当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Effect of the aromatase inhibitor 4-hydroxyandrostene-3,17-dione progesterone synthesis by human luteal cells.

Effect of the aromatase inhibitor 4-hydroxyandrostene-3,17-dione progesterone synthesis by human luteal cells.

Abstract：

:The authors studied the effects of 4-hydroxyandrostene-3,17-dione (4-OHA) on progesterone (P), 17 beta-estradiol (E2), and 20 alpha-hydroxy-4-pregnen-3-one synthesis and pregnenolone accumulation in cultured human midluteal cells. A dose-dependent inhibition with and without human chorionic gonadotropin (hCG) of E2 and P production was observed. The accumulation of pregnenolone was significantly enhanced three to fourfold by 4-OHA in this culture system, as compared with control value. In addition, a sevenfold increase on pregnenolone accumulation was observed in the presence of 4-OHA plus 10 IU of hCG as compared with control values and 2.2-fold as compared with the 4-OHA treatments. These in vitro findings indicate a direct effect of 4-OHA on luteal steroidogenesis. Nevertheless, the suppressive effect of 4-OHA on P and E2 production is located at different sites of the steroidogenic pathway. In addition, the results demonstrate that hCG in the presence of 4-OHA stimulated pregnenolone accumulation, suggesting that the inhibition of P synthesis is in some steps after the formation of pregnenolone. These data indicate that the actions of 4-OHA on P or E2 formation have different inhibitory mechanisms.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Devoto L,Vega M,Castro O,Kohen P

doi

10.1016/s0015-0282(16)54300-3

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

922-6

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)54300-3

journal_volume

55

pub_type

杂志文章

相关文献

FERTILITY AND STERILITY文献大全
  • DNA methylation at H19/IGF2 ICR1 in the placenta of pregnancies conceived by in vitro fertilization and intracytoplasmic sperm injection.

    abstract：:DNA methylation at H19 ICR1 was investigated in the placenta from pregnancies conceived by in vitro fertilization, intracytoplasmic sperm injection, and from natural conception. Our results showed that there were no significant differences in mean methylation between all pregnancy groups; therefore, assisted reproduct...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.fertnstert.2011.05.047

    authors： Wong EC,Hatakeyama C,Robinson WP,Ma S

    更新日期：2011-06-30 00:00:00

  • Current management principles for adolescent varicocele.

    abstract：:The authors review the current approach to management of the adolescent varicocele which has evolved over the past two decades. Principles of observational, surgical and adjunctive management are discussed relative to significant clinical findings. A selective approach to surgical intervention is advocated with the go...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2011.10.034

    authors： Diamond DA,Gargollo PC,Caldamone AA

    更新日期：2011-12-01 00:00:00

  • Placental-type alkaline phosphatase in human seminal plasma from fertile and infertile men.

    abstract：:Solid-phase enzyme immunoassays, based on monoclonal antibodies reactive with different forms of human placental-type alkaline phosphatases, were applied to their detection in human seminal plasma from fertile and infertile men. The placental-like form of alkaline phosphatase (PLAP-like AP), known to occur in testicul...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： McLaughlin PJ,Lewis-Jones I,Hutchinson GE,Johnson PM

    更新日期：1986-11-01 00:00:00

  • Reproductive surgery for müllerian anomalies: a review of progress in the last decade.

    abstract：:Disorders of development, fusion, or resorption of paired müllerian ducts and urogenital sinus may cause various congenital malformations of the corpus uteri, cervix, vagina, and fallopian tubes. Classification systems have been developed to better characterize these anomalies, and each has advantages and disadvantage...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2019.07.005

    authors： Ludwin A,Pfeifer SM

    更新日期：2019-09-01 00:00:00

  • The relationship between total motile sperm count and the success of intrauterine insemination.

    abstract：OBJECTIVES:To determine if the total motile sperm count is predictive of IUI success and to apply life-table analysis to a large database of IUI procedures. DESIGN:Contingency table and life-table analyses were used to analyze a large group of couples (n = 546) undergoing 1,205 cycles of therapeutic IUI with husband's...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)56831-9

    authors： Brasch JG,Rawlins R,Tarchala S,Radwanska E

    更新日期：1994-07-01 00:00:00

  • Characterization of the injection funnel during intracytoplasmic sperm injection reflects cytoplasmic maturity of the oocyte.

    abstract：OBJECTIVE:To quantify cytoplasmic maturity on the basis of intracytoplasmic sperm injection (ICSI) injection funnel manifestation and to evaluate influence factors of the latter. DESIGN:Prospective study. SETTING:Private fertility center. PATIENT(S):A total of 31 patients with good ovarian response. INTERVENTION(S)...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2016.06.015

    authors： Krause I,Pohler U,Grosse S,Shebl O,Petek E,Chandra A,Ebner T

    更新日期：2016-10-01 00:00:00

  • Effect of sperm treatment with exogenous platelet-activating factor on the outcome of intrauterine insemination.

