Abstract:
OBJECTIVE:To evaluate the levels of interleukin-1beta (IL1beta) and its inhibitory soluble interleukin-1 receptor type II (IL1R2) in the peritoneal fluid (PF) of normal women and patients with endometriosis suffering from pelvic pain and infertility. DESIGN:Retrospective study using ELISA to measure peritoneal fluid IL1beta and soluble IL1R2. SETTING:Gynecology clinic and human reproduction research laboratory. PATIENT(S):Sixty-eight normal women and 154 women with endometriosis. INTERVENTION(S):Peritoneal fluid samples were obtained at laparoscopy. MAIN OUTCOME MEASURE(S):IL1beta and soluble IL1R2 concentrations in the PF samples. RESULT(S):This study showed a marked decrease in peritoneal soluble IL1R2 levels in women with endometriosis compared to normal women and a concomitant increase in the levels of IL1beta. Both fertile and infertile women with endometriosis had lower soluble IL1R2 and higher IL1beta concentrations than fertile women having a normal gynecological status, but the difference was more significant in infertile endometriosis patients. Compared with normal controls, the decrease in soluble IL1R2 levels was less significant in women with endometriosis than without pelvic pain, whereas the increase in IL1beta concentrations was statistically significant only in women with endometriosis reporting pelvic pain. CONCLUSION(S):This study revealed an imbalance between IL1beta and its decoy inhibitory receptor type 2 in women with endometriosis, which was particularly obvious in those who were infertile, and suggests that a defect in the local control of IL1 may be involved in the pathophysiology of endometriosis and related infertility.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Akoum A,Al-Akoum M,Lemay A,Maheux R,Leboeuf Mdoi
10.1016/j.fertnstert.2007.06.019subject
Has Abstractpub_date
2008-06-01 00:00:00pages
1618-24issue
6eissn
0015-0282issn
1556-5653pii
S0015-0282(07)01362-3journal_volume
89pub_type
杂志文章abstract:OBJECTIVE:To report a case of monochorionic, diamniotic twin pregnancy diagnosed at 6 weeks of pregnancy with three-dimensional (3D) transvaginal sonography and to discuss the use of this diagnostic method in the evaluation of multifetal pregnancy in the first trimester. DESIGN:Case report. SETTING:University-based I...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00132-6
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To correlate apoptosis of cultured human granulosa-lutein cells (GL cells) with the outcome of IVF (embryo fragmentation and pregnancy rate) and to study the effect of insulin and insulin-like growth factor I (IGF-I) on apoptosis. DESIGN:In vitro assays. SETTING:University laboratory and private IVF center....
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.08.014
更新日期:2006-02-01 00:00:00
abstract::One hundred forty-seven cycles in normal ovulatory patients are reported. All were stimulated with human menopausal/human chorionic gonadotropin. Three estrogen responses were identified: normal, high, and low. Patients who achieved pregnancy formed a fourth category, the pregnancy group. The number of preovulatory an...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47590-4
更新日期:1984-02-01 00:00:00
abstract:OBJECTIVE:To assess the role of the variant p.Asn680Ser in the follicle-stimulating hormone receptor (FSHR) gene in determining ovarian response in patients undergoing in vitro fertilization (IVF) treatment. DESIGN:Prospective observational study. SETTING:Tertiary referral center for reproductive medicine. PATIENT(S...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.08.037
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To compare the agonist flare-up and antagonist protocols in the management of poor responders to the standard long down-regulation protocol. DESIGN:Retrospective comparative study. SETTING:Assisted conception center. PATIENT(S):One hundred thirty-four patients undergoing IVF/ intracytoplasmic sperm injecti...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.07.963
更新日期:2005-02-01 00:00:00
abstract::Rhesus monkeys develop agglutinating and complement-dependent antisperm antibodies after vasectomy. In order to study whether these antibodies affect fertility after vasovasostomy, 15 animals were given vasectomies and 6 months later vasovasostomies. Subsequently, each was mated with females of proven fertility. Five ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1977-05-01 00:00:00
