Abstract：
OBJECTIVE:To analyze the activity of cytosolic carbonic anhydrases (CAs) during the pre- and postimplantation stages of pregnancy in mice. Furthermore, to investigate the CA activity in mice in which abortion was induced by injection of substance P. DESIGN:Controlled animal experiment. SETTING:University research laboratory. ANIMAL(S):A total of 75 ICR mice (weight between 20-25 g) that showed two consecutive 4-day cycles. INTERVENTION(S):Substance P (2.4 microg/g) or CA inhibitor (100 microg/g), or both, were administered. Decidualized uterine tissues were collected on days 0.5-10.5 after administration. MAIN OUTCOME MEASURE(S):The activity, protein expression pattern, and mRNA level of decidual cytosolic CAs. RESULTS:The abortion induced by injection of substance P led to an aberrant expression of cytosolic CA and a decreased number of embryos. Furthermore, substance P-induced abortion could be effectively inhibited by CA inhibitors. CONCLUSIONS:Cytosolic CAs, especially CA II, may act as negative regulators in implantation, development, and maintenance of the pregnancy and therefore, this information could be further applied in developing therapies for human sterility.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Chiang WL,Liu JY,Liao CY,Yang SF,Hsieh YS,Chu SCdoi
10.1016/j.fertnstert.2004.03.033keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
1095-100eissn
0015-0282issn
1556-5653pii
S0015-0282(04)01103-3journal_volume
82 Suppl 3pub_type
杂志文章abstract：:Asherman's syndrome is described in today's context. Meaningful literature as it relates to the description and management of this entity is reviewed, and the forms of treatment used at the Hospital of the University of Pennsylvania or at the Philadelphia General Hospital are presented. Asherman's syndrome describes...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)39918-6
更新日期：1973-09-01 00:00:00
abstract：OBJECTIVE:To develop and validate a simple method of measuring total menstrual blood loss using a pictorial representation of blood loss, the menstrual pictogram. DESIGN:A prospective evaluation of total menstrual blood loss measurement by the menstrual pictogram compared to the alkaline hematin technique. SETTING:Ac...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)01847-7
更新日期：2001-07-01 00:00:00
abstract：:One hundred fifty-eight women underwent artificial insemination with homologous semen (AIH) in an attempt to achieve conception. Only 15 (9.5%) were successful. Women with anatomical abnormalities were not excluded from the study and they were less successful than the normal women, but results were disappointing in bo...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41894-7
更新日期：1976-06-01 00:00:00
abstract：OBJECTIVE:In rodents, evidence suggests that the leptin system is mandatory for embryonic implantation. We aimed to investigate the functional relevance of the endometrial leptin receptor (OB-R) in the adhesion phase of human implantation. DESIGN:We used an in vitro model for embryonic adhesion, composed of a human en...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.12.028
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:To determine whether there is significant quality of life score improvement after uterine artery embolization (UAE) and to compare UAE and myomectomy outcomes. DESIGN:Prospective cohort controlled study. SETTING:Sixteen medical centers in the United States. PATIENT(S):One hundred forty-nine UAE patients an...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2005.05.074
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:To evaluate by serial ultrasound scans how long a Ringer's lactate instillation remains in the peritoneal cavity after laparoscopy. DESIGN:Prospective, randomized, double blind, clinical trial. SETTING:Tertiary care, university hospital. PATIENT(S):Thirty-six patients undergoing diagnostic or minor operati...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2005.01.111
更新日期：2005-07-01 00:00:00
abstract：:Solid-phase enzyme immunoassays, based on monoclonal antibodies reactive with different forms of human placental-type alkaline phosphatases, were applied to their detection in human seminal plasma from fertile and infertile men. The placental-like form of alkaline phosphatase (PLAP-like AP), known to occur in testicul...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1986-11-01 00:00:00
abstract：OBJECTIVE:To investigate the role of different cellular types (epithelial and stromal endometrial cells and peritoneal cells) in the ectopic implantation of endometrium and to evaluate the importance of endocrine environment on the adhesion of endometrial cells to the peritoneum. DESIGN:Experimental prospective study....