    abstract：OBJECTIVE:To evaluate the effect of sperm treatment with exogenous platelet-activating factor (PAF) on IUI clinical pregnancy rate. DESIGN:Prospective randomized study. SETTING:Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece. SUBJECT(...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.fertnstert.2004.07.980

    authors： Grigoriou O,Makrakis E,Konidaris S,Hassiakos D,Papadias K,Baka S,Creatsas G

    更新日期：2005-03-01 00:00:00

  • Discovery of germ cell-specific transcripts by expressed sequence tag database analysis.

    abstract：OBJECTIVE:To identify transcripts whose expression is restricted to germ cells. DESIGN:Expressed sequence tags (ESTs) from unfertilized egg libraries were utilized to perform in silico subtraction and identify germ cell-specific transcripts. SETTING:Baylor College of Medicine, Houston, Texas. ANIMAL(S):C57BL/6J/129S...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(01)01966-5

    authors： Rajkovic A,Yan M S C,Klysik M,Matzuk M

    更新日期：2001-09-01 00:00:00

  • Training in reproductive endocrinology and infertility and assisted reproductive technologies: options and worldwide needs.

    abstract：:Standardized, high-quality training in reproductive endocrinology, infertility, and assisted reproductive technologies (REI-ART) faces challenges owing to the high-tech nature of ART and the important country-to-country differences in clinical practice and regulations overseeing training. Moreover, while the training ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2015.04.031

    authors： de Ziegler D,de Ziegler N,Sean S,Bajouh O,Meldrum DR

    更新日期：2015-07-01 00:00:00

  • In vivo mechanisms of uterine myoma volume reduction with ulipristal acetate treatment.

    abstract：OBJECTIVE:To study the in vivo mechanisms of action of ulipristal acetate (UPA) on uterine myomas. DESIGN:Retrospective histologic and immunohistochemical (IHC) study of myomas. SETTING:Academic research unit. PATIENT(S):Among 59 women with symptomatic myomas who underwent myomectomy, 42 were treated preoperatively ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.fertnstert.2015.04.025

    authors： Courtoy GE,Donnez J,Marbaix E,Dolmans MM

    更新日期：2015-08-01 00:00:00

  • Relook hysteroscopy after antitubercular therapy.

    abstract：:Hysteroscopic visualization of the endometrium after 6 months of antitubercular therapy showed an improvement in the mucosal morphology. A closer visualization at increased magnification was helpful in demonstrating the remnants of a healing tubercular pathology after antitubercular therapy. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2007.07.1346

    authors： Kumar A,Kumar A

    更新日期：2008-03-01 00:00:00

  • Should embryos developing to blastocysts on day 7 be cryopreserved and transferred: an analysis of pregnancy and implantation rates.

    abstract：OBJECTIVE:To compare pregnancy rates (PRs) using blastocysts cryopreserved on day 7 with those cryopreserved on days 5 and 6. DESIGN:Retrospective observational cohort study. SETTING:Infertility center performing IVF. PATIENT(S):Eight hundred women with infertility undergoing frozen ET. INTERVENTION(S):Blastocysts ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2013.06.021

    authors： Kovalevsky G,Carney SM,Morrison LS,Boylan CF,Neithardt AB,Feinberg RF

    更新日期：2013-10-01 00:00:00

  • Expression profiles of the DAZ gene family in human testis with and without spermatogenic failure.

    abstract：OBJECTIVE:To determine the expression profiles of the DAZ gene family in men with and without spermatogenic failure. DESIGN:Prospective case study. SETTING:University-based reproductive clinics and genetics laboratory. PATIENT(S):Thirty-four infertile men presenting with azoospermia. INTERVENTION(S):The mRNA transc...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2003.08.047

    authors： Kuo PL,Wang ST,Lin YM,Lin YH,Teng YN,Hsu CC

    更新日期：2004-04-01 00:00:00

  • Blastocoele expansion degree predicts live birth after single blastocyst transfer for fresh and vitrified/warmed single blastocyst transfer cycles.

    abstract：OBJECTIVE:To evaluate the independent effects of the degree of blastocoele expansion and re-expansion and the inner cell mass (ICM) and trophectoderm (TE) grades on predicting live birth after fresh and vitrified/warmed single blastocyst transfer. DESIGN:Retrospective study. SETTING:Reproductive medical center. PATI...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2015.12.014

    authors： Du QY,Wang EY,Huang Y,Guo XY,Xiong YJ,Yu YP,Yao GD,Shi SL,Sun YP

    更新日期：2016-04-01 00:00:00

  • Reproductive health of women electing bariatric surgery.