abstract::The concentrations of pregnanediol-3-glucuronide (PGD) and pregnanolone (PN) were measured in daily morning urine specimens from 66 infertile women (40 with varying degrees of endometriosis and 26 control subjects) and correlated with daily changes in basal body temperature (BBT) and with midluteal levels of serum pro...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which is known to exert death-inducing as well as nonapoptotic functions, has been shown to be expressed by the early trophoblast. Here we report that TRAIL has no apoptotic effects on human endometrial stromal cells, but differentially regulates cytokin...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.04.017
更新日期:2009-10-01 00:00:00
abstract::Antiphospholipid syndrome patients with recurrent miscarriage have an impairment in fibrinolysis demonstrated by prolonged clot lysis time (CLT) that cannot be attributed to differences in thrombin activatable fibrinolysis inhibitor (TAFI) antigen levels. Patients with unexplained recurrent miscarriage have an impairm...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.02.032
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To review the current literature on genes known to affect fertility in the human and mouse. DESIGN:A literature review was performed and key articles were chosen for focus in the areas of genes with effects only on spermatogenesis and oogenesis, with an emphasis on Y-chromosome-encoded gene families and sper...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(98)00071-5
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:To analyze the activity of cytosolic carbonic anhydrases (CAs) during the pre- and postimplantation stages of pregnancy in mice. Furthermore, to investigate the CA activity in mice in which abortion was induced by injection of substance P. DESIGN:Controlled animal experiment. SETTING:University research lab...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.03.033
更新日期:2004-10-01 00:00:00
abstract::A new flexible protocol for the induction of recipient endometrial cycles is presented. For stimulation of endometrial growth, a fixed dose of conjugated estrogens, 3.75 mg/d was employed. The duration of the proliferative phase varied from 9 to 14 days, thus being adjusted to match the length of the follicular phase ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60988-3
更新日期:1989-10-01 00:00:00
abstract::A new sperm isolation technique was studied in conjunction with the short-term freeze preservation of human spermatozoa. The isolation procedure yielded subpopulations of spermatozoa with very high percentage motility and progressive motility score, and which were virtually free of seminal debris. For 24 semen samples...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)42196-5
更新日期:1976-11-01 00:00:00
abstract:OBJECTIVE:To determine Müllerian inhibiting substance (MIS) levels in follicular fluid (FF) and sera of IVF patients. DESIGN:Prospective study. SETTING:Fertility center. PATIENT(S):Sixty-six patients: 20 with tubal factor infertility, 17 with polycystic ovary syndrome (PCOS), and 29 with endometriosis. INTERVENTION...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)81417-3
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:To examine changes in blood flow in the corpus luteum throughout the luteal phase and during early pregnancy. DESIGN:Longitudinal and cross-sectional prospective studies. SETTING:University hospital and city general hospital. PATIENT(S):Sixty-one women with normal menstrual cycles and normal luteal functio...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2007.10.056
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To achieve maximum post-thaw survival of frozen embryos. DESIGN:Historical controlled study. SETTING:Hospital-based fertility center. PATIENT(S):One hundred forty-five patients whose embryos were frozen and thawed according to the standard method, and 56 patients whose embryos were frozen and thawed accord...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.04.054
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To analyze the HOXA10 genes in CAUV patients for mutations. Congenital absence of the uterus and vagina (CAUV) is the most extreme female reproductive tract developmental defect known. The HOXA10 gene is expressed in the developing and adult uterus. Female mice with loss-of-function Hoxa10 gene mutations have...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.03.033
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:To investigate the mutation profiles and clinical characteristics of Chinese males with isolated hypogonadotropic hypogonadism (IHH) and discover new pathogenic genes that cause IHH. DESIGN:A gene panel, including 31 known IHH genes and 52 candidate genes, was used to perform semiconductor next-generation se...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2018.04.010
