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Estrogenic response in women with amenorrhea during treatment with human menopausal gonadotropin with and without the simultaneous administration of bromocriptine.

Abstract：

:In an attempt to determine whether prolactin influences estrogen biosynthesis in the ovary, the estrogenic responses of women with amenorrhea under treatment with human menopausal gonadotropin (hMG), with and without the simultaneous administration of the prolactin inhibitor bromocriptine, were investigated in a total of 20 treatment cycles. In five of the six women studied, the addition of bromocriptine produced a urinary excretion of estrogenic compounds 79% higher than that produced by treatment with hMG alone. In one woman with a slightly increased serum prolactin level, the addition of bromocriptine necessitated halving the total hMG dosage. One woman with low endogenous levels of follicle-stimulating hormone (FSH) and a limited response to gonadotropin-releasing hormone showed no increased estrogen excretion after bromocriptine administration over that produced by hMG alone. These results suggest that (1) both elevated and normal serum prolactin levels can have a direct inhibitory effect on the ovary and (2) FSH may be necessary for the formation of prolactin receptors in the ovary.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Larsen S,Honoré E

doi

10.1016/s0015-0282(16)44652-2

subject

Has Abstract

pub_date

1980-04-01 00:00:00

pages

378-82

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)44652-2

journal_volume

33

pub_type

杂志文章

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