Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis.


OBJECTIVE:To evaluate basal (constitutive) and stimulated synthesis of tumor necrosis factor alpha (TNF alpha), interleukin (IL)-8, IL-10 by peritoneal macrophages (PM) in women with endometriosis. DESIGN:Peritoneal macrophages were cultured in the presence or absence of lipopolysaccharide (LPS) for 24 hours. Peritoneal fluids (PF) and PM supernatants were assayed for cytokines using ELISA. SETTING:Institute for the Study and Treatment of Endometriosis and university-based research laboratories. SUBJECTS:Fertile controls undergoing tubal ligation (n = 8) and women with endometriosis (n = 17). INTERVENTION:Peritoneal fluid samples were obtained at the time of diagnostic laparoscopy (endometriosis group) or laparoscopy for tubal ligation; both were performed in the midluteal phase of the cycle. RESULTS:Both basal and LPS stimulated production of TNF alpha, IL-8, and IL-10 by the PM were elevated significantly in women with endometriosis as compared with the fertile controls. CONCLUSIONS:This study demonstrated that cytokines TNF alpha, IL-8, and IL-10 are synthesized at greater than normal levels by basal and stimulated PM from women with endometriosis. The levels of TNF alpha and IL-8 correlated with the levels in the PF, suggesting that PM are the principal source of these cytokines in the PF.


Fertil Steril


Fertility and sterility


Rana N,Braun DP,House R,Gebel H,Rotman C,Dmowski WP


Has Abstract


1996-05-01 00:00:00














  • Lipopolysaccharide-promoted proliferation of endometriotic stromal cells via induction of tumor necrosis factor alpha and interleukin-8 expression.

    abstract:OBJECTIVE:To evaluate the effect of lipopolysaccharide (LPS) on the expression of tumor necrosis factor alpha (TNFalpha) and interleukin-8 (IL-8) protein in endometriotic stromal cells (ESC) and their effect on the proliferation of ESC. DESIGN:Prospective study. SETTING:Department of Obstetrics and Gynecology, Tottor...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Iba Y,Harada T,Horie S,Deura I,Iwabe T,Terakawa N

    更新日期:2004-10-01 00:00:00

  • Changing parameters of donor semen.

    abstract::Effective contraception and easily available abortion have contributed to the decline of adoptable children. This decline has resulted in a marked increase in the demand for AID. The provider of donor semen must establish minimal semen criteria to meet this demand effectively. During the past 8 years the authors have ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Leto S,Frensilli FJ

    更新日期:1981-12-01 00:00:00

  • The dilemma of endometriosis: is consensus possible with an enigma?

    abstract::Many will agree that the use of laparoscopy to diagnose and potientially treat endometriosis in patients who suffer from infertility has been superseded by IVF and sometimes oocyte donation, especially in older patients. The findings of our study add another dimension to management of endometriosis in the setting of i...

    journal_title:Fertility and sterility

    pub_type: 评论,杂志文章,评审


    authors: Nezhat C,Littman ED,Lathi RB,Berker B,Westphal LM,Giudice LC,Milki AA

    更新日期:2005-12-01 00:00:00

  • Monoclonal antibodies to rabbit sperm autoantigens.

    abstract::Rabbits were immunized with homologous spermatozoa to investigate their autoimmunogenic nature. Major sperm autoantigens that elicit antisperm antibodies were analyzed molecularly by the sodium dodecylsulfate (SDS) gel/protein blot radioimmunobinding method. IgG fractions of the autoimmune sera were purified by a prot...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lee CY,Wong E,Menge AC

    更新日期:1984-01-01 00:00:00

  • Introduction: Obesity and reproduction.

    abstract::Women bear the predominant burden of our obesogenic environment, with a higher incidence of obesity than men, more impact on their fertility and success with treatment, and significant maternal and perinatal morbidity and mortality. In this series, the causes, consequences, and solutions regarding the obesity pandemic...

    journal_title:Fertility and sterility



    authors: Meldrum DR

    更新日期:2017-04-01 00:00:00

  • Low antimüllerian hormone (AMH) is associated with decreased live birth after in vitro fertilization when follicle-stimulating hormone and AMH are discordant.

    abstract:OBJECTIVE:To evaluate which factor, AMH or FSH, was superior in predicting live birth after assisted reproductive technologies (ART) when the tests are discordant, using data from the Society for Assisted Reproductive Technology Clinical Outcomes Reporting System database. DESIGN:Retrospective cohort. SETTING:Clinic-...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ligon S,Lustik M,Levy G,Pier B

