Advanced follicle development in xenografted prepubertal ovarian tissue: the common marmoset as a nonhuman primate model for ovarian tissue transplantation.


OBJECTIVE:To establish a nonhuman primate model addressing follicular development in cryopreserved prepubertal ovarian tissue after xenografting. DESIGN:Experimental study. SETTING:Academic research center. ANIMAL(S):Ovarian tissue from female prepubertal common marmoset (Callytrix jacchus jacchus) grafted into immunodeficient nude mice (Crl:NU-FoxnI(nu)). INTERVENTION(S):Removal and subsequent cryopreservation of ovarian tissues with dimethyl sulfoxide, followed by grafting to subcutaneous sites of ovariectomized and intact nude mice. MAIN OUTCOME MEASURE(S):Histologic evaluation for the mean number of total and morphologically normal follicles in each class. RESULT(S):The mean number of unadvanced follicles in frozen-thawed grafted ovarian tissues was reduced compared with pregraft controls, but the prevalence of normal follicular morphology was either slightly increased (primordial follicles) or unchanged (primary follicles). Previous ovariectomy in graft recipients increased total follicle numbers without effect on normal follicular morphology and shifted the ratio of primordial to primary follicles toward an increase in primary follicles, indicating activation of follicular maturation. CONCLUSION(S):The marmoset is a suitable primate model for studies on the subsequent use of cryopreserved ovarian tissue, demonstrating graft sustainment and the development of follicles from prepubertal ovarian tissue in immunodeficient hosts up to secondary and preantral stages.


Fertil Steril


Fertility and sterility


von Schönfeldt V,Chandolia R,Kiesel L,Nieschlag E,Schlatt S,Sonntag B




Has Abstract


2011-03-15 00:00:00














  • Pubertal development of the first cohort of young adults conceived by in vitro fertilization in the United States.

    abstract:OBJECTIVE:To characterize pubertal development of the first generation of young adults born as a result of in vitro fertilization (IVF). Demographic, clinical, and body size characteristics were examined regarding developmental milestones. DESIGN:Cross-sectional. SETTING:Academic center. PATIENT(S):Young adults (18-...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Beydoun HA,Sicignano N,Beydoun MA,Bocca S,Stadtmauer L,Oehninger S

    更新日期:2011-02-01 00:00:00

  • Regulation of steroid hormone synthesis by human corpora lutea: failure of follicle-stimulating hormone to support steroidogenesis in vivo and in vitro.

    abstract::The authors studied the role of follicle-stimulating hormone (FSH) in luteal steroidogenesis by replacing gonadotropin-releasing hormone (GnRH) infusion with pure FSH 48 hours after ovulation in two hypogonadotropic patients. Plasma progesterone (P) and estradiol (E2) decreased after FSH administration. Human luteal c...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Devoto L,Vega M,Navarro V,Sir T,Alba F,Castro O

    更新日期:1989-04-01 00:00:00

  • The frozen embryo and its nonresponding parents.

    abstract:OBJECTIVE:To describe patients who at least once did not reply to correspondence of the center about embryo disposition. DESIGN:Anonymous questionnaire. SETTING:Department of Reproductive Medicine, Ghent University Hospital (Belgium). PATIENT(S):Patients whose embryos were stored for at least 2 years. INTERVENTION(...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Provoost V,Pennings G,De Sutter P,Dhont M

    更新日期:2011-05-01 00:00:00

  • The effect of egg yolk medium on human sperm binding in the hemizona assay.

    abstract:OBJECTIVE:To evaluate, using the hemizona assay (HZA), whether egg yolk treatment of human sperm enhances binding to the human zona pellucida in vitro and to determine whether such a treatment is as efficient as the standard swim-up procedure for promoting sperm binding ability. DESIGN:Ejaculates were divided into ali...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lanzendorf SE,Holmgren WJ,Jeyendran RS

    更新日期:1992-09-01 00:00:00

  • Using semen flow cytometry to evaluate association of ploidy status and chromatin condensation of spermatozoa with conventional semen parameters: clinical application in intrauterine insemination.

    abstract:OBJECTIVE:To evaluate the association between the ploidy status and the nuclear chromatin condensation of spermatozoa with conventional semen parameters by using semen flow cytometry (SFC). The prognostic value of SFC on the successful outcome of intrauterine insemination (IUI) was examined. DESIGN:Prospective study. ...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Lazaros L,Kaponis A,Vartholomatos G,Hatzi E,Botsari S,Plachouras N,Makrydimas G,Zikopoulos K,Sofikitis N,Georgiou I

