Abstract：
OBJECTIVE:To assess how genetic evaluations of sperm donor applicants are performed in the United States. DESIGN:A questionnaire was designed to assess: 1) the professionals involved in the family history evaluation and genetic screening; 2) the genetic testing, counseling, and informed consent processes; and 3) how the results of genetic evaluations and new risk information is communicated to donors. SETTING:Semen donor facilities. PARTICIPANT(S):Representatives of semen donor facilities. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Descriptive data. RESULT(S):Thirteen responses were received. All of the facilities assessed donors' family histories; eight of the facilities (62%) routinely informed donors about the results of these evaluations. At the majority of facilities (10/13), informed consent for genetic testing is obtained as part of the overall contract to be a sperm donor. Genetic counselors are employed full-time at two facilities and part-time at five others. CONCLUSION(S):There is variability in the education and informed consent processes for semen donor applicants, including variable communication about the limitations of genetic tests and the potential implications for the donors' own children. Further research into the best practices for education and consent for sperm donor applicants may be beneficial to ensure the well-being of the donors and their future offspring.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Isley L,Callum Pdoi
10.1016/j.fertnstert.2013.01.093subject
Has Abstractpub_date
2013-05-01 00:00:00pages
1587-91issue
6eissn
0015-0282issn
1556-5653pii
S0015-0282(13)00136-2journal_volume
99pub_type
杂志文章,多中心研究abstract：OBJECTIVE:To compare pathologic characteristics and epidemiologic risk factors for uterine fibroids in African American and white women undergoing hysterectomy. DESIGN:Cross-sectional analysis of women undergoing premenopausal hysterectomy. SETTING:Two university-associated hospitals in North Carolina. PATIENT(S):Af...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2012.10.039
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVE:To investigate danazol's effect in vitro and in vivo on the ability of peripheral blood monocytes (PBM) from women with endometriosis to stimulate endometrial cell proliferation. DESIGN:Uterine endometrial cells from untreated or danazol-treated patients with endometriosis were cultured with or without autol...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:Although salpingitis frequently produces tubal damage and infertility, many women with tubal factor as a cause of their infertility do not have a clinical history of salpingitis. In order to investigate whether or not some such cases might be due to subclinical chlamydial infections, we measured antichlamydial antibod...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)46634-3
更新日期：1982-11-01 00:00:00
abstract：OBJECTIVE:To assess live-birth defects after a luteal-phase ovarian-stimulation regimen (LPS) for in vitro fertilization (IVF) and vitrified embryo transfer (ET) cycles. DESIGN:Retrospective cohort study. SETTING:Tertiary-care academic medical center. PATIENT(S):Infants who were born between January 1, 2013 and May ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.02.020
更新日期：2015-05-01 00:00:00
abstract：:Evidence from more than 14,000 reproductive histories in the Collaborative Perinatal Project of the National Institute of Neurological and Communicative Disorders and Stroke indicates that the risk of spontaneous abortion increases considerably with gravidity. Maternal age, memory errors, and sampling bias related to ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
abstract：:This report describes our initial experience with elective single blastocyst transfer in 19 patients who had a mean age of 36.3 +/- 2.4 years. The ongoing pregnancy rate, 53% after the fresh embryo transfer and 68% when thaw cycles are included, suggests that single blastocyst transfer has a place in this relatively o...
