpub_date
2020-10-16 00:00:00eissn
0015-0282issn
1556-5653pii
S0015-0282(20)30611-7pub_type
杂志文章abstract::Anatomic distances along retroperitoneal, inguinal, and infrainguinal segments of the vas deferens were measured in 14 formalin fixed cadavers and in 15 recently postmortem males. There were no significant differences in segment lengths between the two groups nor between the right and left vasa. Data from the recent p...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53959-4
更新日期:1990-11-01 00:00:00
abstract::Freezing and storage of human male gametes is associated with a reduction in the overall semen quality and establishment of pregnancy. This study was done to evaluate the integrity of sperm head ultrastructure (SHU) with computerized and vapor freezing. Comparisons were made between the effect of cryopreservatives gly...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)49650-0
更新日期:1986-10-01 00:00:00
abstract:OBJECTIVE:To determine the effect of P on nitric oxide synthase (NOS) expression in human endometrial epithelial cells. DESIGN:Laboratory-based study. SETTING:University-based research institute. PATIENT(S):None. INTERVENTION(S):The effect of P on the expression of NOS protein isoforms was examined in an in vitro p...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.05.019
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between the results of the Sperm Quality Analyzer (United Medical Systems Inc., Santa Ana, CA), which measures motile sperm concentration by light scattering, conventional manual semen analysis characteristics, and computer-assisted sperm motility analyses. DESIGN:Sperm Quality Ana...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract::A randomized, prospective study was conducted to compare ovarian stimulation with human menopausal gonadotropin (hMG) and human follicle-stimulating hormone (hFSH) in an in vitro fertilization and embryo transfer (IVF-ET) program. Minimal inclusion criteria included age less than or equal to 37, tubal infertility, reg...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(16)60011-0
更新日期:1988-07-01 00:00:00
abstract:OBJECTIVE:Criteria for staging the menopausal transition are not established. This article evaluates five bleeding criteria for defining early transition and provides empirically based guidance regarding optimal criteria. DESIGN/SETTING:Prospective menstrual calendar data from four population-based cohorts: TREMIN, Me...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2007.02.015
更新日期:2008-01-01 00:00:00
abstract::Two women with the polycystic ovary syndrome were treated with bromocriptine (15 to 20 mg/day) in combination with spironolactone (100 mg/day). In the first woman the combined therapy induced a marked reduction of hirsutism, with ensuing ovulation and pregnancy. In the second woman, who had hyperthecosis and had been ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)45554-8
更新日期:1981-06-01 00:00:00
abstract:OBJECTIVE:To examine compliance with ethical guidelines of the American Society for Reproductive Medicine (ASRM) regarding trait-based payment variation, presentation of risks, and minimum recruitment age. DESIGN:In June 2010, we systematically examined 207 websites, of which 102 were egg donor agency or IVF clinic we...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.06.052
更新日期:2012-10-01 00:00:00
abstract::Fertilization characteristics of 152 consecutively obtained oocytes in an in vitro fertilization (IVF) program employing only natural and clomiphene citrate-induced cycles were retrospectively analyzed. Fertilization occurred significantly more often (1) in women with tubal infertility, (2) in spontaneous cycles, and ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53764-9
更新日期:1990-09-01 00:00:00
abstract:OBJECTIVE:To assess racial differences in attitudes and knowledge about sterilization. DESIGN:Cross-sectional survey. SETTING:Questionnaires were mailed to participants' home addresses. PATIENT(S):One hundred ninety-three women, aged 18-45, who had undergone tubal sterilization. INTERVENTION(S):None. MAIN OUTCOME ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.05.031
更新日期:2011-01-01 00:00:00
abstract::Surveillance is a triennial worldwide compendium of national rules and regulations for assisted reproductive technology. It was last published in 2010. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.03.045
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:To present a case of a unilateral endometrioma with extremely elevated serum CA-125 levels. DESIGN:Case report. SETTING:University hospital. PATIENT(S):A 25-year-old woman with left adnexal mass and extremely elevated serum CA-125 level, 7,900 U/mL, underwent laparoscopy. There were unilateral endometrioma...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.12.076
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:To assess the direct effects of three endometriosis chemotherapeutic agents (medroxyprogesterone acetate [MPA], danazol, and leuprolide acetate [LA]) on endometrial cell proliferation. DESIGN:Analysis of cell proliferation in vitro. SETTING:Proliferative phase endometrial stromal cells isolated from biopsy ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract:INTRODUCTION:Polycystic ovary syndrome (PCOS) is a highly prevalent disorder among postmenarcheal premenopausal women, accounting for much of anovulatory infertility, and it is associated with several comorbidities. The natural history of PCOS, as well as hypotheses regarding its etiology, facilitates employment of the...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2005.09.066
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of elagolix, an oral GnRH antagonist, for the reduction of fatigue in women with moderate or severe endometriosis-associated pain. DESIGN:Randomized, double-blind, multicenter, placebo-controlled phase III trial. SETTING:Clinics. PATIENT(S):A total of 860 women treated with elagoli...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.fertnstert.2019.02.031
更新日期:2019-08-01 00:00:00
abstract::Deoxyribonucleic acid (DNA) flow cytometry of testicular tissue has been demonstrated to be a quantitative means of assessing spermatogenesis. This study evaluates testes aspirates and DNA flow cytometry in the evaluation of the infertile male. Testicular tissue obtained from 12 men who underwent bilateral orchiectomy...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59358-3
更新日期:1987-08-01 00:00:00
abstract::Klemetti's birth registry study is put in context of other major studies. Summary advice is offered to practitioners as to what they should tell parents who conceive with assisted reproductive technology. ...
