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Sperm DNA fragmentation and mitochondrial membrane potential combined are better for predicting natural conception than standard sperm parameters.

Abstract：

OBJECTIVE:To evaluate whether DNA fragmentation and/or mitochondrial membrane potential (MMP) predict natural conception better than standard sperm parameters. DESIGN:Prospective cross-sectional study. SETTING:University medical center. PATIENT(S):Eighty-five infertile and 51 fertile men. INTERVENTION(S):Assessment of sperm DNA fragmentation, MMP, and standard semen parameters over a 6- to 12-month observation period. MAIN OUTCOME MEASURE(S):Comparison between the results of DNA fragmentation, MMP, and standard sperm parameters alone or combined and achievement of natural conception. RESULT(S):Twenty-six of the 85 (31%) men from infertile couples conceived naturally. The median values of DNA fragmentation and MMP in the men who conceived within the observation period were similar to those in the fertile controls. Optimal threshold values of DNA fragmentation and MMP were 25% as determined by receiver operating characteristic analysis (area under the curve [AUC], 0.70; 95% confidence interval (CI) 0.58-0.82) and 62.5% (AUC, 0.68, 95% CI 0.56-0.80), respectively. The men in the infertile group with values of DNA fragmentation ≤25% and with MMP values ≥62.5% had significantly higher odds for conception (odds ratio [OR], 5.22; 95% CI 1.82-14.93] and OR, 4.67; 95% CI 1.74-12.5, respectively). Normal semen analysis alone had no predictive value for natural conception (OR, 1.84; 95% CI 0.67-5.07]). Both sperm function tests combined had significant odds for natural conception (OR, 8.24; 95% CI 2.91-23.33]), with a probability of 0.607 (60.7%) for both normal values and 0.158 (15.8%) for abnormal values. CONCLUSION(S):Sperm DNA fragmentation and MMP combined may be superior to standard semen parameters for the prediction of natural conception.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Malić Vončina S,Golob B,Ihan A,Kopitar AN,Kolbezen M,Zorn B

doi

10.1016/j.fertnstert.2015.11.037

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

637-644.e1

issue

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(15)02121-4

journal_volume

105

pub_type

杂志文章

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Sperm DNA fragmentation and mitochondrial membrane potential combined are better for predicting natural conception than standard sperm parameters.