    更新日期:2011-01-01 00:00:00

  • Experimental immunological infertility effect of anti-GAPDH-2 antibodies on the fertility of female mice.

    abstract:OBJECTIVE:To examine the relationship between an antibody against GAPDH-2, a sperm-specific protein, and infertility of female mice. DESIGN:Basic research. SETTING:National Research Institute for Family Planning Beijing, World Health Organization Collaboration Center of Human Reproduction. ANIMAL(S):New Zealand rabb...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Wang Y,Zhang N,Zhang X,Miao S,Zong S,Koide SS,Wang L

    更新日期:2009-12-01 00:00:00

  • Postoperative adhesion formation after ovarian wedge resection with and without ovarian reconstruction in the rabbit.

    abstract::A rabbit model was used to examine adhesion formation after ovarian wedge resection with and without reapproximation of the ovarian cortex. A wedge resection was completed on one ovary with a scalpel, and the ovarian cortex was reapproximated using microsurgical technique. In the contralateral ovary, a wedge resection...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Brumsted JR,Deaton J,Lavigne E,Riddick DH

    更新日期:1990-04-01 00:00:00

  • Gel instillation sonohysterography: first experience with a new technique.

    abstract:OBJECTIVE:A practical attempt to simplify and improve the technique of artificial uterine cavity distension by instilling gel instead of flushing saline. DESIGN:Prospective observational study. SETTING:Teaching hospital. PATIENT(S):One hundred twenty patients with an indication for sonohysterography (abnormal uterin...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Exalto N,Stappers C,van Raamsdonk LA,Emanuel MH

    更新日期:2007-01-01 00:00:00

  • The plausibility of Helicobacter pylori-related infertility in Japan.

    abstract::The aim of the present study was to confirm the seropositive rate of Helicobacter pylori to which antibodies cross-react with spermatozoon flagella in patients with infertility. Of the 204 patients in whom the anti-H. pylori IgG antibody in serum and follicular fluids were measured, 45 (22.1%) were seropositive for H....

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kurotsuchi S,Ando H,Iwase A,Ishida Y,Hamajima N,Kikkawa F

    更新日期:2008-09-01 00:00:00

  • Quality of reporting of test accuracy studies in reproductive medicine: impact of the Standards for Reporting of Diagnostic Accuracy (STARD) initiative.

    abstract:OBJECTIVE:To evaluate the extent to which test accuracy studies published in two leading reproductive medicine journals in the years 1999 and 2004 adhered to the Standards for Reporting of Diagnostic Accuracy (STARD) initiative parameters, and to explore whether the introduction of the STARD statement has led to an imp...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Coppus SF,van der Veen F,Bossuyt PM,Mol BW

    更新日期:2006-11-01 00:00:00

  • Ovulation induction in women with premature ovarian failure: a prospective, crossover study.

    abstract::A prospective crossover study comparing ovulation induction techniques in eight women with premature ovarian failure is presented. These patients were treated with FSH rebound techniques using the GnRH-a, LA, alone in one treatment cycle and the same plus menopausal gonadotropins in the other treatment cycle. Two wome...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Rosen GF,Stone SC,Yee B

    更新日期:1992-02-01 00:00:00

  • Surrogate end points in women's health research: science, protoscience, and pseudoscience.

    abstract::A surrogate end point (e.g., a laboratory test or image) serves as a proxy for a clinical end point of importance (e.g., fracture, thrombosis, or death). Adoption and use of surrogate end points lacking validation, especially in cardiovascular medicine, have caused thousands of patients' deaths, a serious violation of...

    journal_title:Fertility and sterility

    pub_type: 社论,评审


    authors: Grimes DA,Schulz KF,Raymond EG

    更新日期:2010-04-01 00:00:00

  • Spermometer: electrical characterization of single boar sperm motility.

    abstract:OBJECTIVE:To study single sperm boar motility using electrical impedance measurements in a microfluidic system. DESIGN:Comparison of the optical data and electrical impedance data. SETTING:Research laboratory at a university. ANIMAL(S):Boar semen sample were used. INTERVENTION(S):A microfluidic system is developed ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: de Wagenaar B,Geijs DJ,de Boer H,Bomer JG,Olthuis W,van den Berg A,Segerink LI

    更新日期:2016-09-01 00:00:00

  • Role of blood and fibrinogen in development of intraperitoneal adhesions in rats.

