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Hormonal secretions in singleton pregnancies arising from the implantation of fresh or frozen embryos after oocyte donation in women with ovarian failure.

Abstract：

OBJECTIVE:To determine whether levels of human chorionic gonadotropin (hCG), 17 beta-estradiol (E2), and progesterone (P) are different in the peri-implantation phase of fresh versus frozen embryos. DESIGN:Hormonal secretions were measured on days 9 and 11 after implantation and at 4, 5, and 6 weeks gestation. PATIENTS:Thirty-one pregnancies were achieved in 65 patients with ovarian failure. Seventeen singleton pregnancies developed after implantation of 4 frozen and 13 fresh embryos. RESULTS:Human chorionic gonadotropin and E2, contrary to P, were higher in cases of fresh embryos from the 9th day after transfer to the 5th week at which time they become statistically significant (respectively, for hCG and E2, 5,800.3 +/- 332.3 versus 2,027.3 +/- 916.3 [mean +/- SD] mIU/mL for hCG and 562.3 +/- 215 versus 291 +/- 152 pg/mL for E2). CONCLUSIONS:This difference might be explained by either the higher number of fresh embryo replaced or by the fact that the number of blastomeres and also their metabolic activity could be reduced after freezing and thawing.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Salat-Baroux J,Cornet D,Alvarez S,Antoine JM,Mandelbaum J,Plachot M

doi

10.1016/s0015-0282(16)54792-x

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

150-5

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)54792-X

journal_volume

57

pub_type

临床试验,杂志文章

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