Abstract:
:To understand the mechanism of action of danazol, the binding of danazol to multiple classes of intracellular steroid binding proteins was studied in the human uterine endometrium. Danazol bound to endometrial receptors for estrogen, progesterone, and androgen and seemed to bind to endometrial intracellular corticosteroid-binding globulin and sex-hormone-binding globulin. Danazol occupies almost all binding sites of steroids in the steroid target cells in spite of the presence of endogenous steroids. It is speculated that the binding behavior of danazol may be related to its therapeutic effect on endometriosis. :Binding of danazol to multiple classes of intracellular steroid binding proteins was studied in the human uterine endometrium in an effort to understand danazol's mechanism of action. Danazol, which binds to human endometrial cytosol receptors for androgen (AR), progestin (PR), and estrogen (ER), also appears to interact with sex hormone binding globulin and corticosteroid binding globulin present in the cytosol preparations. 17 beta-hydroxy-17 alpha-methyl-estra-4, 9, 11-trine-3-one-[17 alpha-methyl-3h], 87 Ci/mmol (3H-R1881) binds to AR and PR in the human uterine endometirum. Thus, 3H-R1881/PR binding was abolished by the presence of progesterone. Previously reported studies have demonstrated that danazol binds with relatively high affinity to AR. Also, the danazol/AR complex can translocate to the nucleus. These findings are consistent with the observed androgenic effects of danazol in rats and women. Danazol binds with moderate affinity to PR. The danazol/PR complex is poorly translocated to the nucleus, suggesting that danazol is antiprogestational. Yet, a major metabolite of danazol, ethisterone, is progestational. The progestational vs. the antiprogestational effects of danazol remain controversial. Danazol displacement of 6, 7-3H-)stradial-17 beta (3H-E2) from ER is not parallel to E2 displacement of 3H-E2 when compared with that of PR or AR. This discrepancy may derive from an affinity difference. Danazol binds poorly to ER, yet circulating concentrations of danazol in vivo may lead to complete occupancy of the ER by danazol, which may interfere with normal endometrial ER dynamics, resulting in an antiestrogenic effect. Danazol occupies almost all binding sites of steroids in the steroid target cells despite the presence of endogenous steroids. The binding behavior of danazol may be related to its therapeutic effect on endometriosis.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Tamaya T,Wada K,Fujimoto J,Yamada T,Okada Hdoi
10.1016/s0015-0282(16)47840-4subject
Has Abstractpub_date
1984-05-01 00:00:00pages
732-5issue
5eissn
0015-0282issn
1556-5653pii
S0015-0282(16)47840-4journal_volume
41pub_type
杂志文章abstract:OBJECTIVE:To describe the treatments of a patient using the laparoscopic Davydov's method for Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome and ureteral reimplantation for hydronephrosis and hydroureter. DESIGN:Surgical video article. A consent form from the patient was obtained as appropriate; the nature of the stud...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2020.08.1433
更新日期:2020-10-14 00:00:00
abstract:OBJECTIVE:To evaluate and compare transforming growth factor β3 (TGF-β3) serum concentration in patients with uterine fibroids (UFs) without hormone treatment, treated with ulipristal acetate (UPA), and controls; to evaluate TGF-β3 concentrations in UF tissue in patients without hormone treatment and those treated with...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2017.11.023
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To examine differences in inflammation markers in sexually active versus abstinent women and observe changes in inflammation markers across the menstrual cycle. Cycle-related immune fluctuations may have evolved to reduce interference with conception. If so, reproductively active (i.e., sexually active) women...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.11.010
更新日期:2017-03-01 00:00:00
abstract::A study was undertaken comparing the outcomes of 30 women with infertility due to untreated severe (grade IV) pelvic endometriosis with a comparable series of 28 women whose infertility was caused solely by irreversible tubal disease. There were no significant differences in either the follicular phase or luteal phase...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60078-x
更新日期:1988-08-01 00:00:00
abstract::The effect of different concentrations of prolactin (0 to 60 ng) on the release of tetracycline from human spermatozoa labeled with 7-3H-tetracycline hydrochloride was studied. Prolactin significantly enhanced the release of bound tetracycline, indicating that prolactin may influence the processes associated with sper...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)43219-x
更新日期:1978-04-01 00:00:00