    abstract::One hundred and twenty rats were divided into six groups and laparotomized. In three of the groups the cecum was left intact. In one of these groups the cecum was only lifted up through the abdominal incision and then replaced in the abdominal cavity. In another group the intact cecum was bathed with a certain amount ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Nisell H,Larsson B

    更新日期:1978-10-01 00:00:00

  • Pentoxifylline is not useful in enhancing sperm function in cases with previous in vitro fertilization failure.

    abstract:OBJECTIVE:To assess the efficiency of the addition of pentoxifylline to spermatozoa for in vitro fertilization (IVF) in cases with previous fertilization failure. DESIGN:After retrieval, oocytes were divided at random and inseminated with spermatozoa prepared with or without pentoxifylline. SETTING:In vitro fertiliza...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tournaye H,Janssens R,Camus M,Staessen C,Devroey P,Van Steirteghem A

    更新日期:1993-01-01 00:00:00

  • Acupuncture and infertility: we need to stick to good science.

    abstract::The research published to date does not show a definitive positive impact of acupuncture on IVF success rates. However, researchers seem to lack traditional scientific practices when interpreting the data. ...

    journal_title:Fertility and sterility

    pub_type: 评论,杂志文章,评审


    authors: Domar AD

    更新日期:2006-05-01 00:00:00

  • Magnetic resonance imaging using "fat-saturation" technique is useful for diagnosing small endometrioma: a case report.

    abstract::Preoperative MRI using fat-saturation technique was performed in a patient with endometriosis. Endometrial implants as small as 3 mm were accurately diagnosed by MRI. The fat-saturation technique is useful for diagnosing small endometrioma. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Takahashi K,Okada S,Kitao M,Sugimura K

    更新日期:1992-11-01 00:00:00

  • The Lupron screening test: tailoring the use of leuprolide acetate in ovarian stimulation for in vitro fertilization.

    abstract:STUDY OBJECTIVE:To evaluate the prognostic and therapeutic value of a Lupron (leuprolide acetate; Tap Pharmaceuticals, North Chicago, IL) screening test before ovarian stimulation for in vitro fertilization (IVF). DESIGN:Prospective. SETTING:Outpatient IVF program. PATIENTS:Eighty patients exhibited four early estra...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Padilla SL,Smith RD,Garcia JE

    更新日期:1991-07-01 00:00:00

  • Micromanipulation of sperm by a laser generated optical trap.

    abstract::The force generated by the radiation pressure of a low power laser beam induces an optical trap which may be used to manipulate sperm. We studied the effect of the optical trap on sperm motility. A Nd:YAG laser beam was coupled to a conventional microscope and focused into the viewing plane by the objective lens. Sper...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tadir Y,Wright WH,Vafa O,Ord T,Asch RH,Berns MW

    更新日期:1989-11-01 00:00:00

  • One thousand initiated cycles of in vitro fertilization in women > or = 40 years of age.

    abstract:OBJECTIVE:To evaluate the results of IVF in women > or = 40 years of age using their own oocytes. DESIGN:Retrospective study. SETTING:Wolfson and Royal Masonic in vitro fertilization units, London, United Kingdom. PATIENT(S):A total of 1,087 IVF cycles were started in women > or = 40 years of age. INTERVENTION(S):M...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lass A,Croucher C,Duffy S,Dawson K,Margara R,Winston RM

    更新日期:1998-12-01 00:00:00

  • Vasectomy and vasovasostomy in rhesus monkeys: the effect of circulating antisperm antibodies on fertility.

    abstract::Rhesus monkeys develop agglutinating and complement-dependent antisperm antibodies after vasectomy. In order to study whether these antibodies affect fertility after vasovasostomy, 15 animals were given vasectomies and 6 months later vasovasostomies. Subsequently, each was mated with females of proven fertility. Five ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Alexander NJ

    更新日期:1977-05-01 00:00:00

  • Gonadotropin-releasing hormone antagonist administration enhances gonadotrope responsiveness at doses inadequate to suppress immunoassayable gonadotropin levels.

    abstract::Chronic GnRH antagonist therapy produces enhanced gonadotrope responsiveness to supraphysiologic stimuli despite the lack of any measurable suppression of gonadotropin levels. This indicates that GnRH antagonists fundamentally alter gonadotrope response mechanisms without inhibiting gonadotropin release. Beyond the ph...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Scott RT Jr,Illions EH,Carey KD,Navot D

    更新日期:1994-11-01 00:00:00

  • Free sex steroid and sex hormone-binding globulin levels in oligozoospermic men with varicoceles.

