Abstract:
OBJECTIVE:To investigate the role of different cellular types (epithelial and stromal endometrial cells and peritoneal cells) in the ectopic implantation of endometrium and to evaluate the importance of endocrine environment on the adhesion of endometrial cells to the peritoneum. DESIGN:Experimental prospective study. SETTING:University hospital, department of cell biology. ANIMAL(S):One hundred one nude mice. INTERVENTION(S):Monolayer culture of human epithelial and stromal endometrial cells obtained from patients undergoing hysterectomy or laparoscopy for benign disease. Intraperitoneal injection of cells into nude mice. MAIN OUTCOME MEASURE(S):Two weeks after cell injection, adhesion of endometrial cells was evaluated by histological and immunohistochemical examination. RESULT(S):Mixed cultures of stromal and epithelial cells, but not purified epithelial or stromal cells alone, adhered to the mouse peritoneum and led to endometriotic-like nodules. Pretreatment of cells with estrogen alone or with estrogen and progestin resulted in a higher percentage of animals developing endometriotic-like nodules, whereas treatment with progestin alone did not affect endometriotic implantation. CONCLUSION(S):Our data indicate that the success of endometrial cell implantation is dependent on the cooperativeness between stromal and epithelial endometrial cells, as well as on the endocrine environment of endometrial cells, but not that of recipient animals. The results emphasize the role of both endometrial cell types for ectopic implantation.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Beliard A,Noël A,Goffin F,Frankenne F,Foidart JMdoi
10.1016/s0015-0282(02)03370-8keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
973-8issue
5eissn
0015-0282issn
1556-5653pii
S0015028202033708journal_volume
78pub_type
杂志文章abstract:OBJECTIVE:To determine whether the oncofetal protein IMP3 is detectable in endometriomas with or without histological atypia and whether IMP3 staining can be used as a triage tool to identify foci of atypical endometriosis in doubtful cases. DESIGN:Retrospective study. SETTING:Academic department and referral center ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.02.002
更新日期:2013-06-01 00:00:00
abstract::The role of the macromolecular constituents of human oviductal fluid (hOF) in reproductive physiology is poorly understood. Oviductal fluid contains proteins derived by transudation from serum and those synthesized and secreted by the tubal mucosa. In this communication, we describe purification of hOF-specific protei...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60433-8
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:To compare the pregnancy rates (PR) and live birth rates in once- versus twice-frozen ET treatment cycles in the same cohort of women. DESIGN:A retrospective study. SETTING:Fertility clinics, IVF Australia, New South Wales. PATIENT(S):The study population was all women who underwent thawing of twice-frozen...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.04.034
更新日期:2011-07-01 00:00:00
abstract::A surrogate end point (e.g., a laboratory test or image) serves as a proxy for a clinical end point of importance (e.g., fracture, thrombosis, or death). Adoption and use of surrogate end points lacking validation, especially in cardiovascular medicine, have caused thousands of patients' deaths, a serious violation of...
journal_title:Fertility and sterility
pub_type: 社论,评审
doi:10.1016/j.fertnstert.2009.12.054
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To report a case of a gonadotroph adenoma diagnosed after a dramatic increase in estradiol level and ovarian hyperstimulation in response to a gonadotropin-releasing hormone agonist. DESIGN:Case report. SETTING:Outpatient practice and university hospital. PATIENT(S):A 35-year-old woman who presented with i...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)04342-x
更新日期:2002-12-01 00:00:00
abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.08.053
更新日期:2013-10-07 00:00:00
abstract:OBJECTIVE:To assess how genetic evaluations of sperm donor applicants are performed in the United States. DESIGN:A questionnaire was designed to assess: 1) the professionals involved in the family history evaluation and genetic screening; 2) the genetic testing, counseling, and informed consent processes; and 3) how t...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2013.01.093
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To evaluate whether the use of theophylline improves sperm motility and treatment outcome in frozen-thawed testicular sperm extraction (TESE). DESIGN:Artificial sperm activation was offered to azoospermic patients between January and October 2010 in two different centers (identical lab conditions). SETTING:...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.08.041
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To investigate whether unplanned or poorly timed pregnancies (self-reported at enrollment) are associated with preterm or small for gestational age births. DESIGN:Prospective cohort study. SETTING:Not applicable. PATIENT(S):Two thousand six hundred fifty-four pregnant women <18 weeks estimated gestational ...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2015.08.012
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:To develop a murine in vivo bioassay that is sensitive to inherent variability of hMG. DESIGN:Female F1 hybrid mice were mated after injection with fixed dosages of each of four lots of hMG. Oocytes/embryos were collected and monitored during 5 days of culture. Outcome measures were compared with retrospecti...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56414-0
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the association of oocyte donor-recipient characteristics, oocyte donor response, and live birth pregnancy rate following fresh donor oocyte IVF-ET. DESIGN:Retrospective cohort study. SETTING:Academic reproductive medicine practice. PATIENT(S):Two hundred thirty-seven consecutive fresh donor oo...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2017.05.021
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of hypoxia on the production of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in the human fallopian tube. DESIGN:The secretion of VEGF and sFlt-1 by cultured oviductal epithelial cells (OECs) and oviductal stromal fibroblasts (OSFs) in respo...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.10.023
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:To review selected environmental, occupational, and other important risk factors for the following adverse pregnancy outcomes: low birth weight (LBW), intrauterine growth retardation (IUGR), and preterm delivery (PTD). DESIGN:The evidence is explored in greater detail for environmental tobacco smoke, drinkin...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2007.12.041