abstract::In this prospective study, we compared the results of bilateral varicocelectomy and left varicocelectomy for treatment of infertile patients with subclinical right and clinical left varicoceles with oligoasthenospermia. Because there was more improvement in semen parameters and pregnancy rate in patients who underwent...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.05.069
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety and efficacy of an antiprogesterone (mifepristone, RU486; Roussel-Uclaf, Romaineville, France) on endometriosis. DESIGN:An open, prospective clinical trial. SETTING:The clinical practice of an academic faculty. PATIENTS:Nine women with endometriosis were studied. INTERVENTIONS:RU486...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)58022-4
更新日期:1996-01-01 00:00:00
abstract::In this prospective, randomized clinical trial, we tested the hypothesis that a needle-free CO(2) injection system (Biojector 2000) would be better tolerated by patients when compared with traditional sharp needles used for gonadotropin injections during stimulation for IVF. As measured by our questionnaire, the needl...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2009.03.013
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To analyze relationship and parenthood in IVF twin couples, IVF singleton couples, and spontaneously pregnant primiparous couples. SETTING:Southeast region of Sweden. DESIGN:Prospective case-control study. PATIENT(S):In total, 24 women and men who became pregnant with twins, consecutively, and expected the...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.03.064
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To describe patients who at least once did not reply to correspondence of the center about embryo disposition. DESIGN:Anonymous questionnaire. SETTING:Department of Reproductive Medicine, Ghent University Hospital (Belgium). PATIENT(S):Patients whose embryos were stored for at least 2 years. INTERVENTION(...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.02.033
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To study and evaluate a sequential, extended embryo culture system. DESIGN:Prospective study. SETTING:University-affiliated IVF clinic. PATIENT(S):All couples who were treated between October 1997 and July 1998. INTERVENTION(S):A standard human tubal fluid plus 10% serum substitute supplement (SSS) cultur...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00294-0
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the potential clinical application of Raman spectroscopy (RS) as a tool that may identify spermatogenesis within human seminiferous tubules. DESIGN:RS scanning of human testicular tissue at different maturational stages; immunohistochemistry study and metabolomic analysis of nonobstructive azoosp...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.03.035
更新日期:2014-07-01 00:00:00
abstract::Sperm banking with the relatively simple and economical biologic freezer (Linde BF-5; Union Carbide Corporation, Linde Division, New York, N.Y.) was compared with controlled-rate freezer (Linde CRF-1; Union Carbide), using different freezing rates and cryoprotective media. The results were assessed by comparing prefre...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1981-05-01 00:00:00
abstract:OBJECTIVE:To present a report on assisted reproductive technologies (ART) cycles performed in 2005 in Canada. This is the fifth annual report from the Canadian ART Register (CARTR). DESIGN:Prospective cohort study. SETTING:Twenty-five of 25 ART centers in Canada. PARTICIPANT(S):Couples undergoing ART treatment in Ca...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.02.125
更新日期:2009-05-01 00:00:00
abstract::We present a rare case of a congenital isolated missing segment of the fallopian tube, including hysterosalpingographic and laparoscopic images. We conclude that when this occurs without concomitant müllerian anomalies, the mechanism of development would not be expected to be associated with an increase in renal abnor...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.01.012
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:To study the differences in the cleavage time between types of embryo chromosomal abnormalities and elaborate algorithm to exclude aneuploid embryos according to the likelihood to be euploid. DESIGN:Retrospective cohort study. SETTING:University affiliated private center. PATIENT(S):Preimplantational genet...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.09.019
更新日期:2017-01-01 00:00:00
abstract::The immune system plays a critical role in pregnancy establishment and maintenance, but application of immunological principles to the treatment of infertility and pregnancy loss has had a checkered past. Improving knowledge in this area holds great promise for improving the treatment of subfertile patients. ...
