Endometrial preparation for frozen-thawed embryo transfer with or without pretreatment with gonadotropin-releasing hormone agonist.

Abstract:

OBJECTIVE:To test the efficacy of endometrial preparation with exogenous steroids, without pretreatment with gonadotropin-releasing hormone (GnRH) agonist, in women with normal ovarian function. DESIGN:Prospective randomized study. SETTING:Private outpatient infertility clinic. PATIENT(S):Two hundred ninety-six women undergoing frozen-thawed embryo transfer. INTERVENTION(S):In group 1 (146 patients), depot GnRH agonist was administered in the luteal phase; treatment with 17beta-estradiol transdermal patches at steadily increasing dosage from 100 to 300 microg was then given for at least 12 days. In group 2 (150 patients), endometrial preparation began on day 1 of menstrual cycle. The starting dose was 200 microg; this was increased to 300 microg after 7 days. MAIN OUTCOME MEASURE(S):Pregnancy, abortion, implantation and cancellation rates. RESULT(S):In group 2, six cycles (4%) were cancelled due to evidence of ovulation. Groups were similar in the percentage of embryos that survived freezing-thawing (77.1% in group 1 and 76.6% in group 2) and in the number of embryos transferred per patient (2.1 +/- 0.6 and 2.1 +/- 0.7, respectively). Groups 1 and 2 did not differ significantly in rates of pregnancy (19.7% and 24.1%), abortion (17.8% and 11.7%), and implantation (10.4% and 11.9%). CONCLUSION(S):Endometrial preparation for frozen-thawed embryo transfer based exclusively on steroid administration appears to be as effective as the more conventional protocol involving preliminary desensitization with a GnRH agonist. This simplified protocol reduces costs, minimizes pharmacologic treatment, and increases patient compliance.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Dal Prato L,Borini A,Cattoli M,Bonu MA,Sciajno R,Flamigni C

doi

10.1016/s0015-0282(02)02960-6

keywords:

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

956-60

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015028202029606

journal_volume

77

pub_type

临床试验,杂志文章,随机对照试验
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    authors: Schutte SC,Taylor RN

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    abstract:OBJECTIVE:To investigate the serum pattern of free leptin, bound leptin, and soluble leptin receptor throughout the physiological menstrual cycle. DESIGN:Prospective observational study. SETTING:Tertiary care center for gynecological endocrinology and reproductive medicine and a university research laboratory. PATIE...

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    doi:10.1016/j.fertnstert.2003.06.020

    authors: Geisthövel F,Jochmann N,Widjaja A,Horn R,Brabant G

    更新日期:2004-02-01 00:00:00

  • Unilateral triplet ectopic pregnancy after in vitro fertilization and embryo transfer.

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    doi:10.1016/j.fertnstert.2008.03.018

    authors: Berkes E,Szendei G,Csabay L,Sipos Z,Joo JG,Rigo J Jr

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  • Fibrinolytic factors in endometriotic tissue, endometrium, peritoneal fluid, and plasma from women with endometriosis and in endometrium and peritoneal fluid from healthy women.

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  • Body weight, hyperinsulinemia, and gonadotropin levels in the polycystic ovarian syndrome: evidence of two distinct populations.

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    doi:10.1016/s0015-0282(16)55249-2

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  • Induction of hypothalamic opioid activity with transdermal estradiol administration in postmenopausal women.

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    doi:

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    doi:10.1016/s0015-0282(01)02940-5

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    更新日期:2002-01-01 00:00:00

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    更新日期:2008-02-01 00:00:00

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    authors: Khorram O,Han G

    更新日期:2009-05-01 00:00:00

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    更新日期:1998-01-01 00:00:00

  • The influence of gonadal steroids on the dopamine inhibitory effect on gonadotropin release in men.

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    更新日期:1984-12-01 00:00:00

  • Leukemia inhibitory factor is dysregulated in the endometrium and uterine flushing fluid of patients with adenomyosis during implantation window.

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    更新日期:2010-06-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    更新日期:2000-06-01 00:00:00

  • Granulocyte colony-stimulating factor with or without stem cell factor extends time to premature ovarian insufficiency in female mice treated with alkylating chemotherapy.

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    更新日期:2013-06-01 00:00:00

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    更新日期:1982-06-01 00:00:00

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