当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Insemination with isolated and virologically tested spermatozoa is a safe way for human immunodeficiency type 1 virus-serodiscordant couples with an infected male partner to have a child.

Insemination with isolated and virologically tested spermatozoa is a safe way for human immunodeficiency type 1 virus-serodiscordant couples with an infected male partner to have a child.

Abstract：

OBJECTIVE:To enable serodiscordant couples to reproduce while minimizing the risk of infecting the female partner and to demonstrate the feasibility of including these couples in an insemination program. DESIGN:Prospective follow-up study. SETTING:Ambulatory IUIs. PATIENT(S):Fifty-six HIV-1-serodiscordant couples with a male infected partner. INTERVENTION(S):Sperm cell separation by the gradient density method followed by the swim-up method, virological detection, and IUI after ovarian stimulation. MAIN OUTCOME MEASURE(S):Pregnancy rate, HIV-1 test, and p24 antigenemia in women. RESULT(S):Two hundred thirteen IUIs were performed, and 37 pregnancies occurred, resulting in 33 births and 2 ongoing pregnancies. Fifty percent of couples have a child. No women were infected. CONCLUSION(S):Our study demonstrates the efficiency of an IUI program with prepared and virologically tested spermatozoa in serodiscordant couples with an HIV-1-infected male partner, allowing the couples to have children without transmission of the virus to the female partner.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Bujan L,Pasquier C,Labeyrie E,Lanusse-Crousse P,Morucci M,Daudin M

doi

10.1016/j.fertnstert.2004.02.128

keywords:

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

857-62

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(04)01095-7

journal_volume

82

pub_type

临床试验,杂志文章

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