    更新日期:2019-07-01 00:00:00

  • Male immunologic infertility: sperm performance on in vitro fertilization.

    abstract:OBJECTIVE:To analyze sperm performance in a group of patients with male immunologic infertility treated with IVF-ET. DESIGN:Retrospective clinical study. SETTING:Patients attending a private IVF clinic. PATIENT(S):The study group comprised seven men with significant levels of surface-bound antisperm antibodies treat...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Vazquez-Levin MH,Notrica JA,Polak de Fried E

    更新日期:1997-10-01 00:00:00

  • Semen selenium and human fertility.

    abstract::Selenium (Se) was measured in the semen of 125 men from couples consulting for infertility. A mean concentration of 71.3 +/- 29.7 ng/ml of semen was found, with a range of 7 to 230 ng/ml. More than 85% of the Se is in the seminal plasma. There was a significant positive correlation between sperm count and semen Se. Sp...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bleau G,Lemarbre J,Faucher G,Roberts KD,Chapdelaine A

    更新日期:1984-12-01 00:00:00

  • A prospective, randomized study comparing laparoscopic ovarian cystectomy versus fenestration and coagulation in patients with endometriomas.

    abstract:OBJECTIVE:To determine the difference between two laparoscopic methods for the management of endometriomas with regard to recurrence of signs and symptoms and pregnancy rate. DESIGN:Prospective, randomized clinical trial. SETTING:Infertility and gynecologic endoscopy units of two medical university hospitals. PATIEN...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Alborzi S,Momtahan M,Parsanezhad ME,Dehbashi S,Zolghadri J,Alborzi S

    更新日期:2004-12-01 00:00:00

  • Characterization of hormonal profiles during the luteal phase in regularly menstruating women.

    abstract:OBJECTIVE:To characterize the variability of hormonal profiles during the luteal phase in normal cycles. DESIGN:Observational study. SETTING:Not applicable. PATIENT(S):Ninety-nine women contributing 266 menstrual cycles. INTERVENTION(S):The women collected first morning urine samples that were analyzed for estrone-...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ecochard R,Bouchard T,Leiva R,Abdulla S,Dupuis O,Duterque O,Garmier Billard M,Boehringer H,Genolini C

    更新日期:2017-07-01 00:00:00

  • Ovulation induction with pulsatile gonadotropin-releasing hormone administration in patients with polycystic ovarian syndrome.

    abstract::Gonadotropin-releasing hormone (0.025 microgram/kg) was administered intravenously in a pulsatile fashion to four subjects with polycystic ovary syndrome for a total of six cycles. Five of the six cycles culminated in ovulation, although in one course the response occurred too early to be attributed to the therapy alo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ory SJ,London SN,Tyrey L,Hammond CB

    更新日期:1985-01-01 00:00:00

  • Seminal vesicle sperm aspiration from wounded warriors.

    abstract:OBJECTIVE:To assess whether seminal vesicle sperm aspiration (SVSA) is an option for wounded warriors with severe genital and testicular injuries, with the goal of cryopreservation to use in future assisted reproductive technology (ART) cycles. DESIGN:Retrospective case series. SETTING:Tertiary care military hospital...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Healy MW,Yauger BJ,James AN,Jezior JR,Parker P,Dean RC

    更新日期:2016-09-01 00:00:00

  • Mutational analysis of the WNT gene family in women with Mayer-Rokitansky-Kuster-Hauser syndrome.

    abstract::The aim of this study is to determine if Müllerian agenesis has a genetic basis linked to the WNT genes. Genomic DNA analyses for mutations in the coding sequences of four members of this family in a series of 11 women with Mayer-Rokitansky-Kuster-Hauser syndrome found four variants in the coding sequence of these gen...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ravel C,Lorenço D,Dessolle L,Mandelbaum J,McElreavey K,Darai E,Siffroi JP

    更新日期:2009-04-01 00:00:00

  • Immunoglobulin (Ig) G, IgA, and IgA subclass antibodies against fertilization antigen-1 in cervical secretions and sera of women of infertile couples.