journal_title:Fertility and sterility
pub_type:
doi:10.1016/j.fertnstert.2016.07.1090
更新日期:2016-09-01 00:00:00
abstract::It is suggested that heparin given in the peri-implantation period may improve clinical outcomes in women undergoing assisted reproduction techniques (ART). This systematic review evaluates the use of heparin in subfertile women undergoing ART. ...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.fertnstert.2014.09.005
更新日期:2015-01-01 00:00:00
abstract::To examine pregnancy rate in patients undergoing controlled ovarian hyperstimulation (COH) with use of multidose GnRH antagonists in multiple repeated IVF cycle attempts, we conducted a survey in 785 consecutive IVF cycles in our unit. Although pregnancy rate significantly decreased beyond the second IVF cycle attempt...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.07.1725
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To introduce an effective approach for excision of ovarian endometrioma by "water injection"-assisted laparoscopy treatment. DESIGN:Step-by-step video explanation of the surgical procedure with still pictures and surgical video clips to demonstrate the detailed technique, approved by the Shengjing Hospital o...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2019.05.014
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of microdeletions of the long arm of chromosome Y within the AZFa, AZFb, and AZFc subregions in patients with idiopathic azoospermia, and then correlate the microdeletions with clinical phenotypes to determine the most important subregion for screening. DESIGN:Controlled clinical ...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(01)01955-0
更新日期:2001-09-01 00:00:00
abstract::A human embryo consisting of two cells, each containing two pronuclei, was found in the IVF laboratory. The most likely explanation for this phenomenon is a parthenogenetic activation of an oocyte leading to immediate cleavage and followed by double fertilization. Human chimerism may originate in this way. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53780-7
更新日期:1990-09-01 00:00:00
abstract::An attempt was made to develop an interclass somatic cell nuclear transfer method as an alternative means of establishing chicken embryonic stem cells. Chicken-to-cattle interclass embryos that activated calcium ionophore, cycloheximide, and cytochalasin D were developed into blastocysts, and the developing interclass...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.06.019
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:To determine whether retinoic acid (RA) can regulate the expression of interleukin (IL)-6 in human endometrial cells in a manner that might be beneficial to women with endometriosis. DESIGN:In vitro study. SETTING:Academic medical center. PATIENT(S):Patients with endometriosis and controls. INTERVENTION(S...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(00)00483-0
更新日期:2000-05-01 00:00:00
abstract::A prospective longitudinal and standardized study is presented, dealing with ultrasonographic and hormonal characteristics of the luteinized unruptured follicle (LUF) syndrome. Among 600 cycles monitored in 270 infertility patients, 40 cycles in 27 patients showed no evidence of follicle rupture, in spite of signs of ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)48494-3
更新日期:1985-04-01 00:00:00
abstract:OBJECTIVE:To investigate changes in plasma lipoprotein profile, hemostatic factors, platelet aggregation, endothelin-1, and cardiac function during postmenopausal sequential 6-month hormone replacement therapy (HRT). DESIGN:Open longitudinal prospective study. SETTING:Gynecologic department of a medical center. PATI...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)00487-1
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:To compare the localization and quantitation of epidermal growth factor (EGF) receptor in granulosa cells from women with normal and polycystic ovaries. DESIGN:Controlled, comparative study. SETTING:Academic research laboratory. PATIENT(S):Forty-two women with normal or polycystic ovaries who attended our ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(98)00252-0
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:To establish an intracytoplasmic sperm injection treatment program for couples with male infertility and to determine those factors important for success. DESIGN:A retrospective analysis of 171 consecutive cycles of intracytoplasmic sperm injection concerning 145 infertile couples. SETTING:Infertility clini...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57489-5
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVES:To determine, in a rabbit model, whether peritoneal exposure to dermoid cyst material produces inflammation and adhesions above control levels and whether saline lavage reduces the degree of peritoneal reaction. DESIGN:A prospective, randomized, blinded, controlled study of adhesion formation. Thirty New Ze...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)58225-9
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVE:To evaluate if apoptosis occurs in human germ cells between 19 and 33 gestational weeks (GW). DESIGN:Human fetal ovaries were obtained from aborted fetuses aged 19-33 GW. SETTING:Rabin Medical Center, a major tertiary care and referral center. PATIENT(S):Twenty-seven women undergoing pregnancy termination....
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)03218-1
更新日期:2002-08-01 00:00:00