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Inhibition of ghrelin signaling improves the reproductive phenotype of male ob/ob mouse.

Abstract：

OBJECTIVE:To investigate whether ghrelin signaling is involved in the pathogenesis of male factor infertility induced by leptin deficiency. DESIGN:Experimental study. SETTING:University academic medical center. ANIMAL(S):Ten-week-old C57BL/6J mice and ob/ob mice. INTERVENTION(S):Western blotting, (quantitative) reverse transcription-polymerase chain reaction (qRT-PCR), immunohistochemistry, and in situ end labeling of fragmented DNA. MAIN OUTCOME MEASURE(S):Expression levels of ghrelin and its functional receptor growth hormone (GH) secretagogue receptor 1a (GHS-R1α) were examined by Western blotting and immunohistochemistry. Ob/ob mice were injected IP with specific GHS-R1α antagonist, and thereafter germ cell apoptosis and steroidogenic capability were assessed by TUNEL assay, (q) RT-PCR, and radioimmunoassay. RESULT(S):Expression of GHS-R1α and its endogenous ligand ghrelin was both up-regulated in ob/ob testis. Inhibition of the ghrelin pathway restored androgen synthesis, reduced germ cell apoptosis, and thereby resulted in improved sperm production in ob/ob mice. CONCLUSION(S):Ghrelin, as an antagonistic partner of leptin in the endocrinic/paracrine circuit, may be involved in the pathogenesis of male factor infertility induced by leptin deficiency.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Zhu CC,Zhang H,Zhang JS,Li Z,Zhao J,Li W,Zhang YQ

doi

10.1016/j.fertnstert.2012.11.022

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

918-26

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(12)02434-X

journal_volume

99

pub_type

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