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)03370-8
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVE:To determine, in rats, how surgically induced endometriosis and a control surgery (partial hysterectomy; sutures in abdomen) affects micturition thresholds and bladder vascular permeability. DESIGN:Two animal studies, each performed in three groups of urethane-anesthetized rats in proestrus. SETTING:Academi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.03.026
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:To study the regulatory mechanisms of selective intrauterine growth restriction (sIUGR) independent of confounding genetic factors, monochorionic (MC) twins are the ideal model, because they have identical genomic DNA. We hypothesize that the intrauterine growth restriction fetus has mitochondrial activation ...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2013.03.003
更新日期：2013-07-01 00:00:00
abstract：:Luteinization of an unruptured ovarian follicle has been reported as a cause of infertility and has heretofore been diagnosed only by direct visualization of the ovarian surface. Four patients who demonstrated defects in ovulation requiring therapy to induce ovulation and who were not achieving desired conception desp...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)46160-1
更新日期：1982-04-01 00:00:00
abstract：OBJECTIVE:To determine the expression profiles of the DAZ gene family in men with and without spermatogenic failure. DESIGN:Prospective case study. SETTING:University-based reproductive clinics and genetics laboratory. PATIENT(S):Thirty-four infertile men presenting with azoospermia. INTERVENTION(S):The mRNA transc...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2003.08.047
更新日期：2004-04-01 00:00:00
abstract：OBJECTIVE:To compare the agonist flare-up and antagonist protocols in the management of poor responders to the standard long down-regulation protocol. DESIGN:Retrospective comparative study. SETTING:Assisted conception center. PATIENT(S):One hundred thirty-four patients undergoing IVF/ intracytoplasmic sperm injecti...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.07.963
更新日期：2005-02-01 00:00:00
abstract：:Cosmetics contain a vast number of chemicals, most of which are not under the regulatory purview of the Food and Drug Administration. Only a few of these chemicals have been evaluated for potential deleterious health impact: parabens, phthalates, polycyclic aromatic hydrocarbons, and siloxanes. A review of the ingredi...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2016.08.020
更新日期：2016-09-15 00:00:00
abstract：:Uterus transplantation research has been conducted toward its introduction in the human as a treatment of absolute uterine-factor infertility, which is considered to be the last frontier to conquer for infertility research. In this review we describe the patient populations that may benefit from uterus transplantation...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2012.04.001
更新日期：2012-06-01 00:00:00
abstract：:Blood glucose and plasma insulin levels were measured during an oral glucose tolerance test in 18 women before and after 3 months' use of a low-estrogen oral contraceptive containing 0.035 mg of ethinylestradiol and 0.5 mg of norethindrone. There was no significant change in either of these two metabolic parameters. I...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)45620-7
更新日期：1981-07-01 00:00:00
abstract：:Endometriosis has been associated with corpus luteum inadequacy and abnormalities of luteal phase progesterone (P) secretion. In this study, abnormal luteolysis, as a second factor of luteal dysfunction, was assessed in 13 women with endometriosis and 25 control patients by measurement of ovarian vein estradiol (E2) a...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)59224-3
更新日期：1987-06-01 00:00:00
abstract：OBJECTIVE:To describe the prevalence of annexin V antibodies (aANX) in women with early recurrent pregnancy losses (RPLs) or recurrent IVF-ET failure. DESIGN:Retrospective data analysis. SETTING:Tokai University Hospital, Kanagawa, Japan. PATIENT(S):Two hundred thirty-eight patients with RPLs, 48 patients with recur...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)02009-x
更新日期：2001-10-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of P, medroxyprogesterone acetate (MPA), and dydrogesterone (DYD) and its metabolite, 20-alpha-dihydrodydrogesterone (DHD) on endothelial synthesis of nitric oxide (NO) and characterize the signaling events recruited by these compounds. The Women's Health Initiative trial reports an...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.05.018