    abstract：OBJECTIVE:To describe the reproductive health history and characteristics of women having bariatric surgery and to determine whether this differs by age of onset of obesity. DESIGN:Retrospective and cross-sectional analyses of self-reported survey data. SETTING:Six sites of the Longitudinal Assessment of Bariatric Su...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2009.08.028

    authors： Gosman GG,King WC,Schrope B,Steffen KJ,Strain GW,Courcoulas AP,Flum DR,Pender JR,Simhan HN

    更新日期：2010-09-01 00:00:00

  • Y chromosome microdeletions in infertile men with cryptorchidism.

    abstract：OBJECTIVE:To determine whether cryptorchidism associated with azoospermia or oligozoospermia may be due to microdeletions of the Y chromosome. DESIGN:Controlled clinical study. SETTINGS:Division of Medical Genetics and the Andrology Centre, Department of Obstetrics and Gynecology, University Medical Center, Ljubljana...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(03)00375-3

    authors： Kunej T,Zorn B,Peterlin B

    更新日期：2003-06-01 00:00:00

  • Repeated laparoscopic ovarian diathermy is effective in women with anovulatory infertility due to polycystic ovary syndrome.

    abstract：OBJECTIVE:To assess the effectiveness of a second laparoscopic ovarian diathermy (LOD) in women with polycystic ovary syndrome (PCOS). DESIGN:Retrospective study. SETTING:Tertiary infertility clinic. PATIENT(S):Twenty anovulatory infertile women with PCOS who underwent LOD 1-6 years previously. Twelve subjects had p...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(02)04960-9

    authors： Amer SA,Li TC,Cooke ID

    更新日期：2003-05-01 00:00:00

  • Estrogen and progesterone receptors in endometriotic tissue and endometrium: comparison according to localization and recurrence.

    abstract：OBJECTIVE:To study the hormonal regulation of primary and recurrent endometriosis by comparing the levels of estrogen receptors (ER) and progesterone receptors (PR) with the levels in uterine endometrium obtained simultaneously. DESIGN:Tissue samples collected at routine operations. SETTING:One university clinic. PA...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：

    authors： Bergqvist A,Fernö M

    更新日期：1993-07-01 00:00:00

  • Duphaston and human menopausal gonadotropin protocol in normally ovulatory women undergoing controlled ovarian hyperstimulation during in vitro fertilization/intracytoplasmic sperm injection treatments in combination with embryo cryopreservation.

    abstract：OBJECTIVE:To evaluate endocrine characteristics and clinical outcomes in normal ovulatory patients undergoing controlled ovarian hyperstimulation (COH) with the use of a Duphaston and hMG protocol during in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments in combination with frozen-thawed em...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.fertnstert.2017.06.017

    authors： Zhu X,Ye H,Fu Y

    更新日期：2017-09-01 00:00:00

  • Cell-mediated immunity in vasectomized rhesus monkeys.

    abstract：:Cell-mediated immunity in rhesus monkeys that had been vasectomized for 2, 4, 7, or 11 years was measured by lymphocyte blastogenesis following stimulation with concanavalin A, phytohemagglutinin (PHA), and pokeweed mitogens. Several of the 7- and 11-year vasectomized animals had significantly reduced PHA reactivity w...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)42983-3

    authors： Wilson BJ,Alexander NJ,Porter G,Fulgham DL

    更新日期：1977-12-01 00:00:00

  • Evaluation of quantitative polymerase chain reaction markers for the detection of breast cancer cells in ovarian tissue stored for fertility preservation.

    abstract：OBJECTIVE:To develop molecular tools increasing the sensitivity of breast cancer micrometastases detection within ovarian tissue cryopreserved for fertility preservation. DESIGN:Expression of breast markers was evaluated by quantitative polymerase chain reaction in ovarian tissue from patients with benign or cancerous...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2015.04.036

    authors： Bockstaele L,Boulenouar S,Van Den Steen G,Dechène J,Tsepelidis S,Craciun L,Noël JC,Demeestere I

    更新日期：2015-08-01 00:00:00

  • What is the incidence of varicocele in a fertile population?

