Abstract:
OBJECTIVE:To evaluate the effect of preimplantation genetic screening (PGS) on morphologic outcome in children. DESIGN:Follow-up of a randomized controlled trial (RCT). SETTING:University hospital. PATIENT(S):Two-year-old children born to mothers who participated in an RCT on the efficacy of PGS: 50 children born after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) with PGS (intervention group; PGS+) and 72 children born after IVF/ICSI only (control group; PGS-). Sixty-six age-matched children conceived without any form of assisted reproduction were recruited separately in a local public health service center (reference group). INTERVENTION(S):PGS. MAIN OUTCOME MEASURE(S):Body surface examination and anthropometry. The evaluation of morphologic abnormalities allowed assessment of children's phenotype in detail. Morphologic abnormalities were classified as major abnormalities (abnormal development in organogenesis, deformations, disruptions, or dysplasia) and minor anomalies (deviations in phenogenesis). RESULT(S):The percentage of children with ≥ 1 major abnormality was 28% in the PGS+ and 35% in the PGS- group [difference -7%, 95% CI -23% to 10%]. The percentage of children with ≥ 1 minor anomaly was 64% in the PGS+ and 67% in the PGS- group [difference -3%, 95% CI -15% to 20%]. In the reference group 30% of the children had ≥ 1 major abnormality [95% CI 20% to 43%] and 74% had ≥ 1 minor anomaly [95% CI 62% to 84%]. CONCLUSION(S):No statistically significant differences were found in minor anomalies between children conceived after IVF/ICSI with or without PGS. There is < 2.5% chance of ≥ 10% more major abnormalities in children born after PGS.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Beukers F,van der Heide M,Middelburg KJ,Cobben JM,Mastenbroek S,Breur R,van der Lee JH,Hadders-Algra M,Bos AF,Kok JH,PGS Study Group.doi
10.1016/j.fertnstert.2012.10.024subject
Has Abstractpub_date
2013-02-01 00:00:00pages
408-13issue
2eissn
0015-0282issn
1556-5653pii
S0015-0282(12)02336-9journal_volume
99pub_type
杂志文章,随机对照试验abstract::The Ethics Committee recommends development of evidence-based policies that are patient centered for each IVF center. In most cases, the provision of futile therapies is not ethically justifiable. For those treatments with very poor success rates, clinicians must be vigilant in their presentation of risks, benefits, a...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2009.07.979
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To compare the effects on human oocytes of in vitro maturation periods of 28 hours and 36 hours. DESIGN:Retrospective analysis. SETTING:University teaching hospital. PATIENT(S):A total of 48 infertile patients undergoing 55 cycles who volunteered for the experimental treatments. INTERVENTION(S):Immature o...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(99)00574-9
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:To demonstrate a new approach for performing an ovarian cystectomy via transvaginal natural orifice transluminal endoscopic surgery (vNOTES) as an alternative for a laparoscopic ovarian cystectomy. DESIGN:Stepwise explanation of the technique using original video footage. SETTING:Hospital. PATIENT(S):Fourt...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2017.10.037
更新日期:2018-02-01 00:00:00
abstract::We conducted a case-control study and compared the results of IVF treatment in two groups of women with polycystic ovaries. The first group consisted of 42 women who were previously treated unsuccessfully with in vitro maturation (IVM), and the second group, 48 others with no previous IVM (control group). We included ...
journal_title:Fertility and sterility
pub_type: 信件
doi:10.1016/j.fertnstert.2009.09.033
更新日期:2010-06-01 00:00:00
abstract::Hormone patterns during 113 nonconceptual gonadotropin-induced cycles of 65 infertile anovulatory women were analyzed. All but one women ovulated, i.e., the ovulation rate was 98%. Signs of defective corpus luteum function were observed during 8 cycles, and anovulation occurred in 11 treatment cycles. The duration of ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47115-3
更新日期:1983-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the risk that nulliparity poses to the outcome of twin pregnancies, an issue that gained importance due to the rise of twin gestations following assisted reproduction interventions. DESIGN:A prospective cohort study. SETTING AND PATIENT(S):Between January 1, 2004, and January 7, 2008, we prospec...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.12.035
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To report the inheritance of a pericentric inversion in chromosome 7 through the three progenies, congenital hydronephrosis, and recurrent miscarriages in an extended family. DESIGN:Case report. SETTING:Medical Faculty of Cukurova University in Turkey. PATIENT(S):Referred by obstetrics and gynecology clini...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.02.030
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To assess the clinical relevance of daily hormonal changes for achieving a successful pregnancy in anovulatory infertile women. DESIGN:A comparative study of hormonal dynamics in pregnant and nonpregnant cycles during the pulsatile subcutaneous administration of hMG. Subjects received subcutaneous injection ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56093-2
更新日期:1993-08-01 00:00:00
abstract::Surgical ablation of the inferior mesenteric plexus in the rat results in an excessive accumulation of sperm within the cauda epididymidis. The present study examined the effect of ablation of the inferior mesenteric plexus on the motility of cauda epididymal spermatozoa. One to 8 weeks after ablation of the inferior ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract::Eighty-seven patients who underwent a late secretory phase endometrial biopsy while taking clomiphene citrate (CC) for ovulation induction were studied. Of the endometrial biopsies, 21 (24%) showed an endometrium greater than 2 days out of phase (OOP) with respect to the subsequent menstrual cycle. All 87 patients wer...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60726-4
更新日期:1989-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the possible relationship between total acrosin activity in spermatozoa and fertility potential after fertilization in vitro. DESIGN:Total acrosin activity of spermatozoa was measured in 101 in vitro fertilization (IVF) cases by an observer unaware of fertilization and cleavage results. SETTING:...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract::Cell proliferation of endometrial stromal cells treated with peritoneal fluid of women (aged 25 to 43 years) with endometriosis (n = 12) statistically significantly increased compared with the control treatment (peritoneal fluid of women without endometriosis, n = 8). Also, COX-2 gene expression and prostaglandin E(2)...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.11.039