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:To examine changes in blood flow in the corpus luteum throughout the luteal phase and during early pregnancy. DESIGN:Longitudinal and cross-sectional prospective studies. SETTING:University hospital and city general hospital. PATIENT(S):Sixty-one women with normal menstrual cycles and normal luteal functio...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2007.10.056
更新日期：2008-12-01 00:00:00
abstract：OBJECTIVE:To quantify the in vitro effects of gonadotropins on benign, borderline, and malignant ovarian cell lines. DESIGN:In vitro cell culture. SETTING:Research laboratory. PATIENT(S):None. INTERVENTION(S):Three hormonally sensitive ovarian neoplastic cell lines were exposed to control medium, FSH (40 mIU/mL), h...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)03367-8
更新日期：2002-11-01 00:00:00
abstract：:The pharmacokinetic characteristics of RU486 and its acute effects on anterior pituitary hormone secretion after oral administration were examined in six normal women. Serum RU486 concentrations were determined by a radioimmunoassay. The absorption of RU486 was rapid with peak serum levels reached approximately 90 min...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60067-5
更新日期：1988-08-01 00:00:00
abstract：OBJECTIVE:To analyze the data available on the biologic significance of white blood cells (WBC) in semen of infertility patients. DATA RESOURCES:The relevant literature was reviewed. RESULTS:It is not possible to identify reliably WBC by conventional sperm staining techniques. The peroxidase method is sufficient for ...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(16)57588-8
更新日期：1995-06-01 00:00:00
abstract：OBJECTIVE:To determine whether antisperm autoantibody production after prepubertal vas injury is influenced by immediate repair of the vas compared to delay of the reanastomosis until sexual maturity. DESIGN:Animal study comparing early repair, late repair, and sham-operated groups. SETTING:Research laboratory in a m...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(99)00501-4
更新日期：2000-02-01 00:00:00
abstract：:Osteoporosis continues to be a major public health challenge in both women and men. There are more than 2 million low-impact fractures in the United States every year, 39% of which occur in men. The mortality rate in the first year after hip fracture is estimated at 20% to 25% in women and is even higher in men. The g...
journal_title：Fertility and sterility
pub_type：
doi：10.1016/j.fertnstert.2019.10.004
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVE:To identify and characterize a novel sperm motility-stimulating protein (MSP) from caprine serum. DESIGN:Prospective experimental study. SETTING:Research laboratory. ANIMAL(S):Rabbits and male and female BALB/c mice. INTERVENTION(S):Protein purification by conventional methods and functional and immunolog...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.03.012
更新日期：2013-07-01 00:00:00
abstract：:Transvaginal follicular aspiration (TVA) with ultrasonically guided needles allows the transfer of in vitro generated embryos to the fallopian tubes (TET), performing only one surgical procedure in the process. Up to now, this approach has been used to treat 16 couples with infertility due to severe male factor. Folli...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60136-x
更新日期：1988-09-01 00:00:00
abstract：:Varicocelectomy has been found to improve the spermogram in many subfertile men. However, there still remains a sizable group of subfertile men whose counts fail to improve sufficiently following surgery. Clomiphene citrate, which has been shown to improve fertility in idiopathic oligospermia, was similarly tried in m...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)44661-3
更新日期：1980-04-01 00:00:00
abstract：OBJECTIVE:To investigate the association of AMH and AMHRII polymorphisms with reproductive abilities in a sample of women with idiopathic infertility. DESIGN:Case-control study. SETTING:University Department of Obstetrics and Gynecology, and University Unit of Clinical Genetics. PATIENT(S):76 women with idiopathic s...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.05.025
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVE:To systematically compare the endometrial microbiota in infertile women with and without chronic endometritis (CE), as diagnosed by a quantitative and reference range-based method. DESIGN:Case-control observational study. SETTING:University-affiliated hospital. PATIENT(S):One hundred and thirty infertile w...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2019.05.015
更新日期：2019-10-01 00:00:00