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:To review osteoporosis, a disease characterized by low bone mass, microarchitectural deterioration of bone tissue leading to increased bone fragility and a consequent increase in fracture risk. The disorder has become a major health problem in the West, where increased life expectancy has placed new emphasis ...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:
更新日期:1994-12-01 00:00:00
abstract:OBJECTIVE:To report the case of a woman with Kartagener's syndrome with complete immotility of ciliae and normal transport of spermatozoa. DESIGN:Case report. PATIENTS:A 31-year-old woman with Kartagener's syndrome. SETTING:Medical university-affiliated teaching hospital. INTERVENTION(S):Ultrasonography, hysterosal...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.12.079
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To compare pregnancy rates (PRs) using blastocysts cryopreserved on day 7 with those cryopreserved on days 5 and 6. DESIGN:Retrospective observational cohort study. SETTING:Infertility center performing IVF. PATIENT(S):Eight hundred women with infertility undergoing frozen ET. INTERVENTION(S):Blastocysts ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.06.021
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:To develop a consensus regarding the need for luteal phase support during assisted reproductive technology (ART), and to establish the optimal compound and route of administration for this purpose. DESIGN:Review of the published literature on luteal phase support. PATIENT(S):Women undergoing assisted reprod...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(01)02961-2
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:To report a case of laparoscopic repair of bilateral inguinal hernias in a patient with müllerian agenesis. DESIGN:Case report. SETTING:Hospital. PATIENT(S):An 18-year-old woman with müllerian agenesis who presented with symptomatic inguinal hernias containing ovaries. INTERVENTION(S):Laparoscopic repair ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(00)00541-0
更新日期:2000-06-01 00:00:00
abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.08.053
更新日期:2013-10-07 00:00:00
abstract:OBJECTIVE:To determine whether NR5A1 (SF-1) variants are a cause of primary ovarian insufficiency (POI) in 26 young women with similar genetic background. DESIGN:Genetic and functional mutation study. SETTING:University hospitals. PATIENT(S):Genetic analysis of the NR5A1 gene in 26 XX girls with POI. INTERVENTION(S...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.10.026
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:The study was performed to evaluate the correlation between sperm motility index, a novel parameter of semen quality, and routine semen analysis parameters by microscopic evaluation. DESIGN:Sperm motility index was measured by an electro-optical device, the Sperm Quality Analyzer (United Medical Systems Inc....
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)54427-6
更新日期:1991-07-01 00:00:00
abstract::Seminal plasma (n = 12) from cystic fibrosis (CF) patients were analyzed by gel-electrophoresis using seminal plasma and expressed prostatic secretion from fertile men as controls. Heavy precipitation at the entering position of the gel and streaking in the gel matrix was observed, demonstrating a reduced solubility o...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53354-8
更新日期:1990-03-01 00:00:00
abstract::This bulletin will review the various viral etiologies of hepatitis, their mode of transmission, and implications for infertile couples, pregnant women, and health care workers. ...
journal_title:Fertility and sterility
pub_type: 杂志文章,实务指引,评审
doi:10.1016/j.fertnstert.2006.08.081
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To develop an experimental model for embryos with a defect specific to hatching, with the purpose of clarifying the mammalian embryo hatching mechanism. DESIGN:A microneedle was inserted under the zona pellucida (ZP) of mouse embryos, and either 1/2 or 1/4 of the blastomeres were mechanically destroyed. The ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55993-7
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVE:To investigate the ability of N-formyl-methionyl-leucyl-phenylalanine (f-MLP), complement 5a (C5a), and nerve growth factor (NGF) to stimulate human spermatozoal reactive oxygen species generation in fertile and infertile patients. DESIGN:Prospective, controlled study measuring human spermatozoal reactive ox...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55874-9
更新日期:1993-04-01 00:00:00