    abstract:OBJECTIVES:To assess the occurrence of immunoglobulin (Ig) G, IgA, and IgA subclass antibodies against human sperm fertilization antigen-1 (FA-1) in cervical mucus (CM) and serum of women of infertile couples. DESIGN:Enzyme-linked immunosorbent assay methodology was used to detect anti-FA-1 antibodies. Antisperm antib...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Menge AC,Naz RK

    更新日期:1993-10-01 00:00:00

  • Guidelines for development of an emergency plan for in vitro fertilization programs.

    abstract::All in vitro fertilization (IVF) programs and clinics should have a plan to protect fresh and cryopreserved human tissue (embryos, oocytes, sperm) and to provide for continuation of patient care in the event of an emergency or natural disaster. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Practice Committee of Society for Assisted Reproductive Technology.,Practice Committee of American Society for Reproductive Medicine.

    更新日期:2008-11-01 00:00:00

  • Total acrosin activity correlates with fertility potential after fertilization in vitro.

    abstract:OBJECTIVE:To evaluate the possible relationship between total acrosin activity in spermatozoa and fertility potential after fertilization in vitro. DESIGN:Total acrosin activity of spermatozoa was measured in 101 in vitro fertilization (IVF) cases by an observer unaware of fertilization and cleavage results. SETTING:...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tummon IS,Yuzpe AA,Daniel SA,Deutsch A

    更新日期:1991-11-01 00:00:00

  • Ovarian expression of markers associated with proliferation or apoptosis in women with diminished ovarian reserve.

    abstract:OBJECTIVE:To determine DNA fragmentation and several molecules associated with apoptosis or proliferation in ovaries of patients with diminished ovarian reserve. DESIGN:Cross-sectional analysis. SETTING:Tertiary institutional hospital. PATIENT(S):Patients with benign uterine pathology who had undergone a hysterectom...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Vital-Reyes V,Rodríguez-Burford C,Chhieng DC,Alvarado-Cabrero I,Reyes-Fuentes A,Grizzle WE

    更新日期:2006-07-01 00:00:00

  • Peritoneal fluid and serum steroids in infertility patients.

    abstract::Peritoneal fluid and serum were collected from 78 patients at the time of laparoscopy. Twenty-two were fertile controls (CTL), and 56 were infertility patients, who were subdivided into three main groups: endometriosis (EMS), pelvic adhesions (ADH), and ovarian dysfunction (OvDF). Based on control group data, biochemi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lesorgen PR,Wu CH,Green PJ,Gocial B,Lerner LJ

    更新日期:1984-08-01 00:00:00

  • Old insights, same questions.

    abstract::The thing that hath been, it is that which shall be; and that which is done is that which shall be done: and there is no new thing under the sun. -Ecclesiastes 1:9, King James Bible. ...

    journal_title:Fertility and sterility

    pub_type: 社论


    authors: Carpinello O,DeCherney A

    更新日期:2018-05-01 00:00:00

  • The plausibility of Helicobacter pylori-related infertility in Japan.

    abstract::The aim of the present study was to confirm the seropositive rate of Helicobacter pylori to which antibodies cross-react with spermatozoon flagella in patients with infertility. Of the 204 patients in whom the anti-H. pylori IgG antibody in serum and follicular fluids were measured, 45 (22.1%) were seropositive for H....

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kurotsuchi S,Ando H,Iwase A,Ishida Y,Hamajima N,Kikkawa F

    更新日期:2008-09-01 00:00:00

  • Mindfulness-Based Program for Infertility: efficacy study.

    abstract:OBJECTIVE:To present and determine the impact of the Mindfulness-Based Program for Infertility (MBPI). DESIGN:Controlled clinical trial. SETTING:University research unit. PATIENT(S):Fifty-five infertile women completed the MBPI, and 37 infertile women were assigned to a control group. INTERVENTION(S):The MBPI inclu...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Galhardo A,Cunha M,Pinto-Gouveia J

    更新日期:2013-10-01 00:00:00

  • Clinical pregnancy after uterus transplantation.

    abstract:OBJECTIVE:To present the first clinical pregnancy after uterus transplantation. DESIGN:Case study. SETTING:Tertiary center. PATIENT(S):A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation. INTERVENTION(S):Eighteen months after the transplant, ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Erman Akar M,Ozkan O,Aydinuraz B,Dirican K,Cincik M,Mendilcioglu I,Simsek M,Gunseren F,Kocak H,Ciftcioglu A,Gecici O,Ozkan O