journal_title：Fertility and sterility
pub_type： 信件
doi：10.1016/j.fertnstert.2003.10.050
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:To study the apparent association between interstitial fallopian tube polyps and isthmic tubal dilatation. DESIGN:Retrospective clinical study. SETTING:Tertiary academic medical center. PATIENT(S):Sixty-five patients with normal hysterosalpingograms and 40 patients with interstitial tubal polyps (25 unilat...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.10.049
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:To identify the value that women with pelvic inflammatory disease (PID) assign to the health impact of future infertility. DESIGN:Cross-sectional observations on patient preferences. SETTING:Participants in an existing multicenter clinical trial of PID treatment options. PATIENT(S):Five hundred thirty-two ...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2003.09.064
更新日期：2004-05-01 00:00:00
abstract：:Since the advent of preimplantation genetic testing for aneuploidy (PGT-A) in the 1990s, substantial changes in test methodology and technology now allow the detection and reporting of intermediate chromosome copy number (commonly referred to as mosaicism) for aneuploidy in a trophectoderm biopsy sample. Clinicians ar...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2020.05.014
更新日期：2020-08-01 00:00:00
abstract：:In this study of 132 infertile couples, findings with hysterosalpingography (HSG) were compared with those observed at subsequent culdoscopy or laparoscopy. Both procedures correctly revealed normal tubes in 29% of the subjects and identical abnormalities in 24%. A complete agreement between the two procedures was thu...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41531-1
更新日期：1975-12-01 00:00:00
abstract：:We have developed an enzyme-linked immunosorption assay (ELISA) with an antigen extract made by treatment of freeze-thawed sperm pools with 0.3 M lithium 3,5-diiodosalicylate (LIS). This procedure is quick, safe, and simple to perform in a clinical laboratory. When the LIS antigen preparation was compared by ELISA wit...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)47603-x
更新日期：1984-02-01 00:00:00
abstract：OBJECTIVE:To determine the efficacy and safety of Repronex SC as compared with Repronex IM and Pergonal IM in patients undergoing ovulation induction. DESIGN:Randomized, open-label, multicenter, parallel group study. SETTING:Ten academic and private fertility clinics with expertise in ovualtion induction. PATIENT(S)...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0015-0282(01)01856-8
更新日期：2001-07-01 00:00:00
abstract：:Bilateral hypogastric artery ligation followed by dilatation and evacuation under laparoscopic guidance was successful in the treatment of an advanced cesarean scar ectopic pregnancy. This case presents images of ultrasound, magnetic resonance imaging, and gross anatomy unique to cesarean scar pregnancy. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.12.016
更新日期：2006-05-01 00:00:00
abstract：:The preoperative use of a potent, subcutaneously injected gonadotropin-releasing hormone agonist (GnRH-a) was evaluated in a series of 60 women with large submucosal fibroids. Myomectomy by hysteroscopy and Nd:YAG laser was easily performed. In 12 cases, the largest portion of the myoma was not inside the uterine cavi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)53994-6
更新日期：1990-12-01 00:00:00
abstract：:Tamoxifen therapy in premenopausal women with breast cancer may be associated with the development of ovarian cysts. In this report, a case of ovarian torsion associated with TAM therapy is described. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55688-x
更新日期：1993-02-01 00:00:00
abstract：OBJECTIVE:To determine the relationships between sperm acrosin activity, sperm morphology evaluated according to strict criteria, visually observed acrosomal morphology, and IVF rates. DESIGN:Prospective analytic study. Acrosin activity was determined on all semen samples together with a standard semen analysis. Empha...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)58167-9
更新日期：1996-03-01 00:00:00
abstract：OBJECTIVE:To conduct clinical, genetic, and molecular diagnostics of two sisters with typical symptoms of complete androgen insensitivity syndrome. DESIGN:Case report. SETTING:Research laboratory at a university of medical science. PATIENT(S):Two patients with 46,XY karyotype and a female phenotype were diagnosed be...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.11.063
更新日期：2006-06-01 00:00:00
abstract：OBJECTIVES:To investigate whether endometrial thickness on the day of hCG administration is a predictor of intrauterine insemination (IUI) success. DESIGN:A retrospective study. PATIENT(S):Two hundred forty-nine women undergoing IUI cycles. SETTING:University hospital-based infertility center. INTERVENTION(S):Endom...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.12.010