    abstract:OBJECTIVE:To measure free T, free E2, and sex hormone-binding globulin (SHBG) levels in oligozoospermic men with varicoceles. DESIGN:Retrospective study. PATIENTS:Sixty-four infertile patients with varicoceles. SETTING:A university-based tertiary care referral center. INTERVENTIONS:Assessment of seminal cellular ch...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hudson RW

    更新日期:1996-08-01 00:00:00

  • Subfertility increases risk of testicular cancer: evidence from population-based semen samples.

    abstract:OBJECTIVE:To further understand the association between semen quality and cancer risk by means of well defined semen parameters. DESIGN:Retrospective cohort study. SETTING:Not applicable. PATIENT(S):A total of 20,433 men who underwent semen analysis (SA) and a sample of 20,433 fertile control subjects matched by age...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hanson HA,Anderson RE,Aston KI,Carrell DT,Smith KR,Hotaling JM

    更新日期:2016-02-01 00:00:00

  • Can intracytoplasmic morphologically selected sperm injection be used to select normal-sized sperm heads in infertile patients with macrocephalic sperm head syndrome?

    abstract:OBJECTIVE:To study the chromosomal content of spermatozoa selected by intracytoplasmic morphologically selected sperm injection (IMSI) in cases of macrocephalic sperm head syndrome. DESIGN:Case report. SETTING:Obstetrics, gynecology, urology, and reproductive biology departments. PATIENT(S):Two infertile patients wi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Chelli MH,Albert M,Ray PF,Guthauser B,Izard V,Hammoud I,Selva J,Vialard F

    更新日期:2010-03-01 00:00:00

  • Effects of hormonal therapies and dietary soy phytoestrogens on vaginal cytology in surgically postmenopausal macaques.

    abstract:OBJECTIVE:To evaluate the effects of conjugated equine estrogens, medroxyprogesterone acetate (MPA), conjugated equine estrogens combined with MPA, tamoxifen, and soybean estrogens on vaginal cytology in surgically postmenopausal cynomolgus macaques (Macaca fascicularis). DESIGN:Randomized long-term experimental trial...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Cline JM,Paschold JC,Anthony MS,Obasanjo IO,Adams MR

    更新日期:1996-05-01 00:00:00

  • Gonadotropin-releasing hormone antagonist use is associated with increased pregnancy rates in ovulation induction-intrauterine insemination to in vitro fertilization conversions, independent of age and estradiol level on the day of human chorionic gonadot

    abstract:OBJECTIVE:To determine whether the use of GnRH antagonist in cycles converted from ovulation induction-IUI to IVF affects cycle outcome and pregnancy rates. DESIGN:Retrospective cohort study. SETTING:Academic research institution. PATIENT(S):One hundred eighty-two consecutive patients with ovulation induction-IUI to...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Quaas AM,Missmer SA,Ginsburg ES

    更新日期:2010-02-01 00:00:00

  • Correlation of reactive oxygen species levels with the fertilization rate after in vitro fertilization: a qualified meta-analysis.

    abstract::Our meta-analysis analyzed the relationship between levels of reactive oxygen species (ROS) and fertilization rate after in vitro fertilization (IVF), and showed a statistically significant correlation between the ROS levels and the IVF fertilization rate (estimated overall correlation -0.374 [95% CI, -0.520, -0.205])...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析


    authors: Agarwal A,Allamaneni SS,Nallella KP,George AT,Mascha E

    更新日期:2005-07-01 00:00:00

  • An appraisal of serum preptin levels in PCOS.

    abstract::Plasma preptin levels were higher in women with PCOS compared with the control group (mean±SD, 823.2±140.7 vs. 324.9±147.3 pg/mL). This article suggests a potential role of preptin in the pathogenesis of PCOS. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Celik O,Celik N,Hascalik S,Sahin I,Aydin S,Ozerol E

    更新日期:2011-01-01 00:00:00

  • Cryptorchidism concordance in monozygotic and dizygotic twin brothers, full brothers, and half-brothers.

    abstract:OBJECTIVE:To study concordance rates of cryptorchidism (undescended testis) in pairs of boys with varying family structure, to evaluate the risk contribution from the intrauterine environment and genetic factors. DESIGN:Population based study of 1,024,500 Danish boys born from January 1, 1973 to December 31, 2004. Cla...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jensen MS,Toft G,Thulstrup AM,Henriksen TB,Olsen J,Christensen K,Bonde JP

    更新日期:2010-01-01 00:00:00