    更新日期:2013-11-01 00:00:00

  • Lactate dehydrogenase in human cervical mucus: correlation with ovulation, influence of ovarian steroid hormones, and isozyme pattern.

    abstract::The glycolytic enzymes, lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase, and hexokinase in cervical mucus of 96 ovulatory women were serially measured daily during the menstrual cycle. Among all of the enzymes, the cyclic changes in LDH activity were the most significant, being high during the prolifera...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Takehisa T

    更新日期:1980-02-01 00:00:00

  • In vitro fertilization patients support a single blastocyst transfer policy.

    abstract:OBJECTIVE:To determine whether patients support a mandatory single blastocyst transfer (mSBT) policy in IVF. DESIGN:Prospective survey study. SETTING:Academic hospital-based infertility center. PATIENT(S):Two hundred sixty-two female patients presenting for fresh or cryopreserved/thawed ET after IVF. INTERVENTION(S...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Martini S,Van Voorhis BJ,Stegmann BJ,Sparks AE,Shochet T,Zimmerman MB,Ryan GL

    更新日期:2011-10-01 00:00:00

  • Sperm DNA fragmentation and mitochondrial membrane potential combined are better for predicting natural conception than standard sperm parameters.

    abstract:OBJECTIVE:To evaluate whether DNA fragmentation and/or mitochondrial membrane potential (MMP) predict natural conception better than standard sperm parameters. DESIGN:Prospective cross-sectional study. SETTING:University medical center. PATIENT(S):Eighty-five infertile and 51 fertile men. INTERVENTION(S):Assessment...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Malić Vončina S,Golob B,Ihan A,Kopitar AN,Kolbezen M,Zorn B

    更新日期:2016-03-01 00:00:00

  • Effect of prolactin on tetracycline binding to human spermatozoa.

    abstract::The effect of different concentrations of prolactin (0 to 60 ng) on the release of tetracycline from human spermatozoa labeled with 7-3H-tetracycline hydrochloride was studied. Prolactin significantly enhanced the release of bound tetracycline, indicating that prolactin may influence the processes associated with sper...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sheth AR,Shah GV

    更新日期:1978-04-01 00:00:00

  • Discoid or segmental rectosigmoid resection for deep infiltrating endometriosis: a case-control study.

    abstract:OBJECTIVE:To evaluate the efficacy of discoid resection for the treatment of deep infiltrating endometriosis and whether it could be considered to be a valid alternative to the rectosigmoid segmental resection. DESIGN:Case-control study. SETTING:Departments of Obstetrics and Gynecology, Ospedale Sacro Cuore of Negrar...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Fanfani F,Fagotti A,Gagliardi ML,Ruffo G,Ceccaroni M,Scambia G,Minelli L

    更新日期:2010-07-01 00:00:00

  • Superovulation with intrauterine insemination in the treatment of infertility: a possible alternative to gamete intrafallopian transfer and in vitro fertilization.

    abstract::In vitro fertilization and embryo transfer (IVF-ET) and gamete intrafallopian transfer (GIFT) are used to treat intractable infertility in women with no distortion of the pelvic viscera, despite the lack of controlled trials demonstrating efficacy. The mechanism of any purportedly enhanced cycle fecundity in ovulatory...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Dodson WC,Whitesides DB,Hughes CL Jr,Easley HA 3rd,Haney AF

    更新日期:1987-09-01 00:00:00

  • Electroejaculation before chemotherapy in adolescents and young men with cancer.

    abstract:OBJECTIVE:To evaluate the outcome of repeated electroejaculation for obtaining semen from adolescents and young men before initiation of anticancer therapies. DESIGN:Retrospective clinical study. SETTING:Bikur Cholim Hospital, Jerusalem, Israel. PATIENT(S):Six young male patients (average age, 18+/-3 years) with dia...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hovav Y,Dan-Goor M,Yaffe H,Almagor M

    更新日期:2001-04-01 00:00:00

  • Assessing the quality of oocytes derived from in vitro maturation: are we looking under the lamppost?

    abstract::Oocytes are complex cells comprising many cellular systems, each of which is essential for proper oocyte function. Methods to assess the diverse and critical cellular systems in oocytes derived from in vitro maturation are badly needed. ...

    journal_title:Fertility and sterility

    pub_type: 评论,杂志文章,评审


    authors: Trimarchi JR,Keefe DL

    更新日期:2006-04-01 00:00:00