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A randomized prospective study of early follicular or midluteal initiation of long protocol gonadotropin-releasing hormone in an in vitro fertilization program.

Abstract：

OBJECTIVE:To determine the optimum menstrual cycle time to initiate a long-protocol gonadotropin-releasing hormone agonist (GnRH-a) down-regulation regimen before hMG stimulation before IVF. DESIGN:Randomized, prospective, single, first cycle study. SETTING:University teaching hospital. PATIENTS:Eighty-six infertile couples undergoing IVF-ET attempt under rules for Ireland. INTERVENTION:Gonadotropin-releasing hormone agonist administered intranasally from day 1 or 21 of menstrual cycle. Human menopausal gonadotropin commenced when pituitary down-regulation was confirmed. MAIN OUTCOME MEASURES:Ovarian response, cancellation, fertilization, and pregnancy rates. RESULTS:No significant differences found between day 1 and day 21 initiation. But starting on day 1 is more easily recognizable by patients and avoids the possibility of administering GnRH-a in the presence of an unsuspected pregnancy. CONCLUSIONS:Both follicular and luteal phase initiation of GnRH-a long-protocol down-regulation are equally efficacious. In our clinical context, patients and management favor commencing on day 1.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Kondaveeti-Gordon U,Harrison RF,Barry-Kinsella C,Gordon AC,Drudy L,Cottell E

doi

10.1016/s0015-0282(16)58571-9

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

582-6

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)58571-9

journal_volume

66

pub_type

临床试验,杂志文章,随机对照试验

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