Interaction between human cervical mucus and sperm surface antibodies.

Abstract:

:The immunobead test was used to study the immunoglobulin class of antibodies on sperm before and after penetration through a microcolumn of cervical mucus. Sixteen men with positive sperm antibodies (positive sperm immobilization test) and sperm that penetrated cervical mucus in prior tests were selected for study. However, at the time of study, sperm from seven subjects could not be recovered from the microcolumn. The nine subjects from whom motile sperm were obtained after passage through the column had better sperm mucus penetration tests, lower proportions of sperm binding to anti-IgA immunobeads, and higher proportions of sperm with tail-tip-only binding. Sperm recovered after penetration through the mucus microcolumn displayed a greatly reduced binding to anti-IgA immunobeads in all nine subjects, whereas similar reductions in anti-IgG binding occurred only in four subjects. These results confirm that IgA and sperm-head-directed antibodies are more important than IgG and sperm tail-tip-directed antibodies in impairing sperm penetration of cervical mucus.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Wang C,Baker HW,Jennings MG,Burger HG,Lutjen P

doi

10.1016/s0015-0282(16)48916-8

subject

Has Abstract

pub_date

1985-10-01 00:00:00

pages

484-8

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)48916-8

journal_volume

44

pub_type

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