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To evaluate a 2-year follow-up of cryopreserved hemi-ovary autografts in ewes. DESIGN:Animal study. SERTTING: University fertility center, Hospices Civils de Lyon; Ecole Nationale Vétérinaire de Lyon, INSERM U 418 Hocaron;pital Debrousse, Lyon; and Hôpital Edouard Herriot, Lyon, France. PATIENT(S):Grivette ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(03)00554-5
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:To determine the effect of sonographer experience during ultrasound guided embryo transfer on pregnancy outcomes. DESIGN:Retrospective chart review. SETTING:A university-based academic practice. PATIENT(S):A total of 319 women who underwent in vitro fertilization and embryo transfer (IVF-ET) from the site-...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.07.1743
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:To study the differences in the cleavage time between types of embryo chromosomal abnormalities and elaborate algorithm to exclude aneuploid embryos according to the likelihood to be euploid. DESIGN:Retrospective cohort study. SETTING:University affiliated private center. PATIENT(S):Preimplantational genet...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.09.019
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To update results on outcomes with frozen/thawed oocytes using a differential sucrose concentration during dehydration (0.2 M) and rehydration (0.3 M), combined with a one-step propanediol exposure. DESIGN:Retrospective cohort study. SETTING:Private IVF centers. PATIENT(S):Infertile couples undergoing IVF ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.01.127
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To describe the surgical and reproductive outcomes of early diffuse uterine leiomyomatosis with hysteroscopic myomectomy. DESIGN:Retrospective report. SETTING:University hospital. PATIENT(S):Five consecutive women of reproductive age with innumerable small-sized (0.5-3 cm) diffuse uterine myomas with profu...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.01.100
更新日期:2007-12-01 00:00:00
abstract::Carbohydrate and lipid metabolism was evaluated in 31 women before and after 1 year's use of a progesterone-releasing intrauterine device. The studies involved measuring blood glucose and plasma insulin levels during a 3-hour oral glucose tolerance test and also measuring fasting cholesterol and triglyceride levels. T...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)43932-4
更新日期:1979-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between the ploidy status and the nuclear chromatin condensation of spermatozoa with conventional semen parameters by using semen flow cytometry (SFC). The prognostic value of SFC on the successful outcome of intrauterine insemination (IUI) was examined. DESIGN:Prospective study. ...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/j.fertnstert.2010.05.012
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To study the effect of letrozole (Let) and anastrozole (Anas) on apoptosis and cell proliferation in epithelial endometrial cells (EEC) from patients with endometriosis (EDT). DESIGN:Prospective study. SETTING:Research institute and clinical fertility center. PATIENT(S):Eighteen women with untreated EDT. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.01.137
更新日期:2005-08-01 00:00:00
abstract::The role of insulin sensitizing agents is discussed at length in this Committee Opinion. ...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2008.08.004
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To compare pregnancy rates after fallopian tubal and uterine transfer of cryopreserved embryos. DESIGN:Prospective randomized trial with assignment to treatment groups by a random number table. SETTING:University of Iowa Hospitals and Clinics, a tertiary care academic institution. PATIENTS:Forty patients w...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(16)57429-9
更新日期:1995-03-01 00:00:00
abstract::Fresh semen specimens from fertile donors were subjected to one-step and two-step washings in six various commonly used artificial media. It was found that washing procedures per se, in most cases, had an immediate and extended harmful effect on sperm motility which was much more prominent after the second washing. Ho...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)45441-5
更新日期:1981-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between female cystic fibrosis (CF) carrier status and in vitro fertilization (IVF) response and outcomes. The presence of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in male carriers has been associated with infertility, yet possible adverse effects o...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.07.1234
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:Mutation within androgen receptor (AR) can be seen. Presently, prediction of protein nanostructure and function is a great challenge in the proteomics and structural genomics era. To identify the points vulnerable to mutation is a new trend to expand the knowledge on disorders in genomic and proteomic level o...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.06.089
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between an antibody against GAPDH-2, a sperm-specific protein, and infertility of female mice. DESIGN:Basic research. SETTING:National Research Institute for Family Planning Beijing, World Health Organization Collaboration Center of Human Reproduction. ANIMAL(S):New Zealand rabb...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.09.001
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To identify the gene(s) involved in the etiology of premature ovarian insufficiency in a highly consanguineous Tunisian family. DESIGN:Genetic analysis of a large consanguineous family with several affected siblings. SETTING:University hospital-based cytogenetics and molecular genetics laboratories. PATIEN...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2017.07.015
更新日期:2017-10-01 00:00:00
abstract::One hundred four consecutive men who underwent a semen analysis as part of their infertility evaluation were assayed for sperm-associated immunoglobulin (Ig) and the third component of complement (C3). Sixteen (15%) of the 104 men had increased IgG, and 10 (12%) of 86 men tested had increased IgA on their sperm; howev...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1983-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the levels of interleukin-1beta (IL1beta) and its inhibitory soluble interleukin-1 receptor type II (IL1R2) in the peritoneal fluid (PF) of normal women and patients with endometriosis suffering from pelvic pain and infertility. DESIGN:Retrospective study using ELISA to measure peritoneal fluid I...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.06.019
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To determine the cumulative incidence of live delivery in women who underwent reversal of tubal sterilization. DESIGN:Population-based retrospective cohort study. SETTING:Hospitals in Western Australia. PATIENT(S):All women aged 20-44 years, with a history of hospital admission for tubal sterilization, who...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.06.042
更新日期:2015-10-01 00:00:00