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the impact of cryopreservation storage duration on embryo survival, implantation competence, and pregnancy outcome. DESIGN:Retrospective study. SETTING:Academic tertiary-referral infertility center. PATIENT(S):In vitro fertilization patients and recipients of oocyte donation cycles who had cryo...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.09.084
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:To study the effect of mifepristone on heparin-binding epidermal growth factor (HB-EGF) and its receptors HER1 and HER4 in the fallopian tube and in the endometrium. DESIGN:Prospective clinical study. SETTING:Hospital-based unit for obstetrics and gynecology and research laboratories. PATIENT(S):Healthy wo...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.08.011
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:To report the case of a female who presented in childhood with symptoms and signs of hyperandrogenism secondary to an extraovarian steroid cell tumor. DESIGN:Case report. SETTING:Endocrine investigation unit of a university teaching hospital. PATIENT(S):An 11-year-old female presented with symptoms and sig...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.06.055
更新日期：2006-01-01 00:00:00
abstract：:To understand the mechanism of action of danazol, the binding of danazol to multiple classes of intracellular steroid binding proteins was studied in the human uterine endometrium. Danazol bound to endometrial receptors for estrogen, progesterone, and androgen and seemed to bind to endometrial intracellular corticoste...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)47840-4
更新日期：1984-05-01 00:00:00
abstract：OBJECTIVE:Evaluate racial differences in reproducibility of hormone levels over time (estradiol, DHEAS, FSH, and testosterone) while adjusting for covariates previously identified as relevant in the study population. DESIGN:Longitudinal cohort study. SETTING:Healthy, late-reproductive-age women in a community-based s...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(00)01723-4
更新日期：2001-02-01 00:00:00
abstract：:The relaxin content of 92 normal semen samples and 85 semen samples selected at random was correlated to the parameters measured on routine semen analysis in those samples. The concentration of immunoactive relaxin in a sample of semen plasma did not correlate with any of the parameters commonly used for semen analysi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)59130-4
更新日期：1987-04-01 00:00:00
abstract：OBJECTIVE:To determine the incidence of ovarian hyperstimulation syndrome (OHSS) in a large series of GnRH antagonist-stimulated cycles and to assess the predictive value of E2 and the number of follicles on the day of hCG administration. DESIGN:Prospective cohort study of women undergoing IVF treatment with a GnRH an...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/j.fertnstert.2005.07.1292
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:To investigate the role of mutations or polymorphisms in the NPY-Y1R gene in human idiopathic central pubertal disorders. DESIGN:Molecular studies. SETTING:University hospital. PATIENT(S):Thirty-three patients with gonadotropin-dependent precocious puberty, 22 with hypogonadotropic hypogonadism, and 50 con...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.07.1519
更新日期：2007-03-01 00:00:00
abstract：:Surgical treatments offer effective solutions for many couples experiencing male factor infertility. This Views and Reviews collection of articles offers a state-of-the-art overview of the surgical procedures commonly used to treat impaired male reproductive health. ...
journal_title：Fertility and sterility
pub_type：
doi：10.1016/j.fertnstert.2019.01.005
更新日期：2019-03-01 00:00:00
abstract：:In 6-day pregnant New Zealand White rabbits dosed intravenously with 3H-nicotine, the 3H-activity in the uterine fluid was approximately 5 to 11 times greater than that in the plasma at the corresponding times; 3H-nicotine itself accounted for most of this radioactivity. Dichlorodiphenyltrichloroethane (DDT) also accu...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1976-10-01 00:00:00
abstract：OBJECTIVE:To evaluate how endometriosis affects expression of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) in granulosa cells. DESIGN:Prospective study. SETTING:IVF-ET program at Osaka Medical College. PATIENT(S):Seventeen patients with revised American Fertility Society stage IV endometriosis ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)03339-3
更新日期：2002-10-01 00:00:00
abstract：OBJECTIVE:To investigate the use of preimplantation genetic diagnosis (PGD) as a method for increasing pregnancy success rates in patients at high risk for aneuploidy. DESIGN:Literature review and discussion of current evidence. CONCLUSION(S):Preimplantation genetic diagnosis selects euploid embryos for transfer in a...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2005.06.045
更新日期：2006-01-01 00:00:00
