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Inhibition of rat spermatogenesis and seminiferous tubule growth after short-term and long-term administration of a monoamine oxidase inhibitor.

Abstract：

:Seminiferous tubules from rats killed 24 hours after injection of pargyline, a monoamine oxidase inhibitor, did not grow well in tissue culture when compared to control tubules. Treated tubules showed severe tubular degeneration and loss of cellular detail after nine days in culture. Animals injected with pargyline for ten days had varying degrees of semi-niferous tubule degeneration with depletion of the spermatogenic elements. It is suggested that pargyline has a detrimental effect on spermatogenesis. Pargyline possibly acts by decreasing MAO levels which, in turn, may increase potentially damaging amines which may be responsible for the testicular damage.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Urry RL,Dougherty KA

doi

10.1016/s0015-0282(16)40992-1

keywords:

subject

Has Abstract

pub_date

1975-03-01 00:00:00

pages

232-9

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)40992-1

journal_volume

26

pub_type

杂志文章

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