journal_title:Fertility and sterility
pub_type: 评论,信件
doi:10.1016/j.fertnstert.2005.04.067
更新日期:2005-11-01 00:00:00
abstract::In this prospective, randomized study, waiting for the lead follicle to reach 14 mm before initiating GnRH antagonist administration effectively prevents an LH surge and ovulation during an IVF cycle. Furthermore, delaying GnRH start until the dominant follicle reaches 14 mm neither impacts the clinical pregnancy, imp...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2009.05.083
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To measure activin A concentrations in uterine washing fluid collected from women with couple infertility undergoing intrauterine insemination (IUI). DESIGN:Retrospective case-control study. SETTING:Tertiary university center for women's care. PATIENT(S):Fifty women, of whom 25 became pregnant after up to ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.12.125
更新日期:2010-05-01 00:00:00
abstract::After four unsuccessful attempts at multiple follicular induction with exogenous gonadotropins, a patient underwent two attempts at IVF in spontaneous cycles triggered with hCG. The second attempt resulted in the transfer of three embryos and a successful singleton intrauterine pregnancy. We believe that unstimulated ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60746-x
更新日期:1989-06-01 00:00:00
abstract:OBJECTIVE:To investigate the direct effects of sodium nitroprusside, a nitric oxide donor, on the fertilizing ability of human spermatozoa in vitro. DESIGN:Prospective, controlled in vitro study. SETTING:IVF Unit, Medical College Hospital. PATIENT(S):Women undergoing conventional IVF. INTERVENTION(S):Human spermato...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)00537-2
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the association of oocyte donor-recipient characteristics, oocyte donor response, and live birth pregnancy rate following fresh donor oocyte IVF-ET. DESIGN:Retrospective cohort study. SETTING:Academic reproductive medicine practice. PATIENT(S):Two hundred thirty-seven consecutive fresh donor oo...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2017.05.021
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To examine the literature systematically in order to identify prospective comparative trials answering the following question: Is vitrification of human embryos associated with a higher postthawing survival rate as compared with slow freezing? DESIGN:Systematic review and meta-analysis. SETTING:University-b...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.fertnstert.2007.06.010
更新日期:2008-07-01 00:00:00
abstract::Buserelin acetate, a luteinizing hormone-releasing hormone agonist, is known to be effective in the shrinkage of uterine fibroids. A prospective trial was undertaken (1) to compare the efficacy of intranasal (IN) and subcutaneous (SC) administration of buserelin acetate and (2) to assess if tumor regression correlated...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(16)54001-1
更新日期:1990-12-01 00:00:00
abstract::"To understand the actual world as it is, not as we should wish it to be, is the beginning of wisdom." - Bertrand Russell. ...
journal_title:Fertility and sterility
pub_type: 社论
doi:10.1016/j.fertnstert.2018.06.007
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To compare oocyte maturity, fertilization rate and cleavage rate after a short and long GnRH agonist (GnRH-a) stimulation protocol and intracytoplasmic sperm injection (ICSI). DESIGN:Retrospective study of 34 sequential ICSI cycles stimulated with a short or long GnRH-a protocol. SETTING:A university-based ...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)57792-9
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:To present a case of Marfan syndrome and concurrent congenital obstructive azoospermia. DESIGN:Case report. SETTING:Tertiary-care academic hospital. PATIENT(S):A man with Marfan syndrome and obstructive azoospermia. INTERVENTION(S):The patient was evaluated for azoospermia that was proved to be due to con...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)02868-0
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of idiopathic hirsutism among a population of consecutive hirsute patients. DESIGN:Prospective cohort study. SETTING:University-based clinic. PATIENT(S):Premenopausal women with a complaint of hirsutism who were not receiving hormonal therapy. INTERVENTION(S):Evaluations for to...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(98)00141-1
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the degree of enrichment of spermatogonial stem cells (SSCs) from human testicular cell cultures by ITGA6+, HLA-/ITGA6+, GPR125+, and HLA-/GPR125+ magnetic-assisted cell sorting (MACS). DESIGN:Experimental basic science study. SETTING:Reproductive biology laboratory. PATIENT(S):Multiple samples...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.04.022
更新日期:2014-08-01 00:00:00
abstract::Endometrial polyps, adenomyosis, and leiomyomas are commonly encountered abnormalities frequently found in both fertile women and those with infertility. The clinician is frequently challenged to determine which of these entities, when found, is likely to impair fertility, and which are "innocent bystanders" unrelated...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2019.02.008
更新日期:2019-04-01 00:00:00