    abstract：:One hundred men with proven fertility who presented for vasectomy consultation were examined for testicular size and presence of a varicocele, including examination with the Doppler stethoscope for the presence of subclinical varicocele. A diagnosis of varicocele was established in 61%. In 17 patients, the varicocele ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)59432-1

    authors： Kursh ED

    更新日期：1987-09-01 00:00:00

  • Gonadotropin-releasing hormone antagonist use is associated with increased pregnancy rates in ovulation induction-intrauterine insemination to in vitro fertilization conversions, independent of age and estradiol level on the day of human chorionic gonadot

    abstract：OBJECTIVE:To determine whether the use of GnRH antagonist in cycles converted from ovulation induction-IUI to IVF affects cycle outcome and pregnancy rates. DESIGN:Retrospective cohort study. SETTING:Academic research institution. PATIENT(S):One hundred eighty-two consecutive patients with ovulation induction-IUI to...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2009.01.109

    authors： Quaas AM,Missmer SA,Ginsburg ES

    更新日期：2010-02-01 00:00:00

  • Mutation frequency of cystic fibrosis transmembrane regulator is not increased in oligozoospermic male candidates for intracytoplasmic sperm injection.

    abstract：OBJECTIVE:To examine the frequency of anomalies of the vas deferens and the frequency of mutations of the cystic fibrosis transmembrane regulator (CFTR) gene in male candidates for intracytoplasmic sperm injection (ICSI) who had severe oligoasthenoteratozoospermia. DESIGN:The clinical data for male candidates for ICSI...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(98)00050-8

    authors： Tuerlings JH,Mol B,Kremer JA,Looman M,Meuleman EJ,te Meerman GJ,Buys CH,Merkus HM,Scheffer H

    更新日期：1998-05-01 00:00:00

  • Emerging role of embryo secretome in the paracrine communication at the implantation site: a proof of concept.

    abstract：OBJECTIVE:To assess the role of embryo secretome in modifying the molecular profile of glycodelin A (GdA) in endometrial organoids (ORG) mimicking the implantation window. To verify whether the use of embryo-conditioned culture medium at the time of the embryo transfer may increase in vitro fertilization outcome. DESI...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2020.10.058

    authors： Luddi A,Pavone V,Governini L,Capaldo A,Landi C,Ietta F,Paccagnini E,Morgante G,De Leo V,Piomboni P

    更新日期：2021-01-23 00:00:00

  • Pregnancies following ultrasound-guided drainage of tubo-ovarian abscess.

    abstract：OBJECTIVE:To study fertility among women treated by means of ultrasound-guided drainage and antibiotics for tubo-ovarian abscess (TOA). DESIGN:Retrospective cohort study. SETTING:A tertiary referral center. PATIENT(S):One hundred women of reproductive age treated for TOA between June 1986 and July 2003. INTERVENTIO...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2012.03.054

    authors： Gjelland K,Granberg S,Kiserud T,Wentzel-Larsen T,Ekerhovd E

    更新日期：2012-07-01 00:00:00

  • Slow excretion of exogenous human chorionic gonadotropin simulating repeated pregnancies and pregnancy losses.

    abstract：:We report a patient undergoing hMG-induced superovulation who demonstrated delayed excretion of hCG, originally believed to be because of successive biochemical pregnancies. However, sequential hCG titers after administration of exogenous hCG demonstrated a longer than normal half-life for the excretion of hCG in this...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)54618-4

    authors： Maier DB,Metzger DA

    更新日期：1991-10-01 00:00:00

  • Preimplantation genetic diagnosis for Marfan syndrome.

    abstract：OBJECTIVE:To develop and apply efficient and reliable protocols for preimplantation genetic diagnosis (PGD) for Marfan syndrome. DESIGN:Two mutation-specific protocols were developed, and the markers D15S1028, D15S992, D15S196, D15S576, D15S123, and D15S143 were used to set up four multiplex polymerase chain reactions...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2005.12.059

    authors： Spits C,De Rycke M,Verpoest W,Lissens W,Van Steirteghem A,Liebaers I,Sermon K

    更新日期：2006-08-01 00:00:00

  • Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss.

    abstract：OBJECTIVE:To assess the effectiveness of luteal start vaginal micronized P in a recurrent pregnancy loss (RPL) cohort. DESIGN:Observational cohort study using prospectively collected data. SETTING:Not applicable. PATIENT(S):Women seen between 2004 and 2012 with a history of two or more unexplained pregnancy losses <...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2016.11.029

    authors： Stephenson MD,McQueen D,Winter M,Kliman HJ

    更新日期：2017-03-01 00:00:00

  • Somatostatin treatment reduces the exaggerated response of adrenocorticotropin hormone and cortisol to corticotropin-releasing hormone in polycystic ovary syndrome.

    abstract：OBJECTIVE:To evaluate the influence of somatostatin analogue (octreotide) in the function of hypothalamic-pituitary-adrenal (HPA) axis in women with polycystic ovary syndrome (PCOS). SETTING:Women referred to the Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore. PATIENT(S):Twelve PCOS wom...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(97)81852-3

    authors： Lanzone A,Fulghesu AM,Guido M,Cucinelli F,Caruso A,Mancuso S

    更新日期：1997-01-01 00:00:00