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the pregnancy and delivery outcome of robot-assisted tubal reanastomosis. DESIGN:Retrospective cohort study. SETTING:University hospital. PATIENT(S):Ninety-seven patients with available follow-up who underwent the reversal of tubal ligation, with a median age of 37 years (range, 24-47 years). ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.10.028
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To identify if there are certain cutoff levels for P and or the P/E(2) ratio on the day of hCG that would be defined as detrimental for occurrence of pregnancy in women with normal ovarian reserve undergoing cleavage-stage embryo transfer (ET). Secondarily, to determine if these same cutoffs might have the sa...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2010.12.065
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To compare the clinical outcome of controlled ovarian hyperstimulation (COH) in unselected patients undergoing IVF using multidose ganirelix acetate versus 4 days of administration of leuprolide acetate. DESIGN:Retrospective cohort study. SETTING:A fertility and IVF center. PATIENT(S):Two hundred forty-sev...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(03)00500-4
更新日期:2003-07-01 00:00:00
abstract::To understand the mechanism of action of danazol, the binding of danazol to multiple classes of intracellular steroid binding proteins was studied in the human uterine endometrium. Danazol bound to endometrial receptors for estrogen, progesterone, and androgen and seemed to bind to endometrial intracellular corticoste...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47840-4
更新日期:1984-05-01 00:00:00
abstract:OBJECTIVE:To compare blastocyst production, after IVF and ICSI, from sheep oocytes of various quality. Sham-injected oocytes and parthenogenetic activated oocyte groups were considered as control. DESIGN:Prospective experimental study. SETTING:University. ANIMAL(S):Three- to 6-month-old sheep. INTERVENTION(S):Oocyt...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.12.043
更新日期:2012-04-01 00:00:00
abstract::Expanded carrier screening refers to identification of carriers of single-gene disorders outside of traditional screening guidelines. New genetic testing technologies allow for such screening at costs that are comparable to single-gene testing. There is a high degree of variability among genetic testing laboratories a...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2017.11.030
更新日期:2018-02-01 00:00:00
abstract::Fresh semen specimens from fertile donors were subjected to one-step and two-step washings in six various commonly used artificial media. It was found that washing procedures per se, in most cases, had an immediate and extended harmful effect on sperm motility which was much more prominent after the second washing. Ho...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)45441-5
更新日期:1981-04-01 00:00:00
abstract:OBJECTIVE:To determine the expression of glutathione peroxidase (GPx) in the eutopic and ectopic endometria during the menstrual cycle in endometriosis and adenomyosis. DESIGN:Immunohistochemical identification of GPx in endometrial tissues identified using the polyclonal antibody. SETTING:Department of obstetrics an...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(00)00638-5
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVE:To assess the association of total isoflavone intake with ovulatory function, including sporadic anovulation in healthy premenopausal women. DESIGN:Prospective cohort study. SETTING:University. PATIENT(S):Participants included 259 healthy regularly menstruating women aged 18-44 years. INTERVENTION(S):None...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.08.002
更新日期:2013-12-01 00:00:00
abstract::The effects of estradiol (E2) administered by a transdermal system on the induction of hypothalamic opioid activity was examined in 18 postmenopausal women. Women were given 25, 50, 100, or 200 micrograms/d dosages of E2 for 28 days each. Naloxone at a dosage of 2 mg/h was infused intravenously for 4 hours, and serum ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract:OBJECTIVE:To evaluate whether the telomere length of white blood cells (WBC) and cumulus cells (CC) in an infertile population is associated with ovarian and embryonic performance. DESIGN:Prospective cohort study. SETTING:Academic-affiliated private practice. PATIENTS:A total of 175 infertile women undergoing in vit...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2020.09.164
更新日期:2020-11-30 00:00:00
abstract:OBJECTIVE:To compare ovarian response to hyperstimulation during IVF between patients who did and did not undergo salpingectomy. DESIGN:Meta-analysis. SETTING:University-affiliated teaching hospital. PATIENT(S):Patients undergoing IVF who did and did not undergo salpingectomy. INTERVENTION(S):None. MAIN OUTCOME ME...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.fertnstert.2016.03.053
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence and potential causes of reverse cleavage (RC) by human early-cleavage embryos and its associations with embryonic development and implantation after transfer. DESIGN:Clinical retrospective cohort study. SETTING:Private fertility treatment center. PATIENT(S):A total of 126 cons...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.07.1235
更新日期:2014-11-01 00:00:00
abstract::Suppressor activity in in vitro fertilization (IVF) culture medium correlates with successful implantation. High performance liquid chromatography fractionation revealed peak(s) of inhibitory activity in the 1,000- to 5,000-Da molecular weight range. Inhibitory activity was dependent on the presence of fetal bovine se...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:To identify biomarkers associated with reproductive outcome using proton nuclear magnetic resonance ((1)H NMR) metabolomic profiling of embryo culture media. DESIGN:Retrospective study. SETTING:An academic assisted reproductive technology (ART) program; a university research center. PATIENT(S):Women underg...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.07.1739
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To investigate for differences in reproductive hormone levels in male relatives of women with polycystic ovary syndrome (PCOS). DESIGN:Cross-sectional study. SETTING:Academic medical center. PATIENT(S):Sixty-three fathers and 66 brothers of women with PCOS as well as two groups of control men of comparable...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.03.029
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the use of sonohysterography for uterine screening before IVF. DESIGN:Prospective screening with sonohysterography and comparison with available hysterosalpingographic and hysteroscopic evaluations. SETTING:Private practice. PATIENT(S):Seventy-two women undergoing IVF-ET using their own or dono...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(98)00045-4
更新日期:1998